LOCUS       NM_001347343            3630 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAS protein activator like 3 (Rasal3), transcript
            variant 1, mRNA.
ACCESSION   NM_001347343 XM_006524413
VERSION     NM_001347343.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Olivier,J.F., Langlais,D., Jeyakumar,T., Polyak,M.J., Galarneau,L.,
            Cayrol,R., Jiang,H., Molloy,K.R., Xu,G., Suzuki,H., LaCava,J.,
            Gros,P. and Fodil,N.
  TITLE     CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic
            cell function in neuroinflammation and colitis
  JOURNAL   Commun Biol 7 (1), 77 (2024)
   PUBMED   38200184
  REMARK    GeneRIF: CCDC88B interacts with RASAL3 and ARHGEF2 and regulates
            dendritic cell function in neuroinflammation and colitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Saito,S., Cao,D.Y., Victor,A.R., Peng,Z., Wu,H.Y. and
            Okwan-Duodu,D.
  TITLE     RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by
            Neutrophils
  JOURNAL   Front Immunol 12, 744300 (2021)
   PUBMED   34777356
  REMARK    GeneRIF: RASAL3 Is a Putative RasGAP Modulating Inflammatory
            Response by Neutrophils.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Muro,R., Nitta,T., Kitajima,M., Okada,T. and Suzuki,H.
  TITLE     Rasal3-mediated T cell survival is essential for inflammatory
            responses
  JOURNAL   Biochem Biophys Res Commun 496 (1), 25-30 (2018)
   PUBMED   29291408
  REMARK    GeneRIF: Collectively, Rasal3 controls the magnitude of
            inflammatory responses through the survival of both naive T cells
            and activated T cells in vivo.
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Saito,S., Kawamura,T., Higuchi,M., Kobayashi,T.,
            Yoshita-Takahashi,M., Yamazaki,M., Abe,M., Sakimura,K., Kanda,Y.,
            Kawamura,H., Jiang,S., Naito,M., Yoshizaki,T., Takahashi,M. and
            Fujii,M.
  TITLE     RASAL3, a novel hematopoietic RasGAP protein, regulates the number
            and functions of NKT cells
  JOURNAL   Eur J Immunol 45 (5), 1512-1523 (2015)
   PUBMED   25652366
  REMARK    GeneRIF: results suggest that RASAL3 plays an important role in the
            expansion and functions of NKT cells in the liver by negatively
            regulating Ras/Erk signaling
REFERENCE   6  (bases 1 to 3630)
  AUTHORS   Muro,R., Nitta,T., Okada,T., Ideta,H., Tsubata,T. and Suzuki,H.
  TITLE     The Ras GTPase-activating protein Rasal3 supports survival of naive
            T cells
  JOURNAL   PLoS One 10 (3), e0119898 (2015)
   PUBMED   25793935
  REMARK    GeneRIF: Rasal3 is required for in vivo survival of peripheral
            naive T cells, contributing to the maintenance of optimal T cell
            numbers.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3630)
  AUTHORS   Yu,X., Bauer,K., Koczan,D., Thiesen,H.J. and Ibrahim,S.M.
  TITLE     Combining global genome and transcriptome approaches to identify
            the candidate genes of small-effect quantitative trait loci in
            collagen-induced arthritis
  JOURNAL   Arthritis Res Ther 9 (1), R3 (2007)
   PUBMED   17244351
REFERENCE   8  (bases 1 to 3630)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485616.11.
            
            On Jan 21, 2022 this sequence version replaced NM_001347343.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132341.1, AK131128.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                CT485616.11        25793-25853         c
            62-405              CT485616.11        25328-25671         c
            406-477             CT485616.11        24708-24779         c
            478-617             CT485616.11        21562-21701         c
            618-696             CT485616.11        21357-21435         c
            697-758             CT485616.11        21189-21250         c
            759-829             CT485616.11        20293-20363         c
            830-956             CT485616.11        19766-19892         c
            957-1055            CT485616.11        19582-19680         c
            1056-1592           CT485616.11        18620-19156         c
            1593-1737           CT485616.11        18094-18238         c
            1738-1882           CT485616.11        17347-17491         c
            1883-2119           CT485616.11        16310-16546         c
            2120-2321           CT485616.11        16013-16214         c
            2322-2440           CT485616.11        15795-15913         c
            2441-2831           CT485616.11        14670-15060         c
            2832-2989           CT485616.11        14318-14475         c
            2990-3053           CT485616.11        13608-13671         c
            3054-3630           CT485616.11        12931-13507         c
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.55 cM"
     gene            1..3630
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /note="RAS protein activator like 3"
                     /db_xref="GeneID:320484"
                     /db_xref="MGI:MGI:2444128"
     exon            1..61
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            62..405
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            406..477
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            478..617
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            618..696
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            697..758
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            759..829
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..956
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1055
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1592
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1737
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1882
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2119
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2321
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2440
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2831
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2989
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3053
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3630
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3350..3355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3372
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /note="major polyA site"
     regulatory      3600..3605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggaaggaa gctaggcaca gtacagacgg ctgctggttc tggactggcc aggaaatcaa
       61 gcagagactc ctccgccatg gacccaccgt tgcagagtga agaagattcc caaacgcagc
      121 cctcgctgcc ctctccgctg acatcctacc gctggcacac tggaggcagt ggggaaaagg
      181 ctgctggagg gttccgctgg ggccgctttg caggctgggg aagggccctg agccatcagg
      241 agcccatggt gaacagccag ccagccccca gatctctgtt tcgtcgggtc ctctctgcac
      301 cccctaagga gtcacggtcc aatcgcctcc ggttttccaa gaccctgtgg ggaaggcaca
      361 agaacgtggc accactggaa cccaagccaa atccgaaggc cccagaaagg agcaagcaag
      421 ccatggttcc tggagtcaaa ggacaacttt caggagtcag ttctctcctt caattacagc
      481 cagagctgga gttggtagca gacccagatc tacccgttgc acagatccct gagcctccca
      541 ccccggacat gcctgtttgg aacattgatg gctttaccct tctcgaagga aagctggtga
      601 tgctcggtga ggaggagggt cctcgccaaa tccgagtggg aagcgccagt tcagagaaca
      661 gcatgcaggc agctttgggg aacctcaagg atgcagttcg gacccctgga aaaactgagc
      721 cggaagctgc tggttccaac caggtccaca atgttcggaa gttactcaag aggctgaagg
      781 agaagaaaag agccaagtca gaactgggag cctacacccc tcgagatgga cctcccagtg
      841 ccctcggttc cagagaatcg ctggccacac tctctgagct ggacctaggt gctgagaggg
      901 acgtgagagt ctggccactg catcctagcc tcttggggga gccctactgc ttccaggtaa
      961 cctgggcagg tgggagcctc tgtttctcat gtcgctcgag cgctgagaga gaccgttgga
     1021 ttgaggacct tcgtcggcag ttccagccga gccaggacaa cgtggagcgg caagagatgt
     1081 ggctgacggt gtgggtgcac gaggccaaag ggctaccccg agcaactgta cccggagtgc
     1141 gtgcggagct gtggttggat ggcgcgctat tggcgcgcac tgccccccgt gccggcccag
     1201 gccaactctt ctgggctgaa cgcttccact tcgaggcgtt gccacctgcc cgtcgcctgt
     1261 cgctgcggtt gcgcagcgca ggcccggcag gggcaaccgt gggcagggtg gtgctggagc
     1321 tggacgaggt gagcatcccc cgcgcgcctg ccgcgggcct agagcgctgg ttcccggtgc
     1381 ttggggcgcc ggcaggtgcg gtgctacgag cgcggatcag ggtgcgttgt ctgcgcgtgc
     1441 tgccgtcgga gcgctataag gagctggccg agttcctcac cttccactac gcgcgcctgt
     1501 gcggggcgct ggagccggcg ctgtctgctc aggccaaaga ggagctggca gcagccatgg
     1561 tgcgcgtgct acgagccact ggccgagcgc aggcattggt gacagaccta ggaaccgcag
     1621 agctggcacg ctgtggaggc cgtgaagcac tgctattccg agaaaatacc ttagccacaa
     1681 aggccattga tgaatacatg aaactggtgg cacaggagta cctccaggac accctggggc
     1741 aggttgtgcg gtgtctctgt gcctccactg aggactgtga agtggacccc agcaagtgcc
     1801 caacaccaga gctgccaaaa caccaagcta gactgcgaga cagctgtgag gaggtttttg
     1861 aaaacatcat ccattcttac aactgtttcc cagcagagct gggctccgtg ttctcaagtt
     1921 ggcgtgaagc atgcaaagca cgaggctctg aggccctggg cccccggctg gtgtgtgctt
     1981 ccctcttcct gaggctttta tgccctgcca tcttggcacc tagcctcttt ggcctggcac
     2041 cagagcaccc agccccaggc ccagccagaa ctcttacact catcgccaag gtcatccaga
     2101 acctcgccaa ctgtgccccg tttggtgaga aggaagccta catggcgttt atgaatagct
     2161 tcctggaaga tcatggacca gccatgcaac acttcctgga ccaggtagct acggtggatg
     2221 cagataccac acccagtggc taccagggaa gtggagacct ggcccttcag ttagcagttc
     2281 ttcatgtcca gctctgcaca atctttgccg aacttgacca gaaaacccaa gatagcttgg
     2341 aaccactacc caccatcctt cgagccattg aggaaggccg gcctgtccca gtgtctgtac
     2401 caatgcgtct tccccggatc tccactcagg tccaatccag cttcttttca ggggagaaac
     2461 ccggcttcct ggcaccccga gacctcccca agcacactcc cctcatttcc aagagtcaat
     2521 ctctgcgcag ctttcaaggg gcaggaagct gggccagtcg gcggccagat gaggagcggc
     2581 cccagaggcg gccgcggcca gtgctgcgca cacagagcgt ccctgccaga cgtcctaccc
     2641 accgtcgccc ttctgcaggt tccaagccgc ggcccaaagg ctccctacgc atgggccccg
     2701 cgccttgcgg acgggcctgg actagggctt ctgcctcgct acctcggaag ccatcggtac
     2761 catggcagcg ccaaatggac cagccggggg accgatacca aactacggga acgcaccgac
     2821 cagtgggcaa gctagcagag atacaatgtg aggtggctat attccgcgag gcacagaaag
     2881 ctctgtccct tctggtggag tcgttgagta cccaagtcca agccttgaag gagcagcagg
     2941 agcacttccg ctgtcagctg caggatctgt actccagact gggagctggt atctcaaagt
     3001 tggattctaa gggtggtctc ccaagcaacg gaagccacag gctgaaaagt ctggaacagc
     3061 gcctgactga gatggaatgt tctcaggacc agctgaggga tagcctccaa agcctgcaac
     3121 ttctttcaaa aacaccagga tctcggagcc agcccctgcc tctcaaagca ccatgtgtca
     3181 atggagctga tctgtcaatg ggcacttgag catttcaccc cactccatat atggtctgga
     3241 agccaagaga gccactacag aggattttct gactgcctca gcccttcatg gccttcagtg
     3301 ggggacagag tgggaggtgt caatcactct ggtaactgtg aggttgccca gtaaatccat
     3361 ttcagaaaat caccggtttc tctgccccta caaatgatta atacaagaga atgcccagtt
     3421 ctccattcag gtctcccaaa ttcataccta atttgaagtc tcctgaagtt ggaaataatg
     3481 agcagatcct cacaattggt gtgatctaag gttgtcactt taagagactc cattctctcc
     3541 tctgtaaagt gtatctaaaa attctccaca tagtggaaaa ctcttagtta aaggtattca
     3601 ataaagggta ttgatcattt ttggggggaa
//
