LOCUS       NM_029004               2248 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus RasGEF domain family, member 1C (Rasgef1c), transcript
            variant 2, mRNA.
ACCESSION   NM_029004 XM_126185
VERSION     NM_029004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047088.1, AK018593.1 and BX639019.1.
            
            On Aug 18, 2005 this sequence version replaced XM_126185.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 1. It encodes isoform
            2, which has a shorter N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018593.1, SRR7345562.1678047.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AK047088.1         3-213
            212-2236            AK018593.1         201-2225
            2237-2248           BX639019.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.02 cM"
     gene            1..2248
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /note="RasGEF domain family, member 1C"
                     /db_xref="GeneID:74563"
                     /db_xref="MGI:MGI:1921813"
     exon            1..133
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            134..316
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1540
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ras-GEF domain-containing family member 1C"
                     /codon_start=1
                     /product="ras-GEF domain-containing family member 1C
                     isoform 2"
                     /protein_id="NP_083280.1"
                     /db_xref="CCDS:CCDS24625.1"
                     /db_xref="GeneID:74563"
                     /db_xref="MGI:MGI:1921813"
                     /translation="MPRTLTASDMVTPGSLSPPPTESTEGEQAGQPLLDGAPSSASLD
                     TLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKAR
                     VRKFGAKLLQLLAEWTETFPRDFEEESTIGHLTDVVGRISPCDETYGSRVHQLLQTLH
                     QKLASLGQGPESLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRH
                     IGPEEFVQAFVNKDPLAGTKPRFSDKTNNVEAYVKWFNRLCYLVATEICMPAKKKQRA
                     QVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFFILEHQMDP
                     TGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNF
                     EKFLELAKQVGEFITWKQVECPFEQDPSITHYLYTAPIFSEDGLYLASYESESPESQT
                     EKERWKSLRSSILGKT"
     exon            317..439
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            440..577
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            578..778
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            779..853
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            854..943
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1046
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1126
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1222
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1318
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1442
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1515
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2244
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2244
                     /gene="Rasgef1c"
                     /gene_synonym="9130006A14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggctgcgtg cgggatcgcg gcgggctgcg agcgggcgag caggcagcgc ccggtccacg
       61 gtgcagcggc tgcagcgggc gcggcgggcg ctgccgatgg gccgggcccg ggctgccgga
      121 gcgccgggag ccggcaggca tgccccggac actgactgcc tccgacatgg tcaccccagg
      181 cagcctcagc ccgcctccca cagaatccac agaaggagag caggccgggc agcccctcct
      241 ggacggagct ccatcctcag cctctttgga caccctgatc caacacctcg tgcccacagc
      301 cgattactat cccgagaaag cctacatctt caccttcctg ctgagctctc gtctcttcat
      361 cgagccccga gagctcctgg ctcgggtgtg tcacctgtgc atagagcagc aacagctgga
      421 caagccggtg ctggacaagg cccgagtccg gaagtttggt gccaaattgc tccagttgtt
      481 agccgagtgg actgagacct tcccacggga ctttgaagag gagtccacca ttggacacct
      541 gacagacgtg gtgggccgca tctccccgtg tgacgagacc tacgggagca gggtacacca
      601 gctcctgcag actctgcacc agaaattggc gtcacttggc cagggaccag aaagcctggt
      661 gggagccgac aagcccatct cctacaggac caagcctcca gcctccatcc acagggagct
      721 cctgggtgtc tgcagtgacc cctacacgct ggcccagcaa ctgacccacg tggagctgga
      781 gcgactaagg cacattgggc ccgaggagtt tgtccaggct tttgtgaaca aggaccccct
      841 ggcaggcaca aagccccgct tcagtgacaa gacgaacaac gttgaggcct acgtgaagtg
      901 gttcaacaga ctatgctacc tggtagcaac ggaaatctgc atgccagcca agaagaagca
      961 gagagcgcag gtgatcgagt tcttcatcga tgtggcccga gagtgcttca acatcggcaa
     1021 cttcaactcc ctcatggcca ttatctctgg catgaacatg agccctgtct ccaggctgaa
     1081 gaagacttgg gccaaagtga aaacagccaa attcttcatt ctggagcacc agatggaccc
     1141 aacagggaac ttctgcaact ataggacagc cctgcgtggg gcagcccacc gctcactcac
     1201 tgctcacagc agcagggaga agatcgtcat ccccttcttc agtctgctca tcaaggacat
     1261 ttacttcctc aatgagggct gtgccaaccg ccttcccaat gggcatgtca actttgagaa
     1321 atttctggaa ctggccaagc aggttggaga attcattact tggaaacaag tggaatgtcc
     1381 tttcgagcaa gatccgagca tcacccatta cctgtacact gcccccatct tcagcgaaga
     1441 cggtttgtat ttggcttcct atgaaagcga gagcccagag agccagacag aaaaggagag
     1501 gtggaaatct ctaagatctt ctattctggg gaagacatga gaagccctga cacagaggaa
     1561 gagaaaacaa cggagctgac acaggcagtc ccaaccctgt cacagacagc ccaacgggca
     1621 gaggttgacg caaagcctca ttactttgca aaccagatgc tgtggcctgg tacctgccac
     1681 aaaggccatg tgggcacagg aaacctttct cgggacctca gccccagctg acttggcagg
     1741 gcctccaaga gcatgggtga catgccttgg gcaaacattg cctttatgac caagtgggtc
     1801 acatagtcaa tctgtccatt ctggacaggg acacagcact acctggatgg ctgggtgact
     1861 gcaatcacat gatcttgttg agtgccatgt gctgtggaga gtgacaccac tgtctgtcac
     1921 caggtggctt gagagcctct gtaactgcag caggcatcgt ggcacaacat gagatgtccc
     1981 tgcaccagcc ctgagcccac gctagcccct ggcattctgc tgagggtccc caatcctgtc
     2041 cttcccagag gacttgtttc tgcagtcacc atctccttct gcatcctgct ggtatcagga
     2101 tagccctctg gcgacagccg tgaaacaagt cactgaaaca aaccagagtc atggagtcgg
     2161 caatgtgtat attacaacct gctgcctagc tcccttgtaa actttagagt tggagtaaac
     2221 acatgtttgt acgcccgtcc tgcaaaaa
//
