LOCUS       NM_028712               4197 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus RAP2B, member of RAS oncogene family (Rap2b), mRNA.
ACCESSION   NM_028712
VERSION     NM_028712.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4197)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4197)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 4197)
  AUTHORS   Xin,Y., He,Q., Liang,H., Zhang,K., Guo,J., Zhong,Q., Chen,D.,
            Li,J., Liu,Y. and Chen,S.
  TITLE     m6A epitranscriptomic modification regulates neural
            progenitor-to-glial cell transition in the retina
  JOURNAL   Elife 11, e79994 (2022)
   PUBMED   36459087
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4197)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4197)
  AUTHORS   Di,J., Huang,H., Qu,D., Tang,J., Cao,W., Lu,Z., Cheng,Q., Yang,J.,
            Bai,J., Zhang,Y. and Zheng,J.
  TITLE     Rap2B promotes proliferation, migration, and invasion of human
            breast cancer through calcium-related ERK1/2 signaling pathway
  JOURNAL   Sci Rep 5, 12363 (2015)
   PUBMED   26201295
  REMARK    GeneRIF: Taken together, these findings shed light on Rap2B as a
            therapeutic target for breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4197)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4197)
  AUTHORS   Uechi,Y., Bayarjargal,M., Umikawa,M., Oshiro,M., Takei,K.,
            Yamashiro,Y., Asato,T., Endo,S., Misaki,R., Taguchi,T. and
            Kariya,K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   8  (bases 1 to 4197)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4197)
  AUTHORS   Kukimoto-Niino,M., Takagi,T., Akasaka,R., Murayama,K.,
            Uchikubo-Kamo,T., Terada,T., Inoue,M., Watanabe,S., Tanaka,A.,
            Hayashizaki,Y., Kigawa,T., Shirouzu,M. and Yokoyama,S.
  TITLE     Crystal structure of the RUN domain of the RAP2-interacting protein
            x
  JOURNAL   J Biol Chem 281 (42), 31843-31853 (2006)
   PUBMED   16928684
  REMARK    GeneRIF: the putative Rap2 binding site of the RPIPx RUN domain
            interacts with the extended segment in a segment-swapping manner
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115705.13.
            
            On Sep 1, 2006 this sequence version replaced NM_028712.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4197              AC115705.13        53089-57285
FEATURES             Location/Qualifiers
     source          1..4197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.81 cM"
     gene            1..4197
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
                     /note="RAP2B, member of RAS oncogene family"
                     /db_xref="GeneID:74012"
                     /db_xref="MGI:MGI:1921262"
     exon            1..4197
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..1102
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rap-2b"
                     /protein_id="NP_082988.1"
                     /db_xref="CCDS:CCDS17378.1"
                     /db_xref="GeneID:74012"
                     /db_xref="MGI:MGI:1921262"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIR
                     VKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEI
                     VRQMNYAAQPNGDEGCCSACVIL"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
                     /note="hexamer: AACAAG"
     polyA_site      2471
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
     regulatory      2508..2513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
                     /note="hexamer: AATACA"
     polyA_site      2539
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
                     /note="major polyA site"
     regulatory      3902..3907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3926
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
     polyA_site      3986
                     /gene="Rap2b"
                     /gene_synonym="4021402C18Rik"
ORIGIN      
        1 ggagttcggg cggggcaccg cgggcgacgt actgggcatg ctcggctggg cggggagggc
       61 tgggctgcgc gcggcgagta ggaagccctc gcccagcgga ggctgcggga gacagaggag
      121 agagagtgat gggtcgcgga gctggacgca cgttccgcgg ggactcatgc cacgcgtgtc
      181 tcagccggac gcccaattag cagccgcctc tgcaaccagc cgccacctcc tcccggccct
      241 cccaggctgc cggggcgaag agctccagcc gttgtcttgc tccggctgcg cgcattgtcc
      301 tcagggtcct ccgacagggc tgctgcgggg cccgggaccc gcgccctagg gacgcgcccc
      361 cgctgccggt cggcctggcg cggggctctg ctagtctgtt ggcgagcccg tgctaccggg
      421 ctagtctcgc cggggttttt cctgcgaagt tgaggaaggg gagaagtcca cccgtccgcc
      481 cagcccagcc ttccccggcg cgcagccccg acggggccgc ggcaggcgcg acgagggcgc
      541 cgacggagcc atgagagagt acaaagtggt ggtactgggc tcgggcggcg tgggcaagtc
      601 cgcgctcacc gtgcagttcg taacaggttc cttcatcgag aagtacgacc cgaccatcga
      661 ggacttttac cgcaaggaga tcgaggtgga ctcgtcgccg tcggtgctgg agatcttgga
      721 caccgcgggc acggagcagt tcgcctcaat gcgggacctg tacatcaaga atggccaggg
      781 cttcattctc gtctacagcc tggtcaacca gcagagcttc caggacatca agcccatgcg
      841 ggaccagatc atccgcgtga agcggtacga gcgcgtaccc atgatcctgg taggcaacaa
      901 ggtggacttg gagggtgaac gtgaggtctc ctatggcgag ggtaaggccc tggccgagga
      961 gtggagctgc cccttcatgg agacatcggc caaaaacaaa gcctcagtgg atgagctatt
     1021 cgcagagatc gtgaggcaga tgaactacgc ggcacagccc aacggcgacg agggctgctg
     1081 ctcggcctgc gtgatcctgt gaggcgccgt ctgccgccgg gcgctggcca cgctctgtgc
     1141 acaaagccaa acgcacccga ttctcttaat gtgattgtct tcttgctttg agattggaga
     1201 cgactttgtt gtcttggctg ggatgtccga ggaacctggc tgacttgtgt agccagcatc
     1261 cccagccttc agccagggtc tgagagggtg tacgttgcag agcatctgag accccggtgg
     1321 aaaaatggct ctatacagcg tgtacgttcc tcgttgattt tggttcatgc atatttcccc
     1381 gtttaaatag ccattaaggc tctgtattgg ctgcttgaca ccggcaagca aaagtttcaa
     1441 acctgaaaaa aaaaaaatgg gggtggcgaa gcagaggaag tgaaggggaa ggaggcagtg
     1501 ggggagggtt cccctgagca actgttcata gttccaagtt ttaacacaag gaaagaggtc
     1561 caagaaaatc atatgaagga gccagaagag gggacgaaac tttttttcct tgttttccag
     1621 gattatttag aaattaagac caggggttcc ttttctgcca gcttggaagg gcaacccagg
     1681 gactgattac gattctgagg atgtctatgc aaagttgggt tcttgttaca gtgtatccaa
     1741 tctgaagtat tgcacatgtg aactgggact gtttaacact gatgccaata cagtgtgggg
     1801 tgccaggaag tgtctgctga tatttgtggg gaaaaaaaat ctattttgat tacctactgt
     1861 atcaaagggg agtctggggg gagaatggta gtattttttt ttaatcagct gtgaaaaatg
     1921 ttacaaatct gcacattttt tgtgtgtgct attgtgtgtg tgtgtgtgta tgagtgtaag
     1981 tatagctttt tttttttttt tttttttttt ttgtggttgg cagtgacaga ttttgctgac
     2041 tagcttttaa aaatacaata caaagacttc gtaaatgtga ttcagggcgc ccagcacccc
     2101 tgtgtctgca gagtgccttc aaactcagct gttccagccg gtgccaacct gtgaattccc
     2161 accatgtccc agaatctgct gttctgcttt ccccaaaact actttaagca tcttcctgaa
     2221 agagccagga tgaataggac ctgttattcc gtgaattgct tcattaattt tagctttttt
     2281 tttcaatgtt aagtccataa gtcttgaatt ttttccccct tcattttgtt ctaatttcag
     2341 gttttagctc tccttttctg ttgttttcga aatgtctgtt atctgttaca gggtgttcct
     2401 ccagaggcaa agagcaaaat tttattgtga tgtaccaaaa gaattttaac aagttgtaac
     2461 ttttaattcc actcatttag tcactgtctc ttcattttaa gacttttaat acaactgtca
     2521 tttttaaaga aaccccaaac tatttgtggt tttgtgtttc atattcagtg atttacagtc
     2581 tccgtgaata tggtgccagg cggggaggtg gatcgggcca ggtccatgat gccttttgag
     2641 ttatgtgtca aaatttgaag ataggattat ttctatgaaa aattgggtaa caatgtttcc
     2701 aagtctttaa aagtggagaa aagtatcaag gcctaagact cacagggtat ggccagggca
     2761 tctgactgtc cagatgagga agcactgctc tgctgaagaa gagtaatgaa ctttactgtt
     2821 gatagcaaag gggcaagtcc ccccctcccc gactcccccc ccacccccag ctagtaacac
     2881 cctcttaggc ctgggaaagc aaagtggacc tggcagaata actaacaggg gcactttcta
     2941 tttgtcttgg tttgatgttg tctgtttatg tcccacaccg agtcagaagt gatcttaact
     3001 ttgatctcac acaccctgcc ctctacaacg tatggatgga atacaattat tctagccgtt
     3061 atttcaaccc ttccaaagtt tttatttgga accaaatcaa agattgagaa caaaaagtaa
     3121 acaagacgaa gaggattccc ttgctctcct tctatttgcc cacaacagtt tttaaaagta
     3181 ggaggcaatg tgtgttggtg ttttatttgt attttgcttg ggctctccag tacaataatc
     3241 tttacagaat aacaaagtat ctataagata taataccaca ggttcctgag gcaaagctga
     3301 tgtctgaaga gtcttaacta aggaatttac tcccttggca aagccaaaag agatcacagg
     3361 tttctttaaa gctataacaa tatatattgc cttaattttt ttttttctcc atccaagttg
     3421 catctcatca tttcgtgggc aggaagaaca ttttgcctgt cctggccttt gtttattctc
     3481 caactcggat ctcacatctc cattagtgtc agatgtgatt ctgcttccaa gtatacaaat
     3541 tgaaaaataa tgtttttaca agaattcatt cttaacattt gaacgagtgt atttgcttag
     3601 gtcgatgaaa gtgttgcaca tttaaagtgt tgacgcattt tgaagatgtg tcaagcactg
     3661 ttggaggggt tgctttttaa aaaaatgctt atggtggccc tcttctcatg atttggaagg
     3721 ctttgaacaa aagtgttgcc aagtatatag ctcagaaaat acttgaaggt ggacagtgat
     3781 ctagattgtt ggtgcattaa tcacctctcc agaggcttcc cagaggtcat ggaaggcagg
     3841 gcaggctttt gaaaacatgt ttctactgag tactgtaaaa taaatgcttt tggattgtac
     3901 aattaaagct gctgcaggaa aatggagccc tgagttgttt ggcttgcgac tgttattttc
     3961 atggcaacat agacatttgt ctcttggcct ttttgttttt gctttcttgc tttaagaagg
     4021 taatgttaag ggtgacagtt tatttggcta ggaagaactt catctagtgt tgtgctgtga
     4081 ggcaatacaa gcatttgttt cagggcaaaa gtcaggctgg tttaactgct aaaggaactg
     4141 agtcaggtgg gaggagtcag ggtgggaggg gttggatgta aagtgatgtc acttgtc
//
