LOCUS       NM_011242               2232 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus RAS, guanyl releasing protein 2 (Rasgrp2), transcript
            variant 1, mRNA.
ACCESSION   NM_011242 XM_359299
VERSION     NM_011242.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2232)
  AUTHORS   Crittenden,J.R., Zhai,S., Sauvage,M., Kitsukawa,T., Burguiere,E.,
            Thomsen,M., Zhang,H., Costa,C., Martella,G., Ghiglieri,V.,
            Picconi,B., Pescatore,K.A., Unterwald,E.M., Jackson,W.S.,
            Housman,D.E., Caine,S.B., Sulzer,D., Calabresi,P., Smith,A.C.,
            Surmeier,D.J. and Graybiel,A.M.
  TITLE     CalDAG-GEFI mediates striatal cholinergic modulation of dendritic
            excitability, synaptic plasticity and psychomotor behaviors
  JOURNAL   Neurobiol Dis 158, 105473 (2021)
   PUBMED   34371144
  REMARK    GeneRIF: CalDAG-GEFI mediates striatal cholinergic modulation of
            dendritic excitability, synaptic plasticity and psychomotor
            behaviors.
REFERENCE   2  (bases 1 to 2232)
  AUTHORS   Chen,S.Y., Lu,K.M., Ko,H.A., Huang,T.H., Hao,J.H., Yan,Y.T.,
            Chang,S.L., Evans,S.M. and Liu,F.C.
  TITLE     Parcellation of the striatal complex into dorsal and ventral
            districts
  JOURNAL   Proc Natl Acad Sci U S A 117 (13), 7418-7429 (2020)
   PUBMED   32170006
REFERENCE   3  (bases 1 to 2232)
  AUTHORS   Lee,R.H., Piatt,R., Dhenge,A., Lozano,M.L., Palma-Barqueros,V.,
            Rivera,J. and Bergmeier,W.
  TITLE     Impaired hemostatic activity of healthy transfused platelets in
            inherited and acquired platelet disorders: Mechanisms and
            implications
  JOURNAL   Sci Transl Med 11 (522) (2019)
   PUBMED   31826978
REFERENCE   4  (bases 1 to 2232)
  AUTHORS   Casari,C., Paul,D.S., Susen,S., Lavenu-Bombled,C., Harroche,A.,
            Piatt,R., Poe,K.O., Lee,R.H., Bryckaert,M., Christophe,O.D.,
            Lenting,P.J., Denis,C.V. and Bergmeier,W.
  TITLE     Protein kinase C signaling dysfunction in von Willebrand disease
            (p.V1316M) type 2B platelets
  JOURNAL   Blood Adv 2 (12), 1417-1428 (2018)
   PUBMED   29925524
REFERENCE   5  (bases 1 to 2232)
  AUTHORS   Battram,A.M., Durrant,T.N., Agbani,E.O., Heesom,K.J., Paul,D.S.,
            Piatt,R., Poole,A.W., Cullen,P.J., Bergmeier,W., Moore,S.F. and
            Hers,I.
  TITLE     The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder
            Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin
            alphaIIbbeta3 Outside-in Signaling
  JOURNAL   J Biol Chem 292 (5), 1691-1704 (2017)
   PUBMED   27903653
REFERENCE   6  (bases 1 to 2232)
  AUTHORS   Crittenden,J.R., Bergmeier,W., Zhang,Y., Piffath,C.L., Liang,Y.,
            Wagner,D.D., Housman,D.E. and Graybiel,A.M.
  TITLE     CalDAG-GEFI integrates signaling for platelet aggregation and
            thrombus formation
  JOURNAL   Nat Med 10 (9), 982-986 (2004)
   PUBMED   15334074
  REMARK    Erratum:[Nat Med. 2004 Oct;10(10):1139]
REFERENCE   7  (bases 1 to 2232)
  AUTHORS   Li,L., Yang,Y., Wong,G.W. and Stevens,R.L.
  TITLE     Mast cells in airway hyporesponsive C3H/HeJ mice express a unique
            isoform of the signaling protein Ras guanine nucleotide releasing
            protein 4 that is unresponsive to diacylglycerol and phorbol esters
  JOURNAL   J Immunol 171 (1), 390-397 (2003)
   PUBMED   12817022
REFERENCE   8  (bases 1 to 2232)
  AUTHORS   Eto,K., Murphy,R., Kerrigan,S.W., Bertoni,A., Stuhlmann,H.,
            Nakano,T., Leavitt,A.D. and Shattil,S.J.
  TITLE     Megakaryocytes derived from embryonic stem cells implicate
            CalDAG-GEFI in integrin signaling
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 12819-12824 (2002)
   PUBMED   12239348
  REMARK    GeneRIF: CalDAG-GEFI plays a role in inside-out signaling to
            alphaIIbbeta3
REFERENCE   9  (bases 1 to 2232)
  AUTHORS   Kawasaki,H., Springett,G.M., Toki,S., Canales,J.J., Harlan,P.,
            Blumenstiel,J.P., Chen,E.J., Bany,I.A., Mochizuki,N., Ashbacher,A.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A Rap guanine nucleotide exchange factor enriched highly in the
            basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13278-13283 (1998)
   PUBMED   9789079
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Jan 5;96(1):318]
REFERENCE   10 (bases 1 to 2232)
  AUTHORS   Kedra,D., Seroussi,E., Fransson,I., Trifunovic,J., Clark,M.,
            Lagercrantz,J., Blennow,E., Mehlin,H. and Dumanski,J.
  TITLE     The germinal center kinase gene and a novel CDC25-like gene are
            located in the vicinity of the PYGM gene on 11q13
  JOURNAL   Hum Genet 100 (5-6), 611-619 (1997)
   PUBMED   9341881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167245.2.
            
            On Aug 23, 2022 this sequence version replaced NM_011242.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.84404.1,
                                           SRR7345562.3785748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC167245.2         61710-61820
            112-254             AC167245.2         62890-63032
            255-357             AC167245.2         63641-63743
            358-420             AC167245.2         64193-64255
            421-552             AC167245.2         64601-64732
            553-703             AC167245.2         65469-65619
            704-877             AC167245.2         65823-65996
            878-994             AC167245.2         66107-66223
            995-1276            AC167245.2         68210-68491
            1277-1354           AC167245.2         69340-69417
            1355-1477           AC167245.2         69617-69739
            1478-1593           AC167245.2         70008-70123
            1594-1735           AC167245.2         74254-74395
            1736-1772           AC167245.2         74597-74633
            1773-1949           AC167245.2         75034-75210
            1950-2012           AC167245.2         75961-76023
            2013-2232           AC167245.2         76163-76382
FEATURES             Location/Qualifiers
     source          1..2232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.58 cM"
     gene            1..2232
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="RAS, guanyl releasing protein 2"
                     /db_xref="GeneID:19395"
                     /db_xref="MGI:MGI:1333849"
     exon            1..111
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            112..254
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2008
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F25B3.3 kinase like protein; calcium and DAG-regulated
                     guanine nucleotide exchange factor I; RAP 1A
                     protein-specific guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="RAS guanyl-releasing protein 2 isoform 1"
                     /protein_id="NP_035372.2"
                     /db_xref="CCDS:CCDS37898.1"
                     /db_xref="GeneID:19395"
                     /db_xref="MGI:MGI:1333849"
                     /translation="MTSTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHP
                     WYIPSSQLASKLLHFYQQSRKDNSNSLQMKTCHLVRYWISAFPAEFDLNPELAEQIKE
                     LKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPMELAE
                     HLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAT
                     QRALVITHFVHVAERLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGL
                     TELVTATGNYSNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPGRTRLNGAKM
                     RQLFCILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSP
                     TSPTSCTPPPRPPVLEEWTSVAKPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEE
                     FQIIRGNFPYLSAFGDLDQNQDGCISREEMISYFLRSSSVLGGRMGFVHNFQESNSLR
                     PVACRHCKALILGIYKQGLKCRACGVNCHKQCKERLSVECRRRAQSVSLEGSAPSPSP
                     THTHHRAFSFSLPRPGRRSSRPPEIREEEVQSVEDGVFDIHL"
     exon            255..357
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            358..420
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            421..552
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            553..703
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            704..877
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            878..994
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1276
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1354
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1477
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1593
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1735
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1772
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1949
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2012
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2232
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="hexamer: AATAAA"
     polyA_site      2232
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="major polyA site"
ORIGIN      
        1 agatgtcaga gctactgtga tcgagagatc agaggctgag ctggttcaag tgaacagaag
       61 gtctgggagg tgaactgcat tcaggtttgc attctgaagt aaaggacttg ggggtccgaa
      121 ttgagcaccg tgggaggctc tgagagtgta gcttgggtct agcctactgg caccggcagc
      181 catgacgagc actctggacc tggacaaggg ctgcaccgtg gaggagctgc tccgtggttg
      241 catcgaagcg tttgatgact ccggaaaggt gcgagatcca cagctagtgc gcatgtttct
      301 catgatgcac ccctggtaca taccttcctc tcagctggct tcgaaactgc tccacttcta
      361 tcagcaatcc cggaaggaca actccaattc tctacagatg aaaacgtgtc acttggtcag
      421 gtactggatc tcagccttcc cagcagagtt cgacttgaac ccagagctgg ctgaacagat
      481 caaggagctg aaggctctgt tagaccaaga agggaaccgc aggcacagca gcctcatcga
      541 catcgagagt gtccctacct acaaatggaa gcggcaggtg acccagcgga accctgtgga
      601 acagaaaaag cgcaagatgt ccttgttgtt tgatcacttg gagcctatgg agctggcaga
      661 acatcttacc tacctggagt atcgttcctt ctgcaagatc ctgttccaag actaccacag
      721 ctttgtgact catggctgca ccgtagacaa cccggtcctg gagcgattca tctccctctt
      781 caacagtgtc tctcagtggg tccaactcat gatcctcagc aagcccacag ccacgcagcg
      841 ggcgctggtc atcacgcact tcgtgcatgt ggcagagagg ctgctgcagc tgcagaactt
      901 caacacgctg atggccgtcg tgggaggcct gagccacagc tccatctcac gcctcaagga
      961 gacccacagc cacgtcagcc ctgacaccat caagctctgg gaaggtctga cagaactagt
     1021 gacagctact ggcaactaca gcaactaccg gcgcaggctg gcagcctgcg tgggcttccg
     1081 ctttcctatc ctgggagtgc acctcaagga tctagtggct ctgcagctgg ctctgcctga
     1141 ctggctggac ccaggtcgga cccggctcaa tggagccaag atgaggcagc ttttctgcat
     1201 tctggaggag ttggccatgg tgaccagcct tcgcccaccc gtacaagcca accccgacct
     1261 gctgagcctg ctcacggtgt ccctggatca gtatcagaca gaggatgagc tgtaccagct
     1321 ctcactgcag cgagagccac gctccaagtc gtcgccaacc agccccacca gctgcacccc
     1381 gcctccccgg ccccctgtgt tggaagagtg gacctcagtt gccaagccta agctggacca
     1441 agccttggtg gcagagcaca ttgagaagat ggtggagtct gtgttccgga actttgacgt
     1501 ggatggggac ggtcacatct cccaggagga gtttcagatc atccggggca acttccctta
     1561 tctcagcgcc tttggggacc tggaccagaa ccaggatggc tgcatcagcc gggaggagat
     1621 gatttcctac ttcctgcgct ccagctccgt gctgggaggc cgcatgggct tcgtacacaa
     1681 cttccaggag agtaactcgc tacgcccggt tgcctgtcgc cactgcaaag ctctgatcct
     1741 gggcatctac aagcagggcc ttaaatgtag agcttgtggt gtgaactgcc acaagcaatg
     1801 caaagagcgc ctgtcagtgg aatgtcgccg cagggcccag agtgtcagcc tggagggctc
     1861 tgcaccctct ccctcaccca cacataccca ccatcgggcc ttcagctttt ccctgcctcg
     1921 cccaggcagg cgcagctctc ggcctccaga gatccgtgaa gaggaggtgc agtcggtgga
     1981 ggacggagtg tttgacatcc acttataaaa tgctgtgact atcaaggact cattcctgcc
     2041 tcggaggaaa gacttagagt agagaaggga gccagagatt ctggggcagg aggttggggc
     2101 tgggggtggt gggggtcgag ggtggcatgc attgagaaga gggccagggc tggtgtccct
     2161 aaggttgtac agactcctgt gaatatttgt attttccaga tggaataaaa aggcccgaat
     2221 aattaacctg ga
//
