LOCUS       NM_027852                842 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus retinoic acid receptor responder (tazarotene induced)
            2 (Rarres2), transcript variant 2, mRNA.
ACCESSION   NM_027852
VERSION     NM_027852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 842)
  AUTHORS   Chen,Y., Song,Y., Wang,Z., Lai,Y., Yin,W., Cai,Q., Han,M., Cai,Y.,
            Xue,Y., Chen,Z., Li,X., Chen,J., Li,M., Li,H. and He,R.
  TITLE     The chemerin-CMKLR1 axis in keratinocytes impairs innate host
            defense against cutaneous Staphylococcus aureus infection
  JOURNAL   Cell Mol Immunol 21 (6), 533-545 (2024)
   PUBMED   38532043
  REMARK    GeneRIF: The chemerin-CMKLR1 axis in keratinocytes impairs innate
            host defense against cutaneous Staphylococcus aureus infection.
REFERENCE   2  (bases 1 to 842)
  AUTHORS   Man,A.W.C., Zhou,Y., Reifenberg,G., Camp,A., Munzel,T., Daiber,A.,
            Xia,N. and Li,H.
  TITLE     Deletion of adipocyte NOS3 potentiates high-fat diet-induced
            hypertension and vascular remodelling via chemerin
  JOURNAL   Cardiovasc Res 119 (17), 2755-2769 (2023)
   PUBMED   37897505
  REMARK    GeneRIF: Deletion of adipocyte NOS3 potentiates high-fat
            diet-induced hypertension and vascular remodelling via chemerin.
REFERENCE   3  (bases 1 to 842)
  AUTHORS   Lin,X., Qu,J., Yin,L., Wang,R. and Wang,X.
  TITLE     Aerobic exercise-induced decrease of chemerin improved glucose and
            lipid metabolism and fatty liver of diabetes mice through key
            metabolism enzymes and proteins
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (12), 159409 (2023)
   PUBMED   37871796
  REMARK    GeneRIF: Aerobic exercise-induced decrease of chemerin improved
            glucose and lipid metabolism and fatty liver of diabetes mice
            through key metabolism enzymes and proteins.
REFERENCE   4  (bases 1 to 842)
  AUTHORS   Ballet,R., LaJevic,M., Huskey-Mullin,N., Roach,R., Brulois,K.,
            Huang,Y., Saeed,M.A., Dang,H.X., Pachynski,R.K., Wilson,E.,
            Butcher,E.C. and Zabel,B.A.
  TITLE     Chemerin triggers migration of a CD8 T cell subset with natural
            killer cell functions
  JOURNAL   Mol Ther 31 (10), 2887-2900 (2023)
   PUBMED   37641406
  REMARK    GeneRIF: Chemerin triggers migration of a CD8 T cell subset with
            natural killer cell functions.
REFERENCE   5  (bases 1 to 842)
  AUTHORS   Li,Y.Q., Sun,F.Z., Li,C.X., Mo,H.N., Zhou,Y.T., Lv,D., Zhai,J.T.,
            Qian,H.L. and Ma,F.
  TITLE     RARRES2 regulates lipid metabolic reprogramming to mediate the
            development of brain metastasis in triple negative breast cancer
  JOURNAL   Mil Med Res 10 (1), 34 (2023)
   PUBMED   37491281
  REMARK    GeneRIF: RARRES2 regulates lipid metabolic reprogramming to mediate
            the development of brain metastasis in triple negative breast
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 842)
  AUTHORS   Takahashi,M., Takahashi,Y., Takahashi,K., Zolotaryov,F.N.,
            Hong,K.S., Kitazawa,R., Iida,K., Okimura,Y., Kaji,H., Kitazawa,S.,
            Kasuga,M. and Chihara,K.
  TITLE     Chemerin enhances insulin signaling and potentiates
            insulin-stimulated glucose uptake in 3T3-L1 adipocytes
  JOURNAL   FEBS Lett 582 (5), 573-578 (2008)
   PUBMED   18242188
  REMARK    GeneRIF: These data establish that chemerin is a novel adipokine
            that regulates adipocyte function.
REFERENCE   7  (bases 1 to 842)
  AUTHORS   Roh,S.G., Song,S.H., Choi,K.C., Katoh,K., Wittamer,V.,
            Parmentier,M. and Sasaki,S.
  TITLE     Chemerin--a new adipokine that modulates adipogenesis via its own
            receptor
  JOURNAL   Biochem Biophys Res Commun 362 (4), 1013-1018 (2007)
   PUBMED   17767914
  REMARK    GeneRIF: Thus, the adipokine chemerin likely regulates adipocyte
            function by autocrine/paracrine mechanisms.
REFERENCE   8  (bases 1 to 842)
  AUTHORS   Bozaoglu,K., Bolton,K., McMillan,J., Zimmet,P., Jowett,J.,
            Collier,G., Walder,K. and Segal,D.
  TITLE     Chemerin is a novel adipokine associated with obesity and metabolic
            syndrome
  JOURNAL   Endocrinology 148 (10), 4687-4694 (2007)
   PUBMED   17640997
  REMARK    GeneRIF: Rarres2 is highly expressed in adipose tissue and during
            adipocyte differentiation.
REFERENCE   9  (bases 1 to 842)
  AUTHORS   Goralski,K.B., McCarthy,T.C., Hanniman,E.A., Zabel,B.A.,
            Butcher,E.C., Parlee,S.D., Muruganandan,S. and Sinal,C.J.
  TITLE     Chemerin, a novel adipokine that regulates adipogenesis and
            adipocyte metabolism
  JOURNAL   J Biol Chem 282 (38), 28175-28188 (2007)
   PUBMED   17635925
  REMARK    GeneRIF: chemerin is a novel adipose-derived signaling molecule
            that regulates adipogenesis and adipocyte metabolism
REFERENCE   10 (bases 1 to 842)
  AUTHORS   Wittamer,V., Franssen,J.D., Vulcano,M., Mirjolet,J.F., Le Poul,E.,
            Migeotte,I., Brezillon,S., Tyldesley,R., Blanpain,C., Detheux,M.,
            Mantovani,A., Sozzani,S., Vassart,G., Parmentier,M. and Communi,D.
  TITLE     Specific recruitment of antigen-presenting cells by chemerin, a
            novel processed ligand from human inflammatory fluids
  JOURNAL   J Exp Med 198 (7), 977-985 (2003)
   PUBMED   14530373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154013.4.
            
            On Nov 17, 2016 this sequence version replaced NM_027852.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            Variants 2 and 3 encodes the protein (isoform 2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038914.1, CF550837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC154013.4         61030-61238         c
            210-412             AC154013.4         60524-60726         c
            413-517             AC154013.4         60219-60323         c
            518-613             AC154013.4         58680-58775         c
            614-732             AC154013.4         58377-58495         c
            733-842             AC154013.4         58132-58241         c
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.55 cM"
     gene            1..842
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /note="retinoic acid receptor responder (tazarotene
                     induced) 2"
                     /db_xref="GeneID:71660"
                     /db_xref="MGI:MGI:1918910"
     exon            1..209
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            210..412
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..721
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; chemerin; retinoic acid receptor responder
                     protein 2"
                     /codon_start=1
                     /product="retinoic acid receptor responder protein 2
                     isoform 2 preproprotein"
                     /protein_id="NP_082128.1"
                     /db_xref="CCDS:CCDS20105.1"
                     /db_xref="GeneID:71660"
                     /db_xref="MGI:MGI:1918910"
                     /translation="MKCLLISLALWLGTVGTRGTEPELSETQRRSLQVALEEFHKHPP
                     VQLAFQEIGVDRAEEVLFSAGTFVRLEFKLQQTNCPKKDWKKPECTIKPNGRRRKCLA
                     CIKMDPKGKILGRIVHCPILKQGPQDPQELQCIKIAQAGEDPHGYFLPGQFAFSRALR
                     TK"
     exon            413..517
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            518..613
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..732
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            733..842
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      813..818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      842
                     /gene="Rarres2"
                     /gene_synonym="0610007L05Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagaggaagg tcagggaact ttgggaaaca gaaaactcca aaactccgga ctctgggaga
       61 agggtcagtg ggaaaaggcg gggctttggg gaccaagaga gaggagaaaa gggagatgag
      121 agggtgagag ggaacaactg ccagggagct gttccaggga ccacacagaa aaaggcctcg
      181 ctaaagcaac aaacctgatc attttcaaga accataggac tgaggtgaag ccatgaagtg
      241 cttgctgatc tccctagccc tatggctggg cacagtgggc acacgtggga cagagcccga
      301 actcagcgag acccagcgca ggagcctaca ggtggctctg gaggagttcc acaaacaccc
      361 acctgtgcag ttggccttcc aagagatcgg tgtggacaga gctgaagaag tgctcttctc
      421 agctggcacc tttgtgaggt tggaatttaa gctccagcag accaactgcc ccaagaagga
      481 ctggaaaaag ccggagtgca caatcaaacc aaacgggaga aggcggaaat gcctggcctg
      541 cattaaaatg gaccccaagg gtaaaattct aggccggata gtccactgcc caattctgaa
      601 gcaagggcct caggatcctc aggagttgca atgcattaag atagcacagg ctggcgaaga
      661 cccccacggc tacttcctac ctggacagtt tgccttctcc agggccctga gaaccaaata
      721 agccctagac aggacttcac cttactccct gtacagctgt ggcagcaccc agcaggagca
      781 tatcgtctcc cagagacttt caactccagg ctaataaaat tgctgagtct gttcctttcc
      841 aa
//
