LOCUS       NM_145452               4908 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Mus musculus RAS p21 protein activator 1 (Rasa1), transcript
            variant 1, mRNA.
ACCESSION   NM_145452
VERSION     NM_145452.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4908)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (bases 1 to 4908)
  AUTHORS   Benwell,C.J., Johnson,R.T., Taylor,J.A.G.E., Lambert,J. and
            Robinson,S.D.
  TITLE     A proteomics approach to isolating neuropilin-dependent alpha5
            integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5
            integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells
  JOURNAL   Commun Biol 7 (1), 629 (2024)
   PUBMED   38789481
  REMARK    GeneRIF: A proteomics approach to isolating neuropilin-dependent
            alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic
            alpha5 integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4908)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4908)
  AUTHORS   Chen,D., Geng,X., Lapinski,P.E., Davis,M.J., Srinivasan,R.S. and
            King,P.D.
  TITLE     RASA1-driven cellular export of collagen IV is required for the
            development of lymphovenous and venous valves in mice
  JOURNAL   Development 147 (23) (2020)
   PUBMED   33144395
  REMARK    GeneRIF: RASA1-driven cellular export of collagen IV is required
            for the development of lymphovenous and venous valves in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4908)
  AUTHORS   Zhang,X., Guo,H., Xie,A., Liao,O., Ju,F. and Zhou,Y.
  TITLE     MicroRNA-144 relieves chronic constriction injury-induced
            neuropathic pain via targeting RASA1
  JOURNAL   Biotechnol Appl Biochem 67 (2), 294-302 (2020)
   PUBMED   31737949
  REMARK    GeneRIF: MicroRNA-144 relieves chronic constriction injury-induced
            neuropathic pain via targeting RASA1.
REFERENCE   6  (bases 1 to 4908)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   7  (bases 1 to 4908)
  AUTHORS   Eggen,A., Solinas-Toldo,S., Dietz,A.B., Womack,J.E., Stranzinger,G.
            and Fries,R.
  TITLE     RASA contains a polymorphic microsatellite and maps to bovine
            syntenic group U22 on chromosome 7q2.4-qter
  JOURNAL   Mamm Genome 3 (10), 559-563 (1992)
   PUBMED   1421763
REFERENCE   8  (bases 1 to 4908)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   9  (bases 1 to 4908)
  AUTHORS   Jenkins,E.P., Hsieh,C.L., Milatovich,A., Normington,K.,
            Berman,D.M., Francke,U. and Russell,D.W.
  TITLE     Characterization and chromosomal mapping of a human steroid 5
            alpha-reductase gene and pseudogene and mapping of the mouse
            homologue
  JOURNAL   Genomics 11 (4), 1102-1112 (1991)
   PUBMED   1686016
REFERENCE   10 (bases 1 to 4908)
  AUTHORS   Hsieh,C.L., Vogel,U.S., Dixon,R.A. and Francke,U.
  TITLE     Chromosome localization and cDNA sequence of murine and human genes
            for ras p21 GTPase activating protein (GAP)
  JOURNAL   Somat Cell Mol Genet 15 (6), 579-590 (1989)
   PUBMED   2574500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127316.3 and AC154271.2.
            
            On Oct 3, 2022 this sequence version replaced NM_145452.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065082.1, SRR13422598.1612654.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-973               AC127316.3         96225-97197         c
            974-1126            AC127316.3         66147-66299         c
            1127-1262           AC127316.3         64168-64303         c
            1263-1333           AC127316.3         63213-63283         c
            1334-1451           AC127316.3         60255-60372         c
            1452-1483           AC127316.3         58261-58292         c
            1484-1536           AC127316.3         54420-54472         c
            1537-1687           AC127316.3         52017-52167         c
            1688-1766           AC127316.3         45968-46046         c
            1767-1887           AC127316.3         42189-42309         c
            1888-2044           AC127316.3         41418-41574         c
            2045-2132           AC127316.3         38217-38304         c
            2133-2210           AC127316.3         37434-37511         c
            2211-2368           AC127316.3         36437-36594         c
            2369-2445           AC127316.3         36060-36136         c
            2446-2618           AC127316.3         34781-34953         c
            2619-2778           AC127316.3         34363-34522         c
            2779-2921           AC127316.3         33311-33453         c
            2922-3037           AC127316.3         32032-32147         c
            3038-3124           AC127316.3         31287-31373         c
            3125-3192           AC127316.3         29300-29367         c
            3193-3281           AC127316.3         27235-27323         c
            3282-3359           AC127316.3         26011-26088         c
            3360-3494           AC127316.3         24706-24840         c
            3495-4255           AC127316.3         23256-24016         c
            4256-4908           AC154271.2         1-653
FEATURES             Location/Qualifiers
     source          1..4908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 45.05 cM"
     gene            1..4908
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /note="RAS p21 protein activator 1"
                     /db_xref="GeneID:218397"
                     /db_xref="MGI:MGI:97860"
     exon            1..973
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..3578
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     p120-rasGAP; GTPase-activating protein"
                     /codon_start=1
                     /product="ras GTPase-activating protein 1 isoform 1"
                     /protein_id="NP_663427.2"
                     /db_xref="CCDS:CCDS26667.2"
                     /db_xref="GeneID:218397"
                     /db_xref="MGI:MGI:97860"
                     /translation="MMAAEAGSEEGGPATAGPGGGAATGSSAYSAACRVKLPAALPVA
                     AAPCPGLADADLVAALGGGAASGSGFLGTGPVAGVLGGAALTGSAAAGVAGAAAAGPA
                     GDVAFTKGTLSLPAETLGPGGGFPPLPPPPQLPPLGSGLGTVDEGDSLDGPEYEEEEV
                     AIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVV
                     NHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVR
                     AILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREE
                     DPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKI
                     CPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQGQVLNDTVDGKEI
                     YNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPK
                     GLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAF
                     CSLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREG
                     QNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFL
                     LSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDR
                     TLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATAT
                     QFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLAHLLSILSELVEKIFMASEI
                     LPPTLRYIYGCLQKSVQHKWPTNNTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS
                     PIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELP
                     DTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGVQQHVLKKLLAITELLQQKQNQ
                     YTKTNDIR"
     exon            974..1126
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1262
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1333
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1451
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1483
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1536
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1687
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1766
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1887
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2044
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2132
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2210
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2368
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2445
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2618
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2778
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2921
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3037
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3124
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3192
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3281
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3359
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3494
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..4908
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4305..4310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /note="hexamer: AATAAA"
     polyA_site      4344
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /note="major polyA site"
     regulatory      4586..4591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /note="hexamer: AATAAA"
     polyA_site      4608
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /note="major polyA site"
     regulatory      4883..4888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /note="hexamer: AATAAA"
     polyA_site      4908
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
ORIGIN      
        1 ggagatgagg ctacggtggc tctggcatag gcagccccac tggtggctgc ggtgggggcg
       61 gccggaaccc gggcgttgag gcgcggcggc ggcggcggcc gaggcggcgc tgcctcagcc
      121 gctgcagcgg gcttcccttc ctctttagcg tagccaggaa gtttggcgcc cctgtgcatg
      181 tgtgcgcgtg agtgtgggtg tgcgcggcga ggtttgccta gcgtttctgc aggcgctggg
      241 ttttttgccc gcgtcgcttc ccgtaagcca gccagcagcc gcggagcttg gggctgtggc
      301 ccggggaggg ggcgcggcgg cgggcgctct ccttttgttg ttgtttcctc tgcctggaga
      361 gctgaagggg gacgcgcctg ggtggggcgg ctcgcagccc gggcctgctg gcccccgggg
      421 ctcccgggcg gcagggtagc tagaggagag cgggcttcaa catgatggcg gccgaggcgg
      481 gcagtgagga aggcggccct gcgacggcgg gccccggcgg cggcgcggcc acgggctcca
      541 gcgcctactc ggcagcgtgc cgggtcaagt tacccgcggc cctgccggtg gcagccgccc
      601 cgtgtcccgg gctggcggac gccgacttgg ttgcggccct cggtggcgga gccgcgtcgg
      661 ggtccgggtt cctggggacc gggccggtgg ccggtgtctt ggggggcgcc gcgctgaccg
      721 gcagtgctgc tgctggcgtg gctggtgctg cggccgccgg acctgcggga gacgtcgctt
      781 tcaccaaggg gactctgtct ttgcctgctg agacgctcgg gccgggcggc ggattccctc
      841 ctctgccgcc gcctcctcag ctgccccctt tgggctccgg tttggggacc gtggatgaag
      901 gtgactccct ggatggacca gaatacgaag aggaagaggt ggccataccg ctgaccgcac
      961 ctcccactaa ccagtggtat catggaaaac ttgatagaac tatagcagaa gaacgcctca
     1021 ggcaggcagg gaaatctgga agctatctta taagagagag tgatcggagg ccggggtcct
     1081 ttgtactttc attccttagt cagacaaatg ttgtcaatca ttttaggatt attgctatgt
     1141 gtggtgatta ctacattggt ggaaggcgtt tttcttcact ctcagaccta ataggttatt
     1201 acagtcacgt ttcttgttta cttaaaggag aaaaattact ctatccagtt gcaccaccag
     1261 agccagtaga agatagaagg cgtgtacgag ccattctgcc ctacacaaaa gtaccagaca
     1321 ctgatgaaat aagtttttta aaaggagata tgttcattgt tcacaatgag ttagaagatg
     1381 gatggatgtg ggttaccaat ctaagaacag atgagcaagg ccttattgtt gaagacctag
     1441 tggaagaggt gggccgagaa gaagatccac acgaaggcaa aatatggttc cacgggaaaa
     1501 tttccaaaca agaagcttat aatttattaa tgacagttgg acaagtctgc agctttcttg
     1561 tgaggccctc agataatact cctggagatt attctctgta ttttcggacc aatgaaaata
     1621 ttcagcgatt taaaatttgt ccaacaccta acaaccagtt tatgatggga ggccgctatt
     1681 ataacagtat cggggacatc atagaccatt atcggaaaga acagattgtt gaaggctatt
     1741 atcttaagga acctgtacca atgcaggatc aagggcaagt actgaacgac actgtggatg
     1801 ggaaggagat ctataacaca attcgtcgga agacaaagga tgctttttat aaaaatattg
     1861 ttaaaaaagg ttatcttctg aagaagggta aaggaaaacg ttggaaaaat ttatatttta
     1921 tcttagaagg cagtgatgct caacttattt attttgaaag tgaaaaacga gctacaaaac
     1981 caaaagggct aatagacctt agtgtgtgtt ctgtctacgt tgtccatgac agtctcttcg
     2041 gcaggccaaa ctgttttcag atagtagttc agcactttag tgaagaacat tacatctttt
     2101 actttgcagg agaaactcca gaacaagcag aggattggat gaaaggtctg caagcatttt
     2161 gcagtttacg gaaaagtagc ccagggacat ctaataaacg ccttcgtcag gtcagcagcc
     2221 ttgttttaca tattgaagaa gcccataaac taccagtaaa acactttact aatccatatt
     2281 gtaacatcta cttgaatagc gtccaagtag caaaaactca tgcaagggag gggcaaaacc
     2341 cagtatggtc agaggagttt gtctttgatg atcttcctcc tgacatcaat agatttgaaa
     2401 tcacacttag taataaaaca aagaaaagca aagatccaga tatcttattt atgcgttgcc
     2461 agttgagcag gttacagaaa ggacatgcaa cagatgaatg gtttctacta agttcccata
     2521 taccactaaa aggtattgaa ccaggatctt tgcgtgttcg agcacgatac tccatggaaa
     2581 aaatcatgcc agaagaagag tacagtgaat ttaaagagct tatactgcaa aaggaacttc
     2641 atgtcgtcta tgctttatca catgtatgtg gacaagaccg aacactactg gccagcatcc
     2701 tactaaagat atttcttcat gaaaagcttg aatcattgtt gttatgcaca ctaaatgaca
     2761 gagagataag tatggaagat gaagccacta ccctatttcg agctacaaca cttgcaagta
     2821 ccttgatgga gcagtatatg aaagctactg ccacacagtt tgttcatcat gctttgaaag
     2881 actccatttt aaagattatg gaaagcaagc aatcatgtga gttaagtccg tcaaagttag
     2941 aaaaaaatga agatgtgaac actaatttag cacacctatt gagcatactt tcagagcttg
     3001 tggagaaaat attcatggct tcagaaatac ttccaccgac actgagatat atctatgggt
     3061 gtttacagaa atcagttcag cataagtggc ctacaaataa caccatgaga acaagagtcg
     3121 ttagtggttt tgtttttctt cgccttatct gccctgctat cctgaatcca cggatgttta
     3181 atatcatctc agattcccca tctcctattg ctgcaagaac actgacatta gtggctaaat
     3241 ctgtgcagaa tttagcaaat cttgtggaat ttggagctaa ggagccttat atggaaggtg
     3301 tcaatccatt tataaaaagt aataaacatc gcatgatcat gtttttagat gaacttggga
     3361 atgtacctga acttccggac actacagagc attctagaac tgacctgtct cgtgacttag
     3421 cagcattgca tgagatttgt gtagctcatt cagatgaact gagaacactc agcaatgagc
     3481 gtggtgtaca gcagcacgta ctgaaaaagc ttctggcgat aacagaactg cttcaacaaa
     3541 aacaaaacca gtatacaaaa accaatgaca tcaggtagca gcctgtgttc tgcgtggatt
     3601 cagtatgccc accgtggtaa ttcacaccat catgtctcct ttgctcttgc caaaaagaaa
     3661 aaaatagaga aagaaaaaaa atagcacact ttcccacatt ccagtgatgt gtgagctatg
     3721 caagcaaaaa cccaagattc tgctgaagag caactgccag cacctttgta agctatctgt
     3781 gcagaatatt gcgcactttt tccacatgga atctctacca aactctgagc cttggtgtac
     3841 ccttaacaac aacaaaaatg ctatgactga ctgtgtcttg aactttgaaa atatattttc
     3901 agtatatcca attgccaaag ttttgctgtc tcttggaaaa ggaactatga aatcaactga
     3961 caaggaaacg cattctatag acaacagaat ttaactggat cgcagacagt tattactgta
     4021 atttcttctt tatgaacatg accatttgac tgttcactga ctttctttgt atttacagtt
     4081 tccagagttt gacattataa taggaacaat cttgctgtat actttttaaa aatactgtgc
     4141 tattctttct ggaactgttg aaagacaata tataaaatcg atgaatctat tgctcatcag
     4201 ctttattttt taaacatacc acttattttg ttggaattgt caaagactgt atttagatct
     4261 catgcttttg ttaaaatgtt tacaacagta aatagtttaa attcaataaa tattattggt
     4321 cattgtacca attattgcat gttacccatt tgaccatttt atagattgct gatgtctttt
     4381 atgtttaaac gaagtgctag aatacttttg tcacttctaa gatggttttt gttatctttg
     4441 attatgcaga taacctaatc agccacttaa caacttacac atcttttaat ttgtacttgt
     4501 tttacctgct ggatatttag tttgtatagt tcatttgctc ttgtgtatgt atttttgtgt
     4561 gaagtattca caagggttaa gttaaaataa actaagggat agcttgcata actgattagc
     4621 ttactattta actttattat aattttcttc ccactatagg gatagttcaa gctttaatat
     4681 cagagcaaaa tcagggttat ttttattgtt tctttcacaa aggagtccat ttatttactc
     4741 aatatacaac ttgttaattg aagaccggat ttaaaaacag tatgtagcag aggattctta
     4801 gtgatcaaaa taggtttgtt gttttctttt tttaaagaac caccaaggga ggtactaagg
     4861 aaggtattaa taaagttttc tcaataaaaa tatttttctg aaggccta
//
