LOCUS       NM_028478               1995 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus Ras association (RalGDS/AF-6) domain family member 6
            (Rassf6), transcript variant 1, mRNA.
ACCESSION   NM_028478 XM_132163
VERSION     NM_028478.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1995)
  AUTHORS   Morishita,M., Arimoto-Matsuzaki,K., Kitamura,M., Niimura,K.,
            Iwasa,H., Maruyama,J., Hiraoka,Y., Yamamoto,K., Kitagawa,M.,
            Miyamura,N., Nishina,H. and Hata,Y.
  TITLE     Characterization of mouse embryonic fibroblasts derived from Rassf6
            knockout mice shows the implication of Rassf6 in the regulation of
            NF-kappaB signaling
  JOURNAL   Genes Cells 26 (12), 999-1013 (2021)
   PUBMED   34652874
  REMARK    GeneRIF: Characterization of mouse embryonic fibroblasts derived
            from Rassf6 knockout mice shows the implication of Rassf6 in the
            regulation of NF-kappaB signaling.
REFERENCE   2  (bases 1 to 1995)
  AUTHORS   Sanada,Y., Kumoto,T., Suehiro,H., Nishimura,F., Kato,N., Hata,Y.,
            Sorisky,A. and Yanaka,N.
  TITLE     RASSF6 expression in adipocytes is down-regulated by interaction
            with macrophages
  JOURNAL   PLoS One 8 (4), e61931 (2013)
   PUBMED   23626755
  REMARK    GeneRIF: RASSF6 expression in adipocytes is down-regulated by
            interaction with macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1995)
  AUTHORS   Allen,N.P., Donninger,H., Vos,M.D., Eckfeld,K., Hesson,L.,
            Gordon,L., Birrer,M.J., Latif,F. and Clark,G.J.
  TITLE     RASSF6 is a novel member of the RASSF family of tumor suppressors
  JOURNAL   Oncogene 26 (42), 6203-6211 (2007)
   PUBMED   17404571
  REMARK    GeneRIF: Demonstrates properties of a Ras effector and tumor
            suppressor but exhibits biological properties that are unique and
            distinct from those of other family members.
REFERENCE   4  (bases 1 to 1995)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135240.2.
            
            On Jun 7, 2022 this sequence version replaced NM_028478.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC135240.2         18536-18671
            137-235             AC135240.2         27452-27550
            236-314             AC135240.2         41273-41351
            315-457             AC135240.2         43121-43263
            458-555             AC135240.2         49246-49343
            556-749             AC135240.2         50066-50259
            750-851             AC135240.2         52181-52282
            852-903             AC135240.2         52592-52643
            904-1022            AC135240.2         54694-54812
            1023-1120           AC135240.2         54918-55015
            1121-1995           AC135240.2         55110-55984
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..1995
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /note="Ras association (RalGDS/AF-6) domain family member
                     6"
                     /db_xref="GeneID:73246"
                     /db_xref="MGI:MGI:1920496"
     exon            1..136
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            137..235
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1196
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /note="isoform 1 is encoded by transcript variant 1; ras
                     association domain-containing protein 6"
                     /codon_start=1
                     /product="ras association domain-containing protein 6
                     isoform 1"
                     /protein_id="NP_082754.2"
                     /db_xref="CCDS:CCDS39142.1"
                     /db_xref="GeneID:73246"
                     /db_xref="MGI:MGI:1920496"
                     /translation="MTAMDHQFPSWIVVNESTSISREQLNYLLETYNVFYENQKNLHI
                     LYGQTEDGQLIVEGMLDIFWGVKRPIQLKIQDEKQISSFDLLNTPETFSSKGRMTRWG
                     EFDDLYRISELDRTHVLASEARHSPEDYLSYHSTLTPYADEEPESPLLYRTMSEAALV
                     RKRMRAPEMYRKDRMGVLSNHRASINGHVYDHETSIFTPTFGSETKVRANSIMRTEEV
                     IKQLLQKFKIENSPRDFALYIIFGTGEQRKLKKTDVPLLQRLLQGPSKSNARIFLMDK
                     DAEEISRDVAPYINFHFSFLESILQRLDEEEKMEIERIMAKFNTERAFILKCLQSKQA
                     AKTETTV"
     exon            236..314
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            315..457
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            458..555
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..749
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..851
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            852..903
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1022
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1120
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1995
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1973..1978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1995
                     /gene="Rassf6"
                     /gene_synonym="1600016B17Rik"
                     /note="major polyA site"
ORIGIN      
        1 actactgtaa gggacagctc gccacctcag gctccgcgct gcttggtcac aagagtctcc
       61 tttgcccggc acaaaagcag gtgaacttgg aggttgaagc gaagagcccc gctcagtcca
      121 cacacaggca caccagggca ccctcagatc atcttgggaa gggagaaagg atgacagcaa
      181 tggatcacca gttcccttct tggatcgttg tcaatgagag cacatccata agcagggaac
      241 aactcaatta tttactggag acttataatg ttttctatga aaaccagaaa aatctgcata
      301 tactgtatgg gcagaccgaa gacggacagc tgattgttga agggatgctg gacattttct
      361 ggggagtcaa acgacccata cagctgaaaa tacaagatga gaagcaaatc tcttcctttg
      421 atctgttgaa cacaccggaa accttttcca gcaaagggag gatgactcgc tggggagaat
      481 ttgatgacct ttaccgtatc agcgagctgg acaggaccca tgttctagca tctgaagcca
      541 ggcattcccc ggaagactat ttatcttacc acagcactct gacaccatac gcagacgaag
      601 agccggaatc cccattgctc tacaggacca tgagtgaggc agctttggtg agaaaaagga
      661 tgagggcccc agagatgtac agaaaagata gaatgggggt gctaagtaac cacagagcct
      721 ctatcaacgg acacgtctat gaccatgaga catccatctt caccccaact ttcggatcag
      781 agactaaggt cagagccaat agtatcatga gaactgaaga agtaataaag caacttctcc
      841 agaaatttaa gattgagaat agccctcggg atttcgctct ttacattatt tttgggacag
      901 gagagcagag aaagctaaag aagaccgatg tcccactgct gcagaggtta ctacaaggac
      961 catccaaaag caatgctcgg atcttcctca tggataaaga tgcagaagaa atcagcagag
     1021 atgtggctcc gtacattaat tttcactttt ctttcttgga atccatcctt caaagattag
     1081 atgaagaaga gaaaatggag attgagagaa ttatggcaaa attcaatacc gaaagggcct
     1141 ttatcctgaa gtgtctacag agtaaacagg cagctaaaac ggagaccaca gtctagaagc
     1201 cctgctcagc ggagttagag ggagcactgc agaatccgtg tgtggtctgc tctgcatcct
     1261 aatatgcatg gctctgaagc tttggacgaa cgaatgccga gcagcctgct tcctctttga
     1321 aatgcagagg ttggctgcgg ttcagagttg gactaaggca agatgggact tcatttcagt
     1381 aactgaaggg aagcctgcac actgcccatt ccaaatgtcc tcgatagcaa gttctcgggt
     1441 gagctcagac tcaagtggac tctgctctta tcacctggtt taagcttgtt ttatcttgcg
     1501 ctcttaaaag agccgagata cttgatgact cataaatgac gggaagtaaa catttccagt
     1561 tcctgatgtc aacaagaaac acattctcaa gccatcagcg atctgaactg accctgtttc
     1621 acagctgtgt aaacatctga gcattttcat aagatttagg aatagatcta caagggctga
     1681 tgattttaaa ctctgaagta tcagagtacc cgacctttta aaataaagtg gttttggatt
     1741 tttgtaaaga aacctaaact cgaggctgga gtgatggcta cgtggttaag agcattgact
     1801 acgcttccag aaatccccag ttcagttccc agcatctaca gggcaactgg caattatctg
     1861 caacccccgt cctagaggat ctggtaccca cctatgtggg cattgcaagc acggggcaca
     1921 cagacacaga gggaggcaaa acagctatat atgttataaa taaacaaata ttattaaaaa
     1981 aaacctaaac tctga
//
