LOCUS       NM_011244               2892 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus retinoic acid receptor, gamma (Rarg), transcript
            variant 1, mRNA.
ACCESSION   NM_011244
VERSION     NM_011244.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2892)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2892)
  AUTHORS   Koshy,A., Mathieux,E., Studer,F., Bramoulle,A., Lieb,M.,
            Colombo,B.M., Gronemeyer,H. and Mendoza-Parra,M.A.
  TITLE     Synergistic activation of RARbeta and RARgamma nuclear receptors
            restores cell specialization during stem cell differentiation by
            hijacking RARalpha-controlled programs
  JOURNAL   Life Sci Alliance 6 (2), e202201627 (2022)
   PUBMED   36446525
  REMARK    GeneRIF: Synergistic activation of RARbeta and RARgamma nuclear
            receptors restores cell specialization during stem cell
            differentiation by hijacking RARalpha-controlled programs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2892)
  AUTHORS   Mayere,C., Regard,V., Perea-Gomez,A., Bunce,C., Neirijnck,Y.,
            Djari,C., Bellido-Carreras,N., Sararols,P., Reeves,R.,
            Greenaway,S., Simon,M., Siggers,P., Condrea,D., Kuhne,F.,
            Gantar,I., Tang,F., Stevant,I., Batti,L., Ghyselinck,N.B.,
            Wilhelm,D., Greenfield,A., Capel,B., Chaboissier,M.C. and Nef,S.
  TITLE     Origin, specification and differentiation of a rare supporting-like
            lineage in the developing mouse gonad
  JOURNAL   Sci Adv 8 (21), eabm0972 (2022)
   PUBMED   35613264
REFERENCE   4  (bases 1 to 2892)
  AUTHORS   Condrea,D., Souali-Crespo,S., Feret,B., Klopfenstein,M., Faisan,S.,
            Mark,M., Ghyselinck,N.B. and Vernet,N.
  TITLE     Retinoic Acid Receptor Alpha Is Essential in Postnatal Sertoli
            Cells but Not in Germ Cells
  JOURNAL   Cells 11 (5), 891 (2022)
   PUBMED   35269513
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2892)
  AUTHORS   Nakagawa,T., Jorg,D.J., Watanabe,H., Mizuno,S., Han,S., Ikeda,T.,
            Omatsu,Y., Nishimura,K., Fujita,M., Takahashi,S., Kondoh,G.,
            Simons,B.D., Yoshida,S. and Nagasawa,T.
  TITLE     A multistate stem cell dynamics maintains homeostasis in mouse
            spermatogenesis
  JOURNAL   Cell Rep 37 (3), 109875 (2021)
   PUBMED   34686326
REFERENCE   6  (bases 1 to 2892)
  AUTHORS   Rochette-Egly,C., Gaub,M.P., Lutz,Y., Ali,S., Scheuer,I. and
            Chambon,P.
  TITLE     Retinoic acid receptor-beta: immunodetection and phosphorylation on
            tyrosine residues
  JOURNAL   Mol Endocrinol 6 (12), 2197-2209 (1992)
   PUBMED   1283441
REFERENCE   7  (bases 1 to 2892)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   8  (bases 1 to 2892)
  AUTHORS   Lyons,G.E., Houzelstein,D., Sassoon,D., Robert,B. and
            Buckingham,M.E.
  TITLE     Multiple sites of Hox-7 expression during mouse embryogenesis:
            comparison with retinoic acid receptor mRNA localization
  JOURNAL   Mol Reprod Dev 32 (4), 303-314 (1992)
   PUBMED   1353971
REFERENCE   9  (bases 1 to 2892)
  AUTHORS   Ruberte,E., Friederich,V., Morriss-Kay,G. and Chambon,P.
  TITLE     Differential distribution patterns of CRABP I and CRABP II
            transcripts during mouse embryogenesis
  JOURNAL   Development 115 (4), 973-987 (1992)
   PUBMED   1333403
REFERENCE   10 (bases 1 to 2892)
  AUTHORS   Harnish,D.C., Jiang,H., Soprano,K.J., Kochhar,D.M. and Soprano,D.R.
  TITLE     Retinoic acid receptor beta 2 mRNA is elevated by retinoic acid in
            vivo in susceptible regions of mid-gestation mouse embryos
  JOURNAL   Dev Dyn 194 (3), 239-246 (1992)
   PUBMED   1334737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163291.3 and AC123791.4.
            
            On Aug 31, 2022 this sequence version replaced NM_011244.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148064.1, BC012923.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC163291.3         90539-90755         c
            218-287             AC163291.3         89769-89838         c
            288-613             AC123791.4         145391-145716       c
            614-762             AC123791.4         134808-134956       c
            763-904             AC123791.4         134030-134171       c
            905-1065            AC123791.4         133100-133260       c
            1066-1242           AC123791.4         132830-133006       c
            1243-1447           AC123791.4         132362-132566       c
            1448-1606           AC123791.4         131777-131935       c
            1607-2892           AC123791.4         127910-129195       c
FEATURES             Location/Qualifiers
     source          1..2892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.4 cM"
     gene            1..2892
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /note="retinoic acid receptor, gamma"
                     /db_xref="GeneID:19411"
                     /db_xref="MGI:MGI:97858"
     exon            1..217
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            218..287
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..613
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..1806
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear receptor subfamily 1 group B member 3; RAR gamma
                     2; retinoic acid receptor gamma 4"
                     /codon_start=1
                     /product="retinoic acid receptor gamma isoform 1"
                     /protein_id="NP_035374.3"
                     /db_xref="CCDS:CCDS27875.1"
                     /db_xref="GeneID:19411"
                     /db_xref="MGI:MGI:97858"
                     /translation="MATNKERLFAPGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSP
                     SFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHY
                     GVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAV
                     RNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADH
                     RVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRIC
                     TRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAI
                     CLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK
                     GAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGGQGKRGQ
                     SPQPDQGP"
     exon            614..762
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..904
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1065
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1242
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1447
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1606
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..2892
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2872..2877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /note="hexamer: AATAAA"
     polyA_site      2892
                     /gene="Rarg"
                     /gene_synonym="Nr1b3; RAR-gamma; RARD; RARgamma2"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcggt ttgggagaaa atgtgtcgga tattttgggg cggtcacgtg ggcgggcggg
       61 ctccgagagg ccccgggatt gtcccagcct agagccgtgc ccccctgaag ccccccatta
      121 ccgcgagtca ctaacaccgc ggtgctccat ccccgagacc gcccgacgcc gggacctcgg
      181 ggctctgcgg ccttccttcc cccgccctcc cctccagcag tttccaccag gtccctcacc
      241 tcagcctggc ccagtatgta ggagggactc tctgcagagg ccagagggat ccttggaaac
      301 ccactggaca gaccaggcag ggtgggcacg gagcctccca ggccagggca gtgggcatgg
      361 gcgggggctg tagctgaaga ccacccccgc ctgctgcaga gtccaaggga ttcccacgcc
      421 gcagctacca tggccaccaa taaggagaga ctctttgcgc ccggtgccct ggggcctgga
      481 tctggttacc caggagcagg cttcccattc gccttcccag gtgcactcag agggtcgcca
      541 ccatttgaga tgctgagccc tagcttccgg ggcctgggcc agcctgacct ccccaaggag
      601 atggcttctc tctcggtgga gacacagagc accagctcgg aggagatggt acccagctct
      661 ccctcacccc caccacctcc tcgggtctat aagccatgct ttgtatgcaa tgacaagtct
      721 tctggctacc actatggggt cagctcctgt gaaggctgca agggcttctt cagacgcagc
      781 attcagaaaa acatggtgta tacatgtcac cgtgacaaaa actgtatcat caacaaggtc
      841 accagaaatc gatgccagta ctgcaggcta caaaagtgtt tcgaagtggg catgtccaag
      901 gaagctgtaa ggaacgatcg aaacaagaag aaaaaggagg taaaagagga gggctcgccc
      961 gacagctatg aactgagtcc acagttagag gaactcatca ccaaggtcag caaagcccac
     1021 caggagactt ttccctcact ctgccagctg ggcaagtaca ccacgaactc cagtgcagat
     1081 caccgggtgc agctggacct ggggctgtgg gacaagttca gcgagctggc caccaaatgc
     1141 atcatcaaga ttgtggagtt tgcgaagcgg ctgcctggtt ttacagggct cagcattgcc
     1201 gaccagatca cgctgctcaa ggctgcttgt ctggacatcc taatgctgcg gatctgtaca
     1261 aggtataccc cagagcagga cactatgaca ttctcggatg ggctgaccct gaaccgaacc
     1321 cagatgcaca atgctggctt tgggcccctt acagacctcg tctttgcctt tgccgggcag
     1381 ctgctgcccc tggagatgga tgacaccgag actgggctac ttagtgctat ctgcctcatc
     1441 tgtggagacc gaatggacct ggaagagccc gagaaggtgg acaagctgca ggagcccctg
     1501 ctggaagccc tgaggctcta tgcccggcga cggagaccca gccaacccta catgttccca
     1561 aggatgctga tgaaaatcac cgacctccgg ggcatcagca ctaagggagc agaaagggct
     1621 ataaccctga agatggagat tccaggcccg atgccacccc tgatccgaga gatgctggag
     1681 aacccggaga tgtttgagga cgactcctcg aagcctggcc cccaccccaa ggcttccagt
     1741 gaggacgaag ctccaggggg ccagggcaaa aggggccaaa gtccccaacc tgaccagggg
     1801 ccctgaccta ccccgttgtg gggttgggcc ccaggcagca gactgaccat ttcccagata
     1861 ccgccagtga ctgggggagg acctgccccg cccactctcc acccttttaa tgagctcgtt
     1921 attttgccaa agtttctagg ggtgcctgtg ttcatccctg tcctgttcta actggctccc
     1981 tctacagtcc cgcgggactg ctgcacacct accagaagag ctggagaagg ggcgagcctg
     2041 ggtctagact ctaaaatctc agcactgcct ttcggattca ggccacaggc tcccgacgca
     2101 agaggaagcc ccgccttccc atagcctttt cctctgccag gtgcttgggc ctctgggagc
     2161 aaacaggaac actagagacc aaaagggggg ccccccccga gggagggctg agcccaccct
     2221 tgtgccccac cctgagcgcc tgactctgtg tgatgaatct gccgcgctca gtgcccccgg
     2281 tgccccatcc taatcctcct gccgggtgta ggggcaggct ggggcctgcg tttctagggt
     2341 ggggcctgag ggggaaggga gaatgtgagc ccgagcccgt ctgtacctct gctgaagtac
     2401 agcactcatc ctgggccctc cattatataa gcctctccct tacttctgtc tcgtgccttg
     2461 gcctcccgcc ctcatctcag ccatcaggca gggccctcct acactacaga ggggccaggg
     2521 gtccctctcc tagtgccttc tacccttgat ccccccagag cagcttggcc ccggggaggg
     2581 gagatgctgc ttagctgatc ccaccttgac ccagaggaag cctctattta tttattagct
     2641 tttgtttaca ccctggaaat gaccccttcc tccaggggtc ttgggagggg gagcccaggg
     2701 cctctgtgac cccttccttt ctttccccaa gcccccagtt tatatttagc tgccaaataa
     2761 gattcctgca ggctccccca tttctctggg gggttagggt gctgtcccct cccctctgtt
     2821 tacatctcct accccgctgt tcgcatattg ctgagttttc tatttttgca aaataaagtg
     2881 atggaaactc aa
//
