LOCUS       NM_021329                845 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus RAN guanine nucleotide release factor (Rangrf),
            transcript variant 2, mRNA.
ACCESSION   NM_021329
VERSION     NM_021329.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 845)
  AUTHORS   Zhao,M., Han,M., Liang,L., Song,Q., Li,X., Du,Y., Hu,D., Cheng,Y.,
            Wang,Q.K. and Ke,T.
  TITLE     Mog1 deficiency promotes cardiac contractile dysfunction and
            isoproterenol-induced arrhythmias associated with cardiac fibrosis
            and Cx43 remodeling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (9), 166429 (2022)
   PUBMED   35533905
  REMARK    GeneRIF: Mog1 deficiency promotes cardiac contractile dysfunction
            and isoproterenol-induced arrhythmias associated with cardiac
            fibrosis and Cx43 remodeling.
REFERENCE   2  (bases 1 to 845)
  AUTHORS   Chakrabarti,S., Wu,X., Yang,Z., Wu,L., Yong,S.L., Zhang,C., Hu,K.,
            Wang,Q.K. and Chen,Q.
  TITLE     MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada
            syndrome and sick sinus syndrome
  JOURNAL   Circ Arrhythm Electrophysiol 6 (2), 392-401 (2013)
   PUBMED   23420830
REFERENCE   3  (bases 1 to 845)
  AUTHORS   Wu,L., Yong,S.L., Fan,C., Ni,Y., Yoo,S., Zhang,T., Zhang,X.,
            Obejero-Paz,C.A., Rho,H.J., Ke,T., Szafranski,P., Jones,S.W.,
            Chen,Q. and Wang,Q.K.
  TITLE     Identification of a new co-factor, MOG1, required for the full
            function of cardiac sodium channel Nav 1.5
  JOURNAL   J Biol Chem 283 (11), 6968-6978 (2008)
   PUBMED   18184654
  REMARK    GeneRIF: in cardiomyocytes, MOG1 is mostly localized in the cell
            membrane and co-localized with Nav1.5, indicating that MOG1 is a
            critical regulator of sodium channel function in the heart
REFERENCE   4  (bases 1 to 845)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   5  (bases 1 to 845)
  AUTHORS   Li,B., Nair,M., Mackay,D.R., Bilanchone,V., Hu,M., Fallahi,M.,
            Song,H., Dai,Q., Cohen,P.E. and Dai,X.
  TITLE     Ovol1 regulates meiotic pachytene progression during
            spermatogenesis by repressing Id2 expression
  JOURNAL   Development 132 (6), 1463-1473 (2005)
   PUBMED   15716349
REFERENCE   6  (bases 1 to 845)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 845)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 845)
  AUTHORS   Steggerda,S.M. and Paschal,B.M.
  TITLE     The mammalian Mog1 protein is a guanine nucleotide release factor
            for Ran
  JOURNAL   J Biol Chem 275 (30), 23175-23180 (2000)
   PUBMED   10811801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618250.1, BY775054.1, BC087921.1 and BX523534.1.
            
            On Oct 18, 2013 this sequence version replaced NM_021329.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038470.1, AK010288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BB618250.1         1-4
            5-35                BY775054.1         1-31
            36-829              BC087921.1         1-794
            830-845             BX523534.1         335-350
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.24 cM"
     gene            1..845
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /note="RAN guanine nucleotide release factor"
                     /db_xref="GeneID:57785"
                     /db_xref="MGI:MGI:1889073"
     exon            1..214
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..695
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ran-binding protein MOG1"
                     /codon_start=1
                     /product="ran guanine nucleotide release factor isoform 2"
                     /protein_id="NP_067304.1"
                     /db_xref="CCDS:CCDS24875.1"
                     /db_xref="GeneID:57785"
                     /db_xref="MGI:MGI:1889073"
                     /translation="MEPNRNCPLFGGAFSAILPTGAIDVSDLRPVPDNQEVFCHPVTD
                     QSLIIELLELQAHVQGEAAARYHFEDVGRVQGARAVHVLSVQPLCLENLSLRGCCQDA
                     WSLSGKQQVAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPCHSRSLGPENLSCP
                     PWSLSNFEQLVTSLTLHDPNLFGPQ"
     exon            215..331
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /inference="alignment:Splign:2.1.0"
     exon            332..488
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /inference="alignment:Splign:2.1.0"
     exon            489..574
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /inference="alignment:Splign:2.1.0"
     exon            575..832
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      806..811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /note="hexamer: AATAAA"
     polyA_site      832
                     /gene="Rangrf"
                     /gene_synonym="2400006H24Rik; Mog1; Rangnrf"
                     /note="major polyA site"
ORIGIN      
        1 gatcttaaag gtcccattgc ttagtaggac gggaggaggt agtgggtgct ccgggaacac
       61 caggggaaat gatgtctcaa aggctcatgt aggtttcttt aaaacctcgc taatgtccag
      121 actcaagtac tagatctatg gagcccaaca gaaactgtcc actgttcgga ggcgccttct
      181 ccgccatcct ccctacaggg gccattgatg tgagtgacct ccgaccggtg ccagacaacc
      241 aagaagtttt ctgccatcct gtgaccgacc agagtctgat catagaactt ctggagctgc
      301 aggcccacgt gcagggcgaa gcggctgcgc ggtaccattt tgaggacgtt ggccgggtgc
      361 agggggctag ggctgtgcac gtgctatctg tgcagcctct ctgtttggag aacttatccc
      421 tgagaggctg ctgtcaggat gcctggtccc tttctggcaa gcagcaggta gctaaagaaa
      481 accagcaggt agcaaaggat gtcacactgc atcaggcctt gctgcggctg ccccagtatc
      541 agactgatct tttgctcacc ttcaatcagc ccccgtgtca cagcaggtct cttggccctg
      601 aaaatctgtc atgtccacct tggagcctga gtaactttga acagctggta actagtttga
      661 ctcttcatga tcccaacctc tttggtcccc agtaaagatc gttgagacac aacgtgctac
      721 tgaggactcg gggacccagt tctgagaggg ggagtttctt tctgcttctt ccctggatgt
      781 aaacataaga cacttcctct gcagaaataa acttgcttta tgaagaacat aaaaaaaaaa
      841 aaaaa
//
