LOCUS       NM_001411801            2461 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Ras association (RalGDS/AF-6) domain family member 1
            (Rassf1), transcript variant 6, mRNA.
ACCESSION   NM_001411801
VERSION     NM_001411801.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2461)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2461)
  AUTHORS   Gao,A., Bai,P., Zhang,M., Yao,Y., Herman,J.G. and Guo,M.
  TITLE     RASSF1A promotes ATM signaling and RASSF1A methylation is a
            synthetic lethal marker for ATR inhibitors
  JOURNAL   Epigenomics 15 (22), 1205-1220 (2023)
   PUBMED   38093706
  REMARK    GeneRIF: RASSF1A promotes ATM signaling and RASSF1A methylation is
            a synthetic lethal marker for ATR inhibitors.
REFERENCE   3  (bases 1 to 2461)
  AUTHORS   Liu,W., Xie,A., Xiong,J., Li,S., Yang,L. and Liu,W.
  TITLE     WDR3 promotes stem cell-like properties in prostate cancer by
            inhibiting USF2-mediated transcription of RASSF1A
  JOURNAL   J Gene Med 25 (7), e3498 (2023)
   PUBMED   36905106
  REMARK    GeneRIF: WDR3 promotes stem cell-like properties in prostate cancer
            by inhibiting USF2-mediated transcription of RASSF1A.
REFERENCE   4  (bases 1 to 2461)
  AUTHORS   Scheiter,A., Evert,K., Reibenspies,L., Cigliano,A., Annweiler,K.,
            Muller,K., Pohmerer,L.M., Xu,H., Cui,G., Itzel,T.,
            Materna-Reichelt,S., Coluccio,A., Honarnejad,K., Teufel,A.,
            Brochhausen,C., Dombrowski,F., Chen,X., Evert,M., Calvisi,D.F. and
            Utpatel,K.
  TITLE     RASSF1A independence and early galectin-1 upregulation in
            PIK3CA-induced hepatocarcinogenesis: new therapeutic venues
  JOURNAL   Mol Oncol 16 (5), 1091-1118 (2022)
   PUBMED   34748271
  REMARK    GeneRIF: RASSF1A independence and early galectin-1 upregulation in
            PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
REFERENCE   5  (bases 1 to 2461)
  AUTHORS   van Zogchel,L.M.J., Lak,N.S.M., Verhagen,O.J.H.M., Tissoudali,A.,
            Gussmalla Nuru,M., Gelineau,N.U., Zappeij-Kannengieter,L.,
            Javadi,A., Zijtregtop,E.A.M., Merks,J.H.M., van den
            Heuvel-Eibrink,M., Schouten-van Meeteren,A.Y.N., Stutterheim,J.,
            van der Schoot,C.E. and Tytgat,G.A.M.
  TITLE     Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies
            in Patients With Pediatric Solid Tumors
  JOURNAL   JCO Precis Oncol 5 (2021)
   PUBMED   34820594
  REMARK    GeneRIF: Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid
            Biopsies in Patients With Pediatric Solid Tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2461)
  AUTHORS   Tommasi,S., Dammann,R., Zhang,Z., Wang,Y., Liu,L., Tsark,W.M.,
            Wilczynski,S.P., Li,J., You,M. and Pfeifer,G.P.
  TITLE     Tumor susceptibility of Rassf1a knockout mice
  JOURNAL   Cancer Res 65 (1), 92-98 (2005)
   PUBMED   15665283
  REMARK    GeneRIF: Deletion of this gene increases cancer susceptibility in
            mice.
REFERENCE   7  (bases 1 to 2461)
  AUTHORS   Tommasi,S., Dammann,R., Jin,S.G., Zhang,X.F., Avruch,J. and
            Pfeifer,G.P.
  TITLE     RASSF3 and NORE1: identification and cloning of two human
            homologues of the putative tumor suppressor gene RASSF1
  JOURNAL   Oncogene 21 (17), 2713-2720 (2002)
   PUBMED   11965544
REFERENCE   8  (bases 1 to 2461)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2461)
  AUTHORS   Burbee,D.G., Forgacs,E., Zochbauer-Muller,S., Shivakumar,L.,
            Fong,K., Gao,B., Randle,D., Kondo,M., Virmani,A., Bader,S.,
            Sekido,Y., Latif,F., Milchgrub,S., Toyooka,S., Gazdar,A.F.,
            Lerman,M.I., Zabarovsky,E., White,M. and Minna,J.D.
  TITLE     Epigenetic inactivation of RASSF1A in lung and breast cancers and
            malignant phenotype suppression
  JOURNAL   J Natl Cancer Inst 93 (9), 691-699 (2001)
   PUBMED   11333291
REFERENCE   10 (bases 1 to 2461)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672219.7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.5147064.1,
                                           SRR1660813.220069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1079              AL672219.7         127789-128867
            1080-1184           AL672219.7         130602-130706
            1185-1482           AL672219.7         130919-131216
            1483-1598           AL672219.7         131336-131451
            1599-2461           AL672219.7         134548-135410
FEATURES             Location/Qualifiers
     source          1..2461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.12 cM"
     gene            1..2461
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="Ras association (RalGDS/AF-6) domain family member
                     1"
                     /db_xref="GeneID:56289"
                     /db_xref="MGI:MGI:1928386"
     exon            1..1079
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1184
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     CDS             1176..1745
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="isoform 4 is encoded by transcript variant 6; Ras
                     association (RalGDS/AF-6) domain family 1; RASSF1A tumor
                     suppressor; ras association domain-containing protein 1;
                     protein 123F2; 123F protein"
                     /codon_start=1
                     /product="ras association domain-containing protein 1
                     isoform 4"
                     /protein_id="NP_001398730.1"
                     /db_xref="GeneID:56289"
                     /db_xref="MGI:MGI:1928386"
                     /translation="MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGTGRS
                     TAVKRRTSFYLPKDAIKHLHVLSRTRAREVIEALLRKFMVVDDPRKFALFERTERHGQ
                     VYLRKLSDDEQPLKLRLLAGPSEKALSFVLKENDSGEVNWDAFSMPELHNFLRILQRE
                     EEEHLRQILQKYSRCRQKIQEALHACPLG"
     exon            1185..1482
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1598
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..2461
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2443..2448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="hexamer: AATAAA"
     polyA_site      2461
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="major polyA site"
ORIGIN      
        1 agtcctaacg gttgccgcgc ggcgctggcc tccgcgcaag cgcgacctga cacactcaca
       61 cgcacgcacg cacgcacgcg cccgaggcgg tggttagagg ctctccacgc agtggactag
      121 ggatcgggcg ggtaaggcga tgggcgaggc tgaaacacct tccttcgaaa tgacctggag
      181 cagcacaacc agcagtggct actgcagcca ggaggactcg gactcggagc tcgagcagta
      241 cttcacggcg cgtacctcgc tggtccgcag gccgcgtcgg gaccaggtgg ggagcccggg
      301 gggtgccgcc ggcgggtgag gggcggtcgc tggaaccccg cccctccccg gtaagttgcg
      361 gcctggaaag ttaggtgatg ggcagcctcc ccgcctctcc atagcgagcc actcggaggg
      421 tcctgacaaa agcgaggaag cgtacgtagg gttctctgtc ccgagtagaa gcccagttcc
      481 agcgcgatgg tactgaggac ccaggctacc ctgcccttgc agtcacagac cggttgagcc
      541 agggggaagc aactctgaag cttgaagggt ggaccacagg cgggcgtttt tcacccatga
      601 ctaaagccag actcgcaatc caaaccggcg tcttgatttc gcatttgggc gctcccactc
      661 cctccctggg ggaaatgagg aagtggagga ggagtccacc gggaagtgag aagttagttt
      721 gggaggggac tctggccgtg ccgtgatgcg gtcttggatc agccagcaaa gtgcccagcc
      781 gttgctcgac caactctttg acaccagctg ctggactcga tctttctttc ctccatggtg
      841 gaactgtgca gagggatttg gggaattcag gaagagggcc ttaaaagact attaaaaaaa
      901 aaaaagtgtg gtaccagggc agctgaacct ctttaaaaag tctagatgtg cccaaattat
      961 ccgactttct gggaatatca tagttgtggc caccaagctc ggataacttg ttctggagcg
     1021 ggaatccctc ggaacagcac agaggccagc gaatcaggaa agtgaggacg gagactgagg
     1081 atgaggctgt agagcgggag acacccgatc tttctcaagc tgagactgag cagaaaatca
     1141 aggactacaa tggccagatc aacagcaacc tcttcatgag cctgaataag gatggctcct
     1201 acacaggctt catcaaggtt cagctgaaac tagtgcgtcc tgtttcagtg ccttccagca
     1261 agaaaccacc ttccttacag gacgcccgga gaggtacggg gcggagcaca gccgtgaagc
     1321 gccgcacctc tttttacttg cctaaggatg ctattaagca tctgcatgtt ctatcacgaa
     1381 cacgggcacg tgaggtcatt gaggccctgc ttcgaaaatt catggtcgta gatgatcctc
     1441 gcaagtttgc actctttgag cgaactgaac ggcatggcca agtatacctc cggaagctgt
     1501 cggatgacga gcagcccttg aagctgcggc ttcttgcagg gcccagtgaa aaagccctga
     1561 gctttgtcct gaaggaaaat gactcgggag aggtgaactg ggatgccttc agcatgcctg
     1621 aactgcacaa tttcctacga atcctgcagc gggaagaaga ggaacacctt cgccagatcc
     1681 tgcagaagta ttctcgttgt cgccagaaga tccaggaggc tctgcacgcc tgtcctttgg
     1741 ggtgaccttg ggtctccatg gatgacagga ggagaacagg cagtgcaaag agcgtgccgt
     1801 gtgagtgtga cagggcctgt ggggcctgag gagtgcgtgt gcatggaggt cctcctctgc
     1861 tgaccgggat gagcccagag aacagggaaa gagccagccg tctacctgtg gatatagtgg
     1921 ggcggggctt tgcatccctc tgcccgtatg tactgggtca tactctgcgt agctgctcaa
     1981 gtcacagggt cgcagctgtg agaatcttag agactctaca gacaaaacaa ggttatattt
     2041 tcacgggtaa gagaccttac ctatggagaa agattgtttt gagtcatgaa tgggtctcag
     2101 gatagcccta tcagagccaa gggtagctgc tcagaataat acaagcaatt aaggtagagt
     2161 ctggggttcc ctcttaccgt gccttctgac ttccaaacaa acaccctggg gtcagagagg
     2221 gctggccagt acaacaacta cagtggctca gtcagtgcct cctctaaggg aaaggttgct
     2281 ggaccagacc ctcttcttgt ttgccaaagc cagagtctcc ctcagatatt tttgatggaa
     2341 gtgtatgaat gtatgtaatg ttttgtggcc tcaactgaat gtggggaagg gatgggggtg
     2401 tgacagtcat catcagggcc tgatgcctga gagaattggc tgaataaaga tgtaagaatt
     2461 t
//
