LOCUS       NM_001418364            3773 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus RAP2C, member of RAS oncogene family (Rap2c),
            transcript variant 2, mRNA.
ACCESSION   NM_001418364 XM_006541545
VERSION     NM_001418364.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3773)
  AUTHORS   Wang,J.C., Lee,J.Y., Dang-Lawson,M., Pritchard,C. and Gold,M.R.
  TITLE     The Rap2c GTPase facilitates B cell receptor-induced reorientation
            of the microtubule-organizing center
  JOURNAL   Small GTPases 11 (6), 402-412 (2020)
   PUBMED   29457987
  REMARK    GeneRIF: The Rap2c GTPase facilitates B cell receptor-induced
            reorientation of the microtubule-organizing center.
REFERENCE   2  (bases 1 to 3773)
  AUTHORS   Qiao,Y., Peng,C., Li,J., Wu,D. and Wang,X.
  TITLE     Spinal cord ischemia-reperfusion causes damage of neurocyte by
            inhibiting RAP2C
  JOURNAL   Neurol Res 39 (10), 877-884 (2017)
   PUBMED   28714326
  REMARK    GeneRIF: Study found that SCII upregulated the expression of
            miR-204 and downregulated the expression of RAP2C; that hypoxia
            increased the expression of miR-204 and decreased the expression of
            RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia
            on apoptosis rate; and miR-204 could directly bind to RAP2C, and
            could regulate the expression of RAP2C.
REFERENCE   3  (bases 1 to 3773)
  AUTHORS   Brunskill,E.W., Potter,A.S., Distasio,A., Dexheimer,P.,
            Plassard,A., Aronow,B.J. and Potter,S.S.
  TITLE     A gene expression atlas of early craniofacial development
  JOURNAL   Dev Biol 391 (2), 133-146 (2014)
   PUBMED   24780627
REFERENCE   4  (bases 1 to 3773)
  AUTHORS   Monteiro,A.C., Sumagin,R., Rankin,C.R., Leoni,G., Mina,M.J.,
            Reiter,D.M., Stehle,T., Dermody,T.S., Schaefer,S.A., Hall,R.A.,
            Nusrat,A. and Parkos,C.A.
  TITLE     JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c
            and regulate epithelial barrier function
  JOURNAL   Mol Biol Cell 24 (18), 2849-2860 (2013)
   PUBMED   23885123
REFERENCE   5  (bases 1 to 3773)
  AUTHORS   Uechi,Y., Bayarjargal,M., Umikawa,M., Oshiro,M., Takei,K.,
            Yamashiro,Y., Asato,T., Endo,S., Misaki,R., Taguchi,T. and
            Kariya,K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   6  (bases 1 to 3773)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670230.12.
            
            On Mar 18, 2023 this sequence version replaced XM_006541545.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.2246939.1,
                                           SRR13422590.459327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL670230.12        160233-160402       c
            171-995             AL670230.12        159293-160117       c
            996-1308            AL670230.12        156638-156950       c
            1309-3773           AL670230.12        145953-148417       c
FEATURES             Location/Qualifiers
     source          1..3773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 28.03 cM"
     gene            1..3773
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /note="RAP2C, member of RAS oncogene family"
                     /db_xref="GeneID:72065"
                     /db_xref="MGI:MGI:1919315"
     exon            1..170
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            171..995
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1308
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..3773
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2937..2942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2963
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
     regulatory      3748..3753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3773
                     /gene="Rap2c"
                     /gene_synonym="2010200P20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggttcaacc ggagtccctg cggccaccgc cgccgccacc gccgccgccg gtccgccccc
       61 gccccttccc cgtccttccg ctagcagcag ggcccgggcg gcccggtggc catggccttg
      121 gcttgactta gcctcccggg cggctgggag cgtgtggcca ggacagcagg gtcacacgag
      181 ctccgcggga ccctgggggc ccagagaccc cgccccagcg atagcgagcg agcgagcgcg
      241 cgcgcgcgcg cggcggggcc cggaggcttc gggccggctc ggcaggcagc ggcgccggca
      301 ggaagcgggg accccgggcc cctttgtgtg tgtgtgcgcg cagggcgggg gggaggggtg
      361 gcgggcagcc cccggccgcc aggcccccgc cccttcccgc gtgggggtgc gccgcggctc
      421 cccccaaccg tcgctcggac gctcgccggc gcgccctcct ccccacgccc cccaggccgc
      481 cctgggttcc tataggaagg gcatcagcat cccatcccca cccacccgac gacacttggc
      541 tcttttcccc tccccctcct ggaacttcct cctcgtcccc ggtcgggccc tccgcctctc
      601 tccgcactct cctccccagt tcgcacattt ccgcccacct tccgcctggc cttgccgcag
      661 cgcagctagc ggggtgttat tttttccccc ccttgggtaa ggagttggtg aaggtgagac
      721 tcatgaggga atacaaggta gtggtgttag ggagcggagg ggttggcaaa tctgccctca
      781 ccgtgcagtt tgtcaccggg actttcattg agaaatatga ccccaccatt gaagatttct
      841 accgcaaaga gatcgaagtg gactcttccc cgtcagtact ggaaatcctg gacaccgcag
      901 gaaccgagca gtttgcctcc atgagagatc tgtacatcaa gaacggccaa ggtttcatcc
      961 tggtgtatag tttggttaat caacagtctt ttcaggatat caagccaatg agagatcaga
     1021 ttgtgagagt gaagagatac gagaaagtcc cactcatcct agtgggaaac aaagtggatc
     1081 tggaaccaga gagagaggtt atgtcttccg aaggcagagc tctggctcaa gaatggggct
     1141 gtcctttcat ggaaacgtca gcaaaaagta aatcaatggt ggatgaactt tttgctgaga
     1201 tcgtcaggca aatgaactat tcatccctgc ccgagaagca agatcagtgt tgtacaactt
     1261 gtgttgtcca gtaaaaaaga aaacctcagc catggccata ccgagcagat tacaaactca
     1321 gaggaaattt gcacagatgc tgctttggag aactttacaa cctgggttgc agaactgagc
     1381 cttggtaaac ctgtctctat cacagcatgt tgccatacat ctaatgaagt gcataaggtc
     1441 tttggccctc aagatccacg gaccttcaca gtaatgctta gcacgtttac catacattta
     1501 aatctgttct ttatcaatcc gtccttttat agctttttaa gttcttattg atggctaata
     1561 tgaaagggtt aattttaatg ttagttgatt tcgttaatca gtttctcaac ttgtatttat
     1621 tactcaaact cagtattacc tactcaatgc cttttaaaag aaagatataa tggagaaaaa
     1681 aaattgagcc ttaaacaaat ggttacttct gtatattacc tcgtaccaat gcttcatcct
     1741 atttgtaaaa tctttctcct ttaaatggtt ggttaatact ttgagacttt gtttacgtgt
     1801 ggcagtgttg taaaaagaaa ctaaagatca cattttacct gtatcgatgg actatccctt
     1861 ttcttcaagt gcagttttgg taattaacga gttgtgaacg ttacaggtga tattggaggt
     1921 tggctgtaca acatttactt gaagttgaag agttaagtat ttgattccat taggccttca
     1981 catgtgttaa tctcatttac agcattaaat tgcagcagta acatttttct ttctgtgaag
     2041 ttctaaactt agttatgacc tacttagcaa tgcctttgaa aagggatatt gtgtccatgg
     2101 taaattaatt gtatacctaa acagagatag ctcagctttg cccatcaggc ttgtcattga
     2161 catctggtag acttctgcac atgtaaaact gaattcagat aaaaccatgt acaatttcta
     2221 gttcttaata tttgtctttc tgactaatag tttaaagcaa tatttgttaa tgttttcttg
     2281 cactatcaca actgcttttt agttcttttt caagaagcat gttcgtagta gagacagatc
     2341 tgtgtaacag gagggaaagc agcgccgagc ctctggctgg ctgtgtttta tttttgcaaa
     2401 tgtgctttct aatagccatt gccttccatg ttgtttacct aatcagcaca ttttgtctga
     2461 atacttgaac attttaccaa taacgcaggt atagaaaaag aaaaaatact tacaatgagt
     2521 aatctttttg ttcactttta acatcatgat gacgaatcct tttttctagc aattattttt
     2581 caattgtgaa agtttgacag tattttgttt ggggttttat ttggttttat ttgtgtgctt
     2641 ttaatttgca gaagttagta actgcagctc acctactgca ccaaagctct cgattttagg
     2701 agcccagctt tagtcatttg aacatgcttc taaataaaac aaaaccaaaa ctatgctttt
     2761 gatctataat aatagctcaa taactttgtc aaaaaaagct ctattatatg cagtgatggt
     2821 ttgtggaagg gtgtggcaag tttaaatttg tattgtgtgt ggtgttcaaa taaagtgaaa
     2881 tctacattca tgtgacttat tggtcagcat ggccattaat taatgagtag aaactgatta
     2941 aactttgatt tccttttttt aaatcgtgtt gcatttgatt cctgatcaga ttccctcaaa
     3001 gcgagctcgt gttcttacat ttgggatttg acggtgagag gcaactgaaa tgtttgttcc
     3061 ttatttacaa actgtgtgaa ataaatactt aatttgagtt tgcactttaa aacccaacgc
     3121 tccttcagag tagcttaagt gcttgtggct catcattatt agccctgtga aattctaaag
     3181 gaatcaaata attcatgatg gcttcaattt tctgcagatt gatttttata cagttttttc
     3241 cccatggcta tccttctgtc cttcccttct tcgccttctg tcacctcgct ctctatcaca
     3301 gcgttcattg tcattgacct cagcagcaaa tttcactcgg attcacttag gatcacagga
     3361 atcaggggaa agggatttga aaggtggttt ctccagcaca ttttaagaaa agggaccaaa
     3421 agttatttta gcttcctcaa tagattgcat gttgcttatt aggataagaa atgaatatta
     3481 aatgcaatat atgtcttgtc tttattatgg catctgttta ggagttgttc aaatcactgc
     3541 agtagggctc tgcaaataaa gtcatgtaac ctattatgat ggatctaatg tactgtaact
     3601 ttatcagtga acagtaaaat ctcgaataac aagtacaaac attgaacaat tacctatgaa
     3661 gatttgtaaa agtaaatttt ttccaataga tttcattctt gtcattttgt aagacgaccc
     3721 tgcagtccac ctgtttgtaa cttttttaat aaaatagata tctgtattat gga
//
