LOCUS       NM_028544               3169 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus Ras interacting protein 1 (Rasip1), mRNA.
ACCESSION   NM_028544 NM_027253 XM_485931
VERSION     NM_028544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3169)
  AUTHORS   Qu,X., Harmelink,C. and Baldwin,H.S.
  TITLE     Tie2 regulates endocardial sprouting and myocardial trabeculation
  JOURNAL   JCI Insight 5 (13), 96002 (2019)
   PUBMED   31112136
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3169)
  AUTHORS   Liu,X., Gu,X., Ma,W., Oxendine,M., Gil,H.J., Davis,G.E., Cleaver,O.
            and Oliver,G.
  TITLE     Rasip1 controls lymphatic vessel lumen maintenance by regulating
            endothelial cell junctions
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30042182
  REMARK    GeneRIF: Rasip1 regulates Cdc42 activity to regulate cell junctions
            and cytoskeleton organization, which are both activities required
            for lymphatic lumen maintenance
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3169)
  AUTHORS   Azizoglu,D.B., Chong,D.C., Villasenor,A., Magenheim,J., Barry,D.M.,
            Lee,S., Marty-Santos,L., Fu,S., Dor,Y. and Cleaver,O.
  TITLE     Vascular development in the vertebrate pancreas
  JOURNAL   Dev Biol 420 (1), 67-78 (2016)
   PUBMED   27789228
REFERENCE   4  (bases 1 to 3169)
  AUTHORS   Barry,D.M., Koo,Y., Norden,P.R., Wylie,L.A., Xu,K., Wichaidit,C.,
            Azizoglu,D.B., Zheng,Y., Cobb,M.H., Davis,G.E. and Cleaver,O.
  TITLE     Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel
            Tubulogenesis via Nonmuscle Myosin II
  JOURNAL   Circ Res 119 (7), 810-826 (2016)
   PUBMED   27486147
  REMARK    GeneRIF: Rasip1 controls different pools of GTPases, which in turn
            regulates blood vessel tubulogenesis.
REFERENCE   5  (bases 1 to 3169)
  AUTHORS   Koo,Y., Barry,D.M., Xu,K., Tanigaki,K., Davis,G.E., Mineo,C. and
            Cleaver,O.
  TITLE     Rasip1 is essential to blood vessel stability and angiogenic blood
            vessel growth
  JOURNAL   Angiogenesis 19 (2), 173-190 (2016)
   PUBMED   26897025
  REMARK    GeneRIF: Rasip1 is necessary in growing embryonic blood vessels.
REFERENCE   6  (bases 1 to 3169)
  AUTHORS   Xu,K., Sacharidou,A., Fu,S., Chong,D.C., Skaug,B., Chen,Z.J.,
            Davis,G.E. and Cleaver,O.
  TITLE     Blood vessel tubulogenesis requires Rasip1 regulation of GTPase
            signaling
  JOURNAL   Dev Cell 20 (4), 526-539 (2011)
   PUBMED   21396893
  REMARK    GeneRIF: Mice lacking Rasip1 fail to form patent lumens in all
            blood vessels, including the early endocardial tube. Rasipl null
            angioblasts fail to properly localize the polarity determinant Par3
            and display defective cell polarity.
REFERENCE   7  (bases 1 to 3169)
  AUTHORS   Xu,K., Chong,D.C., Rankin,S.A., Zorn,A.M. and Cleaver,O.
  TITLE     Rasip1 is required for endothelial cell motility, angiogenesis and
            vessel formation
  JOURNAL   Dev Biol 329 (2), 269-279 (2009)
   PUBMED   19272373
  REMARK    GeneRIF: Rasip1 expression is undetectable in VEGFR2 null embryos,
            which lack endothelial cells, suggesting that Rasip1 is endothelial
            specific. siRNA-mediated reduction of Rasip1 severely impairs
            angiogenesis and motility in endothelial cell cultures
REFERENCE   8  (bases 1 to 3169)
  AUTHORS   Wallgard,E., Larsson,E., He,L., Hellstrom,M., Armulik,A.,
            Nisancioglu,M.H., Genove,G., Lindahl,P. and Betsholtz,C.
  TITLE     Identification of a core set of 58 gene transcripts with broad and
            specific expression in the microvasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1469-1476 (2008)
   PUBMED   18483404
REFERENCE   9  (bases 1 to 3169)
  AUTHORS   Mitin,N.Y., Ramocki,M.B., Zullo,A.J., Der,C.J., Konieczny,S.F. and
            Taparowsky,E.J.
  TITLE     Identification and characterization of rain, a novel
            Ras-interacting protein with a unique subcellular localization
  JOURNAL   J Biol Chem 279 (21), 22353-22361 (2004)
   PUBMED   15031288
  REMARK    GeneRIF: Rain is a novel protein that can serve as an effector of
            endomembrane-localized Ras
REFERENCE   10 (bases 1 to 3169)
  AUTHORS   Ho,M., Yang,E., Matcuk,G., Deng,D., Sampas,N., Tsalenko,A.,
            Tabibiazar,R., Zhang,Y., Chen,M., Talbi,S., Ho,Y.D., Wang,J.,
            Tsao,P.S., Ben-Dor,A., Yakhini,Z., Bruhn,L. and Quertermous,T.
  TITLE     Identification of endothelial cell genes by combined database
            mining and microarray analysis
  JOURNAL   Physiol Genomics 13 (3), 249-262 (2003)
   PUBMED   12644598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028483.1, BB646451.1, AK033276.1, BU054468.1 and CO039349.1.
            
            On or before May 14, 2005 this sequence version replaced
            NM_027253.3, XM_485931.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150766.1, AK156602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               BC028483.1         1-608
            609-978             BB646451.1         218-587
            979-1572            AK033276.1         267-860
            1573-1623           BU054468.1         527-577
            1624-2868           AK033276.1         912-2156
            2869-3169           CO039349.1         1-301               c
FEATURES             Location/Qualifiers
     source          1..3169
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.39 cM"
     gene            1..3169
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /note="Ras interacting protein 1"
                     /db_xref="GeneID:69903"
                     /db_xref="MGI:MGI:1917153"
     exon            1..54
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            55..195
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2944
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /codon_start=1
                     /product="ras-interacting protein 1"
                     /protein_id="NP_082820.1"
                     /db_xref="CCDS:CCDS21256.1"
                     /db_xref="GeneID:69903"
                     /db_xref="MGI:MGI:1917153"
                     /translation="MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAAS
                     VKSSSSDTGSRSSEPLPPPPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGAGG
                     AGGPGTPGGAQRWASEKKLPELAAGVAPEPPLPTRAAVPPGVLKIFASGLASGANYKS
                     VLATERSTARELVAEALERYGLTGGRGAGDSGCVDAYALCDALGRPAVGVGGGEWRAE
                     HLRVLADAERPLLVQDLWRARPGWARRFELRGREEARRLEQEAFGAADADGTNAPSWR
                     TQKNRSRAASGGAALASPGPGSGSGTPTGSGGKERSENLSLRRSVSELSLQGRRRRQQ
                     ERRQQALSMAPGAADAQMVPTDPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVY
                     VMTREQHVFGRGGPSSSRGGSPAPYVDTFLNAPDILPRHCTVRAGPEPPAMVRPSRGA
                     PVTHNGCLLLREAELHPGDLLGLGEHFLFMYKDPRSGGSGPARPSWLPARPGAAPPGP
                     GWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIVRAAASGAGDLPP
                     LGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWEKIKEIGDRQPENHPEGVP
                     EVPLTPEAVSVELRPLILWMANTTELLSFVQEKVLEMEKEADQEGLSSDPQLCNDLEL
                     CDEALALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELEAMPP
                     GLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWS
                     RAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSIAVNLLCVPRTSLLKASWSSLRTDY
                     PTLTPAQLHHLLSHYQLGPGRGPPPAWDPPPAERDAVDTGDIFESFSSHPPLILPLGS
                     SRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANHRHGPPVASTP"
     exon            196..863
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1219
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1873
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1911
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2063
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2179
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2423
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2596
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2744
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..3152
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /note="hexamer: AATAAA"
     polyA_site      3152
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /note="major polyA site"
ORIGIN      
        1 ttaacggagg ccaacagcac cagggcctcc gggtgctacg ggacccgaag caggggccat
       61 gctatctggt gaacgaaagg agggcggaag cccccgcttc gggaagctcc atcttccagt
      121 gggcctgtgg atcaattccc caaggaaaca gctcgccaaa ctggggcggc gctggcccag
      181 cgctgcctct gtcaagtcct cgtcctccga cacggggagc cgaagcagcg agcccctgcc
      241 gccgccgccg ccgccgccgc acgtggagct gcggcgcgta ggtgcggtga aggcggcggg
      301 gggagcgtcg ggcagccgag ccaagcgcat ctcgcagctg tttcggggct caggggccgg
      361 cggcgccggg ggtcctggca cgcctggggg cgcgcagcgc tgggccagcg agaagaagct
      421 gcctgaactg gcggcgggtg tagctccgga gcccccgttg cccacgcgtg ccgcggtgcc
      481 cccgggagtg ctcaagatct tcgcttctgg gctggcgtcg ggcgccaact acaagagcgt
      541 gctggctacg gagcgatcca ccgcgcgcga gctggtggcg gaggcgctgg agcgctacgg
      601 gctgacgggc ggccgcggag cgggcgacag cggctgcgtg gacgcctacg cgctttgcga
      661 cgctctgggc cggcccgcgg tcggcgtggg cggaggcgag tggcgtgccg agcacctgcg
      721 ggtgttggcc gacgcggagc gccctctgct ggtgcaggac ctgtggcgcg cccgtccggg
      781 ctgggcgcgg cgctttgagc tgcgcggccg cgaggaggct cgacggctgg agcaggaggc
      841 cttcggggct gcggatgcag acggcacaaa cgccccatct tggcggaccc agaagaatag
      901 gtctcgggca gcatctggcg gggcagctct ggccagtcct ggtccaggat caggatccgg
      961 gacccccact gggtccgggg gcaaggagcg atctgaaaat ttgtctctgc gtcgaagcgt
     1021 gtctgagctg agtctacagg ggcggaggcg aaggcagcag gaacgcaggc agcaggccct
     1081 tagcatggcc ccaggggcag ctgatgctca gatggtacca acggaccctg gagacttcga
     1141 tcagttgact cagtgcctca ttcaggcacc cagcaaccgt ccctacttcc ttctgctcca
     1201 gggctaccag gatgctcagg acttcgtggt gtatgtcatg acacgagagc agcacgtgtt
     1261 cggccggggt gggccctcct cgtcccgcgg gggatcccca gccccatatg tggacacctt
     1321 cctcaacgcc ccagacatcc tgcctcgaca ttgcacggtg cgcgcgggcc ctgagccccc
     1381 ggccatggtg cgcccatccc ggggcgcccc cgtcacacac aatggctgtc ttttgctgcg
     1441 ggaggcagag ctgcaccccg gagacctgtt aggcctagga gagcatttcc tgttcatgta
     1501 caaggacccc cgctccgggg gttctgggcc cgctcggcca tcttggctgc cagcgcgccc
     1561 cggggccgcg ccacccggac cgggctgggc cttttcttgt cgtttgtgtg gccgtggcct
     1621 gcaggagcgc ggcgaggcgc tggccgccta cctggatggc cgcgagccgg tgctgcggtt
     1681 cagaccacga gaggaagagg cgctgttggg cgagatcgtg cgagctgcag cctcgggagc
     1741 aggggacctg cccccgctcg ggccagccac tctgctggca ctgtgtgtgc agcattctgc
     1801 gagggagctg gagctgggcc acctgcctcg cttgctgggc cgcctggccc ggctcatcaa
     1861 agaagccgtt tgggaaaaaa ttaaagaaat tggagaccgc cagccagaga accacccaga
     1921 gggagttccc gaggtgcctc tgacccctga ggctgtgtct gtggagctgc gaccactcat
     1981 actatggatg gccaacacca cagagctgtt gagctttgta caggagaaag tgctagagat
     2041 ggagaaggag gctgaccagg agggcctgtc ctcggaccca cagctctgca atgacttgga
     2101 actgtgtgat gaggccttgg ccctcctgga tgaggtcatc atgtgtactt tccagcagtc
     2161 ggtctactac ctcaccaaga ctctttattc aacactgcca gctctcctgg acagtaaccc
     2221 tttcacagct ggagcagagc tgccagggcc tggcgcagag ctggaggcca tgccgcctgg
     2281 gctcaggcct actctgggtg tgttccaggc agctctagaa ctgaccagtc agtgtgagct
     2341 gcatcccgac ctcgtgtccc agacttttgg ctatttgttc ttcttctcca atgcatccct
     2401 tctcaactca ctgatggaac gaggtcaagg ccgacctttc tatcaatggt ctcgagccgt
     2461 ccaaatcaga accaacttgg atcttgtgtt ggattggctt cagggggccg ggctgggtga
     2521 cattgccact gagttcttcc ggaaactttc cattgctgtg aacctgctat gtgtgccccg
     2581 cacctccctg ctcaaggctt catggagcag cttacggact gactacccca ccctgactcc
     2641 agctcagctc caccatctcc tcagccacta ccagttgggt cctggccgtg gtcccccacc
     2701 agcctgggac ccaccacctg cagagcggga tgctgtggac acaggggata tctttgaaag
     2761 tttttcctcg caccctccgc tcatcctgcc cctgggcagc tcacgcctgc gcctcaccgg
     2821 ccctgtgaca gatgacgcat tgcatagaga actgcgcagg ctccgtcgcc tcctctggga
     2881 tcttgaacag caggagctgc cagccaatca tcgccatgga cccccggtgg cttcgacacc
     2941 ttgaaaacca atgagaaagg aacgcgcgca gcttgaaact gcatcgcttc ttaaaaggga
     3001 gcccgcctgg gcgtagagca ttttgggagt tgtagttttc cctgcgtaga cggctgagag
     3061 tttgagttgt tgggttggta gacgatggga cagtgggaag atgggcttgg gatgtgaatg
     3121 ccaagaagta ataaaaatat ctgtggtatt gaaaaaaaaa aaaaaaaaa
//
