LOCUS       NM_001145835            3653 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Mus musculus ral guanine nucleotide dissociation stimulator
            (Ralgds), transcript variant 1, mRNA.
ACCESSION   NM_001145835
VERSION     NM_001145835.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Fernandez-Pisonero I, Clavain L, Robles-Valero J, Lorenzo-Martin
            LF, Caloto R, Nieto B, Garcia-Macias C, Oeste CL, Sanchez-Martin M,
            Abad A, Hortal A, Caballero D, Gonzalez M, Dosil M, Alarcon B and
            Bustelo XR.
  TITLE     A hotspot mutation targeting the R-RAS2 GTPase acts as a potent
            oncogenic driver in a wide spectrum of tumors
  JOURNAL   Cell Rep 38 (11), 110522 (2022)
   PUBMED   35294890
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Wong R and Feig LA.
  TITLE     Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its
            interaction with Ras
  JOURNAL   Biochem Biophys Res Commun 480 (3), 468-473 (2016)
   PUBMED   27773821
  REMARK    GeneRIF: In this paper, we demonstrate a potential biochemical
            mechanism for such phenomena by showing that c-Met receptors
            promote the tyrosine phosphorylation of RalGDS at Y752 in its RBD,
            which blocks the binding of Ras to RalGDS.
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw
            BJ, Araki K, Ahmed R, Kaech SM and Craft J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Rifki OF, Bodemann BO, Battiprolu PK, White MA and Hill JA.
  TITLE     RalGDS-dependent cardiomyocyte autophagy is required for
            load-induced ventricular hypertrophy
  JOURNAL   J Mol Cell Cardiol 59, 128-138 (2013)
   PUBMED   23473774
  REMARK    GeneRIF: Data implicate RalGDS-mediated induction of autophagy and
            exocyst function as a critical feature of load-induced cardiac
            hypertrophy.
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Mishra PJ, Ha L, Rieker J, Sviderskaya EV, Bennett DC, Oberst MD,
            Kelly K and Merlino G.
  TITLE     Dissection of RAS downstream pathways in melanomagenesis: a role
            for Ral in transformation
  JOURNAL   Oncogene 29 (16), 2449-2456 (2010)
   PUBMED   20118982
  REMARK    GeneRIF: constitutive RalGEF activation had a major impact on
            several malignant phenotypes, particularly anchorage-independent
            growth, indicating that this often overlooked pathway should be
            more carefully evaluated as a possible therapeutic target.
            Erratum:[Oncogene. 2011 Apr 14;30(15):1850]
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A,
            Kelley GG and Der CJ.
  TITLE     Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in
            TC21/R-Ras2-mediated transformation
  JOURNAL   J Biol Chem 277 (12), 9966-9975 (2002)
   PUBMED   11788587
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Linnemann T, Kiel C, Herter P and Herrmann C.
  TITLE     The activation of RalGDS can be achieved independently of its Ras
            binding domain. Implications of an activation mechanism in Ras
            effector specificity and signal distribution
  JOURNAL   J Biol Chem 277 (10), 7831-7837 (2002)
   PUBMED   11748241
  REMARK    GeneRIF: we investigated the activation of RalGDS, one of the Ras
            effector proteins with guanine-nucleotide exchange factor activity
            for Ral.
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Wolthuis RM, Bauer B, van 't Veer LJ, de Vries-Smits AM, Cool RH,
            Spaargaren M, Wittinghofer A, Burgering BM and Bos JL.
  TITLE     RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating
            protein
  JOURNAL   Oncogene 13 (2), 353-362 (1996)
   PUBMED   8710374
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Albright CF, Giddings BW, Liu J, Vito M and Weinberg RA.
  TITLE     Characterization of a guanine nucleotide dissociation stimulator
            for a ras-related GTPase
  JOURNAL   EMBO J 12 (1), 339-347 (1993)
   PUBMED   8094051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY346626.1, AK159754.1, AK159020.1 and CF585220.1.
            
            [WARNING] On May 6, 2023 this sequence was replaced by
            NM_001145835.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159754.1, SRR1660815.168874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY346626.1         1-32
            33-2953             AK159754.1         3-2923
            2954-3614           AK159020.1         2911-3571
            3615-3653           CF585220.1         2-40                c
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..3653
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /note="ral guanine nucleotide dissociation stimulator"
                     /db_xref="GeneID:19730"
                     /db_xref="MGI:MGI:107485"
     exon            1..270
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            271..381
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            382..575
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            576..671
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            672..865
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1263
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1479
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1583
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1668
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1737
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1824
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1857
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1979
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2075
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2277
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2520
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2635
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..3626
                     /gene="Ralgds"
                     /gene_synonym="Gnds; mKIAA1308; Rgds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagcgcg gagccgcgcc ggccctgcgc cccgcgctgc cccgggtctc gcggcccgcc
       61 ggccacccgc gccaccgtga gtcgtccatg gtgcagcgca tgtgggctga ggcggccggg
      121 cccatagggg gcaccgagcc gttgtttccc ggttcccggc gcagccgcag cgtgtgggac
      181 gccgtgcgcc tggaggtggg cgtccccgac agctgcccag tggtgctgca cagcttcacg
      241 cagctcgacc ctgatctgcc gcgcctggag agctccacgc aggagattgg ggaggagctg
      301 atcaacgggg tcatctactc catctccctg cgcaaggtcc agctacacca aggagccact
      361 aagggccagc gctggctagg gtgtgagaac gagtcggctc tgaacctcta tgagacctgc
      421 aaggtgcgca cggtgaaggc tggtactctg gagaagctgg tggaacacct ggtgcctgcc
      481 ttccagggca gtgacctttc ctacgtcact gtcttcctgt gcacctacag agccttcact
      541 accacccagc aggtgctaga cctgctgttc aaaaggtacg gtagatgtga cgccctcacg
      601 gcctcctcta gatatggctg catcctcccc tactccagtg aggacggcgg accgcaggac
      661 caactcaaaa atgccatctc ctccatcctg ggcacctggc tggaccaata ctcagaggat
      721 ttctgtcaac ctccggactt tccctgcctc aagcagctgg tggcttatgt acagctcaac
      781 atgcctggct cagatctgga gcgccgcgct caccttctcc tggcccagct ggaggacctg
      841 gagcccagtg aggctgagtc tgaggccctg tccccagctc cagtgctgtc tctgaagcca
      901 gcttcacagc tagaacctgc actgctgctg acgcccagcc aagtggtgac atcaactcca
      961 gtacgagagc ccgctgcggc cccagtgcca gtgctggcct ccagcccagt ggtggcacca
     1021 gctcctgagc tagaaccagt tccagagcca cctcaagagc ctgagccatc cctagcactg
     1081 gctccagagc tggagcccgc cgtctcacag agcctggaac tggagtcagc tcctgtgccc
     1141 actcctgcct tagagccttc ctggtctctg cctgaagcca cggagaatgg actaaccgag
     1201 aagcctcacc ttctgctgtt ccctcctgac ttggtggctg aacagtttac tctgatggat
     1261 gcagaactat tcaagaaagt cgtgccctac cactgcctgg gctccatctg gtcccaacgg
     1321 gacaagaagg gcaaggagca cctcgcgcct accatccgcg ccactgtcgc ccagttcaac
     1381 aacgtggcca actgtgtcat tactacctgc cttggggacc agagtatgaa ggctccggac
     1441 agggcccggg tggtggaaca ctggatcgag gtggccaggg agtgcagagc gctcaagaat
     1501 ttctcctccc tctacgccat cctctctgct ctacagagca atgccatcca ccgcctaaag
     1561 aagacgtggg aagaggtctc cagggacagc tttcgagtgt tccagaaact gtcggagatc
     1621 ttctctgatg agaacaacta ctccctgagc agagagctgc tcatcaagga aggaacctcc
     1681 aagtttgcca cactggagat gaaccctagg agagcccaga ggcggcagaa ggagacagga
     1741 gtcatccagg gcaccgttcc ctacctgggc acattcctca ctgacctggt gatgctggac
     1801 actgccatga aggactatct ctatgggaga ctgatcaact ttgaaaagag aaggaaggag
     1861 ttcgaagtca ttgcccagat caagttgcta cagtcagcct gcaacaacta cagcattgct
     1921 ccggaagaac actttggaac atggttccga gctatggagc gactcagtga ggctgagagc
     1981 tacaccctgt cgtgtgagct ggagcccccg tctgagtcgg ccagcaacac cctgaggagc
     2041 aagaaaagca cagccattgt caagcgctgg agcgaccgcc aggctcccag cacggagctc
     2101 agcaccagta gcagtgccca ctccaagtcc tgtgaccagc ttcggtgcag cccttacctc
     2161 ggcagcgggg acatcaccga cgcgctcagt gtgcactcag ctggctcttc cagctctgat
     2221 gtggaggaga tcaacatgag cttcgtccca gagtctcctg atggccagga aaagaagttc
     2281 tgggagtcag cctcccagtc gtccccagag acctctggca tcagctccgc ctccagcagc
     2341 acctcctctt cgtcagcctc caccacgccc gtgtctacca cgcgcaccca caagcgctcc
     2401 gtctcagggg tctgcagcta cagctcctca ctgcctctct acaaccagca ggtgggcgac
     2461 tgctgcatca tcagggtcag cctggatgtg gacaacggca acatgtacaa gagcatcctg
     2521 gtgaccagcc aggataaggc tccgactgtc atccgaaaag ccatggacaa acacaaccta
     2581 gatgaggacg agccggagga ttatgagctg gtgcagatca tctcagagga tcacaagctg
     2641 aagattccag aaaacgccaa tgtgttctat gccatgaact ctaccgccaa ctatgacttc
     2701 atcctaaaga agcggacctt cactaagggg gctaaagtca agcatggagc cagctccacc
     2761 ctccctcgta tgaagcagaa gggactcagg attgccaaag gcatcttcta aggacgtctc
     2821 ctgggacggg ctgactggct ggagactaag cacttacaga ctagagtggc cctggccaca
     2881 caggtacctc tgcccacctg ccagtccagg ctacccccct actccacttt caccctgaac
     2941 ctctcctgct gccgggattg acacctgcca ctgacaggct gacctggcct ctggggacca
     3001 cttgccgcct tcggtgcctt ctgctctctg aaaccagagg actagctgac ttttgccaag
     3061 gagtgttgcc aactgggcat gggaccttgc ctgccctgga cactatccac cacactttgc
     3121 tgacacctcc ccaggtgcag atcactgcca cccatgctcc cggatgctcc aggacacaca
     3181 tacacccagc agggctgccg actgcattct ctccttgtgc ccacaggcac tggcctggga
     3241 ctttcatgga ggtcctagcc tttcctccca cactctagcc tttctcaggc tgcaccaaag
     3301 attccacctt cagggcctac agagtgaggg agcctcgccc accaggagcc caagccctcc
     3361 cttggatcag agagagaagc cctctcgtga actgcccggt tggtattgaa tcccagtcca
     3421 ctgaaagtgc cattgaccac cgctgcatcc gggctgtaca agacgacacg cagtgggagg
     3481 tttgtgggga ggaggaagac aactgaacat ttgtataaaa cgtaaaaagt ttactgattg
     3541 gggtgggaca atatttattt gttgtaaata gaaaatgcta gacttgaata ttatattaaa
     3601 atcccgtttc tactacggcc tggtcaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
