LOCUS       NM_001243748            1783 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Ras association (RalGDS/AF-6) domain family member 1
            (Rassf1), transcript variant 1, mRNA.
ACCESSION   NM_001243748
VERSION     NM_001243748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Gao,A., Bai,P., Zhang,M., Yao,Y., Herman,J.G. and Guo,M.
  TITLE     RASSF1A promotes ATM signaling and RASSF1A methylation is a
            synthetic lethal marker for ATR inhibitors
  JOURNAL   Epigenomics 15 (22), 1205-1220 (2023)
   PUBMED   38093706
  REMARK    GeneRIF: RASSF1A promotes ATM signaling and RASSF1A methylation is
            a synthetic lethal marker for ATR inhibitors.
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Liu,W., Xie,A., Xiong,J., Li,S., Yang,L. and Liu,W.
  TITLE     WDR3 promotes stem cell-like properties in prostate cancer by
            inhibiting USF2-mediated transcription of RASSF1A
  JOURNAL   J Gene Med 25 (7), e3498 (2023)
   PUBMED   36905106
  REMARK    GeneRIF: WDR3 promotes stem cell-like properties in prostate cancer
            by inhibiting USF2-mediated transcription of RASSF1A.
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Scheiter,A., Evert,K., Reibenspies,L., Cigliano,A., Annweiler,K.,
            Muller,K., Pohmerer,L.M., Xu,H., Cui,G., Itzel,T.,
            Materna-Reichelt,S., Coluccio,A., Honarnejad,K., Teufel,A.,
            Brochhausen,C., Dombrowski,F., Chen,X., Evert,M., Calvisi,D.F. and
            Utpatel,K.
  TITLE     RASSF1A independence and early galectin-1 upregulation in
            PIK3CA-induced hepatocarcinogenesis: new therapeutic venues
  JOURNAL   Mol Oncol 16 (5), 1091-1118 (2022)
   PUBMED   34748271
  REMARK    GeneRIF: RASSF1A independence and early galectin-1 upregulation in
            PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   van Zogchel,L.M.J., Lak,N.S.M., Verhagen,O.J.H.M., Tissoudali,A.,
            Gussmalla Nuru,M., Gelineau,N.U., Zappeij-Kannengieter,L.,
            Javadi,A., Zijtregtop,E.A.M., Merks,J.H.M., van den
            Heuvel-Eibrink,M., Schouten-van Meeteren,A.Y.N., Stutterheim,J.,
            van der Schoot,C.E. and Tytgat,G.A.M.
  TITLE     Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies
            in Patients With Pediatric Solid Tumors
  JOURNAL   JCO Precis Oncol 5 (2021)
   PUBMED   34820594
  REMARK    GeneRIF: Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid
            Biopsies in Patients With Pediatric Solid Tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Tommasi,S., Dammann,R., Zhang,Z., Wang,Y., Liu,L., Tsark,W.M.,
            Wilczynski,S.P., Li,J., You,M. and Pfeifer,G.P.
  TITLE     Tumor susceptibility of Rassf1a knockout mice
  JOURNAL   Cancer Res 65 (1), 92-98 (2005)
   PUBMED   15665283
  REMARK    GeneRIF: Deletion of this gene increases cancer susceptibility in
            mice.
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Tommasi,S., Dammann,R., Jin,S.G., Zhang,X.F., Avruch,J. and
            Pfeifer,G.P.
  TITLE     RASSF3 and NORE1: identification and cloning of two human
            homologues of the putative tumor suppressor gene RASSF1
  JOURNAL   Oncogene 21 (17), 2713-2720 (2002)
   PUBMED   11965544
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Burbee,D.G., Forgacs,E., Zochbauer-Muller,S., Shivakumar,L.,
            Fong,K., Gao,B., Randle,D., Kondo,M., Virmani,A., Bader,S.,
            Sekido,Y., Latif,F., Milchgrub,S., Toyooka,S., Gazdar,A.F.,
            Lerman,M.I., Zabarovsky,E., White,M. and Minna,J.D.
  TITLE     Epigenetic inactivation of RASSF1A in lung and breast cancers and
            malignant phenotype suppression
  JOURNAL   J Natl Cancer Inst 93 (9), 691-699 (2001)
   PUBMED   11333291
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672219.7.
            
            On Sep 2, 2022 this sequence version replaced NM_001243748.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.5665707.1, EU314810.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AL672219.7         124702-124995
            295-401             AL672219.7         127287-127393
            402-506             AL672219.7         130602-130706
            507-804             AL672219.7         130919-131216
            805-920             AL672219.7         131336-131451
            921-1783            AL672219.7         134548-135410
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.12 cM"
     gene            1..1783
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="Ras association (RalGDS/AF-6) domain family member
                     1"
                     /db_xref="GeneID:56289"
                     /db_xref="MGI:MGI:1928386"
     exon            1..294
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1067
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="isoform 1 is encoded by transcript variant 1; Ras
                     association (RalGDS/AF-6) domain family 1; RASSF1A tumor
                     suppressor; ras association domain-containing protein 1;
                     protein 123F2; 123F protein"
                     /codon_start=1
                     /product="ras association domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001230677.1"
                     /db_xref="CCDS:CCDS57699.1"
                     /db_xref="GeneID:56289"
                     /db_xref="MGI:MGI:1928386"
                     /translation="MSAEPELIELRELAPSGRIGPGRTRLERANALRIAPGTTRNPSQ
                     QHVPGRGHRFQPAGPTTHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCC
                     GPRDLGWDSALERDTNVDEAVERETPDLSQAETEQKIKDYNGQINSNLFMSLNKDGSY
                     TGFIKVQLKLVRPVSVPSSKKPPSLQDARRGTGRSTAVKRRTSFYLPKDAIKHLHVLS
                     RTRAREVIEALLRKFMVVDDPRKFALFERTERHGQVYLRKLSDDEQPLKLRLLAGPSE
                     KALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSRCRQKIQEAL
                     HACPLG"
     exon            295..401
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     exon            402..506
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     exon            507..804
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     exon            805..920
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1783
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="hexamer: AATAAA"
     polyA_site      1783
                     /gene="Rassf1"
                     /gene_synonym="123F2; NORE2A; Rassf1A; Rassf1B; Rassf1C;
                     RDA32; REH3P21"
                     /note="major polyA site"
ORIGIN      
        1 actcactagc tgctagtccg ctacagcacc ggcctgaccg ggccatgtcg gcggagccag
       61 aactcattga actacgcgag ctggcaccgt ccgggcgcat cggtccaggc cgtacccggc
      121 tggagcgtgc caacgctctg cgcatcgccc cgggtacaac acgcaatccg tcacagcagc
      181 acgtcccggg tcgtggccac cgtttccagc ctgcagggcc caccacgcac acgtggtgcg
      241 acctctgtgg agacttcatc tggggcgtcg tgcgcaaggg cctacagtgc gcgcactgca
      301 agttcacctg ccattaccgt tgtcgcgcgc tcgtctgctt ggactgctgc gggccccgag
      361 acctgggctg ggactctgca ctagagcggg atacgaacgt ggatgaggct gtagagcggg
      421 agacacccga tctttctcaa gctgagactg agcagaaaat caaggactac aatggccaga
      481 tcaacagcaa cctcttcatg agcctgaata aggatggctc ctacacaggc ttcatcaagg
      541 ttcagctgaa actagtgcgt cctgtttcag tgccttccag caagaaacca ccttccttac
      601 aggacgcccg gagaggtacg gggcggagca cagccgtgaa gcgccgcacc tctttttact
      661 tgcctaagga tgctattaag catctgcatg ttctatcacg aacacgggca cgtgaggtca
      721 ttgaggccct gcttcgaaaa ttcatggtcg tagatgatcc tcgcaagttt gcactctttg
      781 agcgaactga acggcatggc caagtatacc tccggaagct gtcggatgac gagcagccct
      841 tgaagctgcg gcttcttgca gggcccagtg aaaaagccct gagctttgtc ctgaaggaaa
      901 atgactcggg agaggtgaac tgggatgcct tcagcatgcc tgaactgcac aatttcctac
      961 gaatcctgca gcgggaagaa gaggaacacc ttcgccagat cctgcagaag tattctcgtt
     1021 gtcgccagaa gatccaggag gctctgcacg cctgtccttt ggggtgacct tgggtctcca
     1081 tggatgacag gaggagaaca ggcagtgcaa agagcgtgcc gtgtgagtgt gacagggcct
     1141 gtggggcctg aggagtgcgt gtgcatggag gtcctcctct gctgaccggg atgagcccag
     1201 agaacaggga aagagccagc cgtctacctg tggatatagt ggggcggggc tttgcatccc
     1261 tctgcccgta tgtactgggt catactctgc gtagctgctc aagtcacagg gtcgcagctg
     1321 tgagaatctt agagactcta cagacaaaac aaggttatat tttcacgggt aagagacctt
     1381 acctatggag aaagattgtt ttgagtcatg aatgggtctc aggatagccc tatcagagcc
     1441 aagggtagct gctcagaata atacaagcaa ttaaggtaga gtctggggtt ccctcttacc
     1501 gtgccttctg acttccaaac aaacaccctg gggtcagaga gggctggcca gtacaacaac
     1561 tacagtggct cagtcagtgc ctcctctaag ggaaaggttg ctggaccaga ccctcttctt
     1621 gtttgccaaa gccagagtct ccctcagata tttttgatgg aagtgtatga atgtatgtaa
     1681 tgttttgtgg cctcaactga atgtggggaa gggatggggg tgtgacagtc atcatcaggg
     1741 cctgatgcct gagagaattg gctgaataaa gatgtaagaa ttt
//
