LOCUS       NM_016894               2549 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus receptor (calcitonin) activity modifying protein 1
            (Ramp1), transcript variant 1, mRNA.
ACCESSION   NM_016894
VERSION     NM_016894.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Fattori,V., Zaninelli,T.H., Rasquel-Oliveira,F.S., Heintz,O.K.,
            Jain,A., Sun,L., Seshan,M.L., Peterse,D., Lindholm,A.E.,
            Anchan,R.M., Verri,W.A. Jr. and Rogers,M.S.
  TITLE     Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling
            drives endometriosis-associated pain and lesion growth in mice
  JOURNAL   Sci Transl Med 16 (772), eadk8230 (2024)
   PUBMED   39504351
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Ben-Shaanan,T.L., Knopper,K., Duan,L., Liu,R., Taglinao,H., Xu,Y.,
            An,J., Plikus,M.V. and Cyster,J.G.
  TITLE     Dermal TRPV1 innervations engage a macrophage- and
            fibroblast-containing pathway to activate hair growth in mice
  JOURNAL   Dev Cell 59 (21), 2818-2833 (2024)
   PUBMED   38851191
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Yamashita,A., Ito,Y., Osada,M., Matsuda,H., Hosono,K.,
            Tsujikawa,K., Okamoto,H. and Amano,H.
  TITLE     RAMP1 Signaling Mitigates Acute Lung Injury by Distinctively
            Regulating Alveolar and Monocyte-Derived Macrophages
  JOURNAL   Int J Mol Sci 25 (18), 10107 (2024)
   PUBMED   39337592
  REMARK    GeneRIF: RAMP1 Signaling Mitigates Acute Lung Injury by
            Distinctively Regulating Alveolar and Monocyte-Derived Macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Zhu,Y., Meerschaert,K.A., Galvan-Pena,S., Bin,N.R., Yang,D.,
            Basu,H., Kawamoto,R., Shalaby,A., Liberles,S.D., Mathis,D.,
            Benoist,C. and Chiu,I.M.
  TITLE     A chemogenetic screen reveals that Trpv1-expressing neurons control
            regulatory T cells in the gut
  JOURNAL   Science 385 (6708), eadk1679 (2024)
   PUBMED   39088603
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Wu,M., Song,G., Li,J., Song,Z., Zhao,B., Liang,L., Li,W., Hu,H.,
            Tu,H., Li,S., Li,P., Zhang,B., Wang,W., Zhang,Y., Zhang,W.,
            Zheng,W., Wang,J., Wen,Y., Wang,K., Li,A., Zhou,T., Zhang,Y. and
            Li,H.
  TITLE     Innervation of nociceptor neurons in the spleen promotes germinal
            center responses and humoral immunity
  JOURNAL   Cell 187 (12), 2935-2951 (2024)
   PUBMED   38772371
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Mallee,J.J., Salvatore,C.A., LeBourdelles,B., Oliver,K.R.,
            Longmore,J., Koblan,K.S. and Kane,S.A.
  TITLE     Receptor activity-modifying protein 1 determines the species
            selectivity of non-peptide CGRP receptor antagonists
  JOURNAL   J Biol Chem 277 (16), 14294-14298 (2002)
   PUBMED   11847213
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Miret,J.J., Rakhilina,L., Silverman,L. and Oehlen,B.
  TITLE     Functional expression of heteromeric calcitonin gene-related
            peptide and adrenomedullin receptors in yeast
  JOURNAL   J Biol Chem 277 (9), 6881-6887 (2002)
   PUBMED   11733510
  REMARK    GeneRIF: Co-expression of RAMP1 and CRLR reconstituted a CGRP
            receptor that was able to activate the pheromone-signaling pathway
            with pharmacological properties similar to those observed
            previously in mammalian cells.
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Ono,Y., Okano,I., Kojima,M., Okada,K. and Kangawa,K.
  TITLE     Decreased gene expression of adrenomedullin receptor in mouse lungs
            during sepsis
  JOURNAL   Biochem Biophys Res Commun 271 (1), 197-202 (2000)
   PUBMED   10777702
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Husmann,K., Sexton,P.M., Fischer,J.A. and Born,W.
  TITLE     Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
            sequence, expression and function
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 35-43 (2000)
   PUBMED   10854696
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   Derst,C., Engel,H., Grzeschik,K. and Daut,J.
  TITLE     Genomic structure and chromosome mapping of human and mouse RAMP
            genes
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 115-118 (2000)
   PUBMED   11060459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY733497.1, AK165238.1 and AC102874.7.
            
            On Oct 23, 2007 this sequence version replaced NM_016894.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.141417.1, AK165238.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               BY733497.1         1-224
            225-1749            AK165238.1         1-1525
            1750-2549           AC102874.7         75490-76289
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.08 cM"
     gene            1..2549
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
                     /note="receptor (calcitonin) activity modifying protein 1"
                     /db_xref="GeneID:51801"
                     /db_xref="MGI:MGI:1858418"
     exon            1..319
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            320..458
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..2549
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1008..1013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1023
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
                     /note="major polyA site"
     polyA_site      1031
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
                     /note="major polyA site"
     polyA_site      2540
                     /gene="Ramp1"
                     /gene_synonym="9130218E19Rik"
ORIGIN      
        1 ggaacccagc cgtcagagcg aggtgctgag tttggggacc tggagaccct ccaagcccat
       61 ccggccctgc agacattcca ggaggctccc ctctagtccc agccgcgctc cagcctcagg
      121 tgccgcccgc cagcttccgc cctcgacagc cgcgggcgtg ggagccgcag tgggccgggc
      181 gcggtctctc cttagctccc gcccccggcg cgtctccagc gggcgcagag ctcggcaagg
      241 cgctgggacg gtggggctct gcttgccatg gccccgggcc tgcggggcct cccgcggtgc
      301 ggcctctggc tgctgctggc tcaccatctc ttcatggtca ctgcctgccg ggaccctgac
      361 tatgggactc tcatccagga gctgtgcctc agccgcttca aggagaacat ggagactatt
      421 gggaagacgc tatggtgtga ctggggaaag accatacaga gctatgggga gctcacttac
      481 tgcaccaagc acgtggcgca cacgattggc tgtttctggc ccaatccgga agtggacaga
      541 ttcttcatcg ctgtccacca tcgatacttc agcaagtgcc ccatctcggg cagggccctg
      601 cgggaccctc ccaacagcat cctctgccct ttcattgcgc tccccattac ggtcacgctg
      661 ctcatgactg cactggtggt ctggaggagc aagcgcacag agggcatcgt gtaggtatcc
      721 caggtgatga gggattgggg aaccatgggc ctagcccagc aacagcatca ggagcaggtc
      781 ccaccttgca tcctgctcta gcctagttag cacaggactt gagagtggct ctgcattaag
      841 ctgaatatgc cctagccaga ggcttctagc aggggagcag gggcctgcct ctgcttacct
      901 ctgagattgt tctaagcacc aggtctctgg tacacttcat caccactgtg ggcattctga
      961 actccaagga agactgcaca gatgtgtttg tagatgcaca gtttgtgatt aaaagagtat
     1021 tcttaaacct gggaagtgtt ctgtctgggt acaaataacc tatacaggaa atcaagccac
     1081 tcgtggagat ctgtcttttg ctgaggagtt tatcgcaggg tctctaacca gatgacaccc
     1141 agtcaaagat cccctgagtt tgttgagggg ttcccaaatg attctgatgc ccttggcctc
     1201 tactgcatgg tccctgcttt ctttttgcct ttcttgggtt ttttgagaca gggtttctcc
     1261 atgtagctct ggctgtcctg gaacctgctc tgtaaaccaa actggacttg gactcagaga
     1321 tcctcctgcc tctgtctctc aggtgtgcac caccactgac tggcacagcc cctgctctta
     1381 gtacttggaa atagtcatga attaacaact agcgagagag aatgcctacc gtgagccaga
     1441 agcttcggct gagtagcacg tgaagagggt gctgtctctg tgtcccttcc ctaaaggtca
     1501 ccctgtcttc tctgagaaac cctagtgcat aggacaagtg aaggccaaga ggtgccaggg
     1561 atgtgacctc ctcctccact cagcactgtc ccttctgtcc ctgggaagcc atggacagta
     1621 gtgacagcat taatctgaaa aatagggttg agctatggca gcgtgtgcct ggaatcaaag
     1681 cactttgggg tgttgaggta gaaggattgc tgtgagtttg acgtcaacct gggatttata
     1741 agcctgttta taaaaaaaag aaaatgaggg ggaagggtgg ggaagaatga agaagagaca
     1801 gaggaaaaat gcaaaagaaa ataagactgg gctcatttgt gacctgaact ggagaccaga
     1861 gaccagcctg ccttcccgga ctttgacatg gaaatccaaa ggatgggaaa acaagacatg
     1921 cataagtcac agaatccaaa agctgcaaga gaaccaggga gctgacttgg gagatgaagc
     1981 tgacccagtg cctcgttccc ggaactgcgc atactaacaa gttctcaggg tttccagtaa
     2041 accaagaagg ctggggtttg aggtcatctg cagagcgtgg ccatcctgtg ctcagctaag
     2101 cagggggaca ggcaagggag cagtgagccc aagacccctc acacatgacc cctctcacag
     2161 gatgactgct tgtacaccag ccttccaggg aagcctggtc cgctgggagt ggatctccat
     2221 ccattcctca aaaatgagca ttagcggtat cctcctgaaa acaagtcaga agtgtggagc
     2281 agaagtcttg agtgtctgtt tgcagtcatt tctcttgtag gaactcatcc caagtacata
     2341 attaccatgt gcacaagggc ccgtggggac caggagcgga agagaggaga caccctcgat
     2401 ggtccaactg gaggactgct ccatcagatt aactccagat gatggaaggc aatggtttcc
     2461 ttaatggcgt ccttgggggt gggggggggg ggttcccagt gtgtgcagtt cattgaaaat
     2521 gcagatttta aaacaggaaa tcaaggtga
//
