LOCUS       NM_001373989            6386 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rap guanine nucleotide exchange factor (GEF) 5
            (Rapgef5), transcript variant 1, mRNA.
ACCESSION   NM_001373989 XM_006515781
VERSION     NM_001373989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6386)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6386)
  AUTHORS   Alharatani,R., Griffin,J.N. and Liu,K.J.
  TITLE     Expression of the guanine nucleotide exchange factor, RAPGEF5,
            during mouse and human embryogenesis
  JOURNAL   Gene Expr Patterns 34, 119057 (2019)
   PUBMED   31163262
REFERENCE   3  (bases 1 to 6386)
  AUTHORS   McKenzie,M.G., Cobbs,L.V., Dummer,P.D., Petros,T.J., Halford,M.M.,
            Stacker,S.A., Zou,Y., Fishell,G.J. and Au,E.
  TITLE     Non-canonical Wnt Signaling through Ryk Regulates the Generation of
            Somatostatin- and Parvalbumin-Expressing Cortical Interneurons
  JOURNAL   Neuron 103 (5), 853-864 (2019)
   PUBMED   31257105
REFERENCE   4  (bases 1 to 6386)
  AUTHORS   Codner,G.F., Mianne,J., Caulder,A., Loeffler,J., Fell,R., King,R.,
            Allan,A.J., Mackenzie,M., Pike,F.J., McCabe,C.V., Christou,S.,
            Joynson,S., Hutchison,M., Stewart,M.E., Kumar,S., Simon,M.M.,
            Agius,L., Anstee,Q.M., Volynski,K.E., Kullmann,D.M., Wells,S. and
            Teboul,L.
  TITLE     Application of long single-stranded DNA donors in genome editing:
            generation and validation of mouse mutants
  JOURNAL   BMC Biol 16 (1), 70 (2018)
   PUBMED   29925374
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6386)
  AUTHORS   Mattiske,T., Lee,K., Gecz,J., Friocourt,G. and Shoubridge,C.
  TITLE     Embryonic forebrain transcriptome of mice with polyalanine
            expansion mutations in the ARX homeobox gene
  JOURNAL   Hum Mol Genet 25 (24), 5433-5443 (2016)
   PUBMED   27798109
REFERENCE   6  (bases 1 to 6386)
  AUTHORS   Bithell,A., Hsu,T., Kandanearatchi,A., Landau,S., Everall,I.P.,
            Tsuang,M.T., Chana,G. and Williams,B.P.
  TITLE     Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF,
            is altered in individuals with bipolar disorder
  JOURNAL   PLoS One 5 (4), e10392 (2010)
   PUBMED   20436929
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6386)
  AUTHORS   Cobos,I., Borello,U. and Rubenstein,J.L.
  TITLE     Dlx transcription factors promote migration through repression of
            axon and dendrite growth
  JOURNAL   Neuron 54 (6), 873-888 (2007)
   PUBMED   17582329
REFERENCE   8  (bases 1 to 6386)
  AUTHORS   Bithell,A., Alberta,J., Hornby,F., Stiles,C.D. and Williams,B.P.
  TITLE     Expression of the guanine nucleotide exchange factor, mr-gef, is
            regulated during the differentiation of specific subsets of
            telencephalic neurons
  JOURNAL   Brain Res Dev Brain Res 146 (1-2), 107-118 (2003)
   PUBMED   14643017
REFERENCE   9  (bases 1 to 6386)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 6386)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163283.3, AC163286.4 and AC139993.16.
            
            On Sep 6, 2019 this sequence version replaced XM_006515781.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2361965.1,
                                           SRR13422601.1899778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC163283.3         17408-17713         c
            307-357             AC163286.4         173330-173380       c
            358-464             AC163286.4         171208-171314       c
            465-586             AC163286.4         167120-167241       c
            587-755             AC163286.4         164724-164892       c
            756-822             AC163286.4         153628-153694       c
            823-871             AC163286.4         135506-135554       c
            872-945             AC163286.4         101818-101891       c
            946-1071            AC139993.16        232952-233077       c
            1072-1190           AC139993.16        202558-202676       c
            1191-1279           AC139993.16        202004-202092       c
            1280-1358           AC139993.16        181893-181971       c
            1359-1503           AC139993.16        176991-177135       c
            1504-1601           AC139993.16        175836-175933       c
            1602-1632           AC139993.16        173008-173038       c
            1633-1711           AC139993.16        172043-172121       c
            1712-1861           AC139993.16        169849-169998       c
            1862-1959           AC139993.16        165192-165289       c
            1960-2082           AC139993.16        162461-162583       c
            2083-2261           AC139993.16        160522-160700       c
            2262-2352           AC139993.16        151523-151613       c
            2353-2403           AC139993.16        148339-148389       c
            2404-2491           AC139993.16        146980-147067       c
            2492-2556           AC139993.16        142790-142854       c
            2557-2611           AC139993.16        137764-137818       c
            2612-6386           AC139993.16        131503-135277       c
FEATURES             Location/Qualifiers
     source          1..6386
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 63.06 cM"
     gene            1..6386
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /note="Rap guanine nucleotide exchange factor (GEF) 5"
                     /db_xref="GeneID:217944"
                     /db_xref="MGI:MGI:2444365"
     exon            1..306
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2730
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /note="isoform 1 is encoded by transcript variant 1; Mras
                     regulated guanine nucleotide exchange factor; rap guanine
                     nucleotide exchange factor 5; MR-GEF; M-Ras-regulated Rap
                     GEF; guanine nucleotide exchange factor for Rap1"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 5 isoform
                     1"
                     /protein_id="NP_001360918.1"
                     /db_xref="GeneID:217944"
                     /db_xref="MGI:MGI:2444365"
                     /translation="MAVGSVKMQPPCESPALASAAPADGPLRRSPSAREPEREPPAAS
                     LRPRLRDLPALLRSGLTLRRKRSAAGARTLSRRISNPYLEHSPSQIYGENSSCAGRAL
                     RNIIILQAADLVKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDM
                     GIMSSVDQHLYFQDNYVFYQFSSDECSYLYCEFEREEEWQKGVKLLLELVHLIPARAG
                     ICDLSHQKTEDSEESSDEILARLTSAVQRELAAVIALKARKSAIEQDDENADKHVTVT
                     EANNGPDPQAGVMCKLQERDDIGRIELVHKLARENCQFLQTEKKESEKLEQQDDEVTM
                     VQVKEQGQSVLVLKKVASCGPAPTSGSAENDARYVVVSGTPEKILEHLLNDLHLAEVQ
                     HKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGEEENSDVPCRKRKVLHLVS
                     QWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGVYRRHTVDE
                     YSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYITEHSYISVKAKVSSTAQEI
                     LKVVAEKLQRAEEDLALVAITFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTLN
                     PLAENEESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFTFSRQGNGENTV
                     NLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQQNLNSFFAIVMG
                     LNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLL
                     LKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDVSPKEQQELKSYV
                     NHLYVIDSQQALFELSHRLEPRA"
     exon            307..357
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            358..464
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            465..586
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            587..755
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            756..822
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            823..871
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            872..945
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1071
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1190
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1279
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1358
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1503
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1601
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1632
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1711
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1861
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1959
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2082
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2261
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2352
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2403
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2491
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2556
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2611
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..6386
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6364..6369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /note="hexamer: AATATA"
     polyA_site      6386
                     /gene="Rapgef5"
                     /gene_synonym="4932413M22; D030051B22Rik; GFR; mKIAA0277;
                     mmr-gef; Mrgef"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgccc tctcgctgcc tggcgaaggc gcggaggcga gcgcggagga gagcagccgc
       61 gggcgccgcc gcaaccgtca gggcatcagg atggcggtgg gctctgtcaa gatgcagccg
      121 ccttgcgaga gtccggccct ggcctcggcg gccccggccg atggccctct gcgccgcagc
      181 ccgagcgccc gggagccgga gcgcgagccg cccgccgcgt ctctgcggcc gcgcctcagg
      241 gacctgcctg cgctgctgcg gagcgggctc acgctgcgga ggaagcggag cgccgccggc
      301 gcccggactc tctcaagaag aatttctaat ccataccttg aacatagtcc ttctcagatt
      361 tatggagaga attcttcctg tgcaggaaga gcattaagga atattattat ccttcaagca
      421 gctgacctgg taaaggacag agtgaatctc aaggggtttt acaggagaag ctgtgtgggg
      481 tcagagctgg tcgactggct cctggaacac tgtccttttg tccagtgtag atctatggcc
      541 attggagtct ggcagctcct actggatatg gggattatgt catccgtgga ccaacatcta
      601 tactttcaag ataattatgt tttctaccag ttttcttcgg atgagtgcag ctacttgtac
      661 tgcgaatttg aaagagagga agaatggcag aagggagtga agctattgct ggagcttgtg
      721 catctcattc ctgcaagagc tggcatctgt gacctgtctc accagaaaac ggaagactcg
      781 gaggaaagca gtgatgagat tcttgctcgg ctaacatctg cggtgcagag agagctggcg
      841 gctgttattg ctttgaaagc aagaaagtct gcaattgagc aagatgatga aaacgctgac
      901 aagcatgtaa ccgtgacgga ggctaacaac ggtcccgatc ctcaggctgg ggtgatgtgc
      961 aagcttcaag agagagatga tatcggacgt attgagctgg tccacaagct ggcaagagaa
     1021 aactgtcagt ttttacagac agaaaaaaaa gaatcggaga agttggaaca gcaagatgat
     1081 gaagtgacga tggttcaggt taaagagcaa ggccagagtg tgctggtgct gaagaaagta
     1141 gcaagctgtg gcccagcccc cacctcaggg agtgcggaga acgacgcgag atatgtggtg
     1201 gtgtctggta ccccggagaa gatcttggag caccttttga atgacttgca cctggcagag
     1261 gttcagcaca aagaaacaga aacactcctt gatgacttcc tcctcacgta caccgtattc
     1321 atgacaactg atgacttgtg ccaggcgctg ctaagacact attctgccaa gaagtatcaa
     1381 ggggaagaag aaaactcaga tgtcccttgt cggaagcgca aggtcttaca tctggtttcc
     1441 cagtggattt ctctgtacaa ggactggcta catgaagatg agcattcaaa aatgtttcta
     1501 aagaccatat acaggaacgt gctggatgat gtctatgagt acccgattct tgagaaagag
     1561 ctgaaagagt ttcagaagat acttggcgtg taccgccgtc acactgttga tgaatactca
     1621 ccacagaaga agaataaagc ccttttccac caattcagtc ttaaggagaa ctggctccag
     1681 cacagaggaa ctgtggcaga aacagaggaa attttttgcc acgtgtatat aacggagcac
     1741 tcctatatca gtgtgaaggc aaaagtgtcg agtacagccc aggagatcct gaaggtcgtg
     1801 gccgagaagc tgcagcgtgc cgaagaggat ctggctctgg tagccattac attctctgga
     1861 gaaaagcatg aatttcagcc aaatgacttg gccatttcca aatccctgga ggcatctggt
     1921 cggatatatg tctaccgaaa agatctggct gacactttga atcctttggc agaaaatgag
     1981 gaatcccagc aaaggtcaat gaggattttg gggatgaaca cgtgggacct tgctctggaa
     2041 ttaatgagtt ttgattggag tctgttcaat tcaatccacg agcaagagct gatctacttc
     2101 acattcagca gacaggggaa cggagagaat actgtgaacc tcagccttct gctccagaga
     2161 tgtaacgagg tccagctctg ggtagccaca gagattctgc tctgcagcca gctaggcaag
     2221 cgcgtgcagc tggtgaaaaa attcatcaag attgcagctc actgcaaagc ccaacagaac
     2281 ctaaactctt tctttgccat cgtgatgggt ctcaacaccg cctctgtcag ccggctatca
     2341 cagacctggg agaaaatccc tgggaagttt aagaagcttt tctctgaact tgagagttta
     2401 acggatcctt ccctaaacca caaagcctac agggatgcgt tcaaaaagat gaagccacca
     2461 aaaatccctt tcatgccctt actgcttaaa gatgtaacgt ttattcatga aggaaataaa
     2521 acattcttgg ataatctcgt caattttgaa aagctgcaca tgattgcaga cactgtccga
     2581 accctgagac actgcaggac taaccagttt ggaagtgacg tgtctccaaa ggagcagcaa
     2641 gagctgaagt cctatgtcaa ccacctgtat gtcatcgaca gccagcaagc cctgttcgag
     2701 ctctctcaca ggctggagcc tcgagcctga gctgtgccaa tgcatctgcc ctgcatctgc
     2761 aactcttaga gcaagcaaag gcctccgttc agcatgttgc ttcctgtaat aaaagaggtt
     2821 gctgagtttt atcagcatac catgagacaa gtgcaggaaa gccagccaaa gcacgttcag
     2881 gaagtgatgt cagccaccag aggcgagaga gctcccccca ctgctgtcag ggagaagaca
     2941 ggagtcagag catccttgga acagggtctt ccttatgatg acgatttcat tccagtccaa
     3001 gtttcagctt atgaggtgcc agcattagga ggtgattgct catatagcaa gaaggactgt
     3061 cactctgcct ggtcacctta ctgctgattg gctgtctgct caccttattg ccaattggct
     3121 gttaagagac tgtggacagc aagggcaact ccagatgttc cagaaagagg agaggcctct
     3181 gttgctataa acttaacatc accctggagg gcatgtcctt ctgtgcaaat aagaaatgcg
     3241 cggcacacac ttctttgcat ccacaatcat ttgccaatgt atatgcagat gaactagttt
     3301 ctgtaccact gatgtacttc tgtaagcaag gtagactggg tttctcatcc aataaggagc
     3361 ttggcattgt tcagtttcta tgaactgtct ttacatatat tgttgttgtt gctgagtgca
     3421 gttttcagaa aaacacagga cctggatcgt gagcgctcag tgttagttta ctggggtgac
     3481 agaatttcca gtgtctgcat tctggtatct gatggagtct tggtgtctga cattactcct
     3541 ccaagttccc tgcctacagg atgcagaaca tcaacccatg agggagggtg agtgaagcca
     3601 agtatatgaa gcttaacagt tagcctgcta gactcagtaa ttgaaaagta tccagagatg
     3661 cctaaagtct tacttacttg gggagtcaga gccccgtagt ctacttccca agcaaagcca
     3721 gagtctttct gcaatttgcc ttttaccttc ctattctttg tttttataaa ttgggcctca
     3781 tataccaaat aagacctctt ggaattctca aggactggtt tgaggatctc cctgaatctt
     3841 caaatgagct tgtggtttaa aaaaaaaaaa aaatgcctgc tctcccatga tctagatact
     3901 agttccttca ctgtgtgcaa gttcccatct gagtattttg tctgtgcatt tgcaatcttg
     3961 agtatgggta tgctgttcac agccttggga gttggttggg ggtgggggtc agggagggga
     4021 gctgtgtcca cacagatctg cttcctactc tctttgccac ctggtccatt ctcattacca
     4081 aggtctgagc tatgcctgtt gccacctgat ttcctgagag ctatgctgtt ccctggtttt
     4141 gggaccagtg agcttgaaac actgctagaa ggaaccatat gggaaaatct tggtagagct
     4201 ttcagagaga ttgcatctga cctagcatgt aaaatttcag ccctagaaac ttaacagggg
     4261 tttatagaaa cacccccaac tgagggtgat tcactcagaa aatgatttac acgtctgagg
     4321 gccggtgtat gagaccagag ctacagaacc agggagaaca ggctgtcctg acgtgtggac
     4381 aagcacaacc tctgaggata gcacacactt atagcacaaa tacgaatgtc ttccctccaa
     4441 gctagcaact ggactgggct agtgtatcat accaggccat tttgacattg tctgtgttct
     4501 gcgagtatta acgttagctc tacattgttt caagcagagc tttaccttga gaactcattg
     4561 tagatggaga tctgtttcag tagaacactg tctaggctct agctcagctg ggctacactg
     4621 gccacacctg catcatgctt gacacactta gagaatcctg caggacatga atgggaatag
     4681 ccctagagag catggggcaa ggctgcctct ccctccaaag caaaagtcag atgggattgt
     4741 ttgcccatcc tgtctccagc atatctaaaa atctctaaat ccttctcaac tttaacacct
     4801 ggttctaggg atttctcagg cagcagattt aggaacttca gaagcttcgc agagtcttaa
     4861 atctcaaatt aaagaaaagt tcagactggt cagaccctgt ttccacagga agctcttcct
     4921 aaggaagcca agccctgtat atatacccac aggagtcagc acttccaggc atgggatgac
     4981 ccagttcctt ctccaaagcc tccaagggtt cccagaccca gtgctactgt gttggaagag
     5041 tggaccagaa gatgtgtaaa gttccttcca gttctccttt ggattcttgt gatttcatga
     5101 atctccatcc cctccctaga tcttgtataa ttggcacctt cttggcctct ttctgttgac
     5161 aacacagccc tcgaggggtc ctgtgctttg gattctatcc ctgcaaagcg agctcctacc
     5221 agagtcagaa cacaagtcca tctaggaaaa gtcacaaacg ttctgaacat ctcaaaggat
     5281 tcgcacacac atttgcagat gctccacagc ctccacgtgg caacttgccg acaggttacc
     5341 gtagcacatg gtgtaactcg cagtctacct ttttagtatc tttaattgca ttgagaatag
     5401 attccttttc ctgctccaat atctacaagc aagcagtgta actcatacct tgaatttaga
     5461 ggcatgaaaa taaagtccca cccctcctag tttgtaggga ggtatttcat aggcggacag
     5521 tcttctgagt gaggaagcgg gagtatggat acgtggctgc ttgtatagac ctctcatcct
     5581 gaagctcgtg tggctgccta agtgtcagct ctgtggtttt gtacagacta cacatgcatt
     5641 gcaaagcctg aaccaaatga cacaacccac gaaagcttat cagaattggg caaaatcatt
     5701 aagtttagaa gacaagggcc actatagctg tccagcatag aatttcttct caacttcaaa
     5761 gacatgtcct tgaaatttca gcccactcag taatgagtgg gccagttttg ctctagagag
     5821 aacacatttt gaaaattgcc aaaaagtcag aagaaatgta ctactgtata aagcaaagct
     5881 gtatatactg agcattttta gcagagtaat atttatttgc atagcctatt tattgtattt
     5941 gtattacact gttattaaat accaggatga aatcactgac cagaagcaag aactcttgcc
     6001 tttggatgtc tcattgctta ggaccgccgt gatgctgtca gcttgggata acaattagaa
     6061 gatagaaaac ccacagtccg ggcgtctacc taacttctca gggactacac ctcgtagttt
     6121 tccaccatta taagcgctgg taaatatgaa acatttgttg agttaccaga ctgccgttga
     6181 cagtgtttga tttctcatag ttcatgcttt ctgcctctgt gtacatgact ctgctgtgta
     6241 tttatcaaag taggaagcaa taatttatat gtaaaaatgg ccaagcaata taaggttaaa
     6301 acttacataa gtaaccatta ccttatcttg tattttcaag tgttttttaa atctgctttt
     6361 ccaaatataa gactatgtta aagata
//
