LOCUS       NP_852071                578 aa            linear   ROD 02-MAY-2024
DEFINITION  probable arginine--tRNA ligase, mitochondrial precursor [Mus
            musculus].
ACCESSION   NP_852071
VERSION     NP_852071.2
DBSOURCE    REFSEQ: accession NM_181406.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 578)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 578)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928738.8, AK075721.1, AK166986.1 and AW120679.1.
            
            On Jun 18, 2009 this sequence version replaced NP_852071.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156182.1, BC024878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 16.84 cM"
     Protein         1..578
                     /product="probable arginine--tRNA ligase, mitochondrial
                     precursor"
                     /EC_number="6.1.1.19"
                     /note="probable arginyl-tRNA synthetase, mitochondrial;
                     argRS; arginine--tRNA ligase; arginyl-tRNA synthetase 2,
                     mitochondrial (putative); probable arginine--tRNA ligase,
                     mitochondrial"
                     /calculated_mol_wt=63556
     transit_peptide 1..16
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q3U186.1)"
                     /calculated_mol_wt=1798
     mat_peptide     17..578
                     /product="Probable arginine--tRNA ligase, mitochondrial.
                     /id=PRO_0000250732"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U186.1)"
                     /calculated_mol_wt=63556
     Region          65..578
                     /region_name="ArgS"
                     /note="Arginyl-tRNA synthetase [Translation, ribosomal
                     structure and biogenesis]; COG0018"
                     /db_xref="CDD:439789"
     Region          133..144
                     /region_name="'HIGH' region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U186.1)"
     Site            568
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q3U186.1)"
     CDS             1..578
                     /gene="Rars2"
                     /gene_synonym="1500002I10Rik; PRO1992; Rarsl"
                     /coded_by="NM_181406.4:35..1771"
                     /db_xref="CCDS:CCDS18029.1"
                     /db_xref="GeneID:109093"
                     /db_xref="MGI:MGI:1923596"
ORIGIN      
        1 macgfrrsia cqlsrvlalp pesliksisa vpvskkeeva dfqlsvdsll ednnhksqvd
       61 tqdqarrlae klkcdtvvta isagprtlnf kinrelltka vlqqvtedgc kyglkselfs
      121 dlpkkrivve fsspniakkf hvghlrstii gnfianlkea lghqvtriny igdwgmqfgl
      181 lgtgfqlfgy eeklqtnplq hlfdvyvqvn keatddknvt klaheffhrl emgdtqalsl
      241 wqrfrdlsie eytqiykrlg iyfdeysges fyreksqdvl klldskgllq ktaegnvvvd
      301 lsgtgdlssv ctvmrsdgts lyatrdlaaa ihrmdkynfd tmiyvadkgq rrhfqqvfqm
      361 lkimgydwae rcqhvpfgiv kgmktrrggv tfledvlnev qsrmlqnmas ikttkqlenp
      421 qetaervgla aviiqdfrgt llsdyqfswd rvfqsrgdtg vflqytharl csleetfgcg
      481 ylndsnvacl qepqsvsilq hllrfdevly lssqdlqpkh ivsylltlsh laavahktlq
      541 vkdsppdvag arlhlfkavr svlangmkll gitpvcrm
//
