LOCUS       NM_053268               5699 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus RAS p21 protein activator 2 (Rasa2), mRNA.
ACCESSION   NM_053268
VERSION     NM_053268.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5699)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 5699)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   3  (bases 1 to 5699)
  AUTHORS   Kenney-Hunt,J.P., Vaughn,T.T., Pletscher,L.S., Peripato,A.,
            Routman,E., Cothran,K., Durand,D., Norgard,E., Perel,C. and
            Cheverud,J.M.
  TITLE     Quantitative trait loci for body size components in mice
  JOURNAL   Mamm Genome 17 (6), 526-537 (2006)
   PUBMED   16783635
REFERENCE   4  (bases 1 to 5699)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   5  (bases 1 to 5699)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Structure-function relationships of the mouse Gap1m. Determination
            of the inositol 1,3,4,5-tetrakisphosphate-binding domain
  JOURNAL   J Biol Chem 271 (31), 18838-18842 (1996)
   PUBMED   8702543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144935.3 and AC161257.2.
            
            On Sep 8, 2006 this sequence version replaced NM_053268.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154499.1, AB056433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC144935.3         41017-41156
            141-258             AC144935.3         61021-61138
            259-362             AC144935.3         66324-66427
            363-457             AC144935.3         69713-69807
            458-534             AC161257.2         234648-234724       c
            535-618             AC161257.2         225441-225524       c
            619-691             AC161257.2         223185-223257       c
            692-768             AC161257.2         220171-220247       c
            769-870             AC161257.2         218984-219085       c
            871-1027            AC161257.2         214563-214719       c
            1028-1176           AC161257.2         213364-213512       c
            1177-1291           AC161257.2         212389-212503       c
            1292-1366           AC161257.2         211718-211792       c
            1367-1490           AC161257.2         211062-211185       c
            1491-1597           AC161257.2         208714-208820       c
            1598-1681           AC161257.2         203396-203479       c
            1682-1759           AC161257.2         200098-200175       c
            1760-1833           AC161257.2         195811-195884       c
            1834-1940           AC161257.2         195001-195107       c
            1941-2023           AC161257.2         188945-189027       c
            2024-2232           AC161257.2         188287-188495       c
            2233-2336           AC161257.2         187486-187589       c
            2337-2523           AC161257.2         186977-187163       c
            2524-5699           AC161257.2         181998-185173       c
FEATURES             Location/Qualifiers
     source          1..5699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.66 cM"
     gene            1..5699
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /note="RAS p21 protein activator 2"
                     /db_xref="GeneID:114713"
                     /db_xref="MGI:MGI:2149960"
     exon            1..140
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2554
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /codon_start=1
                     /product="ras GTPase-activating protein 2"
                     /protein_id="NP_444498.2"
                     /db_xref="CCDS:CCDS23416.1"
                     /db_xref="GeneID:114713"
                     /db_xref="MGI:MGI:2149960"
                     /translation="MAAAAPAAAASPEAPAVSGSADPETGDEDSREVRVLQSLRGRIY
                     EAKNLLPYLGPNKMRDCFCTINLDQEEVYRTQVVEKSLSPYFSEEFYFEIPRTFQYLS
                     FYVYDKNVLQRDLRIGKVAIKKEDLCSHSGKETWFSLQPIDSNSEVQGKVHLELRLNE
                     LITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNP
                     QFNEVFYFEVTRSSSYSRKSQFQVEEEDIEKLEIRIDLWNNENLVQDVFLGEIKVPVN
                     VLRSDSFHQAWYLLQPRDNGNKSSKTDDLGSLLLTLCYTEDCVLPSEYYGPLKTLLLK
                     SPDVQPVSASAAYILGEICQDQKDAVLPLVRLLLHHNKLVPFITAVAELDLKDTPDAN
                     AIFRGNSLATQCLTEMMKIVGGHYLKVTLKPVLDEICESSKSCEIDPVKLKEGDNVEN
                     NKENLYYYVDKVFNTIVGSSVSCPTVMCDIFYSLRQMAAKKFPNHPHVQYSAVSSFVF
                     LRFFAVAILSPHAFHLRPHYPDTQTVRTLTLISKTIQIIGNWGCQSRKKSRFKKSVMC
                     EFLKMFQEERYFTDVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKN
                     FKKRWFCLTSRELTYHRQQGKDAIYTIPVKNILAVEKLEEGSFNKKNMFQVIHTEKTL
                     YIQANNCVEANEWIDVLCRVSRCNHNRLSSFHPSAYLNGNWLCCQETSESTPGCKPCT
                     AGIPADIQIDIDEDRETERIYSIFTLSLLKLQKMEETCGSIAVYQGPQKEPGYSKFTI
                     EDSVATFKTIQQIKSTIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKIS"
     exon            141..258
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            259..362
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            363..457
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            458..534
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            619..691
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            692..768
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            769..870
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1027
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1176
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1291
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1366
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1490
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1597
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1681
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1759
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1833
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1940
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2023
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2232
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2336
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2523
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..5699
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5680..5685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /note="hexamer: AATAAA"
     polyA_site      5699
                     /gene="Rasa2"
                     /gene_synonym="5430433H21Rik; GAP1m"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcacc atggcggcgg cagcgcctgc tgcggcggct tctcccgagg cgccggccgt
       61 ctcgggcagc gcagacccgg agacgggaga cgaggacagt cgtgaggtcc gagtgctgca
      121 gagcctgcgc ggcaggatct atgaagcaaa aaatttattg ccatatcttg gacccaacaa
      181 aatgcgcgat tgtttctgca ctataaattt ggaccaggaa gaagtttatc gcacccaggt
      241 tgttgaaaag tctttaagtc catatttcag tgaagaattt tattttgaga ttccaagaac
      301 tttccagtat ttgtcttttt atgtttatga taaaaatgtt ttacaaagag atcttcgtat
      361 aggaaaagta gccatcaaaa aagaagactt gtgcagtcat agtggtaaag aaacttggtt
      421 ttcactgcag ccgattgact caaattcaga agttcaggga aaggttcacc ttgagttaag
      481 actgaatgag ctgataacag agaatggaac cgtgtgccag cagcttgttg tacacatcaa
      541 ggcctgccat gggttgcctc tcataaacgg acaaagctgt gatccttatg caacagtgtc
      601 cctcgtgggc ccctctagga atgaccaaaa gaagacaaaa gtaaagaaga aaacaagcaa
      661 tccacagttc aatgaagtct tctattttga ggtaaccaga tccagcagtt acagcaggaa
      721 gtcccagttc caggtggagg aggaggacat tgagaagctg gagatcagga ttgacttgtg
      781 gaataatgaa aacctagtcc aagatgtttt cctgggagag attaaggttc ctgtcaatgt
      841 gttaagaagt gattcctttc atcaagcctg gtacttgcta cagccaagag acaatggaaa
      901 caaatcatct aaaaccgatg acctgggatc tcttctgtta actctctgct atacagaaga
      961 ctgcgtgctt ccatcagagt actatggacc gctgaaaact ttgctgctaa agtcaccaga
     1021 tgttcagcca gtatccgcct cagctgctta tattttgggt gaaatatgtc aagatcaaaa
     1081 ggatgctgtt ttgccccttg tacgactgtt gctgcatcac aataaacttg tcccttttat
     1141 cactgcggtg gccgagctgg acttgaagga tactccagat gccaacgcaa tatttagagg
     1201 aaactccctg gctacccagt gtctgactga gatgatgaag atagtgggag ggcactacct
     1261 gaaagtcacg ctgaagcccg ttctagatga gatatgtgaa tcctcgaaat cctgtgaaat
     1321 agatcctgtt aagttgaaag agggagataa tgtagagaat aataaggaga atctgtacta
     1381 ctatgtggac aaagtattca atacaatcgt aggatcaagt gtgagctgcc ccactgtgat
     1441 gtgtgatatt ttttattctc tgaggcaaat ggctgctaag aaatttccta atcaccctca
     1501 tgttcagtac tctgcagtga gcagctttgt cttccttcgt ttctttgctg tagcgatact
     1561 ctcacctcat gcttttcatt tgcgacctca ttatccagat acacagacag ttaggacatt
     1621 gactctcatc tcaaaaacca ttcagattat tggaaactgg ggatgtcagt ccagaaaaaa
     1681 gtcacggttc aaaaagtcag tcatgtgtga atttctcaaa atgtttcaag aagaaagata
     1741 ttttacagat gtgaaaaagt tcttggatga aatttcatct acggaaacta aagagtccag
     1801 tggtacgagt gagcctgtgc acctgaaaga aggtgagatg tataagagag ctcaaggaag
     1861 aacccgtatt ggaaagaaga acttcaagaa acgatggttc tgcttgacga gcagagagct
     1921 cacctaccac agacagcaag gcaaagatgc aatttacact attccagtaa aaaatattct
     1981 tgctgtggaa aaattggaag aaggctcttt caacaagaaa aatatgttcc aagtgataca
     2041 tacagagaaa acgctgtaca tccaagcaaa caactgtgtg gaagccaatg agtggataga
     2101 tgtcctgtgc agggtgagca gatgcaacca caacaggctc agctctttcc acccctcagc
     2161 gtatctcaac ggaaactggc tctgctgcca ggagacgagt gaaagcacac caggctgcaa
     2221 gccgtgcacc gcaggcatcc ctgcagacat ccagatagat atcgatgaag acagagaaac
     2281 agaaagaatt tattctattt ttaccctcag tttacttaag ctgcagaaaa tggaagagac
     2341 ctgtgggtct atagctgtgt atcaggggcc acagaaagaa cctggttatt ctaagttcac
     2401 cattgaggat tctgttgcaa cctttaagac aattcagcaa atcaaaagca ccatagagaa
     2461 gctcgatgaa cctcatgaga aatacagaaa gaaaagatcg agtagtgcaa aatacggaag
     2521 caaggaaaat ccaattgttg gaaaaatatc atagtttgac caactgatgg agaactggaa
     2581 aatactcttt ttcatcaagt ttttcagttc accccgtttt gttcatagta tgtaagaatg
     2641 gacatcggct ttgatgatac atgctgtctg tcataatgta taatatttaa tgattgaaat
     2701 taactgtttg gggatcctga tgctgatgtg tgtattacta aagaatttga aacccaagat
     2761 ttcctccata gccatgcatc cagccccgtg tccctgcagc ttccttctga tgggaagggt
     2821 cttcctgagg acccaagcag ctccgtaaca agggagcact tgacagcaag accccacctc
     2881 cacctggagc actcctgtgt cactcaccac cgtcagtgcc tcctctgtgc tgccaacatt
     2941 gagtttacta tagagctaga gttccttgtc ggtcagaact ttccattaag ttcatctgga
     3001 cgtttgtctt taaaaaaaaa aaaaaggaaa aaaaaaaacc cttttcctct gttgtgttag
     3061 ccattacagg ttagagacag acacagacat ctgaacacct ttgaaagctg gcgggtgtct
     3121 ctcctggtca caggtgaggg tgctcagctg tgaggggatg tgtgctcctg tgtgcaccat
     3181 gtttacattg gagtgggggg tggtgccaag acagtggacc actaaagtgg ccttcattgt
     3241 tcagctgtca gggactcgct ctctccgaga attcaggtta gcactcctcc tgagggcagc
     3301 tcttcccaac cagaagagaa gcatgagtga gtagtgagga gatcacctga tgttgccttc
     3361 tgtcccacat cataataagg gtgtgtaagg ataccctcca tagtgttagg tcctgctcta
     3421 actagagaac ggtcacttgg cgcactttaa taatctggca cattccaggt tgtggtttgg
     3481 atactccgta gtatctattt ttttgatcag ttgaatgatc agtgtttaaa tatcaaaccg
     3541 tgctttcctg aaaatgttga tattgtattg ctgtttcctt attgcctgct agccaaaggg
     3601 gatcaggggc agcaactgtt gggatacctg tgtttcctta ccctcctctg gccctagaaa
     3661 ccctacctgt aaataagcag ttgaagcgag tgtccctgag gaggagtgat acactcggct
     3721 tcatcagtat taaaacctat ggtacttact tgtctttttt aattaaaact attttctgag
     3781 tgtggtactt tgaaccttgg tctatttcca tatgttcctg ttgaaaactg tgacttactg
     3841 gtggaagtct cactagctgc aatcccctgt cgttgagctt aagctatagt tcaaaatata
     3901 cttaccaatt atgttgttgc tgggtaatta tttttacttc attagcaggt attttaaaga
     3961 tcattaacac agagaattgt cccattataa acgtcatgac tgaaaataga tttttttaca
     4021 aatgactttt aagtcagtgc tggcctgcat tgtgctacgc tgtgactcct ggtccatact
     4081 gaagcttaaa agagtccttc aaatctgaca gacttatgga tctaattaac tatactgtta
     4141 caggtgtttt ttaaaaacat tagccattta ataaatttat catgaacttc atattaaaat
     4201 gcctacttag attctctcaa atgtcttcct aaaaaggaca aaacccaggg gcattgaagt
     4261 tcaagactct agagtggttt gggatcatct gttcgttgtt ttgtttaggg gtttttctcc
     4321 ctcaccccac ccctcaaaaa aggatgattt cctaatgatt tcttcactct atgtccctgg
     4381 ctggcctaga actcatagaa atccacctgc ctccgctcct gagtgcgggg attaaatgtg
     4441 tatcaccaca tctggctcac ctggtctttc taatatcaaa ctccaattgc aagtattttt
     4501 aatgatcata gggtcacagg ggccaaagct gtatacatgt gtaactctga gagctcaata
     4561 ttgtagttct tttattcaca tgacctttta aacagccagc ttgactggaa ttaattagcc
     4621 agcttggtac agtgtaaaaa gagaaataca aaactaattt tctttagtaa gtcttttcca
     4681 atcagaaact atgtccacag agtccaagga cagtcagggc ccttctcggg gcttctccta
     4741 tgctgtgctc ttgcgtactt agagtcttac ctccatggtc tcctttctct gcttctgcaa
     4801 agagcatttg aaaaaaaaaa acatatatac gtacacacac acacacacac acacacacac
     4861 acatggtttt tgtatatgta tatatatata cacacacaca catgtatgtg tatgtatata
     4921 tatatatatg aacagaagat gataggagga aacttagcac agtcactcac tagctctgac
     4981 tcctagtgga gctgtatcca tccattgaga ttatactgat ctgttgttta gctttctttt
     5041 aaatcatcac ctggtaagac actgggcaac agcaaaagtt ttggttttgg tttggttttt
     5101 tttttttttt actcccagga atataattta tcaaatcaaa ctattttgct taccaaagaa
     5161 ctatgttttt aatatcacgg gtaatagcta agcatcaaaa ctgggctctt attttaccaa
     5221 caagaaacat catgtgactg atggctgggg tttgtctgtg tctccaaggc cgaattgcat
     5281 tcttttactg gaaaagttca ttcaagctag gttttagaaa atacattcct tttaagtgaa
     5341 cacaccttct aaattgcttt aagtactatt gaatagccta aaagatggac tccgcagtgc
     5401 tttctagtgt ccccacctat gtgacaaatg caaaactcat tctagagtta aaatgactga
     5461 tttttggttg atattatctg cttccatttt taacttggga attaatatgt tgctagtaaa
     5521 tactggtttg tacggtgtct agtttgtaag tgtaagttat cagaccataa tatagtgact
     5581 ctatgttgtt gagaatgtat ttttatttaa attttatttt cttatgaaga gtattataaa
     5641 aattaaaagc ttttgtaact gtcatttgaa aataactcaa ataaagtaca agaagccta
//
