LOCUS       NM_001365062             614 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus RAS, guanyl releasing protein 2 (Rasgrp2), transcript
            variant 2, mRNA.
ACCESSION   NM_001365062
VERSION     NM_001365062.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 614)
  AUTHORS   Crittenden,J.R., Zhai,S., Sauvage,M., Kitsukawa,T., Burguiere,E.,
            Thomsen,M., Zhang,H., Costa,C., Martella,G., Ghiglieri,V.,
            Picconi,B., Pescatore,K.A., Unterwald,E.M., Jackson,W.S.,
            Housman,D.E., Caine,S.B., Sulzer,D., Calabresi,P., Smith,A.C.,
            Surmeier,D.J. and Graybiel,A.M.
  TITLE     CalDAG-GEFI mediates striatal cholinergic modulation of dendritic
            excitability, synaptic plasticity and psychomotor behaviors
  JOURNAL   Neurobiol Dis 158, 105473 (2021)
   PUBMED   34371144
  REMARK    GeneRIF: CalDAG-GEFI mediates striatal cholinergic modulation of
            dendritic excitability, synaptic plasticity and psychomotor
            behaviors.
REFERENCE   2  (bases 1 to 614)
  AUTHORS   Chen,S.Y., Lu,K.M., Ko,H.A., Huang,T.H., Hao,J.H., Yan,Y.T.,
            Chang,S.L., Evans,S.M. and Liu,F.C.
  TITLE     Parcellation of the striatal complex into dorsal and ventral
            districts
  JOURNAL   Proc Natl Acad Sci U S A 117 (13), 7418-7429 (2020)
   PUBMED   32170006
REFERENCE   3  (bases 1 to 614)
  AUTHORS   Lee,R.H., Piatt,R., Dhenge,A., Lozano,M.L., Palma-Barqueros,V.,
            Rivera,J. and Bergmeier,W.
  TITLE     Impaired hemostatic activity of healthy transfused platelets in
            inherited and acquired platelet disorders: Mechanisms and
            implications
  JOURNAL   Sci Transl Med 11 (522) (2019)
   PUBMED   31826978
REFERENCE   4  (bases 1 to 614)
  AUTHORS   Casari,C., Paul,D.S., Susen,S., Lavenu-Bombled,C., Harroche,A.,
            Piatt,R., Poe,K.O., Lee,R.H., Bryckaert,M., Christophe,O.D.,
            Lenting,P.J., Denis,C.V. and Bergmeier,W.
  TITLE     Protein kinase C signaling dysfunction in von Willebrand disease
            (p.V1316M) type 2B platelets
  JOURNAL   Blood Adv 2 (12), 1417-1428 (2018)
   PUBMED   29925524
REFERENCE   5  (bases 1 to 614)
  AUTHORS   Battram,A.M., Durrant,T.N., Agbani,E.O., Heesom,K.J., Paul,D.S.,
            Piatt,R., Poole,A.W., Cullen,P.J., Bergmeier,W., Moore,S.F. and
            Hers,I.
  TITLE     The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder
            Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin
            alphaIIbbeta3 Outside-in Signaling
  JOURNAL   J Biol Chem 292 (5), 1691-1704 (2017)
   PUBMED   27903653
REFERENCE   6  (bases 1 to 614)
  AUTHORS   Crittenden,J.R., Bergmeier,W., Zhang,Y., Piffath,C.L., Liang,Y.,
            Wagner,D.D., Housman,D.E. and Graybiel,A.M.
  TITLE     CalDAG-GEFI integrates signaling for platelet aggregation and
            thrombus formation
  JOURNAL   Nat Med 10 (9), 982-986 (2004)
   PUBMED   15334074
  REMARK    Erratum:[Nat Med. 2004 Oct;10(10):1139]
REFERENCE   7  (bases 1 to 614)
  AUTHORS   Li,L., Yang,Y., Wong,G.W. and Stevens,R.L.
  TITLE     Mast cells in airway hyporesponsive C3H/HeJ mice express a unique
            isoform of the signaling protein Ras guanine nucleotide releasing
            protein 4 that is unresponsive to diacylglycerol and phorbol esters
  JOURNAL   J Immunol 171 (1), 390-397 (2003)
   PUBMED   12817022
REFERENCE   8  (bases 1 to 614)
  AUTHORS   Eto,K., Murphy,R., Kerrigan,S.W., Bertoni,A., Stuhlmann,H.,
            Nakano,T., Leavitt,A.D. and Shattil,S.J.
  TITLE     Megakaryocytes derived from embryonic stem cells implicate
            CalDAG-GEFI in integrin signaling
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 12819-12824 (2002)
   PUBMED   12239348
  REMARK    GeneRIF: CalDAG-GEFI plays a role in inside-out signaling to
            alphaIIbbeta3
REFERENCE   9  (bases 1 to 614)
  AUTHORS   Kawasaki,H., Springett,G.M., Toki,S., Canales,J.J., Harlan,P.,
            Blumenstiel,J.P., Chen,E.J., Bany,I.A., Mochizuki,N., Ashbacher,A.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A Rap guanine nucleotide exchange factor enriched highly in the
            basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13278-13283 (1998)
   PUBMED   9789079
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Jan 5;96(1):318]
REFERENCE   10 (bases 1 to 614)
  AUTHORS   Kedra,D., Seroussi,E., Fransson,I., Trifunovic,J., Clark,M.,
            Lagercrantz,J., Blennow,E., Mehlin,H. and Dumanski,J.
  TITLE     The germinal center kinase gene and a novel CDC25-like gene are
            located in the vicinity of the PYGM gene on 11q13
  JOURNAL   Hum Genet 100 (5-6), 611-619 (1997)
   PUBMED   9341881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167245.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE332861.1, BE448949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC167245.2         61044-61133
            91-238              AC167245.2         62885-63032
            239-341             AC167245.2         63641-63743
            342-404             AC167245.2         64193-64255
            405-614             AC167245.2         64601-64810
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.58 cM"
     gene            1..614
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="RAS, guanyl releasing protein 2"
                     /db_xref="GeneID:19395"
                     /db_xref="MGI:MGI:1333849"
     exon            1..90
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            91..238
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..591
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="isoform 2 is encoded by transcript variant 2;
                     F25B3.3 kinase like protein; calcium and DAG-regulated
                     guanine nucleotide exchange factor I; RAP 1A
                     protein-specific guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="RAS guanyl-releasing protein 2 isoform 2"
                     /protein_id="NP_001351991.1"
                     /db_xref="CCDS:CCDS89325.1"
                     /db_xref="GeneID:19395"
                     /db_xref="MGI:MGI:1333849"
                     /translation="MTSTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHP
                     WYIPSSQLASKLLHFYQQSRKDNSNSLQMKTCHLVRYWISAFPAEFDLNPELAEQIKE
                     LKALLDQEGNRRHSSLIDIESVCVGAERKGHYACYTICA"
     exon            239..341
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            342..404
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     exon            405..614
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      590..595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="hexamer: AATAAA"
     polyA_site      611
                     /gene="Rasgrp2"
                     /gene_synonym="CalDAG-GEFI; Caldaggef1; CDC25L"
                     /note="major polyA site"
ORIGIN      
        1 agccgcagcc gcagcgaggc cggcgggcgg gagcgcacgg aggtggcgct ggccgggcag
       61 ggttcggggt ccgcgctgcg ggtcccaaga gacaggggtc cgaattgagc accgtgggag
      121 gctctgagag tgtagcttgg gtctagccta ctggcaccgg cagccatgac gagcactctg
      181 gacctggaca agggctgcac cgtggaggag ctgctccgtg gttgcatcga agcgtttgat
      241 gactccggaa aggtgcgaga tccacagcta gtgcgcatgt ttctcatgat gcacccctgg
      301 tacatacctt cctctcagct ggcttcgaaa ctgctccact tctatcagca atcccggaag
      361 gacaactcca attctctaca gatgaaaacg tgtcacttgg tcaggtactg gatctcagcc
      421 ttcccagcag agttcgactt gaacccagag ctggctgaac agatcaagga gctgaaggct
      481 ctgttagacc aagaagggaa ccgcaggcac agcagcctca tcgacatcga gagtgtgtgc
      541 gtgggggcgg agcgcaaggg gcactacgca tgctacacca tatgtgctta ataaatgtct
      601 gttcaattga atga
//
