LOCUS       NP_665823                620 aa            linear   ROD 02-MAY-2024
DEFINITION  ran-binding protein 10 [Mus musculus].
ACCESSION   NP_665823
VERSION     NP_665823.3
DBSOURCE    REFSEQ: accession NM_145824.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 620)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 620)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (residues 1 to 620)
  AUTHORS   Meyer,I., Kunert,S., Schwiebert,S., Hagedorn,I., Italiano,J.E. Jr.,
            Dutting,S., Nieswandt,B., Bachmann,S. and Schulze,H.
  TITLE     Altered microtubule equilibrium and impaired thrombus stability in
            mice lacking RanBP10
  JOURNAL   Blood 120 (17), 3594-3602 (2012)
   PUBMED   22936655
  REMARK    GeneRIF: RanBP10 inhibits premature microtubule polymerization of
            beta1-tubulin and plays a pivotal role in thrombus stabilization.
REFERENCE   4  (residues 1 to 620)
  AUTHORS   Hosono,K., Noda,S., Shimizu,A., Nakanishi,N., Ohtsubo,M.,
            Shimizu,N. and Minoshima,S.
  TITLE     YPEL5 protein of the YPEL gene family is involved in the cell cycle
            progression by interacting with two distinct proteins RanBPM and
            RanBP10
  JOURNAL   Genomics 96 (2), 102-111 (2010)
   PUBMED   20580816
REFERENCE   5  (residues 1 to 620)
  AUTHORS   Kunert,S., Meyer,I., Fleischhauer,S., Wannack,M., Fiedler,J.,
            Shivdasani,R.A. and Schulze,H.
  TITLE     The microtubule modulator RanBP10 plays a critical role in
            regulation of platelet discoid shape and degranulation
  JOURNAL   Blood 114 (27), 5532-5540 (2009)
   PUBMED   19801445
  REMARK    GeneRIF: Data suggest that RanBP10 plays an essential role in
            hemostasis and in maintaining microtubule dynamics with respect to
            both platelet shape and function.
REFERENCE   6  (residues 1 to 620)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (residues 1 to 620)
  AUTHORS   Wang,D., Li,Z., Schoen,S.R., Messing,E.M. and Wu,G.
  TITLE     A novel MET-interacting protein shares high sequence similarity
            with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling
  JOURNAL   Biochem Biophys Res Commun 313 (2), 320-326 (2004)
   PUBMED   14684163
REFERENCE   8  (residues 1 to 620)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 620)
  AUTHORS   Wang,D., Li,Z., Messing,E.M. and Wu,G.
  TITLE     Activation of Ras/Erk pathway by a novel MET-interacting protein
            RanBPM
  JOURNAL   J Biol Chem 277 (39), 36216-36222 (2002)
   PUBMED   12147692
REFERENCE   10 (residues 1 to 620)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152826.2.
            
            On Mar 5, 2019 this sequence version replaced NP_665823.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024698.1, AY337314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..620
                     /product="ran-binding protein 10"
                     /calculated_mol_wt=67058
     Region          1..38
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q6VN20; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Region          77..219
                     /region_name="SPRY_RanBP9_10"
                     /note="SPRY domain in Ran binding proteins 9 and 10;
                     cd12909"
                     /db_xref="CDD:293966"
     Region          257..284
                     /region_name="LisH"
                     /note="Lissencephaly type-1-like homology motif;
                     smart00667"
                     /db_xref="CDD:128913"
     Region          291..>345
                     /region_name="CTLH"
                     /note="CTLH/CRA C-terminal to LisH motif domain;
                     pfam10607"
                     /db_xref="CDD:402305"
     Region          347..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            361
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6VN20; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            362
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            369
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6VN20; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            451
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Site            453
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6VN19.2)"
     Region          507..604
                     /region_name="CRA"
                     /note="CT11-RanBPM; smart00757"
                     /db_xref="CDD:214806"
     CDS             1..620
                     /gene="Ranbp10"
                     /gene_synonym="4432417N03Rik"
                     /coded_by="NM_145824.5:25..1887"
                     /db_xref="CCDS:CCDS22613.1"
                     /db_xref="GeneID:74334"
                     /db_xref="MGI:MGI:1921584"
ORIGIN      
        1 maaatadpga gnpqagdssg gdsggglpsp geqelsrrlq rlypavnqhe tplprswspk
       61 dkynyiglsq gnlrvhykgh gknhkdaasv rathpipaac giyyfevkiv skgrdgymgi
      121 glsaqgvnmn rlpgwdkhsy gyhgddghsf cssgtgqpyg ptfttgdvig ccvnlingtc
      181 fytknghslg iaftdlpanl yptvglqtpg eivdanfgqq pflfdiedym rewrakvqgt
      241 vhgfpisarl gewqavlqnm vssylvhhgy cstatafarm tetpiqeeqa siknrqkiqk
      301 lvlegrvgea iettqrfypg llehnpnllf mlkcrqfvem vngtdsevrs lssrspksqd
      361 sypgspslsp rhgpssshih ntgadspscs ngvastknkq nhskypapss ssssssssss
      421 sspssvnyse snstdstksq phsstsnqet sdsememeae hypngvlesv strivngayk
      481 hddlqtdess mddghprrql cggnqaater iilfgrelqa lseqlgreyg knlahtemlq
      541 dafsllaysd pwscpvghql dpiqrepvca alnsailesq nlpkqpplml algqaseclr
      601 lmaraglgsc sfarvddylh
//
