LOCUS       NM_001080925            4163 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Rap guanine nucleotide exchange factor (GEF)-like 1
            (Rapgefl1), mRNA.
ACCESSION   NM_001080925 XM_484075 XM_979810 XM_994457
VERSION     NM_001080925.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590963.11.
            
            On or before Jan 30, 2007 this sequence version replaced
            XM_994457.1, XM_484075.4, XM_979810.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript and protein alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-889               AL590963.11        20904-21792         c
            890-968             AL590963.11        18239-18317         c
            969-1104            AL590963.11        16247-16382         c
            1105-1202           AL590963.11        15922-16019         c
            1203-1315           AL590963.11        12590-12702         c
            1316-1483           AL590963.11        12288-12455         c
            1484-1581           AL590963.11        11404-11501         c
            1582-1704           AL590963.11        11168-11290         c
            1705-1883           AL590963.11        9281-9459           c
            1884-1974           AL590963.11        9112-9202           c
            1975-2025           AL590963.11        8598-8648           c
            2026-2113           AL590963.11        8396-8483           c
            2114-2178           AL590963.11        8148-8212           c
            2179-2233           AL590963.11        7738-7792           c
            2234-4163           AL590963.11        5572-7501           c
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.7 cM"
     gene            1..4163
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /note="Rap guanine nucleotide exchange factor (GEF)-like
                     1"
                     /db_xref="GeneID:268480"
                     /db_xref="MGI:MGI:3611446"
     exon            1..889
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..2358
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor-like 1"
                     /protein_id="NP_001074394.1"
                     /db_xref="CCDS:CCDS36303.1"
                     /db_xref="GeneID:268480"
                     /db_xref="MGI:MGI:3611446"
                     /translation="MKPLEKFLKKQTSQLAGRAVTGGPGGGPGCCGGPGGGGGPGGGG
                     GPAGGLRPLQRRQSVSRLLLPAFLREPPTEPGLEPPVEEEGGEPLGVSEEPGSGGPCW
                     LQLEEVPGPGPIGSGVPLRSPSSYSSDELSPGEPLASPPWAPLGAPERPEHLLNRVLE
                     RLAGGTTRDSSASDILLDDIVLTHSLFLPTEKFLQELHQYFVQSRNVEGPEGLGRKQA
                     CLALLLHFLDTYQGLLQEEEGAGHIIKELYLLIMKDESLYQDLREDTLRLHQLVETVE
                     LKIPEESQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRL
                     SASVQDILGSVTEKLQYSEEPAEREDALILVAVASSGEKVLLQPTEDCVFTTLGINSH
                     LFACTRDSYEALVPLPEEVQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVD
                     YVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAAICKQ
                     NQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVIS
                     KMKPPLIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLD
                     MEASPHHLQTKAYVRQFQVIDNQNHLFELSYKLEANSQ"
     exon            890..968
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1104
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1202
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1315
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1483
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1581
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1704
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1883
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1974
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2025
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2113
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2178
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2233
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..4163
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4140..4145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /note="hexamer: AATACA"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /note="hexamer: ACTAAA"
     polyA_site      4150
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /note="major polyA site"
     polyA_site      4163
                     /gene="Rapgefl1"
                     /gene_synonym="B230105J10"
                     /note="major polyA site"
ORIGIN      
        1 cccggggcca ggagcgcagc cgccgccgcg tcctcagcct tgcgctccgc ccgctgcctc
       61 tgtcgcctca gcccggcccc ggagcgctga gacggggaca ccagcccctc agcctgccaa
      121 cccttcggcc gcagccggca tggggggccg ctgagagcga gctcctcttc cctctggcac
      181 ctcccccggc cactggccac tggactctgg ccagcgaggc tcggccacct ctcgctcgca
      241 gtccgacgcc tggcacggcc ctcggctctg ctcccccggc tctgagcatc gtgtccccgc
      301 ctccccccgc ccgcgcctgg gacacctggg tcccccggcg gcccctaaga gaggggcggg
      361 ggggggggca tgaagccact ggagaaattt ttgaagaagc agacgtctca gctggcgggg
      421 cgagcggtga ctggaggtcc cggcgggggt ccgggttgct gcggagggcc tggagggggt
      481 gggggccctg gtgggggcgg cggtccggcc gggggactgc ggccactgca gcggcgtcag
      541 agcgtgtctc gcctgctgct cccagctttc ctccgagagc ccccaaccga gcccgggctg
      601 gagccgcccg ttgaggagga agggggagag ccattagggg tctctgagga gccgggcagt
      661 ggggggccct gttggctgca gctagaggag gttcccgggc ctgggccgat aggatctggg
      721 gtgcccctgc gctctccttc ctcgtactcc tcagatgagc tatcccccgg cgaacccctg
      781 gcttcaccac cctgggcccc cctgggcgcc cccgagcggc cagagcatct tctgaaccgg
      841 gttctggagc gcctggctgg agggaccacc agggacagca gcgcctcaga tattcttctt
      901 gacgacattg ttcttaccca ttccctcttc ctgccaacag aaaagtttct acaagagcta
      961 caccagtact ttgttcagtc aaggaatgtg gagggtccag aggggctggg tcggaagcaa
     1021 gcctgccttg ctctcctcct ccatttcctg gatacctacc aaggacttct gcaagaggaa
     1081 gaaggggccg gccacattat caaggaactg tatctactaa ttatgaagga tgagtctctt
     1141 taccaggacc tccgagagga cacactgagg ctacaccagc tggtggagac agtggagcta
     1201 aagattccag aagagagcca gccgcccagc aagcaggtta agccgctctt ccgacacttc
     1261 cgccggatag attcctgtct gcagacccga gtggcattca ggggctccga tgagattttc
     1321 tgccgagtct acatgcctga ccactcttac gtgaccatac gcagtcgcct ctcggcatca
     1381 gtgcaagaca ttctgggctc tgtgacagag aagctgcagt actcggagga gcctgcggag
     1441 cgcgaggatg ccctcatcct tgtagctgtt gcttcctctg gagagaaggt cctcctccag
     1501 ccaacggagg actgcgtttt caccacgctg ggtatcaaca gccacctatt tgcctgtacc
     1561 cgggacagct acgaggccct agtacccctt ccggaggagg tccaggtctc cccaggagac
     1621 acagagatcc accgggtgga gcctgaagat gtggccaatc acctgactgc tttccactgg
     1681 gagctcttcc gatgtgtgca cgagttggag ttcgtggact acgtattcca cggggagcgt
     1741 ggccgccgag agacagccaa cctggagttg ctgctgcagc gttgcagcga ggtcactcac
     1801 tgggtggcca ctgaggtgct gctctgtgag gccccgggca agcgtgtaca gctgcttaag
     1861 aagttcatca agatcgcagc catctgcaag cagaaccagg acctgctgtc cttctatgct
     1921 gtggtcatgg ggctggacaa tgcggctgtc agccgcctgc ggctcacctg ggagaagctg
     1981 ccagggaaat tcaagaacct gttccgtaaa tttgagggct tgacggaccc ctgccggaac
     2041 cataaaagct acagagaagt catctccaaa atgaagcccc ctctgattcc gttcgtgccc
     2101 ctgatcctca aagacctgac cttcctacat gaggggagca agaccctcgt agatggtctg
     2161 gtgaatattg agaagctgca ttcagtggcc gagaaagtga ggacaatccg aaaataccgg
     2221 agccggcccc tctgcctgga catggaggca tccccacatc acctgcagac caaggcgtac
     2281 gtgcgccagt tccaggtcat cgacaaccag aaccacctct ttgagctctc ctacaagttg
     2341 gaggctaata gtcagtgaga gtgagagggc ctggctgccc ccgcctcggt ccttggcacc
     2401 tggcacccaa gcacttttgc acgatgccct caacagacat cggccacctt ctccctggag
     2461 gcgtttccta tcacaaggtg gagttgggtt ggcctaccag gaccataagc ctgccatcct
     2521 gctgaggtcc tcttaccttg ctccttcaca cacaagctac gctcctggtg gctggcctct
     2581 ctgggcaagg gacggaggag cacctctctg ctctccaagg gaggtctgtt ccagagatgg
     2641 ggtttctagc cctcacctcc catgcaggaa ggaagcaccc gctcccggat cacagctgtg
     2701 atgggaggca ctggaagccg ccttcgcggg caactgtttc actggtccct ggatatacac
     2761 cccctaggat tagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2821 gtgtgtatgt gtgtgtgatg tacaatgtac atgtcccctt ttaggatgca ggagtgcatc
     2881 tgataatgta gggagagtgt cacaatcgtt tcgaagaacc cttccgtttg gtgctaccct
     2941 tgttggctat gtctccagtc actccctgcc caaccccacc tgctgtccta catagcaaga
     3001 ctgtgggcca acctgttcct ggaggcagga cgtatcagtg ggcagaagag ttacccatca
     3061 gtccctgcaa accccccacc caagcttctg ggtgtgtgtc agtgagagag aggctaaaag
     3121 atgctcaggg aaacagggaa acgcaggcct aagctgcctc tgggaccctg cctctgcctt
     3181 atactgggtg ggacgcagtg gtatccggag ctagggggta cctgttcccc agacctctct
     3241 gctttgaggg gtttctcact gctaaggagg gagttgttag cttccttttg gttctgtgtc
     3301 tgccaccaac cattgtctgt ctgtctgtct gcctgtctcc atcccccttt gtctttctag
     3361 agagcctagg ggtgggtctc agtacctagg gcagatagct cctcattacc tggggagaag
     3421 agagacagcg gcagctctaa agatggagct gagctttgac agggccttta ttacctctcc
     3481 tgtcacttcc tccactacta aggggttgca ggggctcccg gcagctactg ggtgaggttt
     3541 cctggcacag cctcgcaccc tccttcctgg ccctactgaa gaggtggcag tggccgggac
     3601 agctgtgaaa tcagccctgc tctgggagtg tatatatttt ttacccaaag ctctggaatt
     3661 gtacaattat tttttaaaac ccaaagaggg aacggacctt gtatcatatg taaacactgt
     3721 attataggct atgtacagtc ccttttatac agcagttcct ggcaaaatgt ccacagacat
     3781 gccatacgac ctccctggcc catagtggtg atggtgacca tgccacccct tggcccataa
     3841 tggtgatggt gaccattcct ctcccaaatt ctgctgcttc cctgcaatgc tagctgtgcc
     3901 ccggcagccc agacatcctg tccctcttct gcagcccttc agcaaccccc tctagttccc
     3961 cagccctcca caaacgctgc cccctccccc agcccttggc tgctgcttgc ctctggtcct
     4021 gatgcttgcc ccgctgattt ctcaggggcc ccatccccca accctgtagc tttaacagtg
     4081 aaccatgtat gttgttcaga cctagccttc attgcagaaa ctgctcgaaa ggaaaaaaaa
     4141 atacactaaa gtctatgaac caa
//
