LOCUS       NM_029182               2810 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus RASD family, member 2 (Rasd2), mRNA.
ACCESSION   NM_029182 XM_204287 XM_905295
VERSION     NM_029182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Pan,Y., Tang,B., Li,X.J., Li,S. and Liu,Q.
  TITLE     Rhes depletion promotes striatal accumulation and aggregation of
            mutant huntingtin in a presymptomatic HD mouse model
  JOURNAL   Front Aging Neurosci 15, 1237018 (2023)
   PUBMED   37637962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Cheng,Z., Zhang,C., Zhao,F., Piao,J., Cui,R. and Li,B.
  TITLE     Rasd2 Mediates Acute Fasting-Induced Antidepressant-Like Effects
            via Dopamine D2 Receptor Activation in Ovariectomized Mice
  JOURNAL   Int J Neuropsychopharmacol 26 (3), 217-229 (2023)
   PUBMED   36566472
  REMARK    GeneRIF: Rasd2 Mediates Acute Fasting-Induced Antidepressant-Like
            Effects via Dopamine D2 Receptor Activation in Ovariectomized Mice.
            Erratum:[Int J Neuropsychopharmacol. 2023 Apr 17;26(4):307. PMID:
            37002955]
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Heikkinen,T., Bragge,T., Kuosmanen,J., Parkkari,T., Gustafsson,S.,
            Kwan,M., Beltran,J., Ghavami,A., Subramaniam,S., Shahani,N.,
            Ramirez-Jarquin,U.N., Park,L., Munoz-Sanjuan,I. and
            Marchionini,D.M.
  TITLE     Global Rhes knockout in the Q175 Huntington's disease mouse model
  JOURNAL   PLoS One 16 (10), e0258486 (2021)
   PUBMED   34648564
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Sharma,M., Ramirez Jarquin,U.N., Rivera,O., Kazantzis,M.,
            Eshraghi,M., Shahani,N., Sharma,V., Tapia,R. and Subramaniam,S.
  TITLE     Rhes, a striatal-enriched protein, promotes mitophagy via Nix
  JOURNAL   Proc Natl Acad Sci U S A 116 (47), 23760-23771 (2019)
   PUBMED   31676548
  REMARK    GeneRIF: Rhes is a major regulator of mitophagy via Nix, which may
            determine striatal vulnerability in the brain
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Napolitano,F., De Rosa,A., Russo,R., Di Maio,A., Garofalo,M.,
            Federici,M., Migliarini,S., Ledonne,A., Rizzo,F.R., Avallone,L.,
            Nuzzo,T., Biagini,T., Pasqualetti,M., Mercuri,N.B., Mazza,T.,
            Chambery,A. and Usiello,A.
  TITLE     The striatal-enriched protein Rhes is a critical modulator of
            cocaine-induced molecular and behavioral responses
  JOURNAL   Sci Rep 9 (1), 15294 (2019)
   PUBMED   31653935
  REMARK    GeneRIF: The striatal-enriched protein Rhes is a critical modulator
            of cocaine-induced molecular and behavioral responses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Ciobanu,D.C., Lu,L., Mozhui,K., Wang,X., Jagalur,M., Morris,J.A.,
            Taylor,W.L., Dietz,K., Simon,P. and Williams,R.W.
  TITLE     Detection, validation, and downstream analysis of allelic variation
            in gene expression
  JOURNAL   Genetics 184 (1), 119-128 (2010)
   PUBMED   19884314
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Quintero,G.C., Spano,D., Lahoste,G.J. and Harrison,L.M.
  TITLE     The Ras homolog Rhes affects dopamine D1 and D2 receptor-mediated
            behavior in mice
  JOURNAL   Neuroreport 19 (16), 1563-1566 (2008)
   PUBMED   18845937
REFERENCE   8  (bases 1 to 2810)
  AUTHORS   Errico,F., Santini,E., Migliarini,S., Borgkvist,A., Centonze,D.,
            Nasti,V., Carta,M., De Chiara,V., Prosperetti,C., Spano,D.,
            Herve,D., Pasqualetti,M., Di Lauro,R., Fisone,G. and Usiello,A.
  TITLE     The GTP-binding protein Rhes modulates dopamine signalling in
            striatal medium spiny neurons
  JOURNAL   Mol Cell Neurosci 37 (2), 335-345 (2008)
   PUBMED   18035555
  REMARK    GeneRIF: The absence of Rhes modulates cAMP/PKA signalling in both
            striatopallidal and striatonigral projection neurons by increasing
            Golf protein levels and, in turn, influencing motor responses
            challenged by dopaminergic agonist/antagonist.
REFERENCE   9  (bases 1 to 2810)
  AUTHORS   Spano,D., Branchi,I., Rosica,A., Pirro,M.T., Riccio,A.,
            Mithbaokar,P., Affuso,A., Arra,C., Campolongo,P., Terracciano,D.,
            Macchia,V., Bernal,J., Alleva,E. and Di Lauro,R.
  TITLE     Rhes is involved in striatal function
  JOURNAL   Mol Cell Biol 24 (13), 5788-5796 (2004)
   PUBMED   15199135
  REMARK    GeneRIF: Rhes disruption affects selected behavioral competencies,
            including a gender-dependent increase in anxiety levels and a clear
            motor coordination deficit but no learning or memory impairment.
REFERENCE   10 (bases 1 to 2810)
  AUTHORS   Vargiu,P., De Abajo,R., Garcia-Ranea,J.A., Valencia,A.,
            Santisteban,P., Crespo,P. and Bernal,J.
  TITLE     The small GTP-binding protein, Rhes, regulates signal transduction
            from G protein-coupled receptors
  JOURNAL   Oncogene 23 (2), 559-568 (2004)
   PUBMED   14724584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC076974.33.
            
            [WARNING] On Jun 18, 2024 this sequence was replaced by
            NM_029182.2.
            
            On or before Oct 31, 2008 this sequence version replaced
            XM_905295.3, XM_204287.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036988.1, SRR1660815.24040.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC076974.33        25290-25424
            136-415             AC076974.33        29882-30161
            416-2810            AC076974.33        33065-35459
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.61 cM"
     gene            1..2810
                     /gene="Rasd2"
                     /gene_synonym="4930526B11Rik; Rhes; TEM-2; TEM2"
                     /note="RASD family, member 2"
                     /db_xref="GeneID:75141"
                     /db_xref="MGI:MGI:1922391"
     exon            1..135
                     /gene="Rasd2"
                     /gene_synonym="4930526B11Rik; Rhes; TEM-2; TEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..415
                     /gene="Rasd2"
                     /gene_synonym="4930526B11Rik; Rhes; TEM-2; TEM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..945
                     /gene="Rasd2"
                     /gene_synonym="4930526B11Rik; Rhes; TEM-2; TEM2"
                     /EC_number="3.6.5.2"
                     /note="ras homolog enriched in striatum"
                     /codon_start=1
                     /product="GTP-binding protein Rhes"
                     /protein_id="NP_083458.1"
                     /db_xref="CCDS:CCDS52602.1"
                     /db_xref="GeneID:75141"
                     /db_xref="MGI:MGI:1922391"
                     /translation="MMKTLSSGNCTLNVPAKNSYRMVVLGASRVGKSSIVSRFLNGRF
                     EDQYTPTIEDFHRKVYNIHGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDS
                     RESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICGNKNDHSELCRQVPAMEAELLV
                     SGDENCAYFEVSAKKNTNVNEMFYVLFSMAKLPHEMSPALHHKISVQYGDAFHPRPFC
                     MRRTKVAGAYGMVSPFARRPSVNSDLKYIKAKVLREGQARERDKCSIQ"
     exon            416..2810
                     /gene="Rasd2"
                     /gene_synonym="4930526B11Rik; Rhes; TEM-2; TEM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasd2"
                     /gene_synonym="4930526B11Rik; Rhes; TEM-2; TEM2"
                     /note="hexamer: ATTAAA"
     polyA_site      2808
                     /gene="Rasd2"
                     /gene_synonym="4930526B11Rik; Rhes; TEM-2; TEM2"
                     /note="major polyA site"
ORIGIN      
        1 ccgtacgcag tgaccctgga gcccccgcag acgccgggag actcagcggt cggagcggca
       61 ggcggctccc cgcacctcca ggagcttcca gggagccctc caagccgtgc tcggggtccg
      121 tcccgctgtt ctcagcccag agccatgatg aagaccttgt ccagtgggaa ctgcacactc
      181 aatgtgcctg ctaagaactc ctaccgcatg gtggtgctgg gtgcctcccg agtgggcaag
      241 agctccattg tctcccgctt cctcaatggc cgctttgagg accagtacac gcccactatc
      301 gaggactttc atcgcaaggt gtacaacatc cacggggaca tgtaccagct ggatatcctg
      361 gacacctctg gcaaccaccc attccctgcc atgcgccggc tctccatcct cacaggagat
      421 gtcttcatcc tggtgttcag cctggatagc cgggagtcct ttgatgaggt caagcgcctc
      481 cagaaacaga tcctggaggt caagtcctgc ctgaagaata aaaccaagga ggcagcagag
      541 ctgcccatgg tgatctgtgg gaacaagaat gaccacagtg agctgtgccg ccaggtccct
      601 gccatggagg ctgagctgct ggtgtctggt gatgaaaact gcgcctactt cgaggtgtca
      661 gccaagaaga acactaatgt gaatgagatg ttctatgtgc tgttcagcat ggccaagctg
      721 ccccatgaga tgagccctgc actgcaccat aagatctccg tgcagtacgg cgatgctttt
      781 cacccccggc ccttctgcat gcgtcgcact aaggtcgcag gtgcctatgg catggtctca
      841 ccctttgccc gacgccccag tgtcaacagt gacctcaagt acatcaaggc caaggtccta
      901 cgggagggcc aggcccgaga gagggacaag tgtagcatcc agtgagaggc agggacatcg
      961 gggagggggc ttgggcagtg ccttaaggga ggtggctgag gattcccact gcgcacatcc
     1021 cacagagggc cctaggtgtg taccctgtgc ccattctctt gtttcctgga cacctcctgt
     1081 gagccgtgag tgtggttcct ttgtgggagg acggagacat gtctagggac atgacagcac
     1141 tcatgccgag acaagctttc cgtgggaggg atgcaaaaag gccaggagtc ctgcatcaaa
     1201 gcaagatgct cagtacaagt cacaggatga gaacatctta gccagatgcc ccagccaggt
     1261 tccctggtgg cctctgctcc ctctgttcag accagcttgg tctcagtgtc cctggagaaa
     1321 ccaccatcct gggtcttcag ctcctgccgt ctggcccagc tgtgtacact gccccccaat
     1381 ttagcccctg gggccatcat gaccttgagt ggagggggga gagagaaagg gagagagaga
     1441 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga
     1501 gagagagaga ccggtgtccc ccagatcact gccttttggc tccactccca ggctcctcca
     1561 tacgatattt ctctttgttt tgaagtgtct ttcctgttct gtttgcagta gacatgaagt
     1621 ccttgtactg taagaggcca atgctttgtc tttgaccggg cttcccaatt caaatccatt
     1681 gctttggccg gggtctccct ccctgctccc aggcaggctg tgttctgccc agtgtccatc
     1741 ggcctacaaa gagcccacag tgccacagtc acagcagtaa tctcctgccc tctggagagg
     1801 atgactgagc tttgagagag tgattctaac cccctccgca ctcctaacta gttcaggaca
     1861 gagctctgac tagatgcagc tttcttctgc tttagttcct taaacatctg ccaagcacct
     1921 acctgatact ggtcccttgt gtgctaggca acagagagcg aggggtcctg tgtgtcccca
     1981 gctccggcct ctgccctccc atggtgccct ttctgcgcac acagctgttg gaggaagtgg
     2041 agcagttgag agccagagcc gagtccagga aaggttggaa ggacatattg caggacttac
     2101 cctagtgttc aggctatgct aggtacacag gagtgggggt gaccctgaaa accaaaggtc
     2161 ctgttcacca cctcttaatg catctgtgct ttagtcttat tagtactgca gctggcccat
     2221 ttgagatgac tctgggtaaa gacacctgct gccaagcttt caacctgagt ttggtcccgg
     2281 ggttccatgt ggtggaagga gagaagtcat ccattgacct ccacacatcc atcatggtac
     2341 ccctagcgcg cccccccccc cccatgaatt attgaagctg atgattatca gaaaccacag
     2401 caatctaata gtgcattctc tcaaggccca ggtcactccc tgcaagctgg gtcggccatg
     2461 ggccttccat acacaccacg tcataccctg tctccttgga gctcccagta gccgggattt
     2521 ggatcatgtt acatatgcct tcctcagagc aatcactgag gctatctgtg gatactgtgc
     2581 acattgtcac ccttgctctg cacaccaggc ccagcccaga ctccatacac acacctgctg
     2641 ctcagcacaa ttgcttcagc acctgcttct gtcctacaat gactccagcc ccagtcctga
     2701 gtataccagg tacttgtcca ggcaagtcta tggcctggtc catccggtca agctctactg
     2761 cctggacctc tgtgtacact atcaattaaa gttggtttgt tagctgtgcc
//
