LOCUS       NM_011246               5129 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus RAS guanyl releasing protein 1 (Rasgrp1), mRNA.
ACCESSION   NM_011246
VERSION     NM_011246.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5129)
  AUTHORS   Xiao,L., Qiao,J., Huang,Y., Tan,B., Hong,L., Li,Z., Cai,G., Wu,Z.,
            Zheng,E., Wang,S. and Gu,T.
  TITLE     RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and
            differentiation in mice and pigs
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (3), 452-461 (2024)
   PUBMED   38419500
  REMARK    GeneRIF: RASGRP1 targeted by H3K27me3 regulates myoblast
            proliferation and differentiation in mice and pigs.
REFERENCE   2  (bases 1 to 5129)
  AUTHORS   Chang,Y., Manivannan,P., Doosti,A., Lapinski,P.E., Chen,D.,
            Roose,J.P. and King,P.D.
  TITLE     Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of
            Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for
            Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling
  JOURNAL   J Immunol 211 (6), 917-922 (2023)
   PUBMED   37566514
  REMARK    GeneRIF: Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T
            Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential
            Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.
REFERENCE   3  (bases 1 to 5129)
  AUTHORS   Wang,C., Li,X., Xue,B., Yu,C., Wang,L., Deng,R., Liu,H., Chen,Z.,
            Zhang,Y., Fan,S., Zuo,C., Sun,H., Zhu,H., Wang,J. and Tang,S.
  TITLE     RasGRP1 promotes the acute inflammatory response and restricts
            inflammation-associated cancer cell growth
  JOURNAL   Nat Commun 13 (1), 7001 (2022)
   PUBMED   36385095
  REMARK    GeneRIF: RasGRP1 promotes the acute inflammatory response and
            restricts inflammation-associated cancer cell growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5129)
  AUTHORS   Wen,Z., Finn,R., Gao,X., Li,L., Hebert,A., Ranheim,E.A., Zhou,Y.,
            Yun,G., Roose,J.P., Coon,J.J., Shiang,R., Wen,R., Yu,M., Wang,D.
            and Zhang,J.
  TITLE     Tcof1 haploinsufficiency promotes early T cell precursor-like
            leukemia in NrasQ61R/+ mice
  JOURNAL   Leukemia 36 (4), 1167-1170 (2022)
   PUBMED   35082403
REFERENCE   5  (bases 1 to 5129)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5129)
  AUTHORS   Norment,A.M., Bogatzki,L.Y., Klinger,M., Ojala,E.W., Bevan,M.J. and
            Kay,R.J.
  TITLE     Transgenic expression of RasGRP1 induces the maturation of
            double-negative thymocytes and enhances the production of CD8
            single-positive thymocytes
  JOURNAL   J Immunol 170 (3), 1141-1149 (2003)
   PUBMED   12538669
  REMARK    GeneRIF: In addition to driving the CD8 double-negative to
            double-positive transition, increased expression of RasGRP1
            selectively increases CD8 single-positive thymocyte numbers and
            enhances their responsiveness to T cell receptor signaling.
REFERENCE   7  (bases 1 to 5129)
  AUTHORS   Priatel,J.J., Teh,S.J., Dower,N.A., Stone,J.C. and Teh,H.S.
  TITLE     RasGRP1 transduces low-grade TCR signals which are critical for T
            cell development, homeostasis, and differentiation
  JOURNAL   Immunity 17 (5), 617-627 (2002)
   PUBMED   12433368
REFERENCE   8  (bases 1 to 5129)
  AUTHORS   Dower,N.A., Stang,S.L., Bottorff,D.A., Ebinu,J.O., Dickie,P.,
            Ostergaard,H.L. and Stone,J.C.
  TITLE     RasGRP is essential for mouse thymocyte differentiation and TCR
            signaling
  JOURNAL   Nat Immunol 1 (4), 317-321 (2000)
   PUBMED   11017103
REFERENCE   9  (bases 1 to 5129)
  AUTHORS   Li,J., Shen,H., Himmel,K.L., Dupuy,A.J., Largaespada,D.A.,
            Nakamura,T., Shaughnessy,J.D. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Leukaemia disease genes: large-scale cloning and pathway
            predictions
  JOURNAL   Nat Genet 23 (3), 348-353 (1999)
   PUBMED   10610183
REFERENCE   10 (bases 1 to 5129)
  AUTHORS   Bottorff,D., Ebinu,J. and Stone,J.C.
  TITLE     RasGRP, a Ras activator: mouse and human cDNA sequences and
            chromosomal positions
  JOURNAL   Mamm Genome 10 (4), 358-361 (1999)
   PUBMED   10087292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057341.1 and BE991595.1.
            
            On Apr 24, 2018 this sequence version replaced NM_011246.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057120.1, AK141524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5105              BC057341.1         1-5105
            5106-5129           BE991595.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..5129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.19 cM"
     gene            1..5129
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /note="RAS guanyl releasing protein 1"
                     /db_xref="GeneID:19419"
                     /db_xref="MGI:MGI:1314635"
     exon            1..203
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            204..388
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            389..494
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            495..557
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            558..689
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            690..843
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1017
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1134
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1410
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1491
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1596
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1706
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1851
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1888
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2041
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2421
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..5115
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5085..5090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /note="hexamer: CATAAA"
     polyA_site      5115
                     /gene="Rasgrp1"
                     /gene_synonym="calDAG-GEFII; Rasgrp"
                     /note="major polyA site"
ORIGIN      
        1 cgcacaaact ttgtgcctgc gggtgagcct gggtcggctc gccgggctcc aagagtggtc
       61 ggctccgggc tgcgagggcc agcggcggcc gagggatgcg cggcgcccgg ccgagccgat
      121 cccaccgctc taggtgagac ggctccaggg gcgcagagag ccgcgaccat gggaaccctg
      181 ggcaaggcga gagaggctcc gcggaaacct tgccatggct ccagagctgg ccccaaagca
      241 agactagagg ccaaatcaac caacagccct ctccctgccc agcccagctt ggcccagatc
      301 acccagttcc gaatgatggt gtccctggga catttggcca aaggagccag cctggatgat
      361 cttattgaca gctgcattca atcttttgat gcggatggaa acctgtgtcg gaataaccaa
      421 ctgttacaag tcatgctaac catgcaccgg atcatcatct cctcagccga gctgctacaa
      481 aaagtcatga atctatataa ggatgccctg gaaaagaatt ctccaggagt ttgcctgaag
      541 atctgctatt ttgtcaggta ttggataaca gaattctgga tcatgttcaa gatggatgcc
      601 agcttgacca gcaccatgga agagttccaa gacctggtga aagccaatgg tgaggagacc
      661 cactgccacc tcatcgacac gacccaaatt aattctcgag actggtccag gaaactgact
      721 cagaggataa aatcgaatac tagcaagaag cgcaaagtgt ccctgctgtt tgaccatctg
      781 gaacctgaag aactgtctga acacctcacc taccttgagt tcaagtcctt ccgacggata
      841 tctttctctg attaccaaaa ttaccttgta aatagctgcg taaaagagaa ccccaccatg
      901 gagaggtcca ttgccctgtg caatggcatc tcccagtggg tacaactgat ggttctcagc
      961 cgtcccaccc cgcagctccg ggcagaggtc ttcatcaagt tcatccatgt ggctcagaaa
     1021 ctccaccagc tacagaactt caacacgctg atggctgtga tcgggggact gtgtcacagc
     1081 tccatctcca ggcttaagga aacaagttca catgtcccac atgagatcaa taaggttctg
     1141 ggcgagatga ctgaactgct gtcctcctgc agaaactatg acaactacag gcgagcctat
     1201 ggggagtgca cccacttcaa aatccccata ctgggtgtgc acctcaagga cctcatatcc
     1261 ctgtatgagg ctatgcccga ctatctggaa gatgggaagg tgaatgtcca aaagctcctg
     1321 gccctttaca atcatatcaa tgaattggtc cagctgcagg agatggcccc accattggat
     1381 gccaacaagg acttggtgca tctgctgacg ttatccctgg atctatacta tacagaagat
     1441 gaaatctatg agctttccta tgcccgggag ccgaggaacc acagagctcc gccactgaca
     1501 ccttcgaagc caccagttgt agtagactgg gcctctggag tgtctcccaa acctgaccca
     1561 aagaccatca gcaaacacgt ccaaaggatg gtggattctg tctttaagaa ctatgatctc
     1621 gaccaggatg gctatatctc tcaggaggag tttgagaaga tcgctgcaag ctttccattt
     1681 tccttctgtg tgatggacaa agatagggaa ggcctcatca gcagagacga gatcacggcc
     1741 tacttcatga gggccagctc catctattcc aagctgggcc tgggctttcc acacaacttt
     1801 caagaaacca cttacctgaa gcccaccttc tgtgacaact gtgctggctt tctctggggc
     1861 gtgatcaagc aaggctatcg ctgtaaagac tgcgggatga actgccacaa acagtgcaaa
     1921 gacctggtgg tgttcgagtg caagaagcga atcaagagcc cagcaatatc cacagagaac
     1981 atcagctctg tggtaccaat gtccaccctt tgtccactgg gaaccaaaga tctgctccat
     2041 gcacccgaag aaggatcttt cattttccaa aacggagaga ttgtggacca cagtgaggag
     2101 agcaaggata ggaccatcat gctcctcgga gtgtcctccc agaaaatttc agttcggctg
     2161 aagaggactg ttgcccacaa gagcacccaa acagaatcgt tcccgtgggt tggtggcgag
     2221 acgacccctg gtcactttgt gctgtcttct ccaaggaagt cggcgcaggg cgctctttat
     2281 gtgcacagtc cagcatctcc atgccccagc ccagcactgg tccgaaagcg ggcattcgtc
     2341 aagtgggaga acaaagagtc ccttataaaa ccaaaaccag aacttcacct ccggctccgg
     2401 acctaccaag aactggaaca ggaaataaat accctgaaag cagataacga tgctctgaag
     2461 atccaactga agtacgcaca gaagaaaata gaatccctgc agcttgggaa aagcaatcat
     2521 gtcttagccc agatggacca cggtgatagt gcttaatcca gaatttcaag gaccagaatc
     2581 tgcaggaggg tatactggga tctcacttca aaactcattg cagacgttca gcacctttag
     2641 attgactgac tttaaaaggg tagagctggc cactactgtt gacatccttg gtttttacct
     2701 aaacggtttt taatgtgagt cgttggtttt cagtcagttg aatcaaaggg aagaaaagct
     2761 caagcatgca aagtctgagc attcctattc taaccttctt tctttactga aaccaatacc
     2821 aaacatgcgc taaaataagt ctagagtttc ctgagggtgt cccaggcagc ccgctttact
     2881 gattcatact tagataaaga gtccctggtg aatccatttg ctgccttccg caaactgact
     2941 tactttgttc tacccaaacc ccgctcataa cggaaacaat agcctaagcg tggtgacttt
     3001 gacatgcctg cattgtttgt gaaactgatc cctacagtgt tcgctacctc agacctcatc
     3061 aagagcctct ttccccactg tccttcactt gcccgcctcc ttcctccctt gcttataggc
     3121 acatcagcac atctacctag aagtgaactc ctagcgatgt agcctggttt taaatccaga
     3181 gcttcttaat tgaacttgac attgtctaat tgcaggccaa cttatagctc taggtcttag
     3241 tcattatgaa atacaaaata aaactcactc actacccaca aacagcaatt accatggcat
     3301 acacacagct aaatagctaa gtcaaaccac aataacacgt ttatccagat agtctttcta
     3361 tagtgggtag aattaagaat ctgtgacttt ttaaaagaaa tggtctgtga acagtgttta
     3421 attcttcatg ttctagtctc tctctctctc tctctctcaa gtaatctatc ataaggttct
     3481 cttttgaact gaatttgtgc ttaagttgtc ttcactttta ttatctacaa ataagctaat
     3541 gggtgtgacg gctttcatag ctggcagtat ttacatgtgt gtagaatgta tatatatagt
     3601 atcagacatg catggagctt ggaccttctc ccttagaaaa tgcagacgtg aatcaaacac
     3661 cttttagtca cttacacaaa tttgcaagta tagttctgct cattataagg caaactgcta
     3721 acaatgtaaa ttgttctgct taacaaaacc gtgagtaaca gtgtcccagt attctttcgt
     3781 gaaggttaaa atcagtgggt ttgtcttgtt gcctgtgaag caattcacaa actctcttgt
     3841 cagcttcctt ttagctttca aaaaacatct catctgattg tgtccttttg aggagactgt
     3901 ttccatgcta ggaaggtctg gcaccacact aacttgtaat ttaatatgca agacaagcaa
     3961 tttaagagtc tcatcgaact aaataagttc caaacctagc tgggcaatgg ggacacatgc
     4021 ctttaatccc agcactcggt gggtagaggc aggctgatct ctgtgagttt gaggccagcc
     4081 tggtctacag aatgagttcc aggacagcaa gggatatgct gagaaactct gtctggaaaa
     4141 atcaaaggaa aaagtgttta aaagtttcaa ccctacgacc aagagcataa agtctacaga
     4201 ggaatatgaa ctgtacatgg tgctgccccc taaaggactc aaatcattta agatattcct
     4261 ttgatgaaag accactgcct gtttgcacac ctctttggag catttcagtg acaaagagct
     4321 ggcttgtggt gagtgtctct ctaaacttta atgaactact ttacacacag ttatccttct
     4381 tctacatccc atctcagaaa cgtgaaaagc atagcacctg gtactacgcc tctggcaggt
     4441 gtctatatta tgtggaaact tttatggagt gataggacta atggaagacc tcaaaatttg
     4501 tattttcact ctgttatgca ctagtacaag tgtagagctt gattctttag acaatgcctt
     4561 tttcttattt ctcatcccca ataaagatct cccagtgaga ttttgtgtaa ataatctgta
     4621 atataggaat tcagagggcc tcagtcattt atcacagcta gatgacctta cagacagcag
     4681 aaaggacagg aaagatagtg ggagacagta gttttcctca caaattctta cattccagcc
     4741 aagacaaagg atgtgtgaag tctgagttgg tactgttcct gcagaatggt aggagcaggt
     4801 gggatctcct gatacaatct ggaacaaagt ttggcctgtc acatgaggtt ttgtttacca
     4861 ggctgtcttg aaatgtctgg gcagatgggt gtctgccaaa gcaaggactg atcctgtctg
     4921 tgaacagcaa tgtctctgct cttcttctct gtggagtgac tcacccattt actgaccact
     4981 tgtgaaattg tctaaagatg tatactgtaa aagcttcgaa agaactgtac aaactgtaag
     5041 atattttata cctattttat gttttctgtg tctcatattt atatcataaa aacattggat
     5101 ccctataact tcaaaaaaaa aaaaaaaaa
//
