LOCUS       NP_082820                961 aa            linear   ROD 24-DEC-2024
DEFINITION  ras-interacting protein 1 [Mus musculus].
ACCESSION   NP_082820 NP_081529 XP_485931
VERSION     NP_082820.1
DBSOURCE    REFSEQ: accession NM_028544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 961)
  AUTHORS   Qu,X., Harmelink,C. and Baldwin,H.S.
  TITLE     Tie2 regulates endocardial sprouting and myocardial trabeculation
  JOURNAL   JCI Insight 5 (13), 96002 (2019)
   PUBMED   31112136
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 961)
  AUTHORS   Liu,X., Gu,X., Ma,W., Oxendine,M., Gil,H.J., Davis,G.E., Cleaver,O.
            and Oliver,G.
  TITLE     Rasip1 controls lymphatic vessel lumen maintenance by regulating
            endothelial cell junctions
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30042182
  REMARK    GeneRIF: Rasip1 regulates Cdc42 activity to regulate cell junctions
            and cytoskeleton organization, which are both activities required
            for lymphatic lumen maintenance
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 961)
  AUTHORS   Azizoglu,D.B., Chong,D.C., Villasenor,A., Magenheim,J., Barry,D.M.,
            Lee,S., Marty-Santos,L., Fu,S., Dor,Y. and Cleaver,O.
  TITLE     Vascular development in the vertebrate pancreas
  JOURNAL   Dev Biol 420 (1), 67-78 (2016)
   PUBMED   27789228
REFERENCE   4  (residues 1 to 961)
  AUTHORS   Barry,D.M., Koo,Y., Norden,P.R., Wylie,L.A., Xu,K., Wichaidit,C.,
            Azizoglu,D.B., Zheng,Y., Cobb,M.H., Davis,G.E. and Cleaver,O.
  TITLE     Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel
            Tubulogenesis via Nonmuscle Myosin II
  JOURNAL   Circ Res 119 (7), 810-826 (2016)
   PUBMED   27486147
  REMARK    GeneRIF: Rasip1 controls different pools of GTPases, which in turn
            regulates blood vessel tubulogenesis.
REFERENCE   5  (residues 1 to 961)
  AUTHORS   Koo,Y., Barry,D.M., Xu,K., Tanigaki,K., Davis,G.E., Mineo,C. and
            Cleaver,O.
  TITLE     Rasip1 is essential to blood vessel stability and angiogenic blood
            vessel growth
  JOURNAL   Angiogenesis 19 (2), 173-190 (2016)
   PUBMED   26897025
  REMARK    GeneRIF: Rasip1 is necessary in growing embryonic blood vessels.
REFERENCE   6  (residues 1 to 961)
  AUTHORS   Xu,K., Sacharidou,A., Fu,S., Chong,D.C., Skaug,B., Chen,Z.J.,
            Davis,G.E. and Cleaver,O.
  TITLE     Blood vessel tubulogenesis requires Rasip1 regulation of GTPase
            signaling
  JOURNAL   Dev Cell 20 (4), 526-539 (2011)
   PUBMED   21396893
  REMARK    GeneRIF: Mice lacking Rasip1 fail to form patent lumens in all
            blood vessels, including the early endocardial tube. Rasipl null
            angioblasts fail to properly localize the polarity determinant Par3
            and display defective cell polarity.
REFERENCE   7  (residues 1 to 961)
  AUTHORS   Xu,K., Chong,D.C., Rankin,S.A., Zorn,A.M. and Cleaver,O.
  TITLE     Rasip1 is required for endothelial cell motility, angiogenesis and
            vessel formation
  JOURNAL   Dev Biol 329 (2), 269-279 (2009)
   PUBMED   19272373
  REMARK    GeneRIF: Rasip1 expression is undetectable in VEGFR2 null embryos,
            which lack endothelial cells, suggesting that Rasip1 is endothelial
            specific. siRNA-mediated reduction of Rasip1 severely impairs
            angiogenesis and motility in endothelial cell cultures
REFERENCE   8  (residues 1 to 961)
  AUTHORS   Wallgard,E., Larsson,E., He,L., Hellstrom,M., Armulik,A.,
            Nisancioglu,M.H., Genove,G., Lindahl,P. and Betsholtz,C.
  TITLE     Identification of a core set of 58 gene transcripts with broad and
            specific expression in the microvasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1469-1476 (2008)
   PUBMED   18483404
REFERENCE   9  (residues 1 to 961)
  AUTHORS   Mitin,N.Y., Ramocki,M.B., Zullo,A.J., Der,C.J., Konieczny,S.F. and
            Taparowsky,E.J.
  TITLE     Identification and characterization of rain, a novel
            Ras-interacting protein with a unique subcellular localization
  JOURNAL   J Biol Chem 279 (21), 22353-22361 (2004)
   PUBMED   15031288
  REMARK    GeneRIF: Rain is a novel protein that can serve as an effector of
            endomembrane-localized Ras
REFERENCE   10 (residues 1 to 961)
  AUTHORS   Ho,M., Yang,E., Matcuk,G., Deng,D., Sampas,N., Tsalenko,A.,
            Tabibiazar,R., Zhang,Y., Chen,M., Talbi,S., Ho,Y.D., Wang,J.,
            Tsao,P.S., Ben-Dor,A., Yakhini,Z., Bruhn,L. and Quertermous,T.
  TITLE     Identification of endothelial cell genes by combined database
            mining and microarray analysis
  JOURNAL   Physiol Genomics 13 (3), 249-262 (2003)
   PUBMED   12644598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028483.1, BB646451.1, AK033276.1, BU054468.1 and CO039349.1.
            
            On or before May 14, 2005 this sequence version replaced
            NP_081529.3, XP_485931.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150766.1, AK156602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.39 cM"
     Protein         1..961
                     /product="ras-interacting protein 1"
                     /calculated_mol_wt=103428
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Region          35..70
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Region          96..116
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Site            96
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Region          131..250
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          261..352
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Site            274
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Site            286
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Site            322
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Site            325
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Region          372..484
                     /region_name="FHA_RAIN"
                     /note="forkhead associated (FHA) domain found in
                     Ras-interacting protein 1 (Rain); cd22734"
                     /db_xref="CDD:438786"
     Site            413
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U0S6.3)"
     Region          545..911
                     /region_name="Myo5p-like_CBD_Rasip1"
                     /note="cargo binding domain of myosin 5-like of
                     Ras-interacting protein 1; cd15472"
                     /db_xref="CDD:271256"
     CDS             1..961
                     /gene="Rasip1"
                     /gene_synonym="1110025D03Rik; 2610025P08Rik; Rain"
                     /coded_by="NM_028544.1:59..2944"
                     /db_xref="CCDS:CCDS21256.1"
                     /db_xref="GeneID:69903"
                     /db_xref="MGI:MGI:1917153"
ORIGIN      
        1 mlsgerkegg sprfgklhlp vglwinsprk qlaklgrrwp saasvkssss dtgsrssepl
       61 ppppppphve lrrvgavkaa ggasgsrakr isqlfrgsga ggaggpgtpg gaqrwasekk
      121 lpelaagvap epplptraav ppgvlkifas glasganyks vlaterstar elvaealery
      181 gltggrgagd sgcvdayalc dalgrpavgv gggewraehl rvladaerpl lvqdlwrarp
      241 gwarrfelrg reearrleqe afgaadadgt napswrtqkn rsraasggaa laspgpgsgs
      301 gtptgsggke rsenlslrrs vselslqgrr rrqqerrqqa lsmapgaada qmvptdpgdf
      361 dqltqcliqa psnrpyflll qgyqdaqdfv vyvmtreqhv fgrggpsssr ggspapyvdt
      421 flnapdilpr hctvragpep pamvrpsrga pvthngclll reaelhpgdl lglgehflfm
      481 ykdprsggsg parpswlpar pgaappgpgw afscrlcgrg lqergealaa yldgrepvlr
      541 frpreeeall geivraaasg agdlpplgpa tllalcvqhs arelelghlp rllgrlarli
      601 keavwekike igdrqpenhp egvpevpltp eavsvelrpl ilwmanttel lsfvqekvle
      661 mekeadqegl ssdpqlcndl elcdealall devimctfqq svyyltktly stlpalldsn
      721 pftagaelpg pgaeleampp glrptlgvfq aaleltsqce lhpdlvsqtf gylfffsnas
      781 llnslmergq grpfyqwsra vqirtnldlv ldwlqgaglg diateffrkl siavnllcvp
      841 rtsllkasws slrtdyptlt paqlhhllsh yqlgpgrgpp pawdpppaer davdtgdife
      901 sfsshpplil plgssrlrlt gpvtddalhr elrrlrrllw dleqqelpan hrhgppvast
      961 p
//
