LOCUS       NM_011240               9477 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus RAN binding protein 2 (Ranbp2), mRNA.
ACCESSION   NM_011240 XM_904183
VERSION     NM_011240.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9477)
  AUTHORS   Guglielmi,V., Lam,D. and D'Angelo,M.A.
  TITLE     Nucleoporin Nup358 drives the differentiation of myeloid-biased
            multipotent progenitors by modulating HDAC3 nuclear translocation
  JOURNAL   Sci Adv 10 (23), eadn8963 (2024)
   PUBMED   38838144
  REMARK    GeneRIF: Nucleoporin Nup358 drives the differentiation of
            myeloid-biased multipotent progenitors by modulating HDAC3 nuclear
            translocation.
REFERENCE   2  (bases 1 to 9477)
  AUTHORS   Patil,H., Yi,H., Cho,K.I. and Ferreira,P.A.
  TITLE     Proteostatic Remodeling of Small Heat Shock Chaperones horizontal
            line Crystallins by Ran-Binding Protein 2 horizontal line and the
            Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its
            Cyclophilin Domain
  JOURNAL   ACS Chem Neurosci 15 (10), 1967-1989 (2024)
   PUBMED   38657106
  REMARK    GeneRIF: Proteostatic Remodeling of Small Heat Shock Chaperones
            horizontal line Crystallins by Ran-Binding Protein 2 horizontal
            line and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone
            Activities of Its Cyclophilin Domain.
REFERENCE   3  (bases 1 to 9477)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 9477)
  AUTHORS   Kragness,S., Clark,Z., Mullin,A., Guidry,J. and Earls,L.R.
  TITLE     An Rtn4/Nogo-A-interacting micropeptide modulates synaptic
            plasticity with age
  JOURNAL   PLoS One 17 (6), e0269404 (2022)
   PUBMED   35771867
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9477)
  AUTHORS   He,Y., Yang,Z., Zhao,C.S., Xiao,Z., Gong,Y., Li,Y.Y., Chen,Y.,
            Du,Y., Feng,D., Altman,A. and Li,Y.
  TITLE     T-cell receptor (TCR) signaling promotes the assembly of
            RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via
            PKC-theta;-mediated phosphorylation of RanGAP1
  JOURNAL   Elife 10, e67123 (2021)
   PUBMED   34110283
  REMARK    GeneRIF: T-cell receptor (TCR) signaling promotes the assembly of
            RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via
            PKC-theta-mediated phosphorylation of RanGAP1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9477)
  AUTHORS   Ferreira,P.A., Yunfei,C., Schick,D. and Roepman,R.
  TITLE     The cyclophilin-like domain mediates the association of Ran-binding
            protein 2 with subunits of the 19 S regulatory complex of the
            proteasome
  JOURNAL   J Biol Chem 273 (38), 24676-24682 (1998)
   PUBMED   9733766
  REMARK    GeneRIF: reports identification of a binding domain in RanBP2, the
            cyclophilin-like domain, toward components of the 19S cap of the
            proteasome
REFERENCE   7  (bases 1 to 9477)
  AUTHORS   Ferreira,P.A., Nakayama,T.A. and Travis,G.H.
  TITLE     Interconversion of red opsin isoforms by the cyclophilin-related
            chaperone protein Ran-binding protein 2
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1556-1561 (1997)
   PUBMED   9037092
  REMARK    GeneRIF: reports interaction of the RBD4 and CY domains of RanBP2
            with red/green opsin and the chaperone activity of these domains
            toward red/green opsin.
REFERENCE   8  (bases 1 to 9477)
  AUTHORS   Ferreira,P.A., Nakayama,T.A., Pak,W.L. and Travis,G.H.
  TITLE     Cyclophilin-related protein RanBP2 acts as chaperone for red/green
            opsin
  JOURNAL   Nature 383 (6601), 637-640 (1996)
   PUBMED   8857542
  REMARK    GeneRIF: reports interaction of the RBD4 and CY domains of RanBP2
            with red/green opsin and the chaperone activity of these domains
            toward red/green opsin.
REFERENCE   9  (bases 1 to 9477)
  AUTHORS   Wilken,N., Senecal,J.L., Scheer,U. and Dabauvalle,M.C.
  TITLE     Localization of the Ran-GTP binding protein RanBP2 at the
            cytoplasmic side of the nuclear pore complex
  JOURNAL   Eur J Cell Biol 68 (3), 211-219 (1995)
   PUBMED   8603673
REFERENCE   10 (bases 1 to 9477)
  AUTHORS   Ferreira,P.A., Hom,J.T. and Pak,W.L.
  TITLE     Retina-specifically expressed novel subtypes of bovine cyclophilin
  JOURNAL   J Biol Chem 270 (39), 23179-23188 (1995)
   PUBMED   7559465
  REMARK    GeneRIF: reports identification of the cyclophilin-related protein,
            RanBP2 (note at the time the protein was not designated RanBP2),
            and the cis-trans prolyl isomerase activity of its cyclophilin
            domain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158593.8.
            
            On Jul 25, 2007 this sequence version replaced NM_011240.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC158593.8         21224-21423
            201-268             AC158593.8         26356-26423
            269-380             AC158593.8         27684-27795
            381-533             AC158593.8         28945-29097
            534-764             AC158593.8         29591-29821
            765-910             AC158593.8         30181-30326
            911-1103            AC158593.8         31964-32156
            1104-1191           AC158593.8         34890-34977
            1192-1401           AC158593.8         36208-36417
            1402-1583           AC158593.8         38191-38372
            1584-1759           AC158593.8         38455-38630
            1760-1883           AC158593.8         38777-38900
            1884-2045           AC158593.8         39437-39598
            2046-2183           AC158593.8         39816-39953
            2184-2330           AC158593.8         40035-40181
            2331-2510           AC158593.8         41487-41666
            2511-2594           AC158593.8         41762-41845
            2595-2730           AC158593.8         44999-45134
            2731-2825           AC158593.8         49616-49710
            2826-7488           AC158593.8         50529-55191
            7489-7659           AC158593.8         57401-57571
            7660-7746           AC158593.8         58269-58355
            7747-7925           AC158593.8         58814-58992
            7926-8127           AC158593.8         60052-60253
            8128-8229           AC158593.8         62945-63046
            8230-8375           AC158593.8         64982-65127
            8376-8649           AC158593.8         66783-67056
            8650-8984           AC158593.8         67174-67508
            8985-9477           AC158593.8         68035-68527
FEATURES             Location/Qualifiers
     source          1..9477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.34 cM"
     gene            1..9477
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /note="RAN binding protein 2"
                     /db_xref="GeneID:19386"
                     /db_xref="MGI:MGI:894323"
     exon            1..200
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..9290
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /EC_number="5.2.1.8"
                     /note="ran-binding protein 2; E3 SUMO-protein transferase
                     RanBP2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase RanBP2"
                     /protein_id="NP_035370.2"
                     /db_xref="CCDS:CCDS23861.1"
                     /db_xref="GeneID:19386"
                     /db_xref="MGI:MGI:894323"
                     /translation="MRRSKADVERYIASVQGSAPSPREKSMKGFYFAKLYYEAKEYDL
                     AKKYISTYINVQERDPKAHRFLGLLYEVEENIDKAVECYKRSVELNPTQKDLVLKIAE
                     LLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCKGEDGWNKLFDLIQSELYA
                     RPDDIHVNIRLVELYRSNKRLKDAVAHCHEADRNTALRSSLEWNLCVVQTLKEYLESL
                     QCLDSDKSTWRATNKDLLLAYANLMLLTLSTRDVQEGRELLESFDSALQSVKSSVGGN
                     DELSATFLETKGHFYMHVGSLLLKMGQQSDIQWRALSELAALCYLVAFQVPRPKVKLI
                     KGEAGQNLLETMAHDRLSQSGHMLLNLSRGKQDFLKEVVESFANKSGQSALCDALFSS
                     QSSKERSFLGNDDIGNLDGQVPDPDDLARYDTGAVRAHNGSLQHLTWLGLQWNSLSTL
                     PAIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVIYTSHLQLKEKCNSHHT
                     SYQPLCLPLPVCRQLCTERQKTWWDAVCTLIHRKALPGTSAKLRLLVQREINSLRGQE
                     KHGLQPALLVHWAQSLQKTGSSLNSFYDQREYIGRSVHYWRKVLPLLKMIRKKNSIPE
                     PIDPLFKHFHSVDIQASEIGEYEEDAHITFAILDAVNGNIEDAMTAFESIKNVVSYWN
                     LALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIRILDDSDSNTSVVQKLPVPLE
                     SVKEMLNSVMQELEDYSEGGTLYKNGCWRSADSELKHSTPSPTKYSLSPSKSYKYSPK
                     TPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSNNSASPHRWPAEPYGQDPAPDGYQ
                     GSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHI
                     YAYSQQMHTPPVQSSSACMFSQEMYGPPLRFESPATGILSPRGDDYFNYNVQQTSTNP
                     PLPEPGYFTKPPLVAHASRSAESKVIEFGKSNFVQPMQGEVIRPPLTTPAHTTQPTPF
                     KFNSNFKSNDGDFTFSSPQVVAQPPSTAYSNSESLLGLLTSDKPLQGDGYSGLKPISG
                     QASGSRNTFSFGSKNTLTENMGPNQQKNFGFHRSDDMFAFHGPGKSVFTTAASELANK
                     SHETDGGSAHGDEEDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDGESKE
                     WKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHA
                     LDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQNILKALGTNTSTAPNHTLRIVKES
                     ATQDNKDICKADGGNLNFEFQIVKKEGPYWNCNSCSFKNAATAKKCVSCQNTNPTSNK
                     ELLGPPLVENGFAPKTGLENAQDRFATMTANKEGHWDCSVCLVRNEPTVSRCIACQNT
                     KSASSFVQTSFKFGQGDLPKSVDSDFRSVFSKKEGQWECSVCLVRNERSAKKCVACEN
                     PGKQFKEWHCSLCSVKNEAHAIKCVACNNPVTPSLSTAPPSFKFGTSEMSKPFRIGFE
                     GMFAKKEGQWDCSLCFVRNEASATHCIACQYPNKQNQPTSCVSAPASSETSRSPKSGF
                     EGLFPKKEGEWECAVCSVQNESSSLKCVACEASKPTHKPHEAPSAFTVGSKSQSNESA
                     GSQVGTEFKSNFPEKNFKVGISEQKFKFGHVDQEKTPSFAFQGGSNTEFKSIKDGFSF
                     CIPVSADGFKFGIQEKGNQEKKSEKHLENDPSFQAHDTSGQKNGSGVVFGQTSSTFTF
                     ADLAKSTSREGFQFGKKDPNFKGFSGAGEKLFSSQSGKVAEKANTSSDLEKDDDAYKT
                     EDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEISQWKERGLGNLKIL
                     KNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQ
                     LAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKD
                     FKTFLTNDQVKVTDEENASSGADAPSASDTTAKQNPDNTGPALEWDNYDLREDALDDS
                     VSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGASVGTDE
                     ESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERG
                     IGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQTMKGTERVWVWTACDFAD
                     GERKIEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSHLSTPRESPCGKIAI
                     AVLEETTRERTDLTQGDEVIDTTSEAGETSSTSETTPKAVVSPPKFVFGSESVKSIFS
                     SEKSKPFAFGNSSATGSLFGFSFNAPLKNSNSEMTSRVQSGSEGKVKPDKCELPQNSD
                     IKQSSDGKVKNLSAFSKENSSTSYTFKTPEKAQEKSKPEDLPSDNDILIVYELTPTPE
                     QKALAEKLLLPSTFFCYKNRPGYVSEEEEDDEDYEMAVKKLNGKLYLDDSEKPLEENL
                     ADNDKECVIVWEKKPTVEERAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELRKVC
                     EAQKSQNEKVTDRVGIEHIGETEVTNPVGCKSEEPDSDTKHSSSSPVSGTMDKPVDLS
                     TRKETDMEFPSKGENKPVLFGFGSGTGLSFADLASSNSGDFAFGSKDKNFQWANTGAA
                     VFGTQTTSKGGEDEDGSDEDVVHNEDIHFEPIVSLPEVEVKSGEEDEEVLFKERAKLY
                     RWDRDVSQWKERGIGDIKILWHTMKKYYRILMRRDQVFKVCANHVITKAMELKPLNVS
                     NNALVWTASDYADGEAKVEQLAVRFKTKEMTESFKKKFEECQQNIIKLQNGHTSLAAE
                     LSKDTNPVVFFDVCADGEPLGRIIMELFSNIVPQTAENFRALCTGEKGFGFKNSIFHR
                     VVPDFICQGGDITKYNGTGGQSIYGDKFDDENFDLKHTGPGLLSMANYGQNTNSSQFF
                     ITLKKAEHLDFKHVVFGFVKDGMDTVRKIESFGSPKGSVSRRICITECGQL"
     exon            201..268
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            269..380
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            381..533
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            534..764
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            765..910
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1103
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1191
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1401
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1583
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1759
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1883
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2045
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2183
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2330
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2510
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2594
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2730
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2825
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..7488
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            7489..7659
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            7660..7746
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            7747..7925
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            7926..8127
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            8128..8229
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            8230..8375
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            8376..8649
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            8650..8984
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
     exon            8985..9477
                     /gene="Ranbp2"
                     /gene_synonym="A430087B05Rik; NUP358"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgccctgtg cccatccgtt cgcgacggag ctgcgtcacc ggtgttcggc gctcacctcc
       61 tggagcccgc agtcgctgta ggccccaggg ctggtctgcc gctcctgggg agcctggtcc
      121 gcggcgcgat gaggcgtagc aaggccgacg tggagcggta catcgcctcg gtgcagggct
      181 ccgccccgtc gccccgagag aagtcaatga aaggattcta ttttgcaaag ctgtactatg
      241 aagctaaaga atatgatctt gctaaaaaat acatttctac gtatattaat gtgcaagaga
      301 gagaccctaa agcccacaga tttttgggtc ttctttatga agtcgaagaa aatatagaca
      361 aagctgtaga atgttataag cgttcagtgg aattaaaccc aacgcaaaaa gatcttgtgt
      421 tgaagattgc agaattgctt tgtaaaaatg atgtgactga tggaagagca aaatactggg
      481 ttgaaagagc agccaaactt ttcccaggaa gtcctgccat ttataagtta aaggaacaac
      541 ttttagattg taaaggtgaa gatggatgga ataaactttt tgacttgatt cagtcagaac
      601 tttatgcaag acctgatgat attcatgtaa atatccgact agtagagctt taccgttcaa
      661 ataaaagatt gaaggatgct gtggcccact gccatgaggc agacaggaac acagctttac
      721 gttcaagttt agaatggaat ttatgtgttg tacagactct taaggaatat ctggagtctc
      781 tgcagtgttt ggattctgat aaaagtactt ggagagcaac caataaagac ttacttctag
      841 cctatgctaa ccttatgcta cttacacttt ccaccagaga tgtgcaggaa ggtagagaac
      901 tattggaaag ctttgatagt gctcttcagt ctgtgaagtc ttctgtgggt ggaaatgatg
      961 agctatcagc tactttccta gaaacaaaag gacatttcta catgcatgtt ggttctctgc
     1021 ttttgaagat gggtcagcag agtgacatcc agtggcgagc tctttctgag ctggctgcat
     1081 tgtgctatct tgtagcattt caggttccca gaccaaaggt taaattaata aaaggagaag
     1141 ctggacaaaa tctcctggaa acgatggccc acgatcgcct tagccagtca gggcacatgt
     1201 tgttaaactt aagtcgtggc aagcaagact ttctaaagga agttgtggaa tcttttgcta
     1261 acaaaagcgg ccagtctgct ctctgtgatg ctctgttttc cagtcagtca tccaaggaga
     1321 gatcctttct tgggaatgat gatattggaa accttgatgg acaagtgcca gaccctgatg
     1381 acttggctag atatgatact ggtgccgttc gagcacataa tggtagtctt cagcacctta
     1441 cctggcttgg cttacaatgg aattcactgt ctactttacc agcaattcga aaatggttaa
     1501 aacagctctt ccaccatttg cctcaggaga cgtcaaggct tgaaacaaat gcacctgaat
     1561 caatctgtat tttagatctt gaagtattct tacttggagt tatatatacc agtcacttac
     1621 aattaaagga gaagtgtaat tctcaccaca cttcctatca accattgtgt ttgccacttc
     1681 ctgtgtgcag acagctttgt acagagagac agaagacgtg gtgggatgca gtttgtactc
     1741 tgattcaccg aaaggcgcta cctggaacct cagcaaaatt gcgacttcta gttcaacgtg
     1801 aaataaacag tctgagaggc caggaaaagc acggccttca acctgctctg cttgtgcatt
     1861 gggcccagag tcttcaaaaa acaggcagca gtcttaattc tttttatgat caacgggaat
     1921 acataggcag aagtgttcat tattggagga aagttttacc attgttgaag atgatcagaa
     1981 agaagaatag tattcctgaa cctattgatc ctctgtttaa acatttccat agtgtggata
     2041 ttcaggcatc tgaaattggt gaatatgaag aagatgcaca cataactttt gctatattgg
     2101 atgctgttaa tggaaatata gaagatgcta tgactgcttt tgaatctatt aaaaatgtag
     2161 tttcttattg gaatcttgca ctgattttcc acaggaaagc agaagacatt gaaaatgatg
     2221 ccttgtctcc tgaagaacaa gaagaatgca aaaattatct gagaaagact agggactacc
     2281 tgataaggat tttagatgat agtgattcaa atacttctgt ggttcagaaa ttgcctgttc
     2341 cccttgagtc tgtaaaagag atgctgaact cagttatgca ggaacttgaa gactacagtg
     2401 aaggaggtac tctttataaa aatggttgct ggcgaagtgc tgattcagag ttaaagcatt
     2461 caacaccatc tcctaccaaa tattctctat caccaagtaa aagttacaag tattctccaa
     2521 agacaccacc tcgatgggca gaagatcaaa attctttact gaaaatgatc tgccagcaag
     2581 tagaggccat taagaaagag atgcaggaat tgaagctaaa tagcaataac tctgcatccc
     2641 ctcatcgctg gccggcagag ccttacggac aagacccagc tcctgacgga tatcagggct
     2701 cacaaacttt tcacggggct ccactaacag ttgcaactac tggcccatca gtatattata
     2761 gtcagtcacc tgcatataac tcccagtatc ttctcagacc agctgctaat gtaactccca
     2821 ccaagggtcc agtttatggc atgaataggc ttccacccca acaacatatt tatgcatatt
     2881 cacaacagat gcacacacca ccagtgcaaa gttcatctgc ttgtatgttc tctcaggaga
     2941 tgtatggtcc tcccttgcgt tttgagtctc ctgcaacagg aattctatca cctaggggtg
     3001 atgattattt taattacaat gttcaacaga caagcacaaa tccacctttg ccagaaccag
     3061 ggtatttcac aaagcctcca cttgtagctc acgcttcaag gtcagcagaa tcaaaggtta
     3121 tagaatttgg aaaatccaat ttcgttcagc ccatgcaggg tgaagtaata aggccaccct
     3181 tgacaacacc agcacataca acacagccaa ctccctttaa atttaactca aatttcaaat
     3241 caaatgatgg cgacttcaca ttttcatcac cacaggtagt ggcccagcct ccttcaacag
     3301 cttatagcaa tagtgaaagt cttctaggtc ttctgacttc agataagcct ttacaaggag
     3361 atggctatag tggactaaag ccaatatctg gccaagctag tgggtctcgg aatacattca
     3421 gttttggaag caaaaataca cttacagaaa acatgggccc aaatcagcag aagaattttg
     3481 gttttcatcg cagtgatgac atgtttgctt ttcacggtcc agggaagtct gtatttacaa
     3541 cagctgcttc cgagctggca aataaaagtc atgagacaga tggaggaagt gctcatgggg
     3601 atgaggagga tgatggccct cactttgagc ctgtggtacc tcttcctgac aagatagaag
     3661 taaaaactgg cgaggaagat gaagaagaat tcttttgcaa tcgtgcaaag ttgttccgtt
     3721 ttgatggtga atccaaagaa tggaaggaac gtgggatagg caatgtaaaa atactaaggc
     3781 ataaaacatc tggtaaaatt cgccttctga tgagacgaga gcaagtatta aagatctgtg
     3841 caaatcatta cataagccca gatatgaaac tgacgccaaa tgctggctca gatagatctt
     3901 ttgtatggca tgcccttgat tatgcagatg aattgccaaa accagaacag cttgcaatta
     3961 gattcaaaac tcctgaggaa gcagcactat ttaagtgtaa atttgaagag gcccagaaca
     4021 ttttaaaagc cttaggaaca aacacatcta cagcaccaaa tcatactctt agaattgtaa
     4081 aggagtctgc aactcaggat aacaaggata tttgcaaagc tgatggtgga aacttgaatt
     4141 ttgaattcca gattgtaaag aaggaagggc cttactggaa ttgtaacagc tgctccttta
     4201 agaatgctgc aactgctaag aaatgtgtat catgccagaa tacaaaccca accagtaaca
     4261 aagagctcct aggtcctcca ttagttgaaa atggctttgc tcctaaaact ggcctggaaa
     4321 atgctcaaga tcgatttgca acaatgactg caaataaaga aggccattgg gactgcagtg
     4381 tttgtttagt aagaaatgaa cccaccgtct ctaggtgcat tgcatgtcag aacacaaagt
     4441 ctgcgtcttc gtttgttcaa acttctttca aatttggtca gggagatctt cctaagtctg
     4501 ttgacagtga tttcagatct gttttttcta aaaaagaagg tcagtgggaa tgcagtgtat
     4561 gcctagtccg aaatgaaaga agcgctaaaa aatgtgttgc ttgtgagaac ccaggaaaac
     4621 agttcaaaga atggcattgt agtttgtgct cggtgaaaaa tgaagcacat gctataaaat
     4681 gtgttgcttg taataatcct gttacaccaa gtttatctac tgcacctccc tcttttaagt
     4741 ttggtacctc agagatgagt aagcctttca ggattggatt tgagggtatg ttcgccaaga
     4801 aagaaggaca gtgggactgt agcttgtgtt ttgtccgaaa tgaagccagt gctactcact
     4861 gtattgcttg tcagtatcca aataagcaga atcagcctac atcttgtgta tcagctcctg
     4921 cctcttcaga gacaagcagg tctccaaaga gtggatttga aggcttattc cccaaaaagg
     4981 aaggagagtg ggagtgtgct gtttgttctg tacaaaatga gagctcttcc ctaaaatgtg
     5041 tggcttgtga agcctccaag ccaactcata agcctcatga agctccttca gctttcacag
     5101 tgggctcaaa gtcacagtca aatgaatctg caggaagtca agtgggaaca gaattcaaaa
     5161 gtaactttcc agaaaagaat tttaaagttg gcatttcaga gcagaaattt aaatttgggc
     5221 atgtggatca agaaaaaaca ccttcctttg cctttcaggg tggctctaat acagaattta
     5281 agtcaatcaa ggatggattt agtttttgca ttcctgtatc tgctgatggg tttaaatttg
     5341 gcattcagga aaagggaaat caagagaaaa agagtgaaaa acatcttgaa aatgacccta
     5401 gtttccaagc tcatgatact agtggtcaga agaatggtag tggtgtggtc tttggtcaga
     5461 caagcagcac ctttaccttt gcagatcttg caaagtcaac atcaagagaa gggtttcaat
     5521 ttggcaagaa agaccctaat tttaagggat tttcaggtgc aggagaaaaa ttattctcgt
     5581 cacaaagcgg caaagtggct gagaaagcaa atacgtcttc tgatctcgag aaagatgatg
     5641 atgcatataa gactgaggac agtgatgaca tccattttga gccagtagtg cagatgccag
     5701 aaaaggtgga actagtaaca ggagaagaag atgaaaaagt tttgtattca caaagggtga
     5761 aattatttag atttgatgct gagataagtc agtggaaaga aaggggtttg gggaatttaa
     5821 aaattctcaa aaatgaagtc aatggtaaac tgagaatgct gatgcgaaga gaacaagtgc
     5881 taaaagtttg tgccaatcat tggataacca ctacaatgaa cctgaagcct ctctcggggt
     5941 cagatagagc atggatgtgg ctagctagtg atttctccga tggtgacgcg aaactggaac
     6001 aactggctgc aaagtttaaa acgccagagc tagctgaaga attcaagcag aaatttgagg
     6061 agtgtcaacg tcttctctta gacattccac ttcagacacc ccataaactt gtagatactg
     6121 gcagggctgc taaattaata cagagagctg aggaaatgaa gagcggcctg aaagatttca
     6181 aaaccttttt gacaaatgat caagtaaagg tcaccgatga agagaatgca agttcaggtg
     6241 cagatgctcc cagtgcatca gacaccacag ccaagcaaaa tcctgataac accgggcctg
     6301 ccttagaatg ggataactat gacttacggg aggacgcctt ggatgacagt gtcagcagca
     6361 gctcagttca tgcttctcca ttggcaagca gccctgtgcg gaaaaacctc ttccgctttg
     6421 gtgagtccac tacaggattt aacttcagtt ttaaatctgc tctgagtcca tctaagtctc
     6481 cagccaaatt gaaccagagt ggagcttcag ttggcactga tgaggagtct gatgttactc
     6541 aagaagaaga gagagatgga cagtactttg aacctgttgt tcctttacct gatctagttg
     6601 aagtatccag tggtgaggaa aatgaacaag ttgtttttag tcacagagca aaactttaca
     6661 gatacgataa agatgttggc cagtggaaag aaagaggcat tggagatata aagatcttac
     6721 agaattatga taataaacaa gttcgcatcg tgatgagaag ggaccaggta ttaaaacttt
     6781 gtgccaatca cagaataact ccagatatga ctttgcaaac tatgaaaggg actgaaagag
     6841 tgtgggtgtg gactgcatgt gattttgcag atggagaaag aaaaatagaa catttggctg
     6901 ttcgttttaa actacaggat gttgcagact catttaagaa aatttttgat gaagcaaaaa
     6961 cagcccaaga aaaagattca ttgataacac ctcatgtttc tcatctgagc acccctagag
     7021 agtcaccatg tggcaaaatt gctattgctg ttttagaaga aaccacaaga gaaaggacag
     7081 atttaactca gggagatgaa gtaatagata caacttcaga agctggagaa acatctagca
     7141 cttctgaaac aacaccaaaa gcagtagttt ctcctcctaa gtttgtattt ggctcagaat
     7201 ctgttaaaag catttttagt agtgaaaaat ccaagccatt tgcatttggc aacagttcag
     7261 ccactggttc tttgtttgga tttagtttta atgcaccttt gaaaaatagc aatagtgaaa
     7321 tgacttccag agtccagagt ggatctgaag gaaaagtaaa acccgacaaa tgtgagctgc
     7381 cacagaactc tgacatcaag caatcttctg atggcaaagt caaaaatctc agtgcctttt
     7441 caaaagagaa ctcttcaact agttatacat ttaaaacacc agaaaaggca caagagaaga
     7501 gcaaacctga agatctcccc tcagataatg atattctcat tgtgtatgaa ctcactccca
     7561 cccctgagca gaaagccctg gcagagaaac ttctgcttcc ttcaactttc ttttgttata
     7621 agaataggcc tggctatgtt agtgaagaag aggaggatga tgaagattat gaaatggctg
     7681 tcaagaagct taatggaaaa ctctatctgg atgactcaga aaaaccattg gaagaaaatc
     7741 tagcagataa tgacaaggaa tgtgttattg tttgggaaaa gaagccaaca gttgaagaaa
     7801 gagcaaaagc agatacttta aagcttccac ctacattttt ctgtggagtc tgcagtgata
     7861 ctgatgagga caatggaaat ggggaggatt ttcagtcaga gcttcgaaaa gtctgtgaag
     7921 ctcagaaatc ccagaatgag aaagtgactg atagagttgg tattgagcat ataggtgaga
     7981 ctgaagtaac aaaccctgtt ggctgtaagt ctgaagaacc tgattctgat accaaacaca
     8041 gtagctcatc ccctgtttct gggactatgg acaaacctgt cgatttgtcc actagaaaag
     8101 aaactgacat ggaattccca agcaaagggg aaaacaagcc tgttttgttt ggatttggaa
     8161 gtggtacagg cctgtcattt gcagacttgg cttcaagtaa ttctggagat tttgcttttg
     8221 gctctaaaga taaaaatttc cagtgggcaa atactggagc agctgtgttt ggaacacaga
     8281 caacaagtaa aggtggcgag gatgaagacg gcagtgatga agatgtagtt cataatgagg
     8341 acatccactt tgaacctata gtctccttac cagaggtaga agtgaaatct ggagaggaag
     8401 atgaagaagt tttgttcaaa gagagagcca aactttatag gtgggacaga gatgtcagtc
     8461 agtggaagga gagaggtatt ggagatataa agattctctg gcatacaatg aagaagtatt
     8521 atcggatcct aatgagaaga gaccaggttt ttaaagtgtg tgcaaaccat gttattacca
     8581 aagccatgga attaaaacct ttaaatgttt caaacaatgc tttagtctgg actgcctccg
     8641 attatgctga tggagaagca aaagtagaac agcttgcagt gagatttaag acaaaggaaa
     8701 tgactgagag ttttaagaaa aaatttgaag aatgtcaaca aaatataata aaactccaga
     8761 atggacatac atcccttgca gcagaattat caaaggacac caatcctgtg gtgttttttg
     8821 atgtttgtgc ggatggtgaa cctctaggac ggataatcat ggaattattt tcaaatatcg
     8881 ttcctcaaac tgctgagaac ttcagagcat tatgcactgg agagaagggc tttggtttta
     8941 agaactccat ttttcaccga gtagttccag attttatttg ccaaggggga gatattacca
     9001 aatacaatgg aacaggtgga cagtccattt atggagataa atttgacgat gaaaactttg
     9061 atttgaaaca cactggtcct ggcttactat ccatggccaa ttacggccag aataccaaca
     9121 gttctcaatt ttttataaca ctgaagaaag cagaacattt ggactttaag catgtagtat
     9181 ttgggtttgt taaggatggc atggatactg tgagaaagat tgaatcattt ggttctccta
     9241 aagggtctgt tagtagaaga atttgtatca cagaatgtgg acagctataa aataattttt
     9301 cacagtgagt tttatctata taagcagttg aattgatgcg taattgttac agacagtata
     9361 gtaattatgt tcaccttttg aaaacagatg tttccgatgt ataaatgtaa aattgtagct
     9421 tatagctgtt gtcacttttt agtgtgtaat aattgatctt gcatggtgtg aaataaa
//
