LOCUS       NM_001146174            2954 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus RAN GTPase activating protein 1 (Rangap1), transcript
            variant 2, mRNA.
ACCESSION   NM_001146174
VERSION     NM_001146174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Huang,M., Chen,B., Chen,X., Liu,T., Liang,S., Hu,H., Bai,X. and
            Gong,Y.
  TITLE     RanGAP1 maintains chromosome stability in limb bud mesenchymal
            cells during bone development
  JOURNAL   Cell Signal 120, 111222 (2024)
   PUBMED   38729327
  REMARK    GeneRIF: RanGAP1 maintains chromosome stability in limb bud
            mesenchymal cells during bone development.
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Gong,Y., Zou,S., Deng,D., Wang,L., Hu,H., Qiu,Z., Wei,T., Yang,P.,
            Zhou,J., Zhang,Y., Zhu,W., Xie,X., Liao,Z., Yang,J., Zhang,S.,
            Liu,A., Jiang,Y., Zou,Z. and Bai,X.
  TITLE     Loss of RanGAP1 drives chromosome instability and rapid
            tumorigenesis of osteosarcoma
  JOURNAL   Dev Cell 58 (3), 192-210 (2023)
   PUBMED   36696903
  REMARK    GeneRIF: Loss of RanGAP1 drives chromosome instability and rapid
            tumorigenesis of osteosarcoma.
REFERENCE   3  (bases 1 to 2954)
  AUTHORS   He,Y., Yang,Z., Zhao,C.S., Xiao,Z., Gong,Y., Li,Y.Y., Chen,Y.,
            Du,Y., Feng,D., Altman,A. and Li,Y.
  TITLE     T-cell receptor (TCR) signaling promotes the assembly of
            RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via
            PKC-theta;-mediated phosphorylation of RanGAP1
  JOURNAL   Elife 10, e67123 (2021)
   PUBMED   34110283
  REMARK    GeneRIF: T-cell receptor (TCR) signaling promotes the assembly of
            RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via
            PKC-theta-mediated phosphorylation of RanGAP1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2954)
  AUTHORS   Fujiwara,K., Hasegawa,K., Oka,M., Yoneda,Y. and Yoshikawa,K.
  TITLE     Terminal differentiation of cortical neurons rapidly remodels
            RanGAP-mediated nuclear transport system
  JOURNAL   Genes Cells 21 (11), 1176-1194 (2016)
   PUBMED   27717094
  REMARK    GeneRIF: data suggest that remodeling of the RanGAP-mediated
            nuclear transport system plays a key role in cell cycle exit for
            terminal differentiation of cortical neurons
REFERENCE   5  (bases 1 to 2954)
  AUTHORS   Ritterhoff,T., Das,H., Hofhaus,G., Schroder,R.R., Flotho,A. and
            Melchior,F.
  TITLE     The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly
            machine for Crm1-dependent nuclear export complexes
  JOURNAL   Nat Commun 7, 11482 (2016)
   PUBMED   27160050
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2954)
  AUTHORS   Rush,M.G., Drivas,G. and D'Eustachio,P.
  TITLE     The small nuclear GTPase Ran: how much does it run?
  JOURNAL   Bioessays 18 (2), 103-112 (1996)
   PUBMED   8851043
  REMARK    Review article
REFERENCE   7  (bases 1 to 2954)
  AUTHORS   Ren,M., Villamarin,A., Shih,A., Coutavas,E., Moore,M.S.,
            LoCurcio,M., Clarke,V., Oppenheim,J.D., D'Eustachio,P. and
            Rush,M.G.
  TITLE     Separate domains of the Ran GTPase interact with different factors
            to regulate nuclear protein import and RNA processing
  JOURNAL   Mol Cell Biol 15 (4), 2117-2124 (1995)
   PUBMED   7891706
REFERENCE   8  (bases 1 to 2954)
  AUTHORS   Hattori,M., Tsukamoto,N., Nur-e-Kamal,M.S., Rubinfeld,B., Iwai,K.,
            Kubota,H., Maruta,H. and Minato,N.
  TITLE     Molecular cloning of a novel mitogen-inducible nuclear protein with
            a Ran GTPase-activating domain that affects cell cycle progression
  JOURNAL   Mol Cell Biol 15 (1), 552-560 (1995)
   PUBMED   7799964
REFERENCE   9  (bases 1 to 2954)
  AUTHORS   DeGregori,J., Russ,A., von Melchner,H., Rayburn,H., Priyaranjan,P.,
            Jenkins,N.A., Copeland,N.G. and Ruley,H.E.
  TITLE     A murine homolog of the yeast RNA1 gene is required for
            postimplantation development
  JOURNAL   Genes Dev 8 (3), 265-276 (1994)
   PUBMED   8314081
REFERENCE   10 (bases 1 to 2954)
  AUTHORS   von Melchner,H., DeGregori,J.V., Rayburn,H., Reddy,S., Friedel,C.
            and Ruley,H.E.
  TITLE     Selective disruption of genes expressed in totipotent embryonal
            stem cells
  JOURNAL   Genes Dev 6 (6), 919-927 (1992)
   PUBMED   1317320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY287991.1, AK159525.1 and BY438103.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 3. These
            differences cause translation initiation at a downstream AUG and
            result in an isoform (1) with a shorter N-terminus, compared to
            isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066213.1, AK042930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY287991.1         85-120
            37-2611             AK159525.1         2-2576
            2612-2954           BY438103.1         93-435
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.21 cM"
     gene            1..2954
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /note="RAN GTPase activating protein 1"
                     /db_xref="GeneID:19387"
                     /db_xref="MGI:MGI:103071"
     exon            1..208
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            209..355
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            356..483
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            484..543
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            544..723
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            724..858
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1017
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1131
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1231
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1316
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1509
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1629
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1732
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1821
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1943
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2954
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /note="hexamer: AATAAA"
     polyA_site      2949
                     /gene="Rangap1"
                     /gene_synonym="Fug1; mKIAA1835"
                     /note="major polyA site"
ORIGIN      
        1 aaagaaactg ccggctttca aaaatcctcc tccgccgcca taatcgctgg ggatcgtgga
       61 gcaggtggtg tgcacgagct aaacgaggag ccgcggcagc aaggagaggc aagcagactg
      121 gtcactgggc ctggccccca cgcggactct caagcagtga ccgacgcgcg cgttccgtcc
      181 ccccacgccg cggtgccgct aatttgtgtt tacagacctg caggggagcc cgccactgca
      241 gccatggcct ctgaagacat tgccaaactg gcagagaccc tggctaaaac tcaggtagcc
      301 ggagggcagc tgagttttaa gggcaagggt ctcaaactaa atactgcaga agatgctaaa
      361 gatgtgatta aggagattga agagtttgac ggcctcgaag ctctacgatt ggagggcaac
      421 acggtgggcg tggaagcggc cagagtcatc gccaaggcct tagagaagaa gtctgagctg
      481 aagcgatgcc actggagtga catgttcaca ggaaggcttc ggtctgagat cccaccagct
      541 ctgatctcac taggggaggg actcatcact gcaggagcac agctggtgga actggacctc
      601 agtgacaacg catttggacc cgatggagtg cgaggcttcg aggccctcct caagagccca
      661 gcctgcttca ccctacagga actcaagctt aacaactgtg gcatgggcat cgggggtggc
      721 aagattctgg cagcagctct gactgagtgt caccgcaagt ccagtgccca aggcaagccc
      781 ctggccctga aggtgtttgt ggctggcaga aatcgcctgg agaatgacgg agccactgca
      841 ctggcagaag cttttgggat catcgggact ctggaagagg tgcatatgcc acagaacgga
      901 attaaccatc ctggtgtcac agccctggcc caggcctttg ccatcaaccc cctgttgcga
      961 gtcatcaacc taaatgacaa caccttcact gagaagggtg gggtggccat ggctgagact
     1021 ctgaagactc tgcgacaagt ggaagtgatc aattttggag actgcctggt gcgctctaag
     1081 ggtgccgttg ccatcgcaga tgctgtccgt ggtggcctgc ccaagctaaa ggagctgaat
     1141 ctgtcgttct gcgaaatcaa gagagatgct gccctggttg ttgctgaggc tgtggccgac
     1201 aaggctgagc tggagaagct ggacctcaat ggcaatgccc tcggagaaga gggctgtgag
     1261 cagcttcagg aggtgatgga cagcttcaat atggccaagg tgctggcatc cctcagtgat
     1321 gatgagggag aggatgaaga tgaggaggaa gaaggagaag aggatgatga ggaggaggaa
     1381 gatgaagagg atgaggaaga tgatgatgag gaggaggagg agcaggagga agaggaagag
     1441 cctccgcaga gagggtcagg ggaggagccg gctacaccct cgaggaagat cctggaccct
     1501 aacagtgggg agccagctcc cgtgctgtcc tccccgactc ccacagacct ctccaccttc
     1561 ctgtcattcc cctccccaga gaagctgctg cgtctgggtc ccaaggtctc ggtgctgata
     1621 gtccagcaga ctgatacctc cgacccagag aaggttgttt cagccttcct gaaggtggca
     1681 tctgtgttca gggatgacgc ctcagtaaag accgcagtgc tggatgccat cgatgccctc
     1741 atgaagaagg ccttcagctg ctcctctttc aattccaaca ccttccttac caggctgctc
     1801 atccacatgg gtctgctcaa gagtgaagac aagatcaagg ccatacccag cctgcatggc
     1861 cccctgatgg tgttgaacca cgtggtgagg caggactatt tccccaaggc ccttgcaccc
     1921 ctgctcttgg catttgtgac aaagcccaat ggcgcgctgg aaacctgctc ctttgcccgc
     1981 cacaatctgc tgcagacgct atacaacatc tagatttaaa ggcagctgct tcttgtccct
     2041 cgccctgccc cagtgactga gggtcttgga tggactgagc tcggccagca tctccattgg
     2101 atattttgac cagaggaagg gagagggtct tgtctcctgt gtcatattgg tcctttgata
     2161 ctgtgttggt ttggtgtgtg tgtgtgggta tgtacttcct gtctggattg cagatcttca
     2221 tctccctgct ggactaaccc aagtccactg tggggaattg atgcctaggg gaagggtaga
     2281 aagctgcttt gttattaaac ttaggccaac ttagccatag gccccgttgg ctgtcctgtc
     2341 tgccctgcct tcctgtccca ccaaagcctg gggaattctg tgtgctgtgt ccaccgtgcc
     2401 taaataacag aggctatcag agatgggcta tcattagaaa gtaaaactca gccgggcgtg
     2461 gtggcacatg cctttaatcc cagcactcag gagacagagg caggcagaat tctgagtttg
     2521 aggccagcct ggtctacaaa gtgagttcca ggacagccag gtctatacag aggaaccctg
     2581 tctcaaaaaa acaaaaacaa aaaaaaaaaa acctctgccc ttaaccatgt gacttggagg
     2641 agcagccagg ggagtgggag ctgtctgggg taacctggct ctaggaccag gtggaaaaag
     2701 caccttggct ggcccagccc tgttcttctc ctggggaggg aagggcaggt cccctaatgc
     2761 ctgaaccaca tgttgggcct actctctgag ggttttctaa gacaggagtg tgtaataggg
     2821 atggagccgg gtaagagatg ctctgtgact tcccgaagtg gctgcttggc cacctcctac
     2881 ttcccgttgt gttgtgtgtc tgggctgtgc ctgggagctt cacaaataaa cgtcatctgt
     2941 gtagttgcag aggc
//
