LOCUS       NP_075635               1088 aa            linear   ROD 15-MAY-2025
DEFINITION  ran-binding protein 17 isoform 1 [Mus musculus].
ACCESSION   NP_075635
VERSION     NP_075635.1
DBSOURCE    REFSEQ: accession NM_023146.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1088)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1088)
  AUTHORS   Bao,J., Wu,Q., Song,R., Jie,Z., Zheng,H., Xu,C. and Yan,W.
  TITLE     RANBP17 is localized to the XY body of spermatocytes and interacts
            with SPEM1 on the manchette of elongating spermatids
  JOURNAL   Mol Cell Endocrinol 333 (2), 134-142 (2011)
   PUBMED   21184802
  REMARK    GeneRIF: Interactions between RANBP17 and SPEM1, for the first
            time, point to a potential function of SPEM1 in the
            RANBP17-mediated nucleocytoplasmic transport.
REFERENCE   3  (residues 1 to 1088)
  AUTHORS   Koch,P., Bohlmann,I., Schafer,M., Hansen-Hagge,T.E., Kiyoi,H.,
            Wilda,M., Hameister,H., Bartram,C.R. and Janssen,J.W.
  TITLE     Identification of a novel putative Ran-binding protein and its
            close homologue
  JOURNAL   Biochem Biophys Res Commun 278 (1), 241-249 (2000)
   PUBMED   11071879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669814.16, AL683843.9 and AL772409.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271458.1, AK016583.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.21 cM"
     Protein         1..1088
                     /product="ran-binding protein 17 isoform 1"
                     /note="ran-binding protein 17"
                     /calculated_mol_wt=123924
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9UIA9; propagated from
                     UniProtKB/Swiss-Prot (Q99NF8.1)"
     Region          8..>167
                     /region_name="CRM1"
                     /note="Importin beta-related nuclear transport receptor
                     [Nuclear structure / Intracellular trafficking and
                     secretion]; COG5101"
                     /db_xref="CDD:227432"
     Region          30..95
                     /region_name="IBN_N"
                     /note="Importin-beta N-terminal domain; smart00913"
                     /db_xref="CDD:197981"
     Site            569
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UIA9; propagated from
                     UniProtKB/Swiss-Prot (Q99NF8.1)"
     CDS             1..1088
                     /gene="Ranbp17"
                     /coded_by="NM_023146.4:146..3412"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24534.1"
                     /db_xref="GeneID:66011"
                     /db_xref="MGI:MGI:1929706"
ORIGIN      
        1 malhfqslae levlcthlyv gtdlteriea ekallelids peclskcqll leqgttsyaq
       61 llaatclskl vtrinplpie qridirnyil nyvasqpkla pfviqaliqv iakltklgwf
      121 evqkdefvfr eiiadvkkfl qgtvehciig viilceltqe mnlvdysrps akhrkiatsf
      181 rdtslkdilv lacsllkqvl akplnlqdqd qqslvmqvlk lvlsclnfdf lgssadesad
      241 dlctvqiptt wrtiflepet ldlffnlyhs lppllsqlal sclvqfastr rslfsspera
      301 kylgnlikgv krilenpqgl sdpgnyhefc rflarlktny qlgelvlvke yaeviglian
      361 ftitslqhwe fapnsvhyll tlwqrmvasv pfvksaephl ldtyapeitk afitsrlesv
      421 aivvrdnled plddtatvfq qleqlctvsr ceyektctll vqlfdqnaqn yqkllhaapg
      481 lavdmaiqeg rlawliylvg tvvggrltyt stdehdamdg elscrvfqli slmdtrlphc
      541 tnekielavl wfldqfrkty vgdqlqrtsk vyarmsevlg itddnhvlet fmtkivtnlk
      601 ywgrcepvis rtlqflsdls vgyillkklv kidavkfmlk nhtsehfpfl gisetynvgd
      661 frcrttfyta ltrllmvdlg ededefenfm lpltvsfetv lqifnnnfkq eevkrmligl
      721 ardlrgiafa lntktsytml fdwiypaylp vlqraierwy gepacttpil kllaelmqnr
      781 sqrlnfdvss pngillfrea skmictygnq ilslgslskd kiypmklkgi sicysalksa
      841 lcgnyvsfgv fklygdnhfd nvlqafvkml lsvshsdllq yrklsqsyyp llecltqdhm
      901 sfitnleppv llyvltslse glttldtvvs sscctsldym vtylfkhiak egkkplrsre
      961 amqagqrllh fmqqnpdvlq qmmsvlmnti vfedcrnqws vsrpllglil lnekyfselr
     1021 aslinsqplp kqevlgqcfr nlmegveqnl svknrdrftq nlsvfrrdva ealrsdghtd
     1081 lssldmms
//
