LOCUS       NM_019511               1221 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus receptor (calcitonin) activity modifying protein 3
            (Ramp3), mRNA.
ACCESSION   NM_019511 XM_909986
VERSION     NM_019511.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1221)
  AUTHORS   Hou,Y., Sun,L., LaFleur,M.W., Huang,L., Lambden,C., Thakore,P.I.,
            Geiger-Schuller,K., Kimura,K., Yan,L., Zang,Y., Tang,R., Shi,J.,
            Barilla,R., Deng,L., Subramanian,A., Wallrapp,A., Choi,H.S.,
            Kye,Y.C., Ashenberg,O., Schiebinger,G., Doench,J.G., Chiu,I.M.,
            Regev,A., Sharpe,A.H. and Kuchroo,V.K.
  TITLE     Neuropeptide signalling orchestrates T cell differentiation
  JOURNAL   Nature 635 (8038), 444-452 (2024)
   PUBMED   39415015
REFERENCE   2  (bases 1 to 1221)
  AUTHORS   Kasahara,T., Tanaka,M., Zhao,Y., Kamiyoshi,A., Sakurai,T.,
            Ichikawa-Shindo,Y., Kawate,H., Matsuda,Y., Zhang,Y., Guo,Q., Li,P.,
            Hoshiyama,K., Li,J., Onishi,N., Hayashi,M., Sanjo,H., Ishida,K.,
            Tanaka,S., Kawamata,M. and Shindo,T.
  TITLE     Receptor activity-modifying proteins of adrenomedullin (RAMP2/3):
            Roles in the pathogenesis of ARDS
  JOURNAL   Peptides 171, 171118 (2024)
   PUBMED   38012983
  REMARK    GeneRIF: Receptor activity-modifying proteins of adrenomedullin
            (RAMP2/3): Roles in the pathogenesis of ARDS.
REFERENCE   3  (bases 1 to 1221)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1221)
  AUTHORS   Qiu,T., Huteckova,B., Seppala,M., Cobourne,M.T., Chen,Z.,
            Hovorakova,M., Buchtova,M. and Tucker,A.S.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   5  (bases 1 to 1221)
  AUTHORS   Xu,W., Nelson-Maney,N.P., Balint,L., Kwon,H.B., Davis,R.B.,
            Dy,D.C.M., Dunleavey,J.M., St Croix,B. and Caron,K.M.
  TITLE     Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic
            Development
  JOURNAL   Int J Mol Sci 23 (10), 5712 (2022)
   PUBMED   35628521
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1221)
  AUTHORS   Flahaut,M., Rossier,B.C. and Firsov,D.
  TITLE     Respective roles of calcitonin receptor-like receptor (CRLR) and
            receptor activity-modifying proteins (RAMP) in cell surface
            expression of CRLR/RAMP heterodimeric receptors
  JOURNAL   J Biol Chem 277 (17), 14731-14737 (2002)
   PUBMED   11854283
  REMARK    GeneRIF: role in cell surface expression of CRLR/RAMP heterodimeric
            receptors
REFERENCE   7  (bases 1 to 1221)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
REFERENCE   8  (bases 1 to 1221)
  AUTHORS   Ono,Y., Okano,I., Kojima,M., Okada,K. and Kangawa,K.
  TITLE     Decreased gene expression of adrenomedullin receptor in mouse lungs
            during sepsis
  JOURNAL   Biochem Biophys Res Commun 271 (1), 197-202 (2000)
   PUBMED   10777702
REFERENCE   9  (bases 1 to 1221)
  AUTHORS   Husmann,K., Sexton,P.M., Fischer,J.A. and Born,W.
  TITLE     Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
            sequence, expression and function
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 35-43 (2000)
   PUBMED   10854696
REFERENCE   10 (bases 1 to 1221)
  AUTHORS   Derst,C., Engel,H., Grzeschik,K. and Daut,J.
  TITLE     Genomic structure and chromosome mapping of human and mouse RAMP
            genes
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 115-118 (2000)
   PUBMED   11060459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603787.8.
            
            On Apr 28, 2007 this sequence version replaced NM_019511.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ250491.1, AF146524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL603787.8         71950-72044
            96-228              AL603787.8         88180-88312
            229-1221            AL603787.8         89900-90892
FEATURES             Location/Qualifiers
     source          1..1221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.61 cM"
     gene            1..1221
                     /gene="Ramp3"
                     /note="receptor (calcitonin) activity modifying protein 3"
                     /db_xref="GeneID:56089"
                     /db_xref="MGI:MGI:1860292"
     exon            1..95
                     /gene="Ramp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..484
                     /gene="Ramp3"
                     /note="receptor activity-modifying protein 3"
                     /codon_start=1
                     /product="receptor activity-modifying protein 3 precursor"
                     /protein_id="NP_062384.1"
                     /db_xref="CCDS:CCDS24425.1"
                     /db_xref="GeneID:56089"
                     /db_xref="MGI:MGI:1860292"
                     /translation="MKTPAQRLHLLPLLLLLCGECAQVCGCNETGMLERLPRCGKAFA
                     DMMQKVAVWKWCNLSEFIVYYESFTNCTEMETNIMGCYWPNPLAQSFITGIHRQFFSN
                     CTVDRTHWEDPPDEVLIPLIAVPVVLTVAMAGLVVWRSKHTDRLL"
     exon            96..228
                     /gene="Ramp3"
                     /inference="alignment:Splign:2.1.0"
     exon            229..1221
                     /gene="Ramp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ramp3"
                     /note="hexamer: ATTAAA"
     polyA_site      1221
                     /gene="Ramp3"
                     /note="major polyA site"
ORIGIN      
        1 atgtcgctgt tgctgcaagc cggctgcatc ttagttggcc atgaagaccc cagcacagcg
       61 gctgcacctt cttccactgt tgttgctgct ttgtggtgag tgtgcccagg tatgcggctg
      121 caacgagaca gggatgctgg agaggctgcc tcgctgtggg aaagccttcg ctgacatgat
      181 gcagaaggtg gctgtctgga agtggtgcaa cctgtcggag ttcatcgtgt attatgaaag
      241 cttcactaac tgcaccgaga tggagaccaa catcatgggc tgctactggc ccaacccgct
      301 ggcccagagc ttcatcactg gaatccacag gcagttcttt tccaactgca cggtggacag
      361 gacccactgg gaagaccccc cggatgaagt actcatccca ctgatcgcgg ttcctgtcgt
      421 gctgactgtg gctatggctg gcctggtggt gtggcgcagc aagcacactg atcggctgct
      481 gtgaggatct gctggatgga gggccatgcc tggcaggctg ggagaatgtt gctcagagct
      541 ctgagagctg gcagactcgg cttctgtctg gtttgctttg gccacaccct acctggccat
      601 gccaaagtcc tcctgaccag gctggtgtgg cccttgctgt ctagcctgcc gcctgctggg
      661 gttcagattg tccatacttt gctctttctt gggctagtgg aagaaagtga caaatcccaa
      721 gtttgtggac caggcatgga aatcaactgt tgctgagccc cgctccccag gctcggttcc
      781 ctagtttcta gccgtttctt ggcagagtct tgctcagcct gaaccccgcc ccaggtcctg
      841 acccatttct agtcctgacc ctgacccctg ctacacttgg ccagagaggg caggcaaggt
      901 catctggaag atgtggacgc ccccccgcct ctgttcaaga gactgagcac atcatttatc
      961 agacatgaag gatagcctgg ggtcattagg agccacgtgt gacctactga cccacctgcc
     1021 tgtcctctct gtgatctgtc acgattctgt gtccagtgtg ggctggagct gtggcttgtt
     1081 tagcccttca aagacaccta ccctgcaggt agagcgtgaa cctccttctt gaggggtatt
     1141 cctgggagtg gggcgcactg agtgtgctca agggttctgt ctgctgatgt cagttctttt
     1201 tgattaaagt gtctccttac a
//
