LOCUS       NM_001159967            6914 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Ral GEF with PH domain and SH3 binding motif 2
            (Ralgps2), transcript variant 4, mRNA.
ACCESSION   NM_001159967
VERSION     NM_001159967.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6914)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6914)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6914)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6914)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   5  (bases 1 to 6914)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6914)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   7  (bases 1 to 6914)
  AUTHORS   Ceriani,M., Scandiuzzi,C., Amigoni,L., Tisi,R., Berruti,G. and
            Martegani,E.
  TITLE     Functional analysis of RalGPS2, a murine guanine nucleotide
            exchange factor for RalA GTPase
  JOURNAL   Exp Cell Res 313 (11), 2293-2307 (2007)
   PUBMED   17462626
  REMARK    GeneRIF: RalGPS2 was characterized.
REFERENCE   8  (bases 1 to 6914)
  AUTHORS   Martegani,E., Ceriani,M., Tisi,R. and Berruti,G.
  TITLE     Cloning and characterization of a new Ral-GEF expressed in mouse
            testis
  JOURNAL   Ann N Y Acad Sci 973, 135-137 (2002)
   PUBMED   12485849
REFERENCE   9  (bases 1 to 6914)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 6914)
  AUTHORS   Rebhun,J.F., Chen,H. and Quilliam,L.A.
  TITLE     Identification and characterization of a new family of guanine
            nucleotide exchange factors for the ras-related GTPase Ral
  JOURNAL   J Biol Chem 275 (18), 13406-13410 (2000)
   PUBMED   10747847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ104104.1, AK169368.1 and AC138109.3.
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169368.1, BC043132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                CJ104104.1         1-87
            88-2418             AK169368.1         6-2336
            2419-6914           AC138109.3         68765-73260         c
FEATURES             Location/Qualifiers
     source          1..6914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.71 cM"
     gene            1..6914
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /note="Ral GEF with PH domain and SH3 binding motif 2"
                     /db_xref="GeneID:78255"
                     /db_xref="MGI:MGI:1925505"
     exon            1..138
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            139..278
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1916
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /note="isoform b is encoded by transcript variant 4;
                     ras-specific guanine nucleotide-releasing factor RalGPS2;
                     ralA exchange factor RalGPS2; ral GEF with PH domain and
                     SH3-binding motif 2"
                     /codon_start=1
                     /product="ras-specific guanine nucleotide-releasing factor
                     RalGPS2 isoform b"
                     /protein_id="NP_001153439.1"
                     /db_xref="CCDS:CCDS48406.1"
                     /db_xref="GeneID:78255"
                     /db_xref="MGI:MGI:1925505"
                     /translation="MDLMNGQASSVTIAATVSEKSSSSESLSEKGSELKKSFDAVVFD
                     VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSF
                     WVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWA
                     LLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS
                     TGSILENEQRSNLMNNILRIISDLQQSCEYDIPILPHVQKYLNSVQYIEELQKFVEDD
                     NYKLSLKIEPGASTPRSAASREDLAGPDIGASPQGGRKSSAAAAAAAAAEGALLPQTP
                     PSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFPNAGPRHLLDDSVMEPHAPSRGQ
                     AESSTLSSGISIGSSDGSELSEETSWPAFESSAESEDLAVHLYPGAVTIQGVLRRKTL
                     LKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVVGWMVMMA
                     DDPEHPDLFLLTDSEKGNSYKFQAGSRMNAMLWFKHLSAACQSNKQQVPTNLMTFE"
     exon            279..383
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..434
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..518
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            519..608
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..701
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            702..828
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            829..966
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1057
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1125
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1282
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1434
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1489
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1595
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1688
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1794
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1886
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..6914
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2251
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /note="major polyA site"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2957
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4321
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
     regulatory      6896..6901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6914
                     /gene="Ralgps2"
                     /gene_synonym="1810020P17Rik; 2210408F11Rik;
                     4921528G01Rik; 9130014M22Rik"
ORIGIN      
        1 ggccggggtg gatccagcgc actcccctcc cccgagcgcc ggcggcaggc gctgaatgag
       61 agacgccgac tgctcggttg ggcgagcgat tgcctcggag ccgcgggcga agcggaggcg
      121 acggccgcgg ctgcacagga atgatgcatt tgtggccttg gacatgaagt aatcagacct
      181 ctgttgctgt tactgtaggc tcaggggctg atgaggaaag catggaccta atgaacgggc
      241 aggcaagcag tgttactatc gcagccactg tttccgagaa gagtagcagc tctgagtcac
      301 taagcgagaa gggctctgaa ttgaagaaaa gctttgatgc tgtggtgttt gatgttctta
      361 aggttacgcc agaagaatac gcgggtcaga taacactaat ggatgttcca gtgtttaaag
      421 ctattcagcc agatgaactt tcaagttgtg gatggaataa aaaagaaaaa tatagttctg
      481 caccaaatgc agttgctttc acaagaagat ttaatcacgt aagcttttgg gttgtaagag
      541 agattctcca tgctcaaaca ctgaaaataa gagcagaagt tttgagccac tatattaaga
      601 ctgctaagaa actatatgaa cttaacaacc ttcacgcact tatggctgtg gtttctggct
      661 tacagagtgc gccgattttc cggttgacta agacgtgggc gttattaagt cgaaaagaca
      721 aaactacctt tgaaaaacta gaatatgtaa tgagtaaaga agataactac aaaagactca
      781 gagactatat aagcagctta aagatgactc cttgcattcc ctatttaggc atctatttgt
      841 ctgacttgac ctacattgac tccgcgtacc catccaccgg cagcattcta gaaaatgagc
      901 aaagatcaaa tctgatgaac aacattcttc gaataatttc tgatttgcag cagtcctgtg
      961 aatatgatat tcccatattg cctcatgtcc aaaaatacct gaactctgtt cagtatatag
     1021 aagaactaca aaagtttgtg gaagacgata attacaagct ctccttaaag atagaaccag
     1081 gagcaagtac tccacgctcg gctgcctcca gggaggacct agcaggtcct gacataggcg
     1141 cctcacccca gggagggagg aagagtagtg ctgctgctgc tgccgccgcg gctgccgagg
     1201 gagccttact gccacagacg ccaccttccc ctcggaacct cattccacac ggacacagga
     1261 agtgccacag cctgggttac aatttcattc ataagatgaa cacagcagag tttaagagcg
     1321 caacgttccc aaacgcaggg ccacggcacc tgctggatga tagtgtcatg gagccgcacg
     1381 caccgtcgcg aggccaggct gagagctcta cactttccag tggaatatcc atagggagca
     1441 gtgatggttc tgaactaagc gaagagacct catggccggc ttttgaaagc tctgcggagt
     1501 cggaagattt ggcggtgcat ctgtaccccg gagctgttac tattcaaggt gtgctccgga
     1561 ggaaaacctt gctaaaagaa ggcaagaaac ccacagtagc atcttggaca aagtattggg
     1621 cagccttgtg tggaacacag cttttttact atgccgccaa atctctgaag gctacagaaa
     1681 gaaagcattt caaatcaacg tcaaataaga atgtgtctgt ggtgggctgg atggtgatga
     1741 tggctgacga cccagagcat ccagacctct ttctgctgac tgactccgag aaaggaaatt
     1801 catacaagtt tcaagctggc agcaggatga atgcaatgct gtggtttaaa cacttgagcg
     1861 cggcctgcca gagtaacaag caacaggttc ctacaaactt gatgactttt gagtaaacgc
     1921 ctgagacaga agaggagtgc tattgttccc gtgtggaacc gggacctgcc gagagcccca
     1981 gccgcaccat cccgtgccag gaagagcccc caggctccag cccagcctcc ggagctcaga
     2041 accaaaagca ctaatttcag ggaatgaagt gagatgttcc cagagaaaaa cgatggagtt
     2101 gcaaagcaaa ctgccatgaa cttcgcttct tctctccgaa ctgacctgtg gaagccactg
     2161 ccttaacaga gtgcgaggag agccgacacc aaatagtgtg tgtgcgtctt ctggcggtgc
     2221 tgtgcttgga ataaattgta gctaatttgc atttctttta actttgtact aattttggag
     2281 gggaaaccat cttttttaga tacactttaa aatggaaaaa catttcttat ggattccatc
     2341 aggagctgtt ttaggtgcag tgagaaatac cctgcaggtt ctgctcagcc tctgccagtg
     2401 gctgcctcac gttcccacag caagacctgg gagggacctg ctgtggaagc tgtgggtgca
     2461 ggctgggata gatagggagg gcatgcctcg ctttggatga gggatccatt taaacactac
     2521 cgtttggaat tgagggctag aaggagaaca tgatttcctg caggagggac aaaggctgag
     2581 tgttcacgtg ccagcaggct ccagaacaca ccagggttaa agtttaactt tctgtatgaa
     2641 ttcattgttg ggcccaaatc cgcataggag cacggtgatc ccgcgctcgg gtttctgtag
     2701 ccttttcaca agtcaggtgg gttatccagc cacgggtgtc ccagggaaga ccctggtgtt
     2761 tcttgtgctg ttgccccttg cagtgtttaa tgtgcagtat gccagactta ttttttattg
     2821 aatttgtttt tgttcagtat gaggttcaaa agcatacttg tttaaaaggt tcttcatgta
     2881 tatgtatgta ttttattgta agacaaagca attttaagaa gaataaaggc aaagtttgca
     2941 gttctaggaa ttgaaaatat aaaacctttt cttgtatgac ttcacaaaat gtaccagaac
     3001 attgtattca gaaagttact gtcggtcccc agtgtgaaaa ccatgtttgt tagtaactga
     3061 ccaagcattg gagagagctc tcctaggcaa taacacattt aatttttaaa acgaatgttg
     3121 gacttgacat agcttagaat tttaaccaaa aataacgctt gactgttgag ggtccccact
     3181 tttacagtgg ctccgtgtgc aaaggccttg actgacagac acctcctagc aaactgctct
     3241 ttgggtctca tgtaaaatgt ctcacattgt gtccttcaag aattgtatac tttatcagaa
     3301 gtattttatc accaagccca ttgagcttaa ctagaaaata ctgtctatac agtaattaca
     3361 gtaattagct aaaaaaaaga aattagtcca agagaaaatg aagagccttt tctgagtgtt
     3421 tctaatttga ataattcaaa gacgtcatgt gacagaaata ccttatttga gacttcctag
     3481 acaagcaggg aaaggcacat attgccgtga gagaatgatt tttcagataa cggtctaagc
     3541 taacccgtgt tgtgttgagt atacgcagac agatccgcag tggccagcgg ggctacagcg
     3601 caggctttcc ccgtgtgtct tacttttgtc ttgcctcttt tttttttttt tttttaaagc
     3661 aattccttag tttgttttgc tccagaataa tgttttaaat agtatgcata ctgtttttga
     3721 gatactgtga atgagagccc cgtggctgtt gtagtactac tctgtcatga atatgctaaa
     3781 gccgttacaa tgtaggtgaa tcaggtctgg ggagatgggc agctcgcaca ggccagcctc
     3841 acagttttgc caaagagaaa gggctgagat gggcgttgta tttggtacac ccagctctgg
     3901 acacttacgg gtgtgtagag gaagaaccgg attcagattt gatcagccag gccctattag
     3961 caccatggct cctggctgaa agtaaaacta tttttctacc ttgagattgc tctaaagatc
     4021 agtcattgct ttttaggatg attttagaaa ccgtgagaga tgcattagag taggtgagtt
     4081 gttttttatc tgtaattcac caaatggtat cagattataa ttgaagcaaa gaaaacattg
     4141 ccaaactata ttaaatattt gagtatttta cttactggag aatgaatcct gttatgctta
     4201 ccctcaggtg taaattagtt ctcaccagct catttcccac agacagtaaa gctcatttgt
     4261 ttctctcata gccaaggaga actctttcag aaactcgatt aaaatttaaa ctttacaagc
     4321 agaccgactg ggatattgta tgttctggta tgatagtgtg tagtagtagc catctctcat
     4381 ctaacaactg attcaaacag agaggcttat ttttcagcag tctgttttta aagtgtacct
     4441 gtaacaatga ctgcataatg ccccaagcac cgttttgggc tccatgtgct tgcttttcag
     4501 aatatttcaa tatgctggct aagctgtaag gatcaggaga gttgatggaa tgcagccttc
     4561 tgtttggttt cgttcagtgt gtatttgtgt aaacagttca gaaaggatct gccttgggat
     4621 tgtgtttttc cctctttgta ggcctatgtt cccgtagcag ttatttttct gtgtcaacag
     4681 gaccacccac tattgtgcca ccttcttaca ggctcttgat cctgacgttg agtcagtcac
     4741 agtgttcata actgcagagt ttgcagagtt tgatttatta gaagcccaac aagaacattg
     4801 ttatcccgga ggaatgagcc atgcttagcc cctccatggt tggagcaaag atggacacag
     4861 cctcgtcagt ctctggctgc atttcctctc caatgacctc agcagaaagt cttctcctga
     4921 gattaaatct gtaaattaca tacatctaaa actgaggcag tctattgatt ggaaatcagt
     4981 actaatagat ttaactcatt ggccttttaa gagaacatac ccttcctgtt tattgaggca
     5041 cattcctttc tacctggatt ttaagccatc atgcaaaacc tcctgcaaac aagagttact
     5101 ggtattgctt actggaagat tggctttagt cagaagaaat cctctgcccg caatgctttt
     5161 gaaagacttg gatccttttg aaatggatgc tgagctgcac tgtgcggggc aacagcagtg
     5221 aggaccactg ctgcttgtgg ggtgacagct agcggtggtt ggggtgtggc tgacaagcct
     5281 ccttttaggg cttgcattca ttttctttta tattatttct tagaaacgta gtgccatcct
     5341 ggttttatag ctgggggttt attgcttctt caagcctctg aggtacaaga attgctatta
     5401 aatagtattg atgataaatt gcctatgaac cacttcaaaa tgacttaagt accttttgga
     5461 tttgcttctc aaaaatggct tgtgtctaaa tttcagtttg agaatcttct gaagagatgt
     5521 gtacacacca gctcttcagc ccagtgaaag caatttcttt ttccctatct ccagccatag
     5581 tgtggggaaa ttgggtcagt gtctcagcga tctgaaggtc agtgttaggg cattgaggat
     5641 gactgggatc acctgcccac ctaaccccat gacttgaggg ccgtgcttgt ccctctctcc
     5701 acccactaaa tctggcagtc gtaaaggaga ctacagacat ttggatgctt gcaggcctct
     5761 catcttagat cttagttctt tttcagataa gcctccccca ccctgttgct ctcacgtcca
     5821 ggtaggtgag aaatagagcc actcaagtca gcctcttaat gttggctttg aagaacctcc
     5881 atcgagctga gtatacatat tttgtgttgt tttgagctta ggtttaatga tgaggcctgt
     5941 tggggaaatc cgaaaggagt aagatgcaca cagaagcagt tgttgagatg tcactaaagt
     6001 cctgtgatgg cagtgtgttg agccagaaat ggaacttatt tcagtttcct acttgagaca
     6061 gaaggaacaa gcagtccctt ctcctgcttg ttactgctga cttgaacaat ctttattagt
     6121 agtaggaatg gagcggcact aataataaat cagagggaag actcagccag ggcggggttt
     6181 ggaaacatct tgcttaagac cttggaagtc caggagatac catcatctga gtaggaacac
     6241 tgttttcagg gtccttagag aatagacaga cacacagaca caaggtcttt ggatacaagg
     6301 gaaggactag ctgttccttg ggggtttcag acggttggtc tgcaaaataa gagttacagg
     6361 tgtccataga gcacttgagg gtagaagaca gaaaatgcca aatatcagca ggatatttca
     6421 aatttatatg ccaagtaaaa aatgtcatgt ccctgaagat gtcacctgaa ctactcaaaa
     6481 ggattccaag aagtactaat ttaacaggtg tgactaaggt agctgagggg acactgaagt
     6541 gtttctcaag tgtttctgca ccttggctgt tgacactcgt tctttgacag cctactgaag
     6601 gacctggaag aaagaactca aacatctgta gggataatta cccaaagcta ataatctata
     6661 caaaacaaaa acaaaccaac ccacaagcca ttttcgttgt gtgttccagt taacttgagg
     6721 tacttaatga tgaaccattg gcttgcacta tgacctcctt gagtgatgtg caacttggct
     6781 cctctctgct tttgtttcgt tttaatatgc agaagtgagt gtgtgatctt cagtgtgttt
     6841 gcataagcta acctaaaatg aatttaacaa cagttttctg aaatatttct atcgaaataa
     6901 atgacttaaa agta
//
