LOCUS       NM_001039087            6251 bp    mRNA    linear   ROD 10-JAN-2023
DEFINITION  Mus musculus Rap guanine nucleotide exchange factor (GEF) 1
            (Rapgef1), transcript variant 1, mRNA.
ACCESSION   NM_001039087
VERSION     NM_001039087.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6251)
  AUTHORS   Ishii K, Kohno T, Sakai K and Hattori M.
  TITLE     Reelin regulates the migration of late-born hippocampal CA1 neurons
            via cofilin phosphorylation
  JOURNAL   Mol Cell Neurosci 124, 103794 (2022)
   PUBMED   36435394
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 6251)
  AUTHORS   Vishnu VV, Muralikrishna B, Verma A, Nayak SC, Sowpati DT, Radha V
            and Shekar PC.
  TITLE     C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for
            Differentiation of Embryonic Stem Cells
  JOURNAL   Stem Cell Rev Rep 17 (4), 1465-1477 (2021)
   PUBMED   33624208
  REMARK    GeneRIF: C3G Regulates STAT3, ERK, Adhesion Signaling, and Is
            Essential for Differentiation of Embryonic Stem Cells.
REFERENCE   3  (bases 1 to 6251)
  AUTHORS   Chavkin NW, Leaf EM, Brooks KE, Wallingford MC, Lund SM and
            Giachelli CM.
  TITLE     Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in
            Response to Elevated Phosphate in Vascular Smooth Muscle Cells
  JOURNAL   J Vasc Res 58 (5), 277-285 (2021)
   PUBMED   33951626
  REMARK    GeneRIF: Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling
            in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.
REFERENCE   4  (bases 1 to 6251)
  AUTHORS   Sriram D, Chintala R, Parthasaradhi BVV, Nayak SC, Mariappan I and
            Radha V.
  TITLE     Expression of a novel brain specific isoform of C3G is regulated
            during development
  JOURNAL   Sci Rep 10 (1), 18838 (2020)
   PUBMED   33139841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6251)
  AUTHORS   Nayak SC and Radha V.
  TITLE     C3G localizes to the mother centriole in a cenexin-dependent manner
            and regulates centrosome duplication and primary cilium length
  JOURNAL   J Cell Sci 133 (11) (2020)
   PUBMED   32371504
  REMARK    GeneRIF: C3G localizes to the mother centriole in a
            cenexin-dependent manner and regulates centrosome duplication and
            primary cilium length.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6251)
  AUTHORS   Fernandez-Medarde A, Esteban LM, Nunez A, Porteros A, Tessarollo L
            and Santos E.
  TITLE     Targeted disruption of Ras-Grf2 shows its dispensability for mouse
            growth and development
  JOURNAL   Mol Cell Biol 22 (8), 2498-2504 (2002)
   PUBMED   11909944
  REMARK    GeneRIF: Targeted disruption of Ras-Grf2 shows its dispensability
            for mouse growth and development.
REFERENCE   7  (bases 1 to 6251)
  AUTHORS   Zhai B, Huo H and Liao K.
  TITLE     C3G, a guanine nucleotide exchange factor bound to adapter molecule
            c-Crk, has two alternative splicing forms
  JOURNAL   Biochem Biophys Res Commun 286 (1), 61-66 (2001)
   PUBMED   11485308
REFERENCE   8  (bases 1 to 6251)
  AUTHORS   Ohba Y, Ikuta K, Ogura A, Matsuda J, Mochizuki N, Nagashima K,
            Kurokawa K, Mayer BJ, Maki K, Miyazaki J and Matsuda M.
  TITLE     Requirement for C3G-dependent Rap1 activation for cell adhesion and
            embryogenesis
  JOURNAL   EMBO J 20 (13), 3333-3341 (2001)
   PUBMED   11432821
REFERENCE   9  (bases 1 to 6251)
  AUTHORS   Voss AK, Thomas T and Gruss P.
  TITLE     Efficiency assessment of the gene trap approach
  JOURNAL   Dev Dyn 212 (2), 171-180 (1998)
   PUBMED   9626493
REFERENCE   10 (bases 1 to 6251)
  AUTHORS   Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH and
            Hanafusa H.
  TITLE     The SH3 domain of Crk binds specifically to a conserved
            proline-rich motif in Eps15 and Eps15R
  JOURNAL   J Biol Chem 270 (25), 15341-15347 (1995)
   PUBMED   7797522
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147468.1 and AK077034.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001039087.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147468.1, AK147470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5257              AK147468.1         2-5258
            5258-6251           AK077034.1         3230-4223
FEATURES             Location/Qualifiers
     source          1..6251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.32 cM"
     gene            1..6251
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /note="Rap guanine nucleotide exchange factor (GEF) 1"
                     /db_xref="GeneID:107746"
                     /db_xref="MGI:MGI:104580"
     exon            1..344
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3958
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide releasing factor 2"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 1 isoform
                     1"
                     /protein_id="NP_001034176.1"
                     /db_xref="CCDS:CCDS38091.1"
                     /db_xref="GeneID:107746"
                     /db_xref="MGI:MGI:104580"
                     /translation="MSSGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIK
                     RTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQR
                     QKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPR
                     IQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKEL
                     VRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDS
                     TSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGI
                     NRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRN
                     TSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLG
                     SCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVP
                     VQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQ
                     LLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPK
                     QRQLQASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYK
                     SVFRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHTSQSSDLAVPTVSSPPPSTVDG
                     PLSSSQDSSFHGNPVRLPSETSFTDSEPPSGKDGHPRDPSVSSASGKDSRENGERSPK
                     SLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDR
                     KDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVD
                     ELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLA
                     ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFT
                     EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPI
                     RRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGN
                     PDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWEL
                     SLKIKPRNITRRKTDREEKT"
     exon            345..481
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..595
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..774
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..931
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1020
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1173
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1294
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1478
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1964
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2167
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2323
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2581
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2667
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2779
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2855
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2940
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3033
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3219
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3304
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3399
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3478
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3580
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3678
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3807
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..6251
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6223..6228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /note="putative"
     polyA_site      6251
                     /gene="Rapgef1"
                     /gene_synonym="4932418O06Rik; C3G; Grf2"
                     /note="putative"
ORIGIN      
        1 gggcttccgg caggtggcgc cgtggccgcg gggcccaggc cggcgggcgg gcggcggcgc
       61 ggcgctgcgg ccggcggctc gcggccccgg agcggcggct gcgcgggagg tggagcggcg
      121 gagtggcagg cccggtgcgg gctggagcgc gggcggcgag cgcacgagcc gcggccgcgc
      181 ggagcccgcc atgacggcgc gagtgtgagg cgcggcgagc accggtccag tagagcggcg
      241 ggcgcgccgg cctcttatcc cgcagcggcc gggccgggcc ctgatgagca gcggcctcgg
      301 cctccggcgc agcccggaaa tgtccggcaa gatcgagaaa gcagactctc agcgttctca
      361 tctctcctcc ttcaccatga agctgatgga caaattccac tctcccaaaa tcaagagaac
      421 accatccaag aagggaaagc cagccgaggt gtcgaagatt cctgagaagc ctgtgagcaa
      481 agaggcaaga gacagatttc taccagaggg ctaccctatc cccttggatc tggagcagca
      541 ggcagtagaa tttatgtcca ccagtgctgt ggcttccagg tctcagaggc agaagaacct
      601 gtgctggctg gaggagaaag agaaggaggt tgtcagtgcc ttgcgctact ttaagaccat
      661 tgtggacaaa atggccattg ataagaaggt tctggagatg ctcccggggt cagccagcaa
      721 ggtgctggag gccatcttac ccctggtgca gactgaccct cggatccagc acagctcagc
      781 cctctcctcc tgttatagcc gagtatacca gagcctcgcc aaccttatcc gatggtctga
      841 ccaggtgatg ctagagggcg tgaactcaga agataaggag atggtgacaa ctgtgaaggg
      901 cgttatcaaa gctgtcctgg acggagtgaa ggagctagtg aggctaacca ttgagaagca
      961 ggggcggcca tcgccaacaa gcccagtgaa gcccagttcc ccagccagca agcctgatgg
     1021 ccagcctgag ctccctctga cagaccgaga aatggagatt ctgaacaaga cgacaagtgt
     1081 gtcaccatct gctgaactgc tcccagactc caccagtgaa gaggtcgcac cccccaagcc
     1141 ccctttacct ggcatccggg tggttgataa cagtccacca gcattaccac ccaagaaaag
     1201 gcagtctgct ccatccccca ctcgggtggc tgtggtagcc ccaatgagtc gggctaccag
     1261 tggctccagt ttgcctgttg gaatcaatag gcaggacttt gatgttgaat gttacaccca
     1321 gaggcgcctg tcaggaggca gccgctcctg cggtggtgag tctcctcgcc tgtccccctg
     1381 cagcagcaca ggcaagctca gccgctcaga cgagcagctg tcctccctgg acagggatag
     1441 tgggcagtgc tcacggaaca caagctgtga aacactagat cactacgacc ccgactatga
     1501 attcctccag caagatctct ccaatgcaga ccagatccct ccacaggcag cctgtaacct
     1561 cagccctctg ccggagtccc tgggggaatc tgggcctcca tttcttggcc accctttcca
     1621 gctgcctttg ggcagctgtc tgcagcagga gggacagcag acagacactc cacctgccct
     1681 tccggagaag aagcgtagga gcgcagtctc ccagaccacg gacagctctg gctgcagggt
     1741 gtcctatgag cgacacccct cacagtatga caacatctca gagggtgacc tgcagaaccc
     1801 agtcccagtc cagcctgtgc cctacccacc ctttgctgct gtcctgccct ttcagcaggg
     1861 agcttcctct gcctctgctg agtttgtggg tgatttcagt gttcctgagt tggcgggtga
     1921 cacagagaag ccacctcctc taccagagaa gaagaacaag cacatgctgg cctacatgca
     1981 actgctggag gactactcag agccacagcc ctccatgttc taccagacac cgcagagtga
     2041 gcacatctac cagcagaaga acaagatgct catggaggtg tacggcttca gcgagtcctt
     2101 ctgcggtagt gattccacgc aggagctggc ccctccaccc gctctgcccc ccaagcaacg
     2161 gcagctgcag gcctcctatg ctgcttcttc cttctctgtc tcctactgtg tccagcaaac
     2221 taaagtggcc ttcacccccg aggacggcag tgccgctcag ggcctcagtg tatccgtgtc
     2281 taactccttt ctcaaccggc acggcagctt gcctgtgccc tcgtacaaat ctgtgtttag
     2341 gtcttactcc caggacttca tgcctcacca ccaagcctcc gtccaacctt tccttccgcc
     2401 tacctcctct tcctctccac atttcccacc tgtccacacg tcccagagct cggacttagc
     2461 ggtgcccacc gtaagcagtc cgcctcccag caccgtggac gggcctctct cgtcttctca
     2521 ggacagcagc tttcatggga accctgtccg ccttccttcc gaaacctctt tcactgactc
     2581 ggaaccacca tctgggaagg acggacatcc cagagatcct tcggtcagca gtgcatctgg
     2641 gaaggacagc agagaaaatg gggaaaggtc cccaaagtca ctggatggtc tggagtcagc
     2701 gcagtcagaa gaggaagtgg atgaactgtc cctcattgac cacaatgaaa ttatggccag
     2761 gctgacactc aagcaagagg gtgatgatgg gccagatgtt cgtggtggtt caggagacat
     2821 cttactggtc catgctactg agacagacag aaaagacctg gtgctgtact gtgaagcctt
     2881 cctgaccacc tacaggacct tcatcagccc ggaggagctc atcaagaagc tgcagtaccg
     2941 gtacgagaag ttctctccct ttgctgacac gttcaagaag cgagtgagca agaacacatt
     3001 ctttgtgctg gttcgagtgg tggatgagct ctgcctggtg gagctgacag aggagatcct
     3061 gaagctgctg atggagctgg tcttccgcct agtgtgcagc ggagagctca gcctggccag
     3121 agtcctccgg aagaacattc tggacaaggt ggaccagaag aagctgctca ggtgtgccca
     3181 ttccgaccag cctctggcag ccaggggtgt tgcagccagg ccaggaacct tgcatgattt
     3241 ccacagccac gagatagctg agcagctgac actgctggat gccgagcttt tctacaagat
     3301 agagattcct gaagttttgc tttgggccaa agagcagaat gaggagaaga gtcccaatct
     3361 gacccagttc acagagcact tcaacaacat gtcctactgg gtgcggtcca tcatcatgct
     3421 gcaggagaag gcccaggacc gggagaggct gctcctcaag ttcatcaaga tcatgaagca
     3481 cctgcgcaag ctcaacaact tcaactccta cctggccatc ctctcagcac tagactcggc
     3541 ccccatccgc agactggagt ggcagcggca gacctcagag ggcctggctg agtactgcac
     3601 attgattgac agctcatcct ccttccgagc ctaccgggct gctctctcag aggtggagcc
     3661 cccatgtatc ccatacctag gtctgattct gcaagacctg accttcgttc acctgggaaa
     3721 cccagattat attgacggga aagtaaactt ctccaagcgg tggcaacagt tcaacatatt
     3781 ggacagcatg cggtgcttcc agcaggcgca ctatgaaatc cggagaaacg acgacatcat
     3841 aaatttcttc aatgacttca gtgaccacct ggccgaggaa gccctgtggg aactctctct
     3901 gaagatcaag cctaggaaca taacaaggcg gaaaacagac cgcgaagaga agacctagga
     3961 gcaggctggc tgtgagaacg ctcaagcagc caggagagga cctggaccat cccagcctca
     4021 gcctgtccat gcctggctgt gtggcagcac ctgagtctcc tggccggtct cctgcctcct
     4081 tccctatggc taaagtccca gggttcacaa tgagctggct ggcaggcctc agggctggct
     4141 tgtgtactgg tggcccctgg tctggttttg ttttctgttt tctgtcagtg ctccctcctg
     4201 ttccctcctc tcccctgcag ctggagagca gcagacacct gagcagcaga ccaggggaat
     4261 ggcgggcttc actgtcccca ggccacccta gcctccttaa gtggcagata agtaggggcc
     4321 ccaggaccct tgggtagact gccctccggg accctggagc caggggagct atggctggga
     4381 gacagaagaa ggtagaaagg gaccacgcag gcatcttgtg ctgcccactt cctgcttttt
     4441 aaacatggag ggagaggcat gtcaacctgg cccagaaagt atggtgggtg gtaggcaaga
     4501 gccacagagc tgacacttct cacagcagtg gccccagctc tgtcctgcca tgcacggcca
     4561 ctaaccaagg cacctgctgg gctgacagca gcagcaccag tagcacctgt cgcccaccac
     4621 tggtccagcc ccagccccag ccccagcccc agcccacatc accggtactc tggggatcgg
     4681 gaagaggagg cagaagggac agttcatgct gagctggggc caagactgtg cttcagagag
     4741 tgaataagga tcttcagtga cctagggaga ggcaagcagc ccctccgtgc ttgctgtgtg
     4801 ccttaaatgc catctcctgt tccttccagg cctgtgggct tccctcctat tttgccccac
     4861 cccccgcagc cagcaggttc ctagtccccg tttgctctct gggagtgtct gttcccaaga
     4921 agtctaagca ggcctaggac gtgagggcct ccagaggttt cctgattcca gacaggtggc
     4981 agagccaccc cctgctgctg aggttgacaa tctgttcagg gctcagggct aggatctccc
     5041 tgggcatggc cctgtggcca ccactgtggg ctaaatggca gggtgcagtt cagaatccag
     5101 aggtgctgct ggccctgcac catacctcca attagctttg catggacaag ctcccttttc
     5161 ttctggtcgt ggggcttggt caaacgaata ccaggatctc tgcttcctca accagtccgc
     5221 agagcagaag aaaagacagc agcagctgct ggccgggtac tcgtttgaaa caactgtcac
     5281 tctgaaccct cctgggtttc ggggtttgtt tttttagcag cttttatcaa ataagaactg
     5341 tgggcccctc ttctgtttat ttgtgctgta aatagagagg ggacatctgt aaacagcccc
     5401 ttggtcagct ccctctggtg gcagccggaa ttggattgtt taaggagtgt gtgtgtggag
     5461 tccggcttgt gagcagtcat gtgggtcttt ggtttgttcc tcttttacag gtcctttcat
     5521 ttcagtcttt gcccctgctt cctgtccttc accagctcta agtgctgctg tgtgcaagtg
     5581 gggaacactg cacatgaggt ccttcctccc agcgctgtag aggcccctgc agcctccctg
     5641 tgtagcacag gcctacctga ggcctagcct actggtgctg cagccaacag agtgggtcta
     5701 tggtctatgt ctactggttc ccaagcatga gctgggcaga aaggagggct taccttctag
     5761 acccagaatc accaggccct cctatgatcc tgggagcctt aggcagacta agtcaagagc
     5821 caggacagct ctggagtttc cgtgtgggga tatcgaggtg cgatgtgtgg gtttaactta
     5881 ttagccagca ggcttcccca gtcacctgcc tctggctgcg actgagccca gtgttcaggc
     5941 agcctggctt ccacatgtct gtttcttagt ggtggggtct gggagagctg tgaagattcg
     6001 tctttgtata catactaagc aacatggaca gttgggttcc cagcagaggc cagccattac
     6061 ctgtgggtaa ggcaagcaaa caccggatct ggctggccct taagccgaga cacctgttcc
     6121 atgcctccca gtgtggcact gtaatataaa ccccccacta acctgtctga cagtgcatct
     6181 tcctacagac agaacaagcg cgcaactttt atatgaaaga aaaataaaca gacaaaagcc
     6241 catctgatgc c
//
