LOCUS       NM_024457               1937 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus RAS related protein 1b (Rap1b), mRNA.
ACCESSION   NM_024457 XM_917928 XM_925356
VERSION     NM_024457.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Yamamoto,K., Watanabe-Takano,H., Oguri-Nakamura,E., Matsuno,H.,
            Horikami,D., Ishii,T., Ohashi,R., Kubota,Y., Nishiyama,K.,
            Murata,T., Mochizuki,N. and Fukuhara,S.
  TITLE     Rap1 small GTPase is essential for maintaining pulmonary
            endothelial barrier function in mice
  JOURNAL   FASEB J 37 (12), e23310 (2023)
   PUBMED   38010922
  REMARK    GeneRIF: Rap1 small GTPase is essential for maintaining pulmonary
            endothelial barrier function in mice.
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Hiremath,C., Gao,L., Geshow,K., Patterson,Q., Barlow,H., Cleaver,O.
            and Marciano,D.K.
  TITLE     Rap1 regulates lumen continuity via Afadin in renal epithelia
  JOURNAL   Dev Biol 501, 20-27 (2023)
   PUBMED   37276970
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Sun,H., Lee,H.S., Kim,S.H., Fernandes de Lima,M., Gingras,A.R.,
            Du,Q., McLaughlin,W., Ablack,J., Lopez-Ramirez,M.A., Lagarrigue,F.,
            Fan,Z., Chang,J.T., VanDyke,D., Spangler,J.B. and Ginsberg,M.H.
  TITLE     IL-2 can signal via chemokine receptors to promote regulatory T
            cells' suppressive function
  JOURNAL   Cell Rep 42 (8), 112996 (2023)
   PUBMED   37598341
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Horitani,S., Ueda,Y., Kamioka,Y., Kondo,N., Ikeda,Y., Naganuma,M.
            and Kinashi,T.
  TITLE     The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for
            pulmonary transit and egress from the lymph nodes
  JOURNAL   Front Immunol 14, 1234747 (2023)
   PUBMED   37545505
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Kamioka,Y., Ueda,Y., Kondo,N., Tokuhiro,K., Ikeda,Y., Bergmeier,W.
            and Kinashi,T.
  TITLE     Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1
            and integrin adaptors in T cells under shear flow
  JOURNAL   Cell Rep 42 (6), 112580 (2023)
   PUBMED   37267105
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Ozaki,N., Shibasaki,T., Kashima,Y., Miki,T., Takahashi,K., Ueno,H.,
            Sunaga,Y., Yano,H., Matsuura,Y., Iwanaga,T., Takai,Y. and Seino,S.
  TITLE     cAMP-GEFII is a direct target of cAMP in regulated exocytosis
  JOURNAL   Nat Cell Biol 2 (11), 805-811 (2000)
   PUBMED   11056535
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Traver,S., Bidot,C., Spassky,N., Baltauss,T., De Tand,M.F.,
            Thomas,J.L., Zalc,B., Janoueix-Lerosey,I. and Gunzburg,J.D.
  TITLE     RGS14 is a novel Rap effector that preferentially regulates the
            GTPase activity of galphao
  JOURNAL   Biochem J 350 Pt 1 (Pt 1), 19-29 (2000)
   PUBMED   10926822
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Wani,M.A., Denko,N.C. and Stambrook,P.J.
  TITLE     Expression of Rap 1 suppresses genomic instability of H-ras
            transformed mouse fibroblasts
  JOURNAL   Somat Cell Mol Genet 23 (2), 123-133 (1997)
   PUBMED   9330640
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU848028.1, CK793274.1, CO803632.1, AK180095.1 and BY369341.1.
            
            On Nov 10, 2006 this sequence version replaced NM_024457.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052480.1, AK143910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               BU848028.1         6-558
            554-1148            CK793274.1         71-665
            1149-1770           CO803632.1         103-724
            1771-1886           AK180095.1         119-234
            1887-1918           AK180095.1         236-267
            1919-1937           BY369341.1         179-197
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.32 cM"
     gene            1..1937
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /note="RAS related protein 1b"
                     /db_xref="GeneID:215449"
                     /db_xref="MGI:MGI:894315"
     exon            1..144
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            145..225
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            226..294
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..351
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            352..492
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            493..636
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            637..753
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1937
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1110..1115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1136
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /note="major polyA site"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1937
                     /gene="Rap1b"
                     /gene_synonym="2810443E11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtggaaagca gcccgagcgg cggcggcggc ggcgacggcg acggcggcag cggcagagac
       61 cgccgtggcg ccgggagcag cgacccgaag ggaacgcgcg gcgacggcga gggcgacggc
      121 ggcgacccgg tgacagcgcg agaggtacta agtgtgacag tgtgcaccat gcgtgaatat
      181 aagctcgtcg tgcttggatc aggaggcgtt gggaagtcag ccctgactgt acagtttgtt
      241 caaggaattt ttgttgaaaa atatgatcct acgatagaag attcttatag aaagcaagtt
      301 gaagtagatg cacagcagtg tatgcttgaa atcttggaca ctgcaggaac ggagcaattc
      361 acagccatga gggacctgta catgaagaac ggacaaggct tcgctctggt ttactccatc
      421 acagcacagt cgacatttaa cgacttacaa gatctaagag agcagattct gcgggttaaa
      481 gacactgatg atgttccaat gattctggtt ggcaataaat gcgacttgga agatgaaaga
      541 gttgtaggaa aggaacaagg tcagaaccta gcaagacagt ggaacaactg tgcattctta
      601 gaatcctctg caaagtccaa aataaatgtt aatgagatct tttatgacct agtgcggcaa
      661 attaacagaa aaactccagt gcctgggaag gcccgcaaaa agtcatcgtg tcagctgctt
      721 taatgtactg aatgcattgt agctctgagc caggtctgaa gaactgttgc ccaattcagc
      781 agtgccagca ttccaacttt gttaaaccta ccaacatctt aaacggactt tcctgtggtg
      841 gtaccctgag aggcggatga aagctactct gtcagtttgc acattctaat cactttccag
      901 tatcacgaga gatttttact tatataatag ttctagagta tgcagctggt aaaaccagag
      961 gctacatcca gtattactgc taagagacat tcttcatcca ccaatgttgt acatgtatga
     1021 aaatggtgta ctgtatactt taacacaccc catactttgt attggagagt acaataatgt
     1081 aaatcctaaa agcaccacta ttttagcata ataaaagaaa gtccaaagag ctcctatata
     1141 gactactcca gataactttg cttctttgat acttgtagct tattgtaatt ttttttaaat
     1201 tcaaggtcat tatcattgta ttatacaaaa taagcgcttt gattaacaca gctatatagt
     1261 ttttttaatt tttcaaaaac ctgtggagac agtgatcttg tctttaaaat atgatagtcc
     1321 tttcagtata atgtcttaga ttaaagacgt tgcctttaat atctgttggg aaggaaatgt
     1381 ccagactttt caaatctcct tattatatgt ttcctttttt gtttacatag ggaacaatgt
     1441 ttatagttgt gtgtacagtg ggggtctaca acaagaagtg tatattttca aacaattttt
     1501 taatgattta acaatttttg taaatcattt tcaggcttct gcagctgtag attctcactg
     1561 tgactccctt gcttgctcat gcatatgtgt gtctgcaata ccaaatatac aggtttagta
     1621 tctgcctgtt agtgattgtt tcccatgtgt aacgtttcgg ttgagatgtt aactggtgga
     1681 cgagtactgt ggatgtgaat gtgggatgtc attttaatca tgtgtaactg gtcacaaggc
     1741 ctaatttgca gtaactattg ctgttttatt taacaatgcc ttgttgtttt gtatgcataa
     1801 atgtttgggt gtaaagattg tgtgtccatc caacagggag ccacagtatt taaattgacc
     1861 aacctgatgt tacaacgact ttgaggtggc caaatgtaaa ctaaaagcct taattaaagt
     1921 ggtgcaattt tgtataa
//
