LOCUS       NM_022327               2293 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus v-ral simian leukemia viral oncogene B (Ralb), mRNA.
ACCESSION   NM_022327
VERSION     NM_022327.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   DeGeer,J., Datwyler,A.L., Rickenbach,C., Ommer,A., Gerber,D.,
            Fimiani,C., Gerber,J., Pereira,J.A. and Suter,U.
  TITLE     Ral GTPases are critical regulators of spinal cord myelination and
            homeostasis
  JOURNAL   Cell Rep 40 (13), 111413 (2022)
   PUBMED   36170840
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Naszai,M., Bellec,K., Yu,Y., Roman-Fernandez,A., Sandilands,E.,
            Johansson,J., Campbell,A.D., Norman,J.C., Sansom,O.J., Bryant,D.M.
            and Cordero,J.B.
  TITLE     RAL GTPases mediate EGFR-driven intestinal stem cell proliferation
            and tumourigenesis
  JOURNAL   Elife 10, e63807 (2021)
   PUBMED   34096503
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Ommer,A., Figlia,G., Pereira,J.A., Datwyler,A.L., Gerber,J.,
            DeGeer,J., Lalli,G. and Suter,U.
  TITLE     Ral GTPases in Schwann cells promote radial axonal sorting in the
            peripheral nervous system
  JOURNAL   J Cell Biol 218 (7), 2350-2369 (2019)
   PUBMED   31201267
  REMARK    GeneRIF: While lack of only one Ral GTPase was dispensable for
            early peripheral nerve development, ablation of both RalA and RalB
            resulted in persistent radial sorting defects, associated with
            hallmarks of deficits in Schwann cell process formation and
            maintenance.
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Peschard,P., McCarthy,A., Leblanc-Dominguez,V., Yeo,M.,
            Guichard,S., Stamp,G. and Marshall,C.J.
  TITLE     Genetic deletion of RALA and RALB small GTPases reveals redundant
            functions in development and tumorigenesis
  JOURNAL   Curr Biol 22 (21), 2063-2068 (2012)
   PUBMED   23063435
  REMARK    GeneRIF: findings show either RALA or RALB is sufficient for tumor
            growth; either RALA or RALB is sufficient for cell proliferation;
            RALA and RALB act in a redundant fashion
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Corrotte,M., Nyguyen,A.P., Harlay,M.L., Vitale,N., Bader,M.F. and
            Grant,N.J.
  TITLE     Ral isoforms are implicated in Fc gamma R-mediated phagocytosis:
            activation of phospholipase D by RalA
  JOURNAL   J Immunol 185 (5), 2942-2950 (2010)
   PUBMED   20679536
  REMARK    GeneRIF: Endogenous RalB plays a negative role in the ingestion
            process of Fc gamma receptor-mediated macrophage phagocytosis.
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Zhao,Z. and Rivkees,S.A.
  TITLE     Tissue-specific expression of GTPas RalA and RalB during
            embryogenesis and regulation by epithelial-mesenchymal interaction
  JOURNAL   Mech Dev 97 (1-2), 201-204 (2000)
   PUBMED   11025226
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Shao,H. and Andres,D.A.
  TITLE     A novel RalGEF-like protein, RGL3, as a candidate effector for rit
            and Ras
  JOURNAL   J Biol Chem 275 (35), 26914-26924 (2000)
   PUBMED   10869344
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237628.1, AK159993.1, AK033193.1 and BE943587.1.
            
            On May 7, 2009 this sequence version replaced NM_022327.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159993.1, AK033193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY237628.1         13-68
            57-1219             AK159993.1         2-1164
            1220-2260           AK033193.1         1075-2115
            2261-2293           BE943587.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.29 cM"
     gene            1..2293
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /note="v-ral simian leukemia viral oncogene B"
                     /db_xref="GeneID:64143"
                     /db_xref="MGI:MGI:1927244"
     exon            1..206
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            207..369
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..876
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /EC_number="3.6.5.2"
                     /note="v-ral simian leukemia viral oncogene homolog B (ras
                     related)"
                     /codon_start=1
                     /product="ras-related protein Ral-B"
                     /protein_id="NP_071722.1"
                     /db_xref="CCDS:CCDS15225.1"
                     /db_xref="GeneID:64143"
                     /db_xref="MGI:MGI:1927244"
                     /translation="MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYE
                     PTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFT
                     ATAEFREQILRVKSEEDKIPLLVVGNKSDLEERRQVPVDEARGKAEEWGVQYVETSAK
                     TRANVDKVFFDLMREIRAKKMSENKDKNGRKSSKSKKSFKERCCLL"
     exon            370..578
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..756
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            757..2277
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2252..2257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2274
                     /gene="Ralb"
                     /gene_synonym="5730472O18Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggagggctgc ctctggagag gacagggttg ccgggcggac agcgggaacg cgctccgggg
       61 ggtggggacg cgcgagctca ccactcctca atgacaaatc gactggggac agctggggtc
      121 cggccccagg acggggcggg gcgctcgtga gagcggcgat tctggttgtg cgcatagcca
      181 gagcggcggt gggacggctc ccccagctcc tcacctgggc cacctgtccg tgtgtcacca
      241 cctccgacca gcaggatggc tgccaacaag ggcaagagcc agggctccct ggtacttcac
      301 aaggtcatca tggttggcag tggaggggtc ggcaaatcag ccctgacgct tcagttcatg
      361 tatgatgagt ttgtagaaga ctatgagccc accaaagctg acagttacag aaagaaggtg
      421 gttctcgacg gagaagaggt ccagatagac atcctggaca ccgctggcca ggaggactat
      481 gcggccatcc gtgacaacta cttccgaagc ggagaaggct ttctgctggt gttctccatc
      541 acagagcacg agtctttcac agccacagcc gagttcaggg aacagattct ccgagtcaag
      601 tcagaggagg acaagatccc actgctggtc gtgggcaaca agtccgacct ggaggagcgg
      661 aggcaggtgc ctgtggacga ggcccgaggc aaagcggagg agtggggtgt gcagtacgtg
      721 gagacatctg caaagacccg cgccaatgtg gacaaggtat tctttgatct gatgagagaa
      781 atccgggcaa aaaagatgtc agaaaacaag gacaagaacg gcaggaaaag cagcaagagc
      841 aagaaaagtt tcaaagagcg atgctgcttg ctgtgagcgg gctgcagact gacgcagcag
      901 agtgggccac actgcagcgc agcgagccgg aggtggcctc ccagctggct ccccattcgc
      961 tctccacaac tgcattcact atcacttctt gagatgggac agatatccgt gcgtcagtgg
     1021 ctggcagaag aaagacgcct ttgtctgtgt aatgcctctg ttaactttgc caggagcttt
     1081 gagagtctgc cctctcccac ccttcctgaa ccatgaccac caccagctct agggtcgtaa
     1141 tgttggagat caggaatatt ggttgtgatg acaagaaaga gcccacttac tcctcctcgt
     1201 tctaggacac ggtcatcttt ccttaggaaa ttaaaatgct tcatattatc tgggcatggt
     1261 ggtgcacccc tgtagtctca gaactctaga aggtaaggca gggagggtag cctgagccca
     1321 aggccagcct gggctaccta acaagaccct gtctctaaaa gaaaaaagaa ttaacatctt
     1381 attttcttag attttaagag agagtctctg gcaagacccc cctcatcagt tctaatcatt
     1441 ttagaagtag acagaaaaaa atatctaagc tcaggtaata ctgaaaaagc caaaatgttt
     1501 tgtttcgttt cttttttttt ttttttttta aagataaact tgtgtagttt ggaagcagat
     1561 ttagaaagat gaacttcact tgggccagat aggctgaacc aagcttcctg gcgtttgtag
     1621 agaaagtggg acgctgttct cttcatattt aaatgccagc caggtgctgg ctgtgggctt
     1681 tccctcctca acacccttat ttagaaagga aactgtgtgg ggggagatgc aggcctgagc
     1741 cccatagcga gcttgccttt tctgactggg tcttctggtc ccccctacac cagccatagg
     1801 cctgttcttt ttcttccttc tgaaaactgt gaccagttca aattatgact cagaacgtag
     1861 ggccagcacc agctacctct gcagactccc agtgactctc tcttcacaag cagatgaagg
     1921 gaaggctcag aagggcatct cctgtagctc ctggcagctg gttctggtgg cactgagatg
     1981 agtgccacca gaggctcaca ctcactctct gttgagcttc ttcccaggga aggggattct
     2041 gggacagggg gctgccacta agcacacaca ctcctcctat tttccagaag tgaacatttc
     2101 atgtttaggt gccgaatgtg aatctgggtg gggagagcgg gagcccttcg aatggatttt
     2161 ttttttcttt ttttacagag gttatgggaa ctaaggtctg atccctggaa actgatcttg
     2221 tgtcacttcc aaagaatcat gggctttttc gaataaaaaa atttacactt ttcaggaaaa
     2281 aaaaaaaaaa aaa
//
