LOCUS       NM_001040690            3694 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus RAP1, GTP-GDP dissociation stimulator 1 (Rap1gds1),
            transcript variant 1, mRNA.
ACCESSION   NM_001040690
VERSION     NM_001040690.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3694)
  AUTHORS   Xiong,Y., Cheng,Q., Li,Y., Han,Y., Sun,X. and Liu,L.
  TITLE     Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and
            mice reach middle age
  JOURNAL   Commun Biol 6 (1), 420 (2023)
   PUBMED   37061660
  REMARK    GeneRIF: Vimar/RAP1GDS1 promotes acceleration of brain aging after
            flies and mice reach middle age.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3694)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3694)
  AUTHORS   Nogi,M., Satoh,K., Sunamura,S., Kikuchi,N., Satoh,T., Kurosawa,R.,
            Omura,J., Elias-Al-Mamun,M., Abdul Hai Siddique,M., Numano,K.,
            Kudo,S., Miyata,S., Akiyama,M., Kumagai,K., Kawamoto,S., Saiki,Y.
            and Shimokawa,H.
  TITLE     Small GTP-Binding Protein GDP Dissociation Stimulator Prevents
            Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic
            Preservation of Aortic Smooth Muscle Cells
  JOURNAL   Circulation 138 (21), 2413-2433 (2018)
   PUBMED   29921611
  REMARK    GeneRIF: Apoe(-/-) SmgGDS(+/-) mice showed significantly higher
            levels of oxidative stress, matrix metalloproteinases, and
            inflammatory cell migration in the ascending aorta compared with
            Apoe(-/-) mice.  local delivery of the SmgGDS gene construct
            reversed the dilation of the ascending aorta in Apoe(-/-)
            SmgGDS(+/-) mice.
REFERENCE   4  (bases 1 to 3694)
  AUTHORS   Wang,S., Yin,Z., Zhao,B., Qi,Y., Liu,J., Rahimi,S.A., Lee,L.Y. and
            Li,S.
  TITLE     Microgravity simulation activates Cdc42 via Rap1GDS1 to promote
            vascular branch morphogenesis during vasculogenesis
  JOURNAL   Stem Cell Res 25, 157-165 (2017)
   PUBMED   29145128
  REMARK    GeneRIF: Simulated microgravity activates Cdc42 via Rap1GDS1 to
            promote vascular branch morphogenesis.
REFERENCE   5  (bases 1 to 3694)
  AUTHORS   Kudo,S., Satoh,K., Nogi,M., Suzuki,K., Sunamura,S., Omura,J.,
            Kikuchi,N., Kurosawa,R., Satoh,T., Minami,T., Ikeda,S., Miyata,S.
            and Shimokawa,H.
  TITLE     SmgGDS as a Crucial Mediator of the Inhibitory Effects of Statins
            on Cardiac Hypertrophy and Fibrosis: Novel Mechanism of the
            Pleiotropic Effects of Statins
  JOURNAL   Hypertension 67 (5), 878-889 (2016)
   PUBMED   26975711
REFERENCE   6  (bases 1 to 3694)
  AUTHORS   Stefanini,L. and Bergmeier,W.
  TITLE     RAP1-GTPase signaling and platelet function
  JOURNAL   J Mol Med (Berl) 94 (1), 13-19 (2016)
   PUBMED   26423530
  REMARK    Review article
REFERENCE   7  (bases 1 to 3694)
  AUTHORS   Maddala,R., Nagendran,T., Lang,R.A., Morozov,A. and Rao,P.V.
  TITLE     Rap1 GTPase is required for mouse lens epithelial maintenance and
            morphogenesis
  JOURNAL   Dev Biol 406 (1), 74-91 (2015)
   PUBMED   26212757
REFERENCE   8  (bases 1 to 3694)
  AUTHORS   Tanaka,S., Fukumoto,Y., Nochioka,K., Minami,T., Kudo,S., Shiba,N.,
            Takai,Y., Williams,C.L., Liao,J.K. and Shimokawa,H.
  TITLE     Statins exert the pleiotropic effects through small GTP-binding
            protein dissociation stimulator upregulation with a resultant Rac1
            degradation
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (7), 1591-1600 (2013)
   PUBMED   23640485
  REMARK    GeneRIF: These results indicate that statins exert their
            pleiotropic effects through SmgGDS upregulation with a resultant
            Rac1 degradation and reduced oxidative stress in animals and
            humans.
REFERENCE   9  (bases 1 to 3694)
  AUTHORS   Zemojtel,T., Duchniewicz,M., Zhang,Z., Paluch,T., Luz,H.,
            Penzkofer,T., Scheele,J.S. and Zwartkruis,F.J.
  TITLE     Retrotransposition and mutation events yield Rap1 GTPases with
            differential signalling capacity
  JOURNAL   BMC Evol Biol 10, 55 (2010)
   PUBMED   20170508
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3694)
  AUTHORS   Takakura,A., Miyoshi,J., Ishizaki,H., Tanaka,M., Togawa,A.,
            Nishizawa,Y., Yoshida,H., Nishikawa,Si. and Takai,Y.
  TITLE     Involvement of a small GTP-binding protein (G protein) regulator,
            small G protein GDP dissociation stimulator, in antiapoptotic cell
            survival signaling
  JOURNAL   Mol Biol Cell 11 (5), 1875-1886 (2000)
   PUBMED   10793158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113307.12, AC119881.10 and AC110574.9.
            
            On Aug 24, 2022 this sequence version replaced NM_001040690.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172052.1, AK166315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC113307.12        54673-54866         c
            195-302             AC113307.12        30118-30225         c
            303-425             AC119881.10        154756-154878       c
            426-551             AC119881.10        148489-148614       c
            552-698             AC119881.10        116665-116811       c
            699-827             AC119881.10        98811-98939         c
            828-953             AC119881.10        96768-96893         c
            954-1097            AC119881.10        91979-92122         c
            1098-1229           AC119881.10        91497-91628         c
            1230-1364           AC119881.10        90353-90487         c
            1365-1490           AC119881.10        89137-89262         c
            1491-1630           AC119881.10        88265-88404         c
            1631-1757           AC119881.10        78606-78732         c
            1758-1886           AC119881.10        74673-74801         c
            1887-3694           AC110574.9         2733-4540
FEATURES             Location/Qualifiers
     source          1..3694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.52 cM"
     gene            1..3694
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /note="RAP1, GTP-GDP dissociation stimulator 1"
                     /db_xref="GeneID:229877"
                     /db_xref="MGI:MGI:2385189"
     exon            1..194
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2014
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /note="isoform a is encoded by transcript variant 1; rap1
                     GTPase-GDP dissociation stimulator 1"
                     /codon_start=1
                     /product="rap1 GTPase-GDP dissociation stimulator 1
                     isoform a"
                     /protein_id="NP_001035780.1"
                     /db_xref="CCDS:CCDS51083.1"
                     /db_xref="GeneID:229877"
                     /db_xref="MGI:MGI:2385189"
                     /translation="MDNLSDTLKKLKITAADRTEGSLEGCLDCLLQALAQNNAETSEK
                     IQGSGILQLFANLLTPQASCTAKVADIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKD
                     QEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCGRTDPASEKLMTVFCG
                     MLMNYSNENDSLQAQLISMGVIPTLVKLLGIHCHNAALTEMCLVAFGNLAELESSKEQ
                     FASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ
                     KVDSNKEDDVAELKTASDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQL
                     AGALAIANFARNDGNCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPV
                     VNKAKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNAKLVERL
                     VEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQN
                     EALVALALIAALELGPAEKDLASAQLVQILHRLLADERSAPEIKYNSMVLICALMGSE
                     SLYKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLTVES"
     exon            195..302
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..425
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..551
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..698
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..827
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..953
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1097
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1229
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1364
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1490
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1630
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1757
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1886
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..3694
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3672..3677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /note="hexamer: AATAAA"
     polyA_site      3694
                     /gene="Rap1gds1"
                     /gene_synonym="GDS1"
                     /note="major polyA site"
ORIGIN      
        1 gctcgtcccc gccgcggccg cgccgcccgc agccgcagcc gctgctcctc cccggcggcc
       61 gccccccgcg ggtccctccc tggctgcggg agacgcggag gtagagggag gacgccgccg
      121 ccgctgagcc gcgccgcccg cacccgaacc cttcgcctcg ccctgccggt cctcactctg
      181 tgggaggaac atggataacc tcagtgacac tttaaagaag ctgaagataa cagctgctga
      241 caggacagag ggcagtctgg aaggatgctt ggattgtctg cttcaagcct tggctcagaa
      301 taatgcagaa acaagtgaaa aaatacaagg aagtggaatt cttcagttgt ttgcaaatct
      361 gttgacgcca caggcctcct gcacagccaa agtagccgac atcatagcag aagtagccaa
      421 aaatgaattt atgcgaatcc catgtgtaga tgctggattg atttcaccac tggtacagct
      481 gttaaatagc aaagaccagg aagtgctgct tcaaacgggc agggcattag gaaacatatg
      541 ctacgatagc catgagggca gaagtgcagt tgaccaagca ggtggtgcac agattgtaat
      601 tgaccattta aggtcgctgt gcggtaggac agatcccgcc agtgagaagc tcatgactgt
      661 cttttgtggc atgctgatga actatagcaa tgagaatgat tcccttcagg cccagcttat
      721 tagcatgggt gttatcccga ccttagtgaa gctactgggc attcactgcc acaatgcagc
      781 actcaccgag atgtgtctcg ttgcgttcgg gaatttagca gaacttgagt caagtaaaga
      841 acagtttgct agcacaaaca ttgctgaaga gctggtaaaa ctattcaaga aacaaataga
      901 acacgataaa agagagatga tttttgaagt tctagcgcca ttggcagaga atgatgctat
      961 taagctgcag ctggttgaag caggtttggt agagtgtctc ctagagatcg tccaacagaa
     1021 ggtggatagc aacaaagagg acgacgttgc cgagcttaaa actgcttctg acctcatggt
     1081 tttattactg cttggagatg agtccatgca gaaacttttt gaaggaggaa aaggcagtgt
     1141 gttccaaagg gtgctctcct ggatcccatc gaataaccac cagctgcagc tggctggggc
     1201 attagccatt gcaaattttg ccaggaacga tggaaattgt attcatatgg tagacaatgg
     1261 gattgtagaa aaactcatgg atttgctgga cagacacgta gaagacggga acgtgacggt
     1321 gcagcacgcc gcactaagtg ccctcaggaa tctagccatc ccagttgtaa ataaagcaaa
     1381 gatgttatca gctggtgtca cggagacggt tttgaaattc cttaaatctg aaatgccccc
     1441 agttcagttc aaactcctgg gaacgctaag aatgttaata gatgcacaag cagaagctgc
     1501 tgagcaactg ggaaagaatg ctaaactggt agagcgtttg gttgaatggt gtgaagccaa
     1561 agatcatgcc ggcgtgatgg gcgaatcaaa cagactgctc tctgccctca tccgacacag
     1621 taaatcaaaa gatgtaatta aaaccattgt acagagtggt ggcatcaagc acctggttac
     1681 catggcaact agtgaacatg taatcatgca gaatgaagct cttgtcgccc tggcactgat
     1741 agcagccttg gaactgggtc ccgctgagaa ggatctcgca agtgctcagc ttgttcagat
     1801 cttacaccga ctgctagcag atgagagaag tgccccggag atcaagtaca attccatggt
     1861 cctgatctgc gctctcatgg gatccgaatc tctatacaag gaagtacagg atttggcctt
     1921 tctagatgtt gtctccaaac ttcgaagtca tgagaacaaa agtgttgccc aacaggcctc
     1981 gcttacagag cagagactta cagtggaaag ctgagaactg gccctgctgg caccaggctc
     2041 atcccagctc cgcccactcc actgttctcc atccagctgc ttcttcaact ccattctcta
     2101 ctacatcact tgtgcatgcg tgtaatgttc cagtaccaat ggaagaactg ctataggtac
     2161 ctgcctaata agatttctaa acccatagtt aatgtgaaca tgactgtcag aacaagtctc
     2221 cacccataac tgttaaatcc tatactcctg atgcttgagc tacattaagt agaatgtgca
     2281 tgttgtagtc ctatgatgat gtaaacttgg tactccatgc tgacttgctc ctcacatgca
     2341 gtaagctaca taataatgta ctggtaaact agaaacaaag aatgcagcag gacctgtcta
     2401 gcttatttaa agatgaaact gaatcgtcaa ggtagcacca cgtattctgg tctggttttg
     2461 ttttgttttg ttttggtgct ggggaagcac agcgatcaaa aagcctgtat ggctgctcac
     2521 tcattaatct tctgccaacg tcaggcctgt accacctaaa cttgaatagg tccaatattc
     2581 cttccttccc tacggtttct cctttttctg aactatatag gcagtttgcc aagcaacaca
     2641 gcaaaccttc ctgaggctcc tgattccatc tttaagcgac agtggtacag gggctcagtg
     2701 ctgaaacatg gattttaatg tgagtggagc gtaggaagga gttaaaagaa accctggcat
     2761 actgaaccac tttggatctt gcctgtactt tagattccga tttgtgtgtg gttacatcta
     2821 gaacttccat cagctagcca gcattgtcag catgtctcta aagcgtcctt gatgtttgtt
     2881 cggtgaagga aactgaggcg gcttgtttgg tggagaatgg acttcccccc cccccccccg
     2941 gttttcatct tttagggtga aagcagggag attcatcttt catgctccct ttcaatgtgc
     3001 taattctaat tggacataag aggaaacctg aagtaagctt gtctaaagag aggaaggccg
     3061 gttttaaaag ccatagtagc cagtccagta cattctgcag atggcctcat agcagtcatt
     3121 gttagagttc ttcacctcca ctttcccact gagaaccaca ataatctccc aggctgcaag
     3181 ccaggactcg ccgcaaagac tcttcttggc ataatgtagt gtgctcgtca ctgccactaa
     3241 ccaccaccaa gtgagttctt agagctttga cacacagtct ttataaatta atcgggattc
     3301 cctgtgaccc gccttcctcc tcacacccaa ggttgagtcc tgctgatgtc tgagggaggc
     3361 tgagctccgt tacaggagtg gagggcagtg aggggctgct gagagggacc agctccttcc
     3421 tcccccgaca ggagatacct gtatctctgc gttctctaaa tcggactttg cttttcacac
     3481 ttttaaattc aagaaagatt tacttcatgt aagtgaaaac ctgactgaca gttccctctg
     3541 atgtccaaat aagggaactg tggtgagcgc ctgtgcttgc tcactggaga aatgagtgct
     3601 ttattgtctt tctcctgggc tggataagtg gactaatgtt gcataatact gtccatatta
     3661 ataacttaat aaataaatag tatatgaaac taca
//
