LOCUS       NM_001411230            4818 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus RAS, guanyl releasing protein 3 (Rasgrp3), mRNA.
ACCESSION   NM_001411230 XM_006524271
VERSION     NM_001411230.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4818)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4818)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4818)
  AUTHORS   Moore,A.R., Ran,L., Guan,Y., Sher,J.J., Hitchman,T.D., Zhang,J.Q.,
            Hwang,C., Walzak,E.G., Shoushtari,A.N., Monette,S., Murali,R.,
            Wiesner,T., Griewank,K.G., Chi,P. and Chen,Y.
  TITLE     GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling
            Node in Uveal Melanoma
  JOURNAL   Cell Rep 22 (9), 2455-2468 (2018)
   PUBMED   29490280
  REMARK    GeneRIF: RasGRP3 is specifically required for GNAQ/GNA11-driven Ras
            activation and tumorigenesis.
            Erratum:[Cell Rep. 2020 Oct 13;33(2):108277. doi:
            10.1016/j.celrep.2020.108277. PMID: 33053353]
REFERENCE   4  (bases 1 to 4818)
  AUTHORS   Golec,D.P., Henao Caviedes,L.M. and Baldwin,T.A.
  TITLE     RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early
            Thymic Progenitors
  JOURNAL   J Immunol 197 (5), 1743-1753 (2016)
   PUBMED   27465532
  REMARK    GeneRIF: RasGRP1/3-deficient progenitors show impaired migration
            toward the CCR9 ligand, CCL25, suggesting that RasGRP1 and RasGRP3
            may regulate progenitor entry into the thymus through a
            CCR9-dependent mechanism.
REFERENCE   5  (bases 1 to 4818)
  AUTHORS   Tang,S., Chen,T., Yu,Z., Zhu,X., Yang,M., Xie,B., Li,N., Cao,X. and
            Wang,J.
  TITLE     RasGRP3 limits Toll-like receptor-triggered inflammatory response
            in macrophages by activating Rap1 small GTPase
  JOURNAL   Nat Commun 5, 4657 (2014)
   PUBMED   25118589
  REMARK    GeneRIF: RasGRP3 limits inflammatory response by activating Rap1 on
            low-intensity pathogen infection, setting a threshold for
            preventing excessive inflammatory response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4818)
  AUTHORS   Regier,D.S., Higbee,J., Lund,K.M., Sakane,F., Prescott,S.M. and
            Topham,M.K.
  TITLE     Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3
            and inhibits Rap1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (21), 7595-7600 (2005)
   PUBMED   15894621
REFERENCE   7  (bases 1 to 4818)
  AUTHORS   Roberts,D.M., Anderson,A.L., Hidaka,M., Swetenburg,R.L.,
            Patterson,C., Stanford,W.L. and Bautch,V.L.
  TITLE     A vascular gene trap screen defines RasGRP3 as an
            angiogenesis-regulated gene required for the endothelial response
            to phorbol esters
  JOURNAL   Mol Cell Biol 24 (24), 10515-10528 (2004)
   PUBMED   15572660
REFERENCE   8  (bases 1 to 4818)
  AUTHORS   Aiba,Y., Oh-hora,M., Kiyonaka,S., Kimura,Y., Hijikata,A., Mori,Y.
            and Kurosaki,T.
  TITLE     Activation of RasGRP3 by phosphorylation of Thr-133 is required for
            B cell receptor-mediated Ras activation
  JOURNAL   Proc Natl Acad Sci U S A 101 (47), 16612-16617 (2004)
   PUBMED   15545601
REFERENCE   9  (bases 1 to 4818)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4818)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118018.20 and CT010501.6.
            
            On Aug 23, 2022 this sequence version replaced XM_006524271.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.282646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC118018.20        23763-24035         c
            274-406             CT010501.6         137535-137667       c
            407-609             CT010501.6         134524-134726       c
            610-712             CT010501.6         132235-132337       c
            713-775             CT010501.6         130040-130102       c
            776-907             CT010501.6         129413-129544       c
            908-1055            CT010501.6         127953-128100       c
            1056-1229           CT010501.6         126252-126425       c
            1230-1346           CT010501.6         125728-125844       c
            1347-1622           CT010501.6         123095-123370       c
            1623-1700           CT010501.6         116662-116739       c
            1701-1817           CT010501.6         114389-114505       c
            1818-1933           CT010501.6         112291-112406       c
            1934-2081           CT010501.6         110007-110154       c
            2082-2118           CT010501.6         102299-102335       c
            2119-2244           CT010501.6         101893-102018       c
            2245-2606           CT010501.6         101232-101593       c
            2607-4818           CT010501.6         97430-99641         c
FEATURES             Location/Qualifiers
     source          1..4818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 46.55 cM"
     gene            1..4818
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /note="RAS, guanyl releasing protein 3"
                     /db_xref="GeneID:240168"
                     /db_xref="MGI:MGI:3028579"
     exon            1..273
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            274..406
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            407..609
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..2615
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /codon_start=1
                     /product="ras guanyl-releasing protein 3"
                     /protein_id="NP_001398159.1"
                     /db_xref="GeneID:240168"
                     /db_xref="MGI:MGI:3028579"
                     /translation="MGSNGLGKAATLDELLSTCIEMFDDNGDLNDSYLPRIVLLMHRW
                     YLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEF
                     REVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHL
                     TFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQR
                     AEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTE
                     LVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLS
                     VTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSP
                     TTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAA
                     NFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFC
                     EHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPGSLPGSPAL
                     PPVQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAV
                     WGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPTVQAGVDVVDRGTAFEPDQDDGQD
                     EAKQGGEDG"
     exon            610..712
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            713..775
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            776..907
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1055
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1229
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1346
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1622
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1700
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1817
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1933
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2081
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2118
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2244
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2606
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..4818
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4797..4802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /note="hexamer: AATAAA"
     polyA_site      4818
                     /gene="Rasgrp3"
                     /gene_synonym="Gm327"
                     /note="major polyA site"
ORIGIN      
        1 attgagctca aagcctagcc ccttcaaggt agtggtttgt tgggcacgaa taggcttgca
       61 aatctctttc tttctttctt cttcttttta ttattttgct tttcctcttc acttatgaat
      121 tggacttgag caatggaggg gacaacagct ctttcagggg gagcccagcc atcttgaggg
      181 gttcaggcac cttgaagaga ctttcaagaa cctggtgaaa ggaggatcca cacctcttgt
      241 gaacttccac tgactacatg actgcggatt cgggttttcc agagccctta tcatttgagt
      301 ttaacgaacc agttcttcac tctgcttcct tcatgccctt cccagggatg acaactgccc
      361 ttggcatctt ttcagacctg gaactctatc tgtatgaaaa tagattagca ttcttgaagt
      421 ataattaaga aggaacatta cctgccaaag ggcgagagaa ccactgcctc gtacagatat
      481 ggagatagtc tgtctgctgc tggaaatgtc tccagatttt tgacaacggc taaagaacca
      541 tggggtccaa cgggctcggg aaagcggcaa cactagatga acttctcagc acatgcattg
      601 agatgtttga tgacaatgga gacctgaacg acagttactt gcccagaatc gtgttactga
      661 tgcaccgatg gtatttatcc tccactgaac tggcaggaaa actcctctgc atgtatcgga
      721 atgccagtgg agaaagctgt gatgagttcc gactgaagat ctgctatttc atgaggtact
      781 ggattctgaa atttcctgca gagtttaatt tggatcttgg tttgattcgc atgactgagg
      841 agttccggga agtagctagt caactaggac atgaaaaaca catcagcctc atggacatat
      901 ctagcgttcc ttcctatgac tggatgagga gagtcacaca gaggaaaaaa gtatccaaaa
      961 ggggaaaggc ctgcctctta tttgaccatc tggagcccat tgagttggcg gagcacctca
     1021 cttttctgga gcataaatct tttagaagga tctcattcac agattatcag agctatgtca
     1081 tccatggctg tctggagaat aacccgacat tggagagatc tattgcttta tttaatggaa
     1141 tctctaagtg ggtccagttg atggttctta gcaaaccaag tgcgcaacaa agggcagaag
     1201 tcatcacaaa gttcatcaat gtagcccaga aactccttca actaaaaaat tttaacacct
     1261 tgatggcagt ggttggtggc cttagtcaca gctccatttc ccgactcaaa gacacccatt
     1321 ctcacctctc ttccgaagtt acaaagaact ggaatgaaat gacagagttg gtctcctcca
     1381 atggcaatta ctgcaattac cgcaaagcct ttgctgactg tgatggcttc aaaatcccca
     1441 tccttggcgt gcacttgaaa gacttgatag cagtccatgt cattttccca gactggatgg
     1501 aggagaacaa agtgaacgtt gtgaaaatgc accagctttc tgttaccctg agtgaactgg
     1561 tctccctgca gaatgcctct caccacttgg aacctaacat ggatttgatc aacctactca
     1621 ctctctctct ggacctctac cacacagagg atgatattta caaactgtca ctggtgttgg
     1681 agcctagaaa ttccaaatcg cagccaacct ccccaacgac acctaataag cctgtggtac
     1741 ctctggagtg ggcttcagaa gtggtaccaa agccagaccc cacaatcatc aacaaacaca
     1801 taaggaagtt ggttgagtct gtgtttcgaa actacgatca tgaccacgat ggttacatct
     1861 cccaagagga ctttgagagc atagctgcca atttcccctt cctggattcc ttctgcgtac
     1921 tagacaaaga tcaggacggc ctaattagca aagacgaaat gatggcttat ttcctgagag
     1981 ctaaatctca gctacactgc aaaatgggac caggcttcat ccataatttt caggagatga
     2041 actatctcaa gccgaccttc tgcgaacact gtgcgggatt tctctggggc ataatcaaac
     2101 aaggctacaa gtgcaaagac tgtggagcca actgccacaa gcagtgcaaa gacctcttgg
     2161 ttctggcctg caggagactt gccagggcac cctccttgag cagcaacccc gggtcactgc
     2221 ctggaagccc agccttgccc ccagtgcagg atgaggtatt tgagtttcct ggggtcacgg
     2281 ctggacaccg agacctggac agcagagcca ttaccctggt tacaggatct tcccggaaga
     2341 tctccgtgag gctgcagaga gccaccacta gtcaagccac ccagacggaa cctgtgtggt
     2401 cagaggctgt ctggggagac tcagggtccc ataccttccc caaaatgaaa tccaagttcc
     2461 atgacaaagc agcaaaggac aagggctttg ccaagtggga aaacgagaag cccacggtac
     2521 aagctggtgt ggatgttgta gatcgaggca ctgcatttga acctgaccag gatgatgggc
     2581 aagatgaagc caagcagggt ggtgaggatg gctgaggtca agcttgggaa accaaaggca
     2641 atcaagtcgg ctatgaggag gagagagaag aggcgctctg aaaggcacgg tctctctcag
     2701 aagcggtctg gaaaagagat ttggatatgc tcacagcctc cagtcatcct ggaatcccca
     2761 tgactggact acgggataga gaatttaccc tgactgaact atttatttcc tgtactctgt
     2821 ctgcccctgc tgaggtgcca cgaaaactac ttaagcagct tcccacatct ctctaaagcc
     2881 atttgtagcc agggggatga aagctttggt gcacgtgcgt ggttttctct aaaatcaaaa
     2941 cttagctctt ttggacaata ttatttttgt aaagtgtgtg cgtgtgtgta ggggtgtctc
     3001 aaaagaagtt gaatttgagc tcctttgtgt gtgcctttta gatgggacca ggacttgaag
     3061 ttttattgag ggacaaagac attctttaga ccctgaaagg cagtgaaccc tctgctgctg
     3121 attggctgta aggagtgttt atagtgtcct accacacagt ggctgtgctt gtaatgccat
     3181 gtgtgtgtat cacctaggtc tcaatcaatc ctggatcact aaggggaatc atatccccaa
     3241 agccccccta atactcatgc tagatatggt aaaaacaaac aaaacaaaac aaaacaaatc
     3301 aaaacagcat acacctggcc acctaattga gttccccact ctttctgaag attcccaaaa
     3361 tagaatgtta attaagaaag caaatcaagt tctgagggat gaaatttagt agaaagaccc
     3421 accaaattac taggttaaag ataaacaacc agtttggtaa gctgaaagta agcctatgat
     3481 ttttatttta gataatttct agatgcaaaa ggtaacttaa tttcttccta ataaattctc
     3541 acccatagtt agaaaaacat ttacaattct catctctagc tcttcttctt ccccaccctt
     3601 cccccctttc tccatgtggc catggctggc cacagggctc tctcttccaa ccttctctct
     3661 tcttctctgc ctttctacag taaagcttta aaaccatgaa aaaaaaattc acaaaagaaa
     3721 aaatgaccat aaacttcaac tatggattga tattccatgt acacatttaa aatattaata
     3781 atttaaatgt ctttctttga gtgtgtatct tttgaaatag agacgccagg ctgatattcc
     3841 aatacctata atctctgcac ttgggccatg agataggagg accccaagtc tgaggtcatc
     3901 ctgggcaatt tagcaagaat ctgtctaaaa aaaaaatgta ggggctggag agatggctca
     3961 gcagttaaga gcactggctg ctcttctaga ggtcctgagt tcaattccta gcaaccacat
     4021 ggcggctcac aaccatctag ggatctgatg ccctctccta gtatgtctga agacagctac
     4081 agtgcactca tatacataag tctttaaaaa gtaataatca aaataaaaga aaaattgagg
     4141 tgattgagtc tgtcattgag ggaaccatat catatcaaat aaccagttag gaaatattcc
     4201 aggtgggtac caggtgggct aacgtgtgta tcccatgtaa aactgactat ggtcttattt
     4261 gtgaaagtca cttccataca gctcaactgc taatactatg ctcctcctta gaaatggaga
     4321 gcatgaggcc ataactgcta agtggttcca gtgtcttaag acaaccttgg tagaggtgac
     4381 acaatgtgcc ccgaaggttc tggaatgggg catgattcag attggggata ctaaacaata
     4441 agtgatgtct ctacttgaag gagccgtgat taactagatg agaacgagaa ctcattaatg
     4501 gtcgagcgcc tcgggcagtg ctgttggatc tatgtatata gactgttact attcataaat
     4561 acagcagagt acgtgttaac ggattcaaaa cagaaactga caagtcaagt gctggcaaac
     4621 cctctaaaaa cacccagaag gaaaccttag ggaaggctgg agtctttgta tttcttttca
     4681 aaggaattat ctcacctgcc atttggttta tatatttatt agttttcata tatagaagga
     4741 attttgtatc tctggtcttc ctatgataag gaagacaaaa tgtaccttca atgaaaaata
     4801 aacatacaca aaaagaaa
//
