LOCUS       NM_019491               2662 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus v-ral simian leukemia viral oncogene A (ras related)
            (Rala), mRNA.
ACCESSION   NM_019491 XM_985790 XM_985825
VERSION     NM_019491.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   Xia,W., Veeragandham,P., Cao,Y., Xu,Y., Rhyne,T.E., Qian,J.,
            Hung,C.W., Zhao,P., Jones,Y., Gao,H., Liddle,C., Yu,R.T.,
            Downes,M., Evans,R.M., Ryden,M., Wabitsch,M., Wang,Z., Hakozaki,H.,
            Schoneberg,J., Reilly,S.M., Huang,J. and Saltiel,A.R.
  TITLE     Obesity causes mitochondrial fragmentation and dysfunction in white
            adipocytes due to RalA activation
  JOURNAL   Nat Metab 6 (2), 273-289 (2024)
   PUBMED   38286821
  REMARK    GeneRIF: Obesity causes mitochondrial fragmentation and dysfunction
            in white adipocytes due to RalA activation.
REFERENCE   4  (bases 1 to 2662)
  AUTHORS   Chan,M.P., Takenaka,N. and Satoh,T.
  TITLE     Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in
            Skeletal Muscle of the Leptin-Deficient Obese Mouse
  JOURNAL   Int J Mol Sci 24 (14), 11531 (2023)
   PUBMED   37511290
  REMARK    GeneRIF: Impaired Insulin Signaling Mediated by the Small GTPase
            Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2662)
  AUTHORS   DeGeer,J., Datwyler,A.L., Rickenbach,C., Ommer,A., Gerber,D.,
            Fimiani,C., Gerber,J., Pereira,J.A. and Suter,U.
  TITLE     Ral GTPases are critical regulators of spinal cord myelination and
            homeostasis
  JOURNAL   Cell Rep 40 (13), 111413 (2022)
   PUBMED   36170840
REFERENCE   6  (bases 1 to 2662)
  AUTHORS   Perou,C.M., Perchellet,A., Jago,T., Pryor,R., Kaplan,J. and
            Justice,M.J.
  TITLE     Comparative mapping in the beige-satin region of mouse chromosome
            13
  JOURNAL   Genomics 39 (2), 136-146 (1997)
   PUBMED   9027500
REFERENCE   7  (bases 1 to 2662)
  AUTHORS   Park,S.H. and Weinberg,R.A.
  TITLE     A putative effector of Ral has homology to Rho/Rac GTPase
            activating proteins
  JOURNAL   Oncogene 11 (11), 2349-2355 (1995)
   PUBMED   8570186
REFERENCE   8  (bases 1 to 2662)
  AUTHORS   Jenkins,N.A., Justice,M.J., Gilbert,D.J., Chu,M.L. and
            Copeland,N.G.
  TITLE     Nidogen/entactin (Nid) maps to the proximal end of mouse chromosome
            13 linked to beige (bg) and identifies a new region of homology
            between mouse and human chromosomes
  JOURNAL   Genomics 9 (2), 401-403 (1991)
   PUBMED   1672300
REFERENCE   9  (bases 1 to 2662)
  AUTHORS   Drivas,G., Massey,R., Chang,H.Y., Rush,M.G. and D'Eustachio,P.
  TITLE     Ras-like genes and gene families in the mouse
  JOURNAL   Mamm Genome 1 (2), 112-117 (1991)
   PUBMED   1686838
REFERENCE   10 (bases 1 to 2662)
  AUTHORS   Justice,M.J., Silan,C.M., Ceci,J.D., Buchberg,A.M., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     A molecular genetic linkage map of mouse chromosome 13 anchored by
            the beige (bg) and satin (sa) loci
  JOURNAL   Genomics 6 (2), 341-351 (1990)
   PUBMED   2307475
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT009754.11.
            
            On Nov 17, 2006 this sequence version replaced NM_019491.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031741.1, SRR7345562.5032854.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               CT009754.11        131961-132161       c
            202-351             CT009754.11        84897-85046         c
            352-560             CT009754.11        81066-81274         c
            561-735             CT009754.11        76451-76625         c
            736-2662            CT009754.11        68519-70445         c
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.05 cM"
     gene            1..2662
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /note="v-ral simian leukemia viral oncogene A (ras
                     related)"
                     /db_xref="GeneID:56044"
                     /db_xref="MGI:MGI:1927243"
     exon            1..201
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..351
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..560
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..735
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..2662
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /note="hexamer: AATAAA"
     polyA_site      926
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /note="major polyA site"
     regulatory      2641..2646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /note="hexamer: AATAAA"
     polyA_site      2662
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /note="major polyA site"
ORIGIN      
        1 gctgctgcag agcggccggg aggagggtgg gtctccctag agcggagcgc cggagtcctc
       61 ctcctccgcc gccgcccagg ccgccgccgc tgccgccgcc ctccggactc ctcttgccgc
      121 gccccgcgcg gaactccgag cgcggtccga tcggcgcagc cgaggcccaa gagcccgcgg
      181 gtcgagcggc tcgcggtgca gatttttctt aatcctctga ggactctgga aaacaggatg
      241 gctgcaaaca agcccaaggg tcagaattct ttggccttac acaaagtcat catggtgggc
      301 agtggtggtg tgggcaagtc tgccctgact ctgcagttca tgtacgacga gtttgtagag
      361 gactatgaac ctaccaaagc ggacagctac aggaagaagg tagtcctgga cggggaagaa
      421 gtgcagatcg acatcttaga tacagcgggg caggaggact atgctgcaat tagagacaac
      481 tacttccgaa gtggggaggg attcctctgt gtcttctcta tcacagagat ggagtccttc
      541 gcagctaccg cggacttcag ggagcagatt ttaagagtaa aagaagatga gaatgttcca
      601 tttctcctgg ttggtaacaa gtcagatcta gaagataaaa ggcaggtttc tgtagaagag
      661 gcaaaaaaca gagctgacca gtggaacgtt aactatgtgg agacgtctgc taaaacgcgc
      721 gccaacgttg acaaggtatt ttttgattta atgagggaaa tacgagccag aaagatggaa
      781 gacagcaaag aaaaaaatgg aaaaaagaag aggaaaagtt tagccaagag aatcagagaa
      841 agatgctgca ttttataatc aaagcccaaa ctcctttctt atcctgacct gaccatacta
      901 ataaatataa tttataagca ttgccattgg aggctcaatt gactgaaatt actttaacat
      961 tttggaaatt gttatgtatc actaaaagca tgaattggaa ctgcactgga agtcaaattc
     1021 acttaaaaaa gaaattgtgt ggcttcacca agaagcagag ttcaacttat ttcataattg
     1081 cctacattta tcacagtcct gaatgtagcg tgtaagcttg gttttttttt gggggggggg
     1141 cagtctttct caaactgtta atcaagaggt aagatggggg cggggaagaa atgaccattt
     1201 cctctggtgt ttattataaa gcttaaattt tatattattt taaaatgtct tggtcttcta
     1261 ctgccttgaa aaatgacaat tgtgaacacg atagttaact gtactacttt ttaagctgtt
     1321 gttatgcaaa tcttgaagaa gttactggca tggttgttgc atatagtaaa actgagagta
     1381 attcacctgt gaatctgcat attaattacc tgatgattaa cttagaaaag agatgggaac
     1441 ttattataca tggacatttt tgaatatgcc ttaatttaga aactgaaaaa taatccagtg
     1501 acatcattct gggtgtgttc tcactagctc gcggggccac ttgctgccca tgtgacgaat
     1561 aacagaagat cttatcttgc caggccgtgg agagctacaa gaaagattcc tgagaaatgt
     1621 ccaactgcta ggagtctgac caaattacag atgtgtgcca tactctggtt cttagagttc
     1681 cagagctcct tcattggttt taataaactc taaggtagtt aaagatgaag ggccagcata
     1741 tatttatatg ataagtttag attatgagcg tgagtaccaa ttaagtttga atgaatgccc
     1801 cttttatgta gagtgctggt ccccagtcat tgctgtctgc aagtgatgcg catttaagtg
     1861 tttaatctcc tgggagcagg gcacagggaa gactatgagg agagctaatg tggtctgtac
     1921 aaggacactg gaggaagtat gtttgctacc tgtaagttct aaatgtgtac tcctgaggtt
     1981 acagtttggg tgttaggaga agtctttgta gtctctttat gttcataatg aatactgtat
     2041 caatatttcc taacatgaag cagtcaaaca tgtatggcac atactgacca gacgtcagtc
     2101 tgtgatgttt ccgctgcaag aattcaagca tgctgttagg aatgtaattt caatgggaag
     2161 taaaccacta ttaggttttt tttcttttcc tctgtggggc taagacactt gattaaacag
     2221 tttttcttgt tgcacagtcc taatttcata aggtcaagga gacactcagg cattccagga
     2281 aacaaatgtg tacatgatgt taccagaaac aggcattcag gaactctact gtctagatac
     2341 tacattcagc ttaccataaa tatttgtcct tgaagggttt gatttaatat tttcacagac
     2401 taggccatgt gcaaaattag agttccctgt gtaaccccag ccagcaggcc cagcatggct
     2461 gcgtgcactc attgcagtct tgttgaacca gggtcctaac cactaacatt gcaatttgct
     2521 ttgagacctt ccctgtcctg ggtactaggt gctatgaagc cagctgacag aagcatcaca
     2581 tgtcttgggc tgatgccgct acccggttca tttatttgca atttgagcca tttaaagacc
     2641 aataaaattc cttttctata aa
//
