LOCUS       NM_019444                872 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus receptor (calcitonin) activity modifying protein 2
            (Ramp2), mRNA.
ACCESSION   NM_019444
VERSION     NM_019444.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Kasahara,T., Tanaka,M., Zhao,Y., Kamiyoshi,A., Sakurai,T.,
            Ichikawa-Shindo,Y., Kawate,H., Matsuda,Y., Zhang,Y., Guo,Q., Li,P.,
            Hoshiyama,K., Li,J., Onishi,N., Hayashi,M., Sanjo,H., Ishida,K.,
            Tanaka,S., Kawamata,M. and Shindo,T.
  TITLE     Receptor activity-modifying proteins of adrenomedullin (RAMP2/3):
            Roles in the pathogenesis of ARDS
  JOURNAL   Peptides 171, 171118 (2024)
   PUBMED   38012983
  REMARK    GeneRIF: Receptor activity-modifying proteins of adrenomedullin
            (RAMP2/3): Roles in the pathogenesis of ARDS.
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 872)
  AUTHORS   Wei,Y., Tanaka,M., Sakurai,T., Kamiyoshi,A., Ichikawa-Shindo,Y.,
            Kawate,H., Cui,N., Kakihara,S., Zhao,Y., Aruga,K., Sanjo,H. and
            Shindo,T.
  TITLE     Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating
            TGF-ss-Smads Signaling and Myofibroblast Differentiation
  JOURNAL   Endocrinology 162 (8) (2021)
   PUBMED   33955458
  REMARK    GeneRIF: Adrenomedullin Ameliorates Pulmonary Fibrosis by
            Regulating TGF-ss-Smads Signaling and Myofibroblast
            Differentiation.
REFERENCE   5  (bases 1 to 872)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 872)
  AUTHORS   Flahaut,M., Rossier,B.C. and Firsov,D.
  TITLE     Respective roles of calcitonin receptor-like receptor (CRLR) and
            receptor activity-modifying proteins (RAMP) in cell surface
            expression of CRLR/RAMP heterodimeric receptors
  JOURNAL   J Biol Chem 277 (17), 14731-14737 (2002)
   PUBMED   11854283
  REMARK    GeneRIF: role in cell surface expression of CRLR/RAMP heterodimeric
            receptors
REFERENCE   7  (bases 1 to 872)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
REFERENCE   8  (bases 1 to 872)
  AUTHORS   Ono,Y., Okano,I., Kojima,M., Okada,K. and Kangawa,K.
  TITLE     Decreased gene expression of adrenomedullin receptor in mouse lungs
            during sepsis
  JOURNAL   Biochem Biophys Res Commun 271 (1), 197-202 (2000)
   PUBMED   10777702
REFERENCE   9  (bases 1 to 872)
  AUTHORS   Husmann,K., Sexton,P.M., Fischer,J.A. and Born,W.
  TITLE     Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
            sequence, expression and function
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 35-43 (2000)
   PUBMED   10854696
REFERENCE   10 (bases 1 to 872)
  AUTHORS   Derst,C., Engel,H., Grzeschik,K. and Daut,J.
  TITLE     Genomic structure and chromosome mapping of human and mouse RAMP
            genes
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 115-118 (2000)
   PUBMED   11060459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY312723.1, AK003810.1 and BC051201.1.
            
            On Jul 28, 2005 this sequence version replaced NM_019444.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF146523.1, BY704069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY312723.1         1-79
            80-767              AK003810.1         2-689
            768-872             BC051201.1         804-908
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.47 cM"
     gene            1..872
                     /gene="Ramp2"
                     /note="receptor (calcitonin) activity modifying protein 2"
                     /db_xref="GeneID:54409"
                     /db_xref="MGI:MGI:1859650"
     exon            1..239
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..688
                     /gene="Ramp2"
                     /note="receptor activity-modifying protein 2"
                     /codon_start=1
                     /product="receptor activity-modifying protein 2 precursor"
                     /protein_id="NP_062317.1"
                     /db_xref="CCDS:CCDS25457.1"
                     /db_xref="GeneID:54409"
                     /db_xref="MGI:MGI:1859650"
                     /translation="MAPLRVERAPGGSRLGVTRAQRPTALCLPPLLLLLLLLLGAVSA
                     SPESLNQSLPESQNQSHPTEDSLVSKGKMEDYETHVLPCWYEYKSCMDSVKDWCNWTL
                     ISRHYSDLQNCLEYNADKFGLGFPNPLAENIILEAHLIHFANCSLVQPTFSDPPEDVL
                     LAMIIAPICLIPFLVTLVVWRSKDSDAQA"
     exon            240..329
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..432
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..872
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      850..855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ramp2"
                     /note="hexamer: AATAAA"
     polyA_site      872
                     /gene="Ramp2"
                     /note="major polyA site"
ORIGIN      
        1 gtgccagccc ctccgaggaa gcggcgcagc ttcctgcggc tcgggccggg gatataggcg
       61 cccccgcccg ggccagctca gctccgctgc ccctcctcgc catctcaccc aaggcgtgat
      121 ggccccgctc cgggtagagc gcgccccggg tggatctcgg cttggtgtga cccgcgccca
      181 gcggccgaca gcgttgtgcc tccctccgct gttgctgctg ctgctgctgc tgctgggcgc
      241 tgtctcagcc tctccggagt ccctgaacca atctcttccg gagtcccaga atcaatctca
      301 tcccactgag gacagccttg tgtcaaaagg gaagatggaa gactacgaaa cacatgtcct
      361 accttgctgg tatgagtaca agagttgcat ggactctgtc aaggactggt gcaactggac
      421 tttgattagc aggcattaca gcgacctgca gaactgcttg gaatacaatg cagacaagtt
      481 tgggctgggc ttcccaaatc ccttggcaga aaacatcatc cttgaggctc acctgataca
      541 ctttgcgaac tgctccctgg tgcagcccac cttctctgat cccccagagg atgtgctcct
      601 ggccatgatc atagccccca tctgcctcat cccgttcctt gttactcttg tggtgtggag
      661 gagtaaagac agcgatgccc aggcctaggg tccatttctc agcagccatt tttcccccct
      721 tttccctgct ggaaccagga atggcgctcc tcccctccct acccacttac tctcatcctt
      781 cccacagacc tgtggattgg tggaaatggc agcaaagggg actcacgaca caatgtttgt
      841 agtctttaaa ataaagttat gtttttgtac aa
//
