LOCUS       NM_009391               2288 bp    mRNA    linear   ROD 20-DEC-2022
DEFINITION  Mus musculus RAN, member RAS oncogene family (Ran), mRNA.
ACCESSION   NM_009391
VERSION     NM_009391.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2288)
  AUTHORS   Patil H, Yoon D, Bhowmick R, Cai Y, Cho KI and Ferreira PA.
  TITLE     Impairments in age-dependent ubiquitin proteostasis and structural
            integrity of selective neurons by uncoupling Ran GTPase from the
            Ran-binding domain 3 of Ranbp2 and identification of novel
            mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9)
            and Ranbp2
  JOURNAL   Small GTPases 10 (2), 146-161 (2019)
   PUBMED   28877029
  REMARK    GeneRIF: data support that Ran GTPase-dependent and independent and
            moonlighting roles of Ranbp2 or domains thereof and ubc9 control
            selectively age-dependent, neural-type and mitochondrial functions
REFERENCE   2  (bases 1 to 2288)
  AUTHORS   Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z,
            Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L,
            Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW
            and Maxwell CA.
  TITLE     HMMR acts in the PLK1-dependent spindle positioning pathway and
            supports neural development
  JOURNAL   Elife 6, e28672 (2017)
   PUBMED   28994651
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2288)
  AUTHORS   Chen WS, Chen YJ, Huang YA, Hsieh BY, Chiu HC, Kao PY, Chao CY and
            Hwang E.
  TITLE     Ran-dependent TPX2 activation promotes acentrosomal microtubule
            nucleation in neurons
  JOURNAL   Sci Rep 7, 42297 (2017)
   PUBMED   28205572
  REMARK    GeneRIF: Depleting TPX2 decreases microtubule formation frequency
            specifically at the tip and the base of the neurite, and these
            correlate precisely with the regions where active GTP-bound Ran
            proteins are enriched.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2288)
  AUTHORS   Shibano T, Mamada H, Hakuno F, Takahashi S and Taira M.
  TITLE     The Inner Nuclear Membrane Protein Nemp1 Is a New Type of
            RanGTP-Binding Protein in Eukaryotes
  JOURNAL   PLoS One 10 (5), e0127271 (2015)
   PUBMED   25946333
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2288)
  AUTHORS   Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM,
            Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano
            AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A and Gan
            L.
  TITLE     Early retinal neurodegeneration and impaired Ran-mediated nuclear
            import of TDP-43 in progranulin-deficient FTLD
  JOURNAL   J Exp Med 211 (10), 1937-1945 (2014)
   PUBMED   25155018
  REMARK    GeneRIF: Augmented expression of Ran in progranulin-deficient
            neurons restores nuclear TDP-43 levels and improves their survival.
REFERENCE   6  (bases 1 to 2288)
  AUTHORS   Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell
            D, Alejos E, Silva M, Galanos C, Freudenberg M,
            Ricciardi-Castagnoli P, Layton B and Beutler B.
  TITLE     Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations
            in Tlr4 gene
  JOURNAL   Science 282 (5396), 2085-2088 (1998)
   PUBMED   9851930
REFERENCE   7  (bases 1 to 2288)
  AUTHORS   Kang AD, Wong PM, Chen H, Castagna R, Chung SW and Sultzer BM.
  TITLE     Restoration of lipopolysaccharide-mediated B-cell response after
            expression of a cDNA encoding a GTP-binding protein
  JOURNAL   Infect Immun 64 (11), 4612-4617 (1996)
   PUBMED   8890215
REFERENCE   8  (bases 1 to 2288)
  AUTHORS   Coutavas EE, Hsieh CM, Ren M, Drivas GT, Rush MG and D'Eustachio
            PD.
  TITLE     Tissue-specific expression of Ran isoforms in the mouse
  JOURNAL   Mamm Genome 5 (10), 623-628 (1994)
   PUBMED   7849398
REFERENCE   9  (bases 1 to 2288)
  AUTHORS   Dietrich JM and McCormick PJ.
  TITLE     Analysis of the factors involved in the retinoic acid-induced
            differentiation of a retinoid-hypersensitive embryonal carcinoma
            cell mutant
  JOURNAL   Exp Cell Res 210 (2), 201-208 (1994)
   PUBMED   8299717
REFERENCE   10 (bases 1 to 2288)
  AUTHORS   Chavrier P, Simons K and Zerial M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002436.1, AK075900.1 and AC110566.17.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_009391.4.
            
            On Sep 15, 2006 this sequence version replaced NM_009391.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075900.1, AK151341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK002436.1         92-153
            63-1256             AK075900.1         1-1194
            1257-2288           AC110566.17        107078-108109
FEATURES             Location/Qualifiers
     source          1..2288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..2288
                     /gene="Ran"
                     /note="RAN, member RAS oncogene family"
                     /db_xref="GeneID:19384"
                     /db_xref="MGI:MGI:1333112"
     exon            1..123
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            124..170
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..785
                     /gene="Ran"
                     /note="GTPase Ran; ras-like protein TC4; ras-related
                     nuclear protein"
                     /codon_start=1
                     /product="GTP-binding nuclear protein Ran"
                     /protein_id="NP_033417.1"
                     /db_xref="CCDS:CCDS19693.1"
                     /db_xref="GeneID:19384"
                     /db_xref="MGI:MGI:1333112"
                     /translation="MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLG
                     VEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVP
                     NWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKP
                     FLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL"
     exon            171..255
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            256..381
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            382..569
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            570..740
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            741..2288
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgccctct cccggctcct ccccccctcc gcgcgccggc gtccgctgcg tctccggcat
       61 ttgaatcgcg cttccgccat ctttccagct ccagtcggac aggcgcggag actcttctgg
      121 aaggatccgc cgcgatggcc gcccagggag agccgcaggt ccagttcaag ctcgtcctgg
      181 tgggcgacgg cggcaccggg aagacaacct tcgtgaagcg ccacttgacg ggcgagtttg
      241 agaagaagta tgtagccacc ctgggcgtgg aggtgcaccc gctcgtcttc cataccaaca
      301 gaggacccat caagttcaac gtgtgggaca cggccggcca ggagaagttc gggggcctgc
      361 gcgatggcta ctacatccaa gcccagtgtg ccattataat gtttgatgta acctcaagag
      421 ttacttacaa gaatgtacct aactggcata gagatctggt acgagtgtgt gaaaacatcc
      481 ccattgtatt gtgtggcaac aaagtggata ttaaagacag gaaagtgaag gcaaaatcta
      541 ttgtcttcca ccggaagaag aatcttcagt actatgacat ttctgccaaa agtaactaca
      601 actttgaaaa gcctttcctc tggcttgcca gaaagctcat tggagatcct aacttggagt
      661 ttgttgccat gcctgctctt gccccacctg aggtggtcat ggacccagct ttggcagcac
      721 agtacgagca tgatttagag gttgctcaga cgactgctct cccagatgag gatgatgacc
      781 tgtgagaaag tgaagctgga gccctgcgtc agaagtctag ttttataggc aactgtcctg
      841 tgatgtcagc ggtgcagcgc gtgtgccacc ttatttagct aagcagatcg tgtacttcat
      901 tgggatgctg aaggagatga atgggcttcg agtgaatgtg gcagttaaac ataccttcat
      961 tttttggact tgcatattta gctgtttgga acagagttgt ttcctttctg aatttcaaag
     1021 ataagactgc tgcagtccca tcgcaatatc cagtggggaa atcttgtttg ttactgtcat
     1081 tcccattctt ttcgtttaga atcagaataa agttgtattt caaataatct aaacaagtga
     1141 atcatccctt gcttattaaa gccactaaca cgagggagct tgtgccatat tatagtttaa
     1201 aatgcttctg ctattacctg aggtctattc agttatgttc tccttgtgcc taccttcata
     1261 aacatttaga ttgtctgtga ctcagctagg atgatatctg ccctacctgc atttagccag
     1321 gtagtttaac ctaagagaag accttgtgta aaactaaaga tttaagtatg tacgcatcag
     1381 atgtttaagg attgcagttg acaatttctg taacctaggc cttcagaagt tagaactgca
     1441 gttgacggac ggaagcttga gggttttctg agatggacta catttcttca tttccatgtc
     1501 taatgttggt tctctaagat gtcctctgct ttcaaatatt ggctcctata ttgagtggta
     1561 gtctcaggag gtagaggcag gaggatctct tgagtttgcc cccaacctta gtctacagag
     1621 caagttccag gactgagaga cctgtctcaa aaaattcatg gtaggctgtt acagtattac
     1681 agcagctgat cttttttttc tcccacgggg tttatatagg ttgtgcagga gaggaaatgc
     1741 tagggctact gccactgagg agtagggtgg gcttctctga tgtgatagtg ttagttgaga
     1801 cttaggtgtg tgatcccggc acaactgtgt tgctcagatg tatttacagc aagccattcc
     1861 gtgtgctctg ctggtccagt ctaccaaagt tcctagaagg gtggatacct tcacatagtt
     1921 gttggtgttt gttttgtttt gtttttttct ccccaaagaa ggtagatgac ttaaatacag
     1981 tggggaaggt ggaaggaact catactgtgc attctagctt cagcagactg attgcaagac
     2041 tcaaatttga tgtatgtgct atgctatgat caggtgaaga ccctctcccc tgactgggat
     2101 gaaacctcat ttagatgtct tgaattaata cattgtgtgt aaacctggta tagaatgtag
     2161 aacctttatg actttctgat ttttgtaaca gttaaatgtg ggagctgctt acgtgtgttt
     2221 aaccagagtg cagagattta cattatttat tggaagaact taaatatata tcatttctgc
     2281 tttgcctc
//
