LOCUS       NM_001198949            3788 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ralA binding protein 1 (Ralbp1), transcript variant 2,
            mRNA.
ACCESSION   NM_001198949
VERSION     NM_001198949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Awasthi,S., Hindle,A., Sawant,N.A., George,M., Vijayan,M.,
            Kshirsagar,S., Morton,H., Bunquin,L.E., Palade,P.T., Lawrence,J.J.,
            Khan,H., Bose,C., Reddy,P.H. and Singh,S.P.
  TITLE     RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in
            Alzheimer's Disease
  JOURNAL   Cells 10 (11), 3113 (2021)
   PUBMED   34831336
  REMARK    GeneRIF: RALBP1 in Oxidative Stress and Mitochondrial Dysfunction
            in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3788)
  AUTHORS   Dominguez,S., Varfolomeev,E., Brendza,R., Stark,K., Tea,J.,
            Imperio,J., Ngu,H., Earr,T., Foreman,O., Webster,J.D., Easton,A.,
            Vucic,D. and Bingol,B.
  TITLE     Genetic inactivation of RIP1 kinase does not ameliorate disease in
            a mouse model of ALS
  JOURNAL   Cell Death Differ 28 (3), 915-931 (2021)
   PUBMED   32994544
  REMARK    GeneRIF: Genetic inactivation of RIP1 kinase does not ameliorate
            disease in a mouse model of ALS.
REFERENCE   3  (bases 1 to 3788)
  AUTHORS   Awasthi,S., Tompkins,J., Singhal,J., Riggs,A.D., Yadav,S., Wu,X.,
            Singh,S., Warden,C., Liu,Z., Wang,J., Slavin,T.P., Weitzel,J.N.,
            Yuan,Y.C., Awasthi,M., Srivastava,S.K., Awasthi,Y.C. and
            Singhal,S.S.
  TITLE     Rlip depletion prevents spontaneous neoplasia in TP53 null mice
  JOURNAL   Proc Natl Acad Sci U S A 115 (15), 3918-3923 (2018)
   PUBMED   29572430
  REMARK    GeneRIF: Rlip deficiency suppresses spontaneous malignancy in
            p53(-/-) mice.
REFERENCE   4  (bases 1 to 3788)
  AUTHORS   Wurtzel,J.G., Lee,S., Singhal,S.S., Awasthi,S., Ginsberg,M.H. and
            Goldfinger,L.E.
  TITLE     RLIP76 regulates Arf6-dependent cell spreading and migration by
            linking ARNO with activated R-Ras at recycling endosomes
  JOURNAL   Biochem Biophys Res Commun 467 (4), 785-791 (2015)
   PUBMED   26498519
  REMARK    GeneRIF: RLIP76 acts as a scaffold at recycling endosomes by
            binding activated R-Ras, recruiting ARNO to activate Arf6, thereby
            contributing to cell spreading and migration.
REFERENCE   5  (bases 1 to 3788)
  AUTHORS   Lee,S., Wurtzel,J.G. and Goldfinger,L.E.
  TITLE     The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and
            Rac signaling, cell spreading and migration
  JOURNAL   Biochem Biophys Res Commun 454 (4), 560-565 (2014)
   PUBMED   25450693
  REMARK    GeneRIF: The results show that ARNO interaction with the RLIP76
            N-terminus regulates cell spreading and motility via PI3K and Arf6,
            independent of RLIP76 control of Rac.
REFERENCE   6  (bases 1 to 3788)
  AUTHORS   Ring,H.Z., Vameghi-Meyers,V., Nikolic,J.M., Min,H., Black,D.L. and
            Francke,U.
  TITLE     Mapping of the KHSRP gene to a region of conserved synteny on human
            chromosome 19p13.3 and mouse chromosome 17
  JOURNAL   Genomics 56 (3), 350-352 (1999)
   PUBMED   10087204
REFERENCE   7  (bases 1 to 3788)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   8  (bases 1 to 3788)
  AUTHORS   Yamaguchi,A., Urano,T., Goi,T. and Feig,L.A.
  TITLE     An Eps homology (EH) domain protein that binds to the Ral-GTPase
            target, RalBP1
  JOURNAL   J Biol Chem 272 (50), 31230-31234 (1997)
   PUBMED   9395447
REFERENCE   9  (bases 1 to 3788)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 3788)
  AUTHORS   Park,S.H. and Weinberg,R.A.
  TITLE     A putative effector of Ral has homology to Rho/Rac GTPase
            activating proteins
  JOURNAL   Oncogene 11 (11), 2349-2355 (1995)
   PUBMED   8570186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ146118.1 and BC067073.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054329.1, AK159404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               CJ146118.1         2-493
            493-3788            BC067073.1         252-3547
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 35.26 cM"
     gene            1..3788
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /note="ralA binding protein 1"
                     /db_xref="GeneID:19765"
                     /db_xref="MGI:MGI:108466"
     exon            1..246
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            247..545
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..2248
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="DNP-SG ATPase; dinitrophenyl S-glutathione ATPase;
                     Ral-interacting protein 1"
                     /codon_start=1
                     /product="ralA-binding protein 1"
                     /protein_id="NP_001185878.1"
                     /db_xref="CCDS:CCDS37678.1"
                     /db_xref="GeneID:19765"
                     /db_xref="MGI:MGI:108466"
                     /translation="MTECFLPPSSSPSEHRRAEHGSGLTRTPSSEEISPTKFPGLYRT
                     GEPSPPHDVLHEPPDTVSDDDKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSK
                     VKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVV
                     KQWKEKKKKKKPIQEPEVPQMDAPSVKPIFGVPLVDAVERTMMYDGVRLPAVFRECVD
                     YMEKHGMKCEGVYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPE
                     NLLTKELMPRFEEACGKTTEMEKVQEFQRLLRELPECNHLLLSWLIVHLDHVIAKELE
                     TKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRWSNMATMPTLP
                     ETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQE
                     CETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIA
                     SEKEEIDRLRAEIAEIQSRQQHGRSETEEYSSDSESESEDEEELQLILEDLQRQNEEL
                     EIKNNHLNQAVHEEREAIIELRVQLRLLQMQRAKSEQQPQEEEEPERRGGIGPPPCDG
                     VLEVRVAKEQAKASPSKDRKETPI"
     exon            546..1004
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1354
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1516
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1648
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1756
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1878
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2002
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..3783
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2458..2463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /note="hexamer: AATAAT"
     polyA_site      2490
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /note="major polyA site"
     polyA_site      3645
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
                     /note="hexamer: ATTACA"
     polyA_site      3693
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
     polyA_site      3715
                     /gene="Ralbp1"
                     /gene_synonym="Rip1; RLIP76"
ORIGIN      
        1 ggccaaggag ccgaggaccc gggaagccgg ctgcggcggg aggagggcgt gcgcgtgcgc
       61 gctgggccgg ctcgtcctgt tctgtcccaa tcattgtaaa caggcgaagg ctgggcgggg
      121 tgggaatggg gctcccgcgg ccggcccggg gtgcagcgca ggaggcggcg gttgtggcgg
      181 aagcgtgagt gcgaggaggc ggcggcggct gcagcggagc ggacggtcgc tcggcggcag
      241 gcactggtgt aatggatagg taacagagaa gaccacttcc cttcctcggc agggcatcag
      301 catgactgag tgcttcctgc ccccgagcag cagccctagt gaacaccgca gggccgagca
      361 tggcagcggg ctgacccgga cccccagctc tgaggagatc agtcctacaa agttccctgg
      421 attgtaccgg acaggcgagc cctcgcctcc ccatgacgtc ctccatgagc ctcctgatac
      481 agtgtcagat gacgacaaag accatggaaa gaaaaaaggg aaatttaaga aaaaggagaa
      541 aaggactgaa ggctacgctg ccttccagga agacagctct ggagatgaag ctgaaagtcc
      601 ttccaaggtg aagaggtcca agggaatcca tgtgttcaaa aagcccagtt tctctaaaaa
      661 gaaggaaaaa gattttaaaa tcaaagaaaa acccaaagaa gaaaagcata aagaagaaaa
      721 gcacaaagag gaaaagcata aagaaaagaa atcgaaagac ttgacagcag ctgatgttgt
      781 taaacagtgg aaggaaaaga agaaaaagaa aaagccaatt caggagccag aggtgcctca
      841 gatggacgca ccgagtgtca agcccatttt tggggttccc ttggttgacg cagtagagag
      901 gaccatgatg tacgacggcg tccggctgcc agctgtcttc cgggagtgtg tggactacat
      961 ggagaagcac ggcatgaagt gtgaaggcgt ctaccgggtg tcaggaatca aatcaaaggt
     1021 agatgagcta aaagcagcct atgaccgaga ggagtctcca aacttagaag aatatgagcc
     1081 taacactgta gccagcttgc tgaagcagta tttgcgagac cttccagaga atttgcttac
     1141 caaagagctt atgccccggt ttgaagaggc ttgtgggaag accacagaga tggagaaagt
     1201 gcaggaattc cagcgcttgc tccgggaact gccggagtgc aatcatcttc tgctttcctg
     1261 gctcattgtg cacctggacc acgtcattgc gaaggagctg gaaacgaaga tgaacatcca
     1321 gaacatctct atagtgctga gccccaccgt gcagatcagc aatcgggtcc tgtacgtgct
     1381 tttcacacat gtgcaagagc tctttggcac cgtggtcctg aagcaagtaa caagacctct
     1441 gcgctggtcc aacatggcca cgatgcccac actgccagag acccaagcag gcatcaagga
     1501 ggagatcagg agacaggagt tccttttgaa ttgtttacat cgagatctgc agggcgggat
     1561 aaaggactta tctaaagaag aaagattatg ggaagtacag aggattctga ctgccctcaa
     1621 gagaaagctg agggaagcta aaagacaaga gtgtgaaacc aagattgcac aggagatagc
     1681 tagtctttca aaagaggatg tttccaaaga agaaatgaat gaaaacgaag aagttataaa
     1741 tatccttctt gcccaggaga atgaaatcct gacagaacag gaggagctcc tggccatgga
     1801 gcagttcctg cgtcgtcaga tcgcctcaga gaaagaagag atcgaccgcc tccgagctga
     1861 aattgcggag atccagagcc gtcagcagca tggccgcagt gagacggagg agtactcgtc
     1921 cgacagcgag agtgagagcg aggacgagga ggagctgcag ctcatcctgg aggacctgca
     1981 gcggcagaac gaggagttag aaataaagaa caatcacttg aaccaagcag tccatgagga
     2041 gcgggaggcc atcatcgagc tccgagtgca gctccggctg ctccagatgc agcgagccaa
     2101 gtctgagcag cagccgcagg aggaggagga gcccgagagg cgagggggca taggcccacc
     2161 gccctgtgac ggtgtcctcg aggtgcgggt agccaaggag caggcgaagg cctcgcccag
     2221 caaagaccgg aaggagacgc ccatctgagc tgcgggccgg gccctgtgca tcttactgtg
     2281 agtgtgagtg agccgcctgc ctgctggaca ctctgtaaag gctcgctctc agagacgtcc
     2341 cctctcacac acgtctgact ccgtgtcagg ctcagggcct gggaggctga agcagtggac
     2401 acacgggggg cttgcaggga acacaggcat ttccagatag tgtcagctta tttgaaaaat
     2461 aattttcttt gttaaaaata actattttaa cctttgagtg gcttcttttt aaaccaaaaa
     2521 ttcttttctt tggctttttt tttttaaatc acagcagaat caggctctct ttcttatcaa
     2581 agggtaggaa ccaaatcagg tcacttctgc gcctgcctcg tggacgctcg tggtctcccc
     2641 agccctgcag ggtctctggc cactcttgtt tgtgccttcc acaccttttg gtgcagattg
     2701 ttcagtgggg agctgcctca tattctctga ctggccagaa aggctctcgc tggggttccc
     2761 tgcaccacgt tgcttttcca cttccgagtt gggtctgtct gtgtgagtca ggacggccca
     2821 ggttggtggc agacagaagt tacctgtgca gcctgccacc agcctgggca gtgcaagcca
     2881 ctcactcact gccagggatc agcaaaggcc tcttctctga ggtggtcgga ggtgaccacc
     2941 ttgactctga ggcgttgcac aggaagcttc tcaaaccaga gcccttctcc acactgacct
     3001 tccaagaaaa ccacagtgac ttcagctgct agcttgggct aggatacaca cctctgccag
     3061 gataagccat gtaaatgctc tcacgcagaa cgttcacctt tccgcgtcat ctcaaggggc
     3121 tgctataagg actctgacag aaccgagccg aaccggtagc tgtgactgac cccacctggt
     3181 gtttgcttct aactcagatg actgctcccc gagtctggga ggcctgcctc ttaggcagcc
     3241 agatctcact gtcagatgag tggcccccag ggaggtcccc tgtggctctg aagacaaatc
     3301 ccacactcta aagtgagcga caaacccaca ggagggctct ggtctcctcc tagttagtat
     3361 ttatttcagc gcctgtcttt tgtgcggttt tttgttcgcc tctgcctatt gcactgttgt
     3421 gacttgttgg ccattatttg atttttgtac ggaaaaaaag ctttgttata gaaatcagca
     3481 tactattttt ttaaatctgg agagaagata ttatggtgac tggaaatatg gtcaggtgtc
     3541 aaatataaat gtacaaacgc cttgctgcat cccgtccggt gtacaacatc cactttatat
     3601 ttgctggcaa tattgaagaa ttctttttgt ttgtgtaaac tctaatttct atcaaggtat
     3661 catgggtttt taaaattagt atttcattac aaatgtctcg atgttggtta actaattttt
     3721 gccaggacca ttattgatca aggaaataaa ttcaacagcc atttgagaaa aaaaaaaaaa
     3781 aaaaaaaa
//
