LOCUS       NM_025936               2140 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus arginyl-tRNA synthetase 1 (Rars1), mRNA.
ACCESSION   NM_025936
VERSION     NM_025936.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF748175.1, AK076160.1 and CB523934.1.
            
            On Oct 28, 2009 this sequence version replaced NM_025936.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020132.1, AK011383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CF748175.1         1-26
            27-2129             AK076160.1         2-2104
            2130-2140           CB523934.1         640-650
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 21.96 cM"
     gene            1..2140
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /note="arginyl-tRNA synthetase 1"
                     /db_xref="GeneID:104458"
                     /db_xref="MGI:MGI:1914297"
     exon            1..92
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2030
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /EC_number="6.1.1.19"
                     /note="arginyl-tRNA synthetase, cytoplasmic; argRS"
                     /codon_start=1
                     /product="arginine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_080212.2"
                     /db_xref="CCDS:CCDS24544.1"
                     /db_xref="GeneID:104458"
                     /db_xref="MGI:MGI:1914297"
                     /translation="MDGLVAQCSARLLQQEREIKALTAEIDRLKNCGCLEASPSLEQL
                     REENLKLKYRLNILRRSLQEERRKPTKNMININSRLQEVFGCAIRAAYPDLENPPLIV
                     TPSQQPKFGDYQCNSAMGISQMLKAKEQKVSPREIAENITKHLPNNKYIDKVEIAGPG
                     FINVHLRKDFVSEQLTSLLVNGVQLPVLGDKEKVIVDFSSPNIAKEMHVGHLRSTIIG
                     ESMSRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQAFYKES
                     KKRFDADEEFKKRAYQCVVLLQSKNPDIMKAWNLICDVSREEFKKIYDALDITLIERG
                     ESFYQDRMKDIVKEFEDKGFVQVDDGRKIVFVPGCSVPLTIVKSDGGYTYDTSDLAAI
                     KQRLFEEKANKIIYVVDNGQAIHFQTIFAAAQMIGWYDPKVTLVTHVGFGVVLGEDKK
                     KFKTRSGETVRLMDLLEEGLKRSMDKLKEKERDKVLTEEELKAAQTSVAYGCIKYADL
                     SHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEAMLQRAARETKIIL
                     DHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQT
                     GKVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM"
     exon            93..227
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            228..416
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            417..525
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            526..626
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            627..748
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            749..869
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            870..999
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1104
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1283
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1393
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1499
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1672
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1920
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2131
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /note="hexamer: AGTAAA"
     polyA_site      2131
                     /gene="Rars1"
                     /gene_synonym="2610011N19Rik; 2610037E21Rik; Rars"
                     /note="major polyA site"
ORIGIN      
        1 gacacttccg cttccggccg cttggcatgt gagtcgctga cgagaggatg gacggtctgg
       61 tggctcagtg ctccgcgcgg ttgctgcagc aggaaaggga gattaaggct ctgactgctg
      121 agatcgaccg gctgaagaac tgtggctgct tggaagcttc tccaagtttg gaacagttac
      181 gagaagaaaa tttaaaattg aagtataggc tgaatattct tcgaaggagt cttcaggaag
      241 aaaggagaaa accaactaaa aacatgatta acatcaacag ccgcctgcag gaagtctttg
      301 gctgtgccat tagggctgca tatccagact tggagaaccc tcccctgatc gtgacaccaa
      361 gtcagcagcc caagtttgga gactatcagt gtaatagtgc catgggtatt tctcagatgc
      421 tcaaggcaaa ggaacagaaa gtcagtccca gagaaatcgc agaaaacatt accaaacacc
      481 tgccgaacaa taaatatatt gacaaagttg aaattgcggg tcctggtttc attaatgtgc
      541 acctgagaaa agactttgtg tcagaacagc taaccagtct cctagtgaat ggagtccagc
      601 tgcctgtgct tggagacaag gagaaggtta tagttgactt ttcctctccc aacatagcta
      661 aggagatgca tgttggccac ctcaggtcaa ccatcatagg agagagcatg agccgcctct
      721 ttgaatttgc aggatacgat gtgctaaggt taaaccatgt aggagattgg ggaacccagt
      781 ttggcatgct catcgctcac ctgcaagata aatttccgga ttatctgaca gtttcacctc
      841 ctattgggga tctgcaggcc ttttataagg aatctaagaa gaggtttgat gctgatgagg
      901 agtttaagaa gcgagcctat cagtgtgtcg ttttgctgca gagtaaaaac ccagatatca
      961 tgaaagcctg gaacctcatc tgtgacgtgt cccgggaaga gtttaagaaa atctatgatg
     1021 cattggacat cactttaata gagagaggag aatccttcta tcaagatagg atgaaggaca
     1081 ttgtaaagga atttgaagat aaagggtttg tgcaagtgga tgatggcaga aaaattgtgt
     1141 tcgtgcctgg gtgttctgtg ccattaacga tagtgaaatc agatgggggc tatacctatg
     1201 acacatctga cctggctgcc atcaaacaga gactgtttga agaaaaagca aacaagatta
     1261 tttatgtggt ggacaatgga caagctatac acttccagac aatatttgct gctgctcaga
     1321 tgattggctg gtatgacccg aaagtaactc tagtgaccca cgtgggattt ggtgtcgtcc
     1381 taggagaaga caagaagaaa tttaaaacac gttcaggtga aactgtgcgc cttatggacc
     1441 tgctggaaga agggctgaaa cggtccatgg acaagctaaa ggagaaagag agagacaagg
     1501 tcttaactga agaggaattg aaagcagctc agacatccgt tgcatatggc tgcatcaaat
     1561 acgccgacct ttctcataat cgcctcaatg actacatctt ctcctttgac aagatgctgg
     1621 atgacagagg gaacacagct gcttacctac tgtatgcctt caccagaatc aggtctattg
     1681 cgcgcctcgc caacattgat gaggcgatgc tacagagagc cgctcgggaa accaagatca
     1741 ttttggacca tgaaaaggag tggaagctgg ggcggtgcat cttacggttc cccgagatcc
     1801 tccagaagat cttagacgac ctgtttctcc acaccctctg tgactacatt tacgagctgg
     1861 caaccacctt cacagagttc tacgatagct gctactgtgt ggagaaagat cgacagactg
     1921 ggaaagtatt gaaagtgaac atgtggcgga tgctcctgtg tgaggccgtg gctgctgtca
     1981 tggccaaggg gttcgatata ctggggataa aacccgtcca aaggatgtaa tccttacgct
     2041 gggaactgtt tttaccaaag cagccattag tactgtttgt tttttaaaca atcatgtgca
     2101 cacaagagta gtaaaagaat tttcacagct aaaaaaaaaa
//
