LOCUS       NM_145541               2474 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus RAS-related protein 1a (Rap1a), mRNA.
ACCESSION   NM_145541
VERSION     NM_145541.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Williams,M.D., Morgan,J.S., Bullock,M.T., Poovey,C.E.,
            Wisniewski,M.E., Francisco,J.T., Barajas-Nunez,J.A., Hijazi,A.M.,
            Theobald,D., Sriramula,S., Mansfield,K.D., Holland,N.A. and
            Tulis,D.A.
  TITLE     pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation
            through Rap1A
  JOURNAL   Am J Physiol Heart Circ Physiol 327 (5), H1210-H1229 (2024)
   PUBMED   39269448
  REMARK    GeneRIF: pH-sensing GPR68 inhibits vascular smooth muscle cell
            proliferation through Rap1A.
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Kosuru,R., Romito,O., Sharma,G.P., Ferraresso,F., Ghadrdoost
            Nakhchi,B., Yang,K., Mammoto,T., Mammoto,A., Kastrup,C.J.,
            Zhang,D.X., Goldspink,P.H., Trebak,M. and Chrzanowska,M.
  TITLE     Rap1A Modulates Store-Operated Calcium Entry in the Lung
            Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular
            Inflammation and Permeability
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (11), 2271-2287 (2024)
   PUBMED   39324266
  REMARK    GeneRIF: Rap1A Modulates Store-Operated Calcium Entry in the Lung
            Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular
            Inflammation and Permeability.
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Shahwar,D., Baqai,S., Khan,F., Khan,M.I., Javaid,S., Hameed,A.,
            Raza,A., Saleem Uddin,S., Hazrat,H., Rahman,M.H., Musharraf,S.G.
            and Chotani,M.A.
  TITLE     Proteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6
            Mouse Pancreas and Functional Studies Identify an Essential Role of
            Rap1A in Pancreas Physiology
  JOURNAL   Int J Mol Sci 25 (15), 8013 (2024)
   PUBMED   39125590
  REMARK    GeneRIF: Proteomic Analysis of Rap1A GTPase Signaling-Deficient
            C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential
            Role of Rap1A in Pancreas Physiology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2474)
  AUTHORS   Yamamoto,K., Watanabe-Takano,H., Oguri-Nakamura,E., Matsuno,H.,
            Horikami,D., Ishii,T., Ohashi,R., Kubota,Y., Nishiyama,K.,
            Murata,T., Mochizuki,N. and Fukuhara,S.
  TITLE     Rap1 small GTPase is essential for maintaining pulmonary
            endothelial barrier function in mice
  JOURNAL   FASEB J 37 (12), e23310 (2023)
   PUBMED   38010922
  REMARK    GeneRIF: Rap1 small GTPase is essential for maintaining pulmonary
            endothelial barrier function in mice.
REFERENCE   5  (bases 1 to 2474)
  AUTHORS   Sun,H., Lee,H.S., Kim,S.H., Fernandes de Lima,M., Gingras,A.R.,
            Du,Q., McLaughlin,W., Ablack,J., Lopez-Ramirez,M.A., Lagarrigue,F.,
            Fan,Z., Chang,J.T., VanDyke,D., Spangler,J.B. and Ginsberg,M.H.
  TITLE     IL-2 can signal via chemokine receptors to promote regulatory T
            cells' suppressive function
  JOURNAL   Cell Rep 42 (8), 112996 (2023)
   PUBMED   37598341
REFERENCE   6  (bases 1 to 2474)
  AUTHORS   Traver,S., Bidot,C., Spassky,N., Baltauss,T., De Tand,M.F.,
            Thomas,J.L., Zalc,B., Janoueix-Lerosey,I. and Gunzburg,J.D.
  TITLE     RGS14 is a novel Rap effector that preferentially regulates the
            GTPase activity of galphao
  JOURNAL   Biochem J 350 Pt 1 (Pt 1), 19-29 (2000)
   PUBMED   10926822
REFERENCE   7  (bases 1 to 2474)
  AUTHORS   Wani,M.A., Denko,N.C. and Stambrook,P.J.
  TITLE     Expression of Rap 1 suppresses genomic instability of H-ras
            transformed mouse fibroblasts
  JOURNAL   Somat Cell Mol Genet 23 (2), 123-133 (1997)
   PUBMED   9330640
REFERENCE   8  (bases 1 to 2474)
  AUTHORS   Kondoh,N., Noda,M., Fisher,R.J., Schweinfest,C.W., Papas,T.S.,
            Kondoh,A., Samuel,K.P. and Oikawa,T.
  TITLE     The S29 ribosomal protein increases tumor suppressor activity of K
            rev-1 gene on v-K ras-transformed NIH3T3 cells
  JOURNAL   Biochim Biophys Acta 1313 (1), 41-46 (1996)
   PUBMED   8781548
REFERENCE   9  (bases 1 to 2474)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   10 (bases 1 to 2474)
  AUTHORS   Kitayama,H., Sugimoto,Y., Matsuzaki,T., Ikawa,Y. and Noda,M.
  TITLE     A ras-related gene with transformation suppressor activity
  JOURNAL   Cell 56 (1), 77-84 (1989)
   PUBMED   2642744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139316.4, AK030897.1, CX206795.1, AK152504.1 and AA210264.1.
            
            On Mar 13, 2013 this sequence version replaced NM_145541.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.15506.1,
                                           SRR1660821.96782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC139316.4         128676-128726       c
            52-630              AK030897.1         2-580
            631-868             CX206795.1         544-781
            869-1436            AK152504.1         789-1356
            1437-2376           AK030897.1         1386-2325
            2377-2474           AA210264.1         253-350
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.45 cM"
     gene            1..2474
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /note="RAS-related protein 1a"
                     /db_xref="GeneID:109905"
                     /db_xref="MGI:MGI:97852"
     exon            1..143
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..227
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..725
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /EC_number="3.6.5.2"
                     /note="GTP-binding protein SMG-P21A; ras-related protein
                     Krev-1"
                     /codon_start=1
                     /product="ras-related protein Rap-1A"
                     /protein_id="NP_663516.1"
                     /db_xref="CCDS:CCDS17711.1"
                     /db_xref="GeneID:109905"
                     /db_xref="MGI:MGI:97852"
                     /translation="MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQV
                     EVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILR
                     VKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYD
                     LVRQINRKTPVEKKKPKKKSCLLL"
     exon            228..296
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..353
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..494
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..638
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..754
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..2459
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1416..1421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /note="hexamer: ATTAAA"
     polyA_site      1437
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /note="major polyA site"
     regulatory      2436..2441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
                     /note="hexamer: AATAAA"
     polyA_site      2456
                     /gene="Rap1a"
                     /gene_synonym="G-22K; Krev-1; Rap1"
ORIGIN      
        1 gtgctgcgtg cgtgcgcgtt ccggaggcgc cgccgccgcc gctcccgagg ccgctgctcc
       61 tgccgccgcc gtgcagagcc cgagcccgag ccgcggccga gaggagggag gaggaggagg
      121 tggaggaggc gccgggccgc gggattgtca atatttaaac agagcgcatc atgcgtgagt
      181 acaagctagt agtccttggt tcaggaggcg tggggaagtc tgctctgaca gttcagtttg
      241 ttcaggggat ttttgttgaa aaatatgacc caacgataga agattcctac agaaagcaag
      301 tcgaggtaga ttgccaacag tgcatgctgg agatcctgga cactgcagga accgagcaat
      361 ttacagcaat gagggatttg tatatgaaga atggccaagg gtttgcacta gtttattcaa
      421 ttacagctca gtctacgttt aatgatttac aagacttgag agaacagatt ttacgggtta
      481 aagacacaga agatgttcca atgattttgg ttggcaataa atgtgacttg gaagatgaac
      541 gggtagttgg caaagaacaa ggccagaatt tagcaagaca gtggtgtaac tgtgcctttt
      601 tagaatcttc tgcaaagtca aagatcaacg ttaatgagat attttatgac ctggtcagac
      661 agataaatag aaaaacacca gtggaaaaga agaagcctaa aaagaaatca tgtttgctgc
      721 tctagacctg aagtcagcag cagctctgag ccagattaca gaaatgaaga actgttgcct
      781 aattggaaag tgccagcatt ccagacttca aaaacgaaat ctgaagaggc ttctcctgtt
      841 ttatatatta tgtgaagaat ttagatctta tattggtttg cacaagttcc ctggagacaa
      901 agttgctctg tgtatatctc ttggaaataa gacatagtat ttctcctttg caatagcagt
      961 tataacagat gtgaaataag atacttgact ctaatacaat tatacagaag agcatggatg
     1021 catttcaaat gttagatgta ctactataat caaatgattt catattgacg tttttatcat
     1081 gactcctccc tgtcaagcac taaaaaattg aaccatcata ctttatatct gtaatgatat
     1141 agattatgaa atctcctctc aaactcattg cagcagataa cttttttgag tcattgactt
     1201 cattttatat ttaaaattat gaaaatatca tctgtcatta tattctaatt aaaattgttt
     1261 gtgcataatg ctttggaaaa atgggtcttt tatagggaaa aactgggata actgatttct
     1321 atggctttca aagctagaat atataatata ctaaaccaac tctaatattg cttcttgtgt
     1381 tttactgtca gattaaatta cagcttttat ggatgattaa attttagtac attttcattt
     1441 ggtttgtgtc tttttgttat tgtttattga catagtcctt tattttataa tgaccacatt
     1501 gtttagagtg cagcagtagc tcttcctttc tgcctggatt cagcagaaca cttggcttta
     1561 aactacccta actggtgatc tctctaggaa cagacctcgc actcctgctc tagatagagt
     1621 tattcctact atacagtaag atgcaccatg tgacatagaa tagttttata tatactctct
     1681 tgaccttaaa gattgtatca tattgaataa agtatcccac tctgtattat ttttatatgt
     1741 aaaaagataa gttcaatact gtattaccag ggtttgactt tgactatcgc aaatcctaca
     1801 tacacagttt gtaacttcat ccagggaatc cttgccattg ttaatttgtt ggtgtgtgtc
     1861 caccaatgaa gtgttaaatg aaaattttca aacttgctct ctagtagatg gaagaacttg
     1921 agggaagtgg ttgcaagtca gaacacaaaa agggacgtgt gacttgactg tatgagcagt
     1981 gtagaggaat gctgtgaaga tggatacagc agcttgctgg ctgtacagag gtgcttttct
     2041 tttccttccc agttgcattt tacaaaggtg gggcatatgt aggacatgga gccagggcga
     2101 tactgctgta tgttctccat gaagaaagag aaagcaaatg gcctgttggc caggtgcata
     2161 caggagaaga aagcagattg caagcttagg aaaccctgtg ccttgtccct gaaaatcaag
     2221 gagaccagtc ctagaaagta aatctttgct cagggatcta gatatggtct cattgcaact
     2281 aggtgtgaag gtgttcatgc cttgctgaga tatgccaggt gtgtggacag ccctttagtt
     2341 accaagtcag ctttcaaatg taagatccaa ccaacctgaa gaaatgtcaa aaagtactgt
     2401 ttgaaacatt ggaaattgta ttcttttgat attctaataa acttagctac ttaacattta
     2461 aaaaaaaaaa aaaa
//
