LOCUS       NM_145839               2996 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus RasGEF domain family, member 1B (Rasgef1b), transcript
            variant 1, mRNA.
ACCESSION   NM_145839
VERSION     NM_145839.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Fernandes,H.B., Oliveira,B.D.S., Machado,C.A., Carvalho,B.C., de
            Brito Toscano,E.C., da Silva,M.C.M., Vieira,E.L.M., de
            Oliveira,A.C.P., Teixeira,A.L., de Miranda,A.S. and da Silva,A.M.
  TITLE     Behavioral, neurochemical and neuroimmune features of RasGEF1b
            deficient mice
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 129, 110908 (2024)
   PUBMED   38048936
  REMARK    GeneRIF: Behavioral, neurochemical and neuroimmune features of
            RasGEF1b deficient mice.
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Fernandes,H.B., de Oliveira,I.M., Postler,T.S., Lima,S.Q.,
            Santos,C.A.C., Oliveira,M.S., Leao,F.B., Ghosh,S., Souza,M.C.,
            Andrade,W. and Silva,A.M.
  TITLE     Transcriptomic analysis reveals that RasGEF1b deletion alters basal
            and LPS-induced expression of genes involved in chemotaxis and
            cytokine responses in macrophages
  JOURNAL   Sci Rep 13 (1), 19614 (2023)
   PUBMED   37950057
  REMARK    GeneRIF: Transcriptomic analysis reveals that RasGEF1b deletion
            alters basal and LPS-induced expression of genes involved in
            chemotaxis and cytokine responses in macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Cao,J., Shi,D., Zhu,L. and Song,L.
  TITLE     Circ_RASGEF1B Promotes LPS-Induced Apoptosis and Inflammatory
            Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in Septic Acute
            Kidney Injury Cell Model
  JOURNAL   Nephron 145 (6), 748-759 (2021)
   PUBMED   34438395
  REMARK    GeneRIF: Circ_RASGEF1B Promotes LPS-Induced Apoptosis and
            Inflammatory Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in
            Septic Acute Kidney Injury Cell Model.
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Andrade,W.A., Silva,A.M., Alves,V.S., Salgado,A.P., Melo,M.B.,
            Andrade,H.M., Dall'Orto,F.V., Garcia,S.A., Silveira,T.N. and
            Gazzinelli,R.T.
  TITLE     Early endosome localization and activity of RasGEF1b, a toll-like
            receptor-inducible Ras guanine-nucleotide exchange factor
  JOURNAL   Genes Immun 11 (6), 447-457 (2010)
   PUBMED   20090772
  REMARK    GeneRIF: Upon toll-like receptor activation, RasGEF1b may trigger
            Ras-like proteins and regulate specific biological activities of
            macrophages.
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Colasante,G., Sessa,A., Crispi,S., Calogero,R., Mansouri,A.,
            Collombat,P. and Broccoli,V.
  TITLE     Arx acts as a regional key selector gene in the ventral
            telencephalon mainly through its transcriptional repression
            activity
  JOURNAL   Dev Biol 334 (1), 59-71 (2009)
   PUBMED   19627984
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Fulp,C.T., Cho,G., Marsh,E.D., Nasrallah,I.M., Labosky,P.A. and
            Golden,J.A.
  TITLE     Identification of Arx transcriptional targets in the developing
            basal forebrain
  JOURNAL   Hum Mol Genet 17 (23), 3740-3760 (2008)
   PUBMED   18799476
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Ferreira,L.R., Abrantes,E.F., Rodrigues,C.V., Caetano,B.,
            Cerqueira,G.C., Salim,A.C., Reis,L.F. and Gazzinelli,R.T.
  TITLE     Identification and characterization of a novel mouse gene encoding
            a Ras-associated guanine nucleotide exchange factor: expression in
            macrophages and myocarditis elicited by Trypanosoma cruzi parasites
  JOURNAL   J Leukoc Biol 72 (6), 1215-1227 (2002)
   PUBMED   12488504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY130572.1, AK149812.1, BC052726.1 and BY431575.1.
            
            On Apr 18, 2007 this sequence version replaced NM_145839.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.75602.1, AY129963.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               BY130572.1         2-215
            215-1420            AK149812.1         134-1339
            1421-2990           BC052726.1         1312-2881
            2991-2996           BY431575.1         411-416
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.46 cM"
     gene            1..2996
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /note="RasGEF domain family, member 1B"
                     /db_xref="GeneID:320292"
                     /db_xref="MGI:MGI:2443755"
     exon            1..214
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            215..397
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1642
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GPI-gamma 4; ras-GEF domain-containing family member 1B"
                     /codon_start=1
                     /product="ras-GEF domain-containing family member 1B
                     isoform 1"
                     /protein_id="NP_665838.1"
                     /db_xref="CCDS:CCDS39179.1"
                     /db_xref="GeneID:320292"
                     /db_xref="MGI:MGI:2443755"
                     /translation="MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLE
                     ALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSEGDGDKNQ
                     MRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRMASGEEQTYRKNVQQMMQCL
                     IRKLAALSQYEEVLAKLSSTATDRLTVLKTKPQSIQRDIMTVCSDPYTLAQQLTHIEL
                     ERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMP
                     VKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDI
                     LEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCVNRL
                     PNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKVLQYLLSVPVFSEDALYLASYES
                     EGPENNIEKDRWKSLRSSLLGRV"
     exon            398..520
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            521..658
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            659..874
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            875..949
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1045
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1148
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1228
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1324
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1420
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1544
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1617
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..2996
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2971..2976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /note="hexamer: AATACA"
     polyA_site      2990
                     /gene="Rasgef1b"
                     /gene_synonym="4732452O09Rik; Gpig4; GPIgamma4"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggcggg ggcgtggcct gcggcaggag gcgggcattt ccccagcaag ggggtgtgcg
       61 cggctcgggc tggagtttca gtataaacaa ggaccccgac tggatcggcg ggttttccct
      121 ttcttctggc gttcgaccct tcccggtcct gagctcgcct tttggggcgc ctcggtacgg
      181 cagccaggag gcagaggctc cgagctgtgt gcgggaaagt atgcctcaga cgcccccctt
      241 ctcagcaatg tttgacagca gtggctacaa ccgaaacctc taccagtccg cagaggacag
      301 ctgtggaggc ttgtactacc atgacaacaa cctcctttct gggtctctgg aagcccttat
      361 ccaacacttg gtacccaatg tggattacta tcctgatagg acatacatct tcaccttcct
      421 gcttagttct cggttattca tgcatccgta cgagctcatg gctaaggttt gccacctgtg
      481 tgttgagcac cagcgactga gtgaagggga cggcgataag aaccagatga gaaaaattgc
      541 acctaaaatc cttcagctct tgacagagtg gacagaaaca tttccgtatg acttccggga
      601 cgagagaatg atgaggaacc tcaaggacct ggcgcacagg atggccagtg gcgaggagca
      661 gacgtaccgg aagaacgtcc agcagatgat gcagtgtctg atccgaaaac tcgccgccct
      721 cagccagtat gaggaagtcc tggccaaact cagctccaca gccacggacc ggctcacggt
      781 tctgaagacc aagccccagt ccatacagcg ggacatcatg accgtctgca gcgaccctta
      841 cacattggcc cagcagctga cccacatcga gctggagaga ctcaattaca ttggcccaga
      901 agagtttgtt caggcatttg tgcagaagga tcctttggac aacgataaga gttgctacag
      961 cgaacggaag aaaacacgga acttggaggc gtacgtagaa tggtttaatc gtctaagcta
     1021 cttggttgct acagaaatct gcatgcctgt gaagaagaag caccgagcga ggatgatcga
     1081 gtatttcatc gatgtggctc gagagtgttt caacattgga aacttcaatt ctttgatggc
     1141 aatcatctct ggtatgaata tgagcccggt ctcgagactt aagaaaacct gggccaaagt
     1201 gaagactgca aagtttgaca ttcttgagca tcagatggat ccatccagca atttctacaa
     1261 ctacagaacg gctctccgag gggcagcgca aaggtccctg actgctcaca gtagcagaga
     1321 gaagattgtg ataccattct tcagtctctt aatcaaagac atttatttcc tcaacgaggg
     1381 ctgtgtcaac cgtcttccaa atggccatgt caactttgag aaattttggg aactggccaa
     1441 acaagtgagt gaatttatga catggaaaca ggtggagtgt ccgttcgagc gggaccggaa
     1501 ggtcttacaa tacctgctct ccgtgcctgt attcagtgaa gatgcgctct acttggcttc
     1561 atacgagagt gaaggacccg aaaataatat agagaaggac agatggaagt ctttaaggtc
     1621 cagccttttg ggcagagttt aacatctgga aaatgctgct gctgctgttg ctgctgctgc
     1681 tgccactgct gcatcagagg accctggagg ggctggcctt tgttttctgg catccagtac
     1741 tagggactgc ctcccagacc ctgcaagcaa gcccagctgt agatcagacg ggaaattcat
     1801 ttcccacagc tgacagatgg acttggatct cttttgagac tgaaatcgtc actgaagaca
     1861 cttgagggag aatcttctga aagccccggc tctgcgcatg attcatcttc tggaatttcc
     1921 atgtgaatca cagctctgca cctggatgga cttttgtttg tgatatattt ttttttttgg
     1981 cctgaacatt tgctgctaat ggaacttaca cagagtgcgg ctctatggaa gcccaagttt
     2041 ctttgttaat ttaaatgaaa aagggagagg gagggagggg aaacccctcc cacccaccaa
     2101 gtttggatcc tggacctcag cttgaacagt attccagtga gggcaaagat tgggtggggt
     2161 tctactgcag acatcccctt acccagtgcg gtattgtcaa cacccctccc ccgtccccct
     2221 cttcctccaa ggctttgagt tggctgctgg ctagcaaact ccttcttacc cattaagtta
     2281 tttaatataa taatgaagcg caacactgtg gtaggaaaat agccactagg ggggaaaaaa
     2341 ggcagagatt gtcactgtcg gactgcccat cctgcaggaa gggtcactgt aggattgctc
     2401 atcctgcggg aagggaccat gttttcttta cccttctgag ctgtttacag ctgaccactg
     2461 tgtcctatag atgtattttt cagtaggttt tgtttttgtt gttgttaact tagttttcca
     2521 tgatgctgcc ccatccccat aaatgtaaat gctatgactt taagggtctt ggggggagga
     2581 tccatgacct aaacacagtc gttttttttt tttttcctaa cttatttttc attattctct
     2641 ggagtcagtt ggtggctaaa catataaaca aggaatccat taagaaaact tacctcctcg
     2701 ccccgcagca gtgaccaaat gcaaaccagg ttgctgataa ttctgatcaa ctttaacatc
     2761 taaattaggt ctgtagttgt tctgcaggca gccattacga tactctagga gaaactttag
     2821 agtagtgatc ccctgctaat gaaaatgcac aatgccaagt tccagccatg ttggttaacc
     2881 cttctgacgc catcctgaga atcagcatgt cttaaccgtg cgtcatctca acaggcttgg
     2941 cctgtctcca agttgtccct tcacaatgtc aatacatttt aagctctgca gccagg
//
