LOCUS       NM_175258               8209 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus Rap guanine nucleotide exchange factor (GEF) 6
            (Rapgef6), transcript variant 2, mRNA.
ACCESSION   NM_175258 XM_484023 XM_484024 XM_899813 XM_899817 XM_899820
            XM_899825 XM_899831 XM_899833 XM_899839 XM_899844 XM_899852
            XM_899857 XM_899864 XM_899870 XM_914359 XM_923133 XM_923142
            XM_923148 XM_923153 XM_923157 XM_923164 XM_923169 XM_923176
            XM_923184 XM_923193 XM_923207
VERSION     NM_175258.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8209)
  AUTHORS   Ishihara S, Sato T, Du G, Guardavaccaro D, Nakajima A, Sawai S,
            Kataoka T and Katagiri K.
  TITLE     Phosphatidic acid-dependent localization and basal
            de-phosphorylation of RA-GEFs regulate lymphocyte trafficking
  JOURNAL   BMC Biol 18 (1), 75 (2020)
   PUBMED   32600317
  REMARK    GeneRIF: Phosphatidic acid-dependent localization and basal
            de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8209)
  AUTHORS   Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy SE, Miyakawa T
            and Kataoka T.
  TITLE     Comprehensive behavioral analysis of mice deficient in Rapgef2 and
            Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap
            small GTPases possessing the Ras/Rap-associating domain
  JOURNAL   Mol Brain 11 (1), 27 (2018)
   PUBMED   29747665
  REMARK    GeneRIF: Rapgef2-conditional knockout (cKO) mice and Rapgef6-KO
            mice exhibited hyperlocomotion phenotype and working-memory defect,
            both of which could be recognized as schizophrenia-like behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8209)
  AUTHORS   Quesnel-Vallieres M, Dargaei Z, Irimia M, Gonatopoulos-Pournatzis
            T, Ip JY, Wu M, Sterne-Weiler T, Nakagawa S, Woodin MA, Blencowe BJ
            and Cordes SP.
  TITLE     Misregulation of an Activity-Dependent Splicing Network as a Common
            Mechanism Underlying Autism Spectrum Disorders
  JOURNAL   Mol Cell 64 (6), 1023-1034 (2016)
   PUBMED   27984743
REFERENCE   4  (bases 1 to 8209)
  AUTHORS   Maeta K, Edamatsu H, Nishihara K, Ikutomo J, Bilasy SE and Kataoka
            T.
  TITLE     Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide
            Exchange Factors for Rap1 Small GTPase, in Formation of Apical
            Surface Adherens Junctions and Neural Progenitor Development in the
            Mouse Cerebral Cortex
  JOURNAL   eNeuro 3 (3) (2016)
   PUBMED   27390776
  REMARK    GeneRIF: Study show that double knockout of Rapgef6 in Rapgef2-cKO
            mice (Rapgef2/6-dKO) results in marked enlargement of the ectopic
            cortical mass. While Rapgef2-cKO affects late-born neurons only,
            Rapgef2/6-dKO affects both early-born and late-born neurons in the
            developing brain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8209)
  AUTHORS   Levy RJ, Kvajo M, Li Y, Tsvetkov E, Dong W, Yoshikawa Y, Kataoka T,
            Bolshakov VY, Karayiorgou M and Gogos JA.
  TITLE     Deletion of Rapgef6, a candidate schizophrenia susceptibility gene,
            disrupts amygdala function in mice
  JOURNAL   Transl Psychiatry 5 (6), e577 (2015)
   PUBMED   26057047
  REMARK    GeneRIF: Rapgef6 deletion mice were impaired in hippocampal and
            amygdalar function and had reduced spine density and primary
            dendrite number in pyramidal neurons of the CA3 hippocampal region.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8209)
  AUTHORS   Okada K, Miyake H, Yamaguchi K, Chiba K, Maeta K, Bilasy SE,
            Edamatsu H, Kataoka T and Fujisawa M.
  TITLE     Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide
            exchange factor for Rap1, in mouse spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 445 (1), 89-94 (2014)
   PUBMED   24491570
  REMARK    GeneRIF: Data indicate that the testes of RA-GEF-2(-)knockout male
            mice were significantly smaller than those of wild-type mice and
            were markedly atrophied as well as hypospermatogenic.
REFERENCE   7  (bases 1 to 8209)
  AUTHORS   Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF,
            Smith RJ, Cornell RA, Fritzsch B and Banfi B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   8  (bases 1 to 8209)
  AUTHORS   Yoshikawa Y, Satoh T, Tamura T, Wei P, Bilasy SE, Edamatsu H, Aiba
            A, Katagiri K, Kinashi T, Nakao K and Kataoka T.
  TITLE     The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis
            factor-alpha dependent regulation of integrin activation in
            splenocytes
  JOURNAL   Mol Biol Cell 18 (8), 2949-2959 (2007)
   PUBMED   17538012
  REMARK    GeneRIF: These findings proved a crucial role of the cross-talk
            between two Ras-family GTPases M-Ras and Rap1, mediated by
            RA-GEF-2, in adhesion signaling.
REFERENCE   9  (bases 1 to 8209)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 8209)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK167055.1, AK143331.1, AK220459.1 and AW493254.1.
            
            On Nov 16, 2011 this sequence version replaced NM_175258.3.
            
            Transcript Variant: This variant (2) lacks an in-frame coding exon,
            compared to variant 1. The resulting isoform (2) is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2104              AK167055.1         2-2105
            2105-6343           AK143331.1         492-4730
            6344-8189           AK220459.1         4272-6117
            8190-8209           AW493254.1         341-360
FEATURES             Location/Qualifiers
     source          1..8209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..8209
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /note="Rap guanine nucleotide exchange factor (GEF) 6"
                     /db_xref="GeneID:192786"
                     /db_xref="MGI:MGI:2384761"
     exon            1..274
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..345
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            346..402
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..486
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..556
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..700
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..832
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1010
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1147
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1306
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1459
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1624
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1732
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1936
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2045
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2286
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2444
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2685
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..3069
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3281
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3405
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3626
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3815
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..3950
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4179
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4682
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            4683..4985
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
     exon            4986..8192
                     /gene="Rapgef6"
                     /gene_synonym="A530068K01; C030018K18Rik; mKIAA4052;
                     PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgttctcgg ccagtctcgc ccccgcgcag gcgtctttct ggccagtcgc gcgtgggctg
       61 aggccctggg cgggcgttgc gaagacttgt ttgcttgagt ttggaccctg cgacagttct
      121 catttccctc ccggtggggc tggcgtacac ccggagctgg agaatgggca gctagacgca
      181 ggctagggag cctgtggctg cggacatgaa ctcgcccgtg gaccccggcg ctcggcaggc
      241 actgaggaag aagccgcccg agcggactcc tgaggactta aatattattt attcttatct
      301 gcatgggatg gaaatactat caaacctcag ggagcatcag cttaggttaa tgtctacaag
      361 agcacgctat gagagataca gtggcaatca aatgcttttt tgttcagaaa ctattgccag
      421 atgttggtat atcctgcttt ctggatctgt acttgtaaaa gattctatgg tccttcctcc
      481 ttgcagtttt ggtaagcagt ttggaggaaa aagaggatgt gattgtcttg tgttagaacc
      541 ttcagaaatg attgtggtag agaattccaa agataatgaa gacagtattt tacaaagaga
      601 aattcctgcc agacagtctc gacgaaggtt tcggaaaatt aactataaag gagaacgcca
      661 aaccataata gatggagtgg atattaataa ctacctttcg cttccagctg atcttaccaa
      721 gatgcacctc acagacaacc ctcatccaca ggtgacgcat gtgtcttcta gtcagtctgg
      781 ctgtagcatt gccagtgact ctgggagcag cagtttatcc gatatctatc aggctacaga
      841 gagtgaagta ggagatgtag atttaacacg ccttccagaa ggacctgttg attctgagga
      901 tgaagaggag gaggaagaag agattgatag aacagatcca ctgcagggtc gagatcttgt
      961 tcgggagtgt cttgaaaagg aacccgcaga caaaactgat gatgatgttg aacagttact
     1021 tgagttcatg caccagctgc ctgcctttgc gaacatgacc atgtctgtaa ggagagaact
     1081 ctgctccgtc atggtttttg aagtagtaga gcaggctggg gctgttattc ttgaagatgg
     1141 gcaagagctt gactcatggt atgtcatttt aaatggcact gtagaaatta gtcatccaga
     1201 tgggaaaata gaaaatctct tcatgggaaa tagttttggg attgtcccca cgctggataa
     1261 gcagcacatg catggagctg tcaggaccaa agtcgatgat tgtcagtttg tctgcatagc
     1321 tcaacaagac tattggagaa ttttaaatca tgtggaaaaa aatactcaca aagttgagga
     1381 agagggagag attgtcatgg tacatgagca ccgtgagcta gaccggagcg gaaccaggaa
     1441 aggacacatt gtaatcaagg caacacctga gcgtctcatc atgcatttga tagaagaaca
     1501 ttctattgtg gacccaacat acatagaaga tttcctctta acttacagga catttcttga
     1561 aactcctttg gatgttggga tcaagctttt ggaatggttt aagattgaca acctaaggga
     1621 taaggtgaca cggattgtac tcttatgggt aaataatcat tttaatgatt ttgaaggtga
     1681 tcctgctatg actcaatttc tagaagaatt tgaaagaaat ttggaagata caaaaatgaa
     1741 tggtcacctc aggttattga atattgcctg tgctgcaaag gctaagtgga ggcaagttgt
     1801 actgcagaag gcgtcccgtg agtccccgct gcacttctgc cttactgggg gcagtgagaa
     1861 gggatttgga gtctttgttg aagaagtaga atctggtagc aaagctgctg acgcaggact
     1921 gaaaaggggt gatcaggtaa tggaagtcaa tggacaaaac tttgagaata ttacacttgc
     1981 taaagccctt gaaattttga gaaataatac tcatcttgca cttactgtga agaccaacat
     2041 ttttgtgttc aaagaattgc tcagtaggac tgaacaagag aaatctggtg ttcctcatat
     2101 tcccaaaatt gctgaaaaaa aaagtaatcg ccattcaatt caagatgtcc caggggatat
     2161 ggagcaggca ccacaggaga aaggaaataa gaaaattaaa gcaaataccg tttcaggtgg
     2221 aagaaacaaa atcaggaaaa ttttggataa aacacgattt agtatcttgc ctccaaaact
     2281 atttagtgac ggaggcctga gtcaatcaca agatgacagc attgtgggaa ccaggcactg
     2341 taggcacagc ctggctataa tgccaattcc cggaacactt tcatccagca gcccagatct
     2401 cttacagcct accactagca tgttggactt ttccaatcct tcagatattc ctgatcaagt
     2461 tataagagtt ttcaaagcag atcaacaaag ttgctacatt atcatcagta aggataccac
     2521 agctaaagaa gtggtctgcc aagctgtaca ggaattcggt ttgactggtg catctgacac
     2581 atactccctc tgtgaagtgt ctgttactcc tgagggtgtt ataaagcaga gaagacttcc
     2641 ggaccagttc tccaaattag ctgatagaat tcaactcaat ggaaggtatt acctaaaaaa
     2701 caacatggaa acagaaacat tgtgttctga tgaagatgct caggaactac ttaaggaaag
     2761 ccagctctcc atgctgcagc tcagtaccat cgaggtcgcc acccagctct ccatgagaga
     2821 ctttgattta tttcgtaaca ttgagcctac tgaatacatt gatgatcttt ttaaattaga
     2881 ttccaaaaca ggaaatactc acttgaaaca atttgaggat attgtaaacc aagagacatt
     2941 ctgggttgcc tcagagattt taagtgagtc aaatcagctg aaaagaatga agattattaa
     3001 acattttatc aaaattgctc ttcattgccg agaatgcaag aatttcaatt ccatgtttgc
     3061 aataataagt ggcttgaacc tggcaccggt agcacgactc agaggcactt gggaaaagtt
     3121 gccaagcaaa tatgagaaac atcttcaaga tctacaagac ctttttgatc catctagaaa
     3181 tatggcaaaa tacagaaata ttcttagtag tcaaagcatg cagcctccaa ttattccact
     3241 cttccctgtt gtcaagaaag atatgacatt tctccatgaa ggaaatgact ccaaagtaga
     3301 tggcttagta aacttcgaga agctaagaat gattgccaag gaaatccgtc atattattcg
     3361 aatgacttct gccaacatgg accctgccat gatgttccga cagaggtcat tgagtcaagg
     3421 cagcacaaat tctaacatgc tagatgtcca gggaggtgct cacaaaaaaa gagcacgccg
     3481 cagctcactg ctgaatgcca agaaactgta tgaagatgcc caaatggcaa ggaaagtgaa
     3541 acagtatctt tctagtctgg acatagacac agatgaggag aagttccaga tgatgtcact
     3601 gcagtgggaa cctgcatatg gtaccttgac aaagaactta actgaaaaaa ggtcagccaa
     3661 atcatctgag atgtctcctg taccattgag gtcagttggc caaacagcta aagtccactt
     3721 gcatcagcca cacagagtga gccaggtgct tcaggtgcca gcagttaact tgcaccccat
     3781 ccggaagaaa ggacaagcca aagaccatgt gctgagtaca agtttacctc agaaaggttt
     3841 aggaccaact gaggaagtga gtgttaagaa acacacagaa gacactattt ctgtagcgtc
     3901 ctctctgcac tctagccctc ctgcatctcc tcagaactcc ccacgcaaag gttatacact
     3961 cacaccatca agtaaatgtg acaacttgtc tgactccagc cacagtgaaa tctcctctcg
     4021 gtccagcatt gtgagcaatg gttctgttga ctccatgtct gcagctgggc aggatgaacg
     4081 ctgttcctcc cacagtctgg cagttcctga gcccacaggg gcattggaaa agacagatca
     4141 cccttccggg atctcagacc acagtcagct tgctcacggg tggatgctgt caaagccgtg
     4201 tcttatcaag ggtgtagctg tctcatcttc tctgagcagc gaagagatgt ctcatgagca
     4261 tgttgtgctg gaagcagctg acagtgggcg gggcagttgg acttcctgtt ccagcagctc
     4321 ccatgacaac ttccaaagcc ttcaaaatca aaaaagctgg gacttcctga attcttacag
     4381 acacatgcat ttagatgacc ctattgcaga agttgagccc actgactgtg agccctgtgc
     4441 ctgtcctaaa ggctgctcaa gaacttgtgg ccagtgcaaa ggcagcctag agacgaacca
     4501 gctgaggcag agttgggcct cctccagctc actctcggac acatgtgaac caaactacgg
     4561 gacagttaag cggagggtgt tggaaagtgc accagcagag gcacctgatg gcttggagcc
     4621 cagggatacc actgaccctg tttataaaac tgtcacttcc agtacagaca agggcttgat
     4681 tgtgtactgt gtcacctcac ccaagaaagg tgataggtat agggagccac cgcccactcc
     4741 tccaggatat ctgggaattt ctttagcgga cctaaaggaa ggaccccacc cgcacctaaa
     4801 acctccagac tatagtgtgg cagtacagag atcaaagatg atgcttaaca gcctgtctag
     4861 actgccgcca gctcctccca gtagccacac ctcggcctgg gttccctcga agattggatc
     4921 ccagcctcaa aggcatagcc atcccaagct agcagatgtg gctgatgcag atagcgaagc
     4981 agatgaaaac gagcaggtgt cagcagtcta gcctttggac agagtgttgg agagcactgg
     5041 aagtcaggac catggacaag agctcgtggt tctgtaggcc aaggccatca gctcgctgct
     5101 gccactcatg ctgagggttc cacactgggc tctgaggatg agctcttctg agtcgtgctt
     5161 ccttttgttc tgtccctgca ggtgcagttt ccttacctgg gtgttgcacc tgatctcagc
     5221 ctatactttg cacatcactc ctgccttggg accacattca agctcagagt tctccccctg
     5281 tatatcacta tgagtttttc ttttcgagag tcattttaaa gatagtggta ttattattat
     5341 ttccaagcca tagcttgggc taaaaggaca cattcagaat gtctgccaat accaaggata
     5401 gtcttgtgta tttgaaaagt aacttattat tgcaagtatt gtgattttgt ttgcattcaa
     5461 aagctcttgt tagctgttat ttgtcttagt ctataaagct gtctgtgtgt ggtctgagca
     5521 gcagttgtca tcccaacaca ggtacggaga tgtgacagca ttgtagcaga cactcaggtg
     5581 ggaacaagac acccgtgcag gtgcagtgca ggtggccagc tcatcatgat gtgggctaca
     5641 gcagccacag gggtctcagc agtctttcgg aaaggagaac aaagcgcaag taggaagaaa
     5701 gaactctaat ttccaaagaa ggaaagatta acattgaact tgtttctgaa atgaacatca
     5761 tgttgcaccc aattgtgagg atactacaaa cccactggca gtggcttctc aaaggctttc
     5821 tttctataga aaccctaagc taccatttca caacacaagt atggaatccc tagattaaaa
     5881 gaaatattgt aggagctgga gagatggcga agatactctt gcagagggct ggatttaatt
     5941 tcagccctca catggtggct tacaactgcc tgcaactcca catccagggg atccgacacc
     6001 ctcgtctgac ctccacaggc acttcatgca tgtggcccat aggcatacat gcagtcagaa
     6061 tacccctaca cacacaaaat aataagaaaa aaaaatttat catggatgca ataatgaagt
     6121 ttcccttggc ttgtgctgtg actttacagc acacaaccac atgtgcaatc attgaacttg
     6181 agctttgaga cctccacaga gctcagtccc caagagatag tagactcata taagagagag
     6241 aggctaaaat aatggagggg acttcatcct ggaaaggaca tcctttgtga cctcctggac
     6301 atggcactct taactatata attcaaatca gtgactgctt actaaaaaaa tgtacttttc
     6361 acatttttac aaattaagta taacattttg tatatatata tttaaaggtt ttgatttgct
     6421 ttttaatgta aaggcaaata agagttcata aacttctgta attacaaaaa aagccaaagc
     6481 cattgaaagt gcactgacca tgacagcttt gctacagagc agtcatgtta ccaaccgcct
     6541 tttcaagttt gtacttttcc cttacgctct cttcctgttt ttctgtccaa tcacttgaga
     6601 gtcagaacag ttccaaatgt aacagtattg tgtcttccca cagaatgcct gtctctagga
     6661 agcataatgg ctgaagattc ccctggggag acagtaaccc ggaagcctta gacttgagcc
     6721 caggtgccga gcagtgcagt gaggcgcagc cttactggcc ctttgagtgt cagctgccac
     6781 tttacagcca tgcttcacta atctggccta tgaactaact gtgctggttt ctgattgtga
     6841 atctttttat tcacctactt gcagattgtt ttcatgtcca aaacaaaaga aatatttttg
     6901 ctatatccac ctttgtaatc caagtttgag tactcattgt caccattttc tatccattgc
     6961 tccagaaaaa tgtgctgtct gcacagcttc tgtctatcca ccaggtcttc agacagatgg
     7021 acccttgcct gccttggtcc ttaaaggtgt acattaaatg tctttcacag agagttaaga
     7081 tctgtggctt tgaacctgca ttgtgtagct gccttgattt taatcaagct ttatctgtga
     7141 gtgttcagac caactgatca cattgatcag aataaaaacc aaatgctttg tagtttgatg
     7201 tgtatgagtc cctgaaaaaa atcatgtctg cctttttttt tactttgtta ggtgactaga
     7261 gcaagggaag ccttaaagcc catgattgct ccagttctaa gcccccattt gtccttgttc
     7321 taagtgtgca acattactaa acagactagt gcccagcacc tgccaagact gtcaaagcag
     7381 gagactttta gtgcagagtt ttgccaaata ataaatttca acaaaatctc agagtaaacc
     7441 attaagagat tagtgaatcc agccactgct tacagcaagg ttactcggaa tcaccagatt
     7501 tcatttcctc taattgatgt ctttataaat gatctttggg gaaaaaaatc ctttagagag
     7561 tattcatgag ggtggcatgt tggttacctc catgatctct accaagctgg aagagcagga
     7621 atagccatag ggtcacctta tataattaca aagaaagagg aaggaagaaa ggtttcctta
     7681 aacattcaac ccagtgatta tttgggtgga aacattctag aagacgctgg gtgtgcccgt
     7741 gcagcgttct gttacacgct acaggcgggg tccaccgaga caagtcgggt acattttcaa
     7801 atcaaacttg agccccagtc atctttagct ttcttgttgt ttaaaaggcc tctttatttt
     7861 tattgtacag aatgaatgca gttgaacttg atagatgttt taaaattgaa atgtgagttt
     7921 atcaaaaaca aaagcaaaat tgcacagttg ctatgatcaa gtgacaatta tctgcacaat
     7981 tcattgattg taaggcatcc tgtcacaagc aatgttgtct cctactttct gatgcctctt
     8041 aaacttatgt cttttagaaa gacagtgcct ctgtatgctt tgtattttta ctgagtgtaa
     8101 atacttgtta tattttggtt aagaaaatgt aagggtatca tttattacca catctcctaa
     8161 tacatcggaa ccaataaaga acatgcatca acaaaaaaaa aaaaaaaaa
//
