LOCUS       NM_009026               1624 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAS, dexamethasone-induced 1 (Rasd1), mRNA.
ACCESSION   NM_009026
VERSION     NM_009026.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1624)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1624)
  AUTHORS   Zhang,J., Gao,J., Zhang,D., Liu,H., Gou,K. and Cui,S.
  TITLE     miR-375 acts as a novel factor modulating pituitary prolactin
            synthesis through Rasd1 and Esr1
  JOURNAL   J Endocrinol 250 (1), 25-35 (2021)
   PUBMED   34014836
  REMARK    GeneRIF: miR-375 acts as a novel factor modulating pituitary
            prolactin synthesis through Rasd1 and Esr1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1624)
  AUTHORS   Seok,J.W., Kim,D., Yoon,B.K., Lee,Y., Kim,H.J., Hwang,N., Fang,S.,
            Kim,H.J. and Kim,J.W.
  TITLE     Dexras1 plays a pivotal role in maintaining the equilibrium between
            adipogenesis and osteogenesis
  JOURNAL   Metabolism 108, 154250 (2020)
   PUBMED   32335074
  REMARK    GeneRIF: Dexras1 is critical for maintaining the equilibrium
            between adipogenesis and osteogenesis upon steroid treatment.
REFERENCE   4  (bases 1 to 1624)
  AUTHORS   Khan,R.S., Baumann,B., Dine,K., Song,Y., Dunaief,J.L., Kim,S.F. and
            Shindler,K.S.
  TITLE     Dexras1 Deletion and Iron Chelation Promote Neuroprotection in
            Experimental Optic Neuritis
  JOURNAL   Sci Rep 9 (1), 11664 (2019)
   PUBMED   31406150
  REMARK    GeneRIF: Dexras1 Deletion and Iron Chelation Promote
            Neuroprotection in Experimental Optic Neuritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1624)
  AUTHORS   Bouchard-Cannon,P., Lowden,C., Trinh,D. and Cheng,H.M.
  TITLE     Dexras1 is a homeostatic regulator of exercise-dependent
            proliferation and cell survival in the hippocampal neurogenic niche
  JOURNAL   Sci Rep 8 (1), 5294 (2018)
   PUBMED   29593295
  REMARK    GeneRIF: Study reveals Dexras1 as an important stage-specific
            regulator of exercise-induced neurogenesis in the adult hippocampus
            by enhancing pro-mitogenic signaling to neural progenitor cells and
            modulating cell survival.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1624)
  AUTHORS   Cheng,H.Y., Obrietan,K., Cain,S.W., Lee,B.Y., Agostino,P.V.,
            Joza,N.A., Harrington,M.E., Ralph,M.R. and Penninger,J.M.
  TITLE     Dexras1 potentiates photic and suppresses nonphotic responses of
            the circadian clock
  JOURNAL   Neuron 43 (5), 715-728 (2004)
   PUBMED   15339652
  REMARK    GeneRIF: Genetic deletion of Dexras1 reduces photic entrainment by
            eliminating a pertussis-sensitive circadian response to NMDA.
            Mechanistically, Dexras1 couples NMDA and light input to Gi/o and
            ERK activation. In
REFERENCE   7  (bases 1 to 1624)
  AUTHORS   Takahashi,H., Umeda,N., Tsutsumi,Y., Fukumura,R., Ohkaze,H.,
            Sujino,M., van der Horst,G., Yasui,A., Inouye,S.T., Fujimori,A.,
            Ohhata,T., Araki,R. and Abe,M.
  TITLE     Mouse dexamethasone-induced RAS protein 1 gene is expressed in a
            circadian rhythmic manner in the suprachiasmatic nucleus
  JOURNAL   Brain Res Mol Brain Res 110 (1), 1-6 (2003)
   PUBMED   12573527
  REMARK    GeneRIF: the Dexamethasone-induced RAS protein 1 (Dexras1) gene is
            a cycling gene in the suprachiasmatic nucleus
REFERENCE   8  (bases 1 to 1624)
  AUTHORS   Fang,M., Jaffrey,S.R., Sawa,A., Ye,K., Luo,X. and Snyder,S.H.
  TITLE     Dexras1: a G protein specifically coupled to neuronal nitric oxide
            synthase via CAPON
  JOURNAL   Neuron 28 (1), 183-193 (2000)
   PUBMED   11086993
REFERENCE   9  (bases 1 to 1624)
  AUTHORS   Tu,Y. and Wu,C.
  TITLE     Cloning, expression and characterization of a novel human
            Ras-related protein that is regulated by glucocorticoid hormone
  JOURNAL   Biochim Biophys Acta 1489 (2-3), 452-456 (1999)
   PUBMED   10673050
REFERENCE   10 (bases 1 to 1624)
  AUTHORS   Kemppainen,R.J. and Behrend,E.N.
  TITLE     Dexamethasone rapidly induces a novel ras superfamily
            member-related gene in AtT-20 cells
  JOURNAL   J Biol Chem 273 (6), 3129-3131 (1998)
   PUBMED   9452419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK038932.1 and AW060444.1.
            
            On Sep 18, 2015 this sequence version replaced NM_009026.4.
            
            Summary: This gene encodes a member of the Ras superfamily of small
            GTPases and is induced by dexamethasone. The encoded protein is an
            activator of G-protein signaling and acts as a direct nucleotide
            exchange factor for Gi-Go proteins. This gene may play a role in
            dexamethasone-induced alterations in cell morphology, growth and
            cell-extracellular matrix interactions. [provided by RefSeq, Nov
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF009246.1, BC034166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1473              AK038932.1         2-1474
            1474-1624           AW060444.1         1-151               c
FEATURES             Location/Qualifiers
     source          1..1624
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..1624
                     /gene="Rasd1"
                     /gene_synonym="Dexras1"
                     /note="RAS, dexamethasone-induced 1"
                     /db_xref="GeneID:19416"
                     /db_xref="MGI:MGI:1270848"
     exon            1..425
                     /gene="Rasd1"
                     /gene_synonym="Dexras1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..982
                     /gene="Rasd1"
                     /gene_synonym="Dexras1"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="dexamethasone-induced Ras-related protein 1"
                     /protein_id="NP_033052.1"
                     /db_xref="CCDS:CCDS24781.1"
                     /db_xref="GeneID:19416"
                     /db_xref="MGI:MGI:1270848"
                     /translation="MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRF
                     LTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILV
                     FSLDNRDSFEEVQRLKQQILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVEQREI
                     EQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLH
                     KKALRNKKLLRAGSGGGGDHGDAFGILAPFARRPSVHSDLMYIREKTSVGSQAKDKER
                     CVIS"
     exon            426..1611
                     /gene="Rasd1"
                     /gene_synonym="Dexras1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1488
                     /gene="Rasd1"
                     /gene_synonym="Dexras1"
     regulatory      1592..1597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasd1"
                     /gene_synonym="Dexras1"
                     /note="hexamer: AATAAT"
     polyA_site      1611
                     /gene="Rasd1"
                     /gene_synonym="Dexras1"
                     /note="major polyA site"
ORIGIN      
        1 gagcctgctg tctgtaccca agagcccaga ccagctcgcg cagtcccgaa gccaagctct
       61 tccgtcactc cggagttctc tgcagccctc tctctacctt ctctcggcca cgcatccgcc
      121 cctggggccc ctctacccaa tgaaactggc cgcgatgatc aagaagatgt gcccaagcga
      181 ctctgaactg agtatcccgg ccaagaactg ctacaggatg gtcatcctcg gctcatccaa
      241 agtgggcaag acggccattg tgtcgcgctt cctcacgggc cgtttcgagg atgcttacac
      301 ccctaccatc gaggacttcc accgaaagtt ttactcgatc cgcggcgaag tctaccagtt
      361 ggacatactg gacacatccg gcaatcatcc gtttcccgcc atgcggcgcc tctctatcct
      421 cacaggagac gttttcattc tggtgttcag cttagacaac cgcgactcat tcgaagaggt
      481 gcaaaggctc aaacagcaga tcctagacac caagtcctgt ctcaagaaca aaaccaaaga
      541 gaatgtggac gtgccgctgg tcatttgcgg taacaaaggg gaccgggact tctaccggga
      601 agtagagcag cgggagattg agcagctggt gggtgacgac cctcagcgtt gtgcctactt
      661 cgagatctca gccaagaaga acagcagctt ggaccagatg ttccgtgcgc tctttgccat
      721 ggccaagctg cctagcgaga tgagccccga cttgcaccgc aaggtatctg tgcagtactg
      781 cgacgtactg cacaagaagg ctctgaggaa caagaagctt ctgcgtgcgg gcagcggagg
      841 cgggggcgac cacggcgatg cctttggcat cttggcgccc tttgctcgca gacccagcgt
      901 gcacagcgac ctcatgtaca ttcgtgaaaa aaccagtgtc ggcagccagg ctaaggacaa
      961 ggagcgctgt gtcatcagtt aggagccccc agggtcagcc acacaacctg aggacctttt
     1021 ttgttcaaaa gtcaaatcgg attcctggac tagcggtccg tgccacagga gcgccaattg
     1081 gccttctcct tccctccctg agacccagcc cggggagacc aagccagtaa gggacagtca
     1141 cctgctgtga aaggaaagag aactagctaa gacaggagct gtcacctccg attctgggat
     1201 gccaggaccc agcagagggg cgcttggcat ttttctcaag aggtttgaga aaaagcgtgt
     1261 gaagttcatc agcctgtgag acttaaagta actgtcctgc tcgcttcagg gcaggactaa
     1321 taatagggca ttatcttgtc tgtgattggt gttgccatgg ccgctgtcag ccacctctgt
     1381 cctcagcaaa ctggaaactt tggctggagg tggggggggg gggtgttcaa tcatagccaa
     1441 gtgacttgtt tacatgtgtg tgtgcaatta cccaaaagaa aaacaaaaca caaaacttgc
     1501 actttaatag ttccagtgtc aatgtgacat gaacaaaatc tctacatttc tattgtgtga
     1561 ggtctttatt attatttttt atttaaaata aaataattta gaaacggaaa aaaaaaaaaa
     1621 aaaa
//
