LOCUS       NP_062364                206 aa            linear   ROD 27-APR-2025
DEFINITION  ras-related protein Ral-A [Mus musculus].
ACCESSION   NP_062364 XP_990884 XP_990919
VERSION     NP_062364.3
DBSOURCE    REFSEQ: accession NM_019491.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Xia,W., Veeragandham,P., Cao,Y., Xu,Y., Rhyne,T.E., Qian,J.,
            Hung,C.W., Zhao,P., Jones,Y., Gao,H., Liddle,C., Yu,R.T.,
            Downes,M., Evans,R.M., Ryden,M., Wabitsch,M., Wang,Z., Hakozaki,H.,
            Schoneberg,J., Reilly,S.M., Huang,J. and Saltiel,A.R.
  TITLE     Obesity causes mitochondrial fragmentation and dysfunction in white
            adipocytes due to RalA activation
  JOURNAL   Nat Metab 6 (2), 273-289 (2024)
   PUBMED   38286821
  REMARK    GeneRIF: Obesity causes mitochondrial fragmentation and dysfunction
            in white adipocytes due to RalA activation.
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Chan,M.P., Takenaka,N. and Satoh,T.
  TITLE     Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in
            Skeletal Muscle of the Leptin-Deficient Obese Mouse
  JOURNAL   Int J Mol Sci 24 (14), 11531 (2023)
   PUBMED   37511290
  REMARK    GeneRIF: Impaired Insulin Signaling Mediated by the Small GTPase
            Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 206)
  AUTHORS   DeGeer,J., Datwyler,A.L., Rickenbach,C., Ommer,A., Gerber,D.,
            Fimiani,C., Gerber,J., Pereira,J.A. and Suter,U.
  TITLE     Ral GTPases are critical regulators of spinal cord myelination and
            homeostasis
  JOURNAL   Cell Rep 40 (13), 111413 (2022)
   PUBMED   36170840
REFERENCE   6  (residues 1 to 206)
  AUTHORS   Perou,C.M., Perchellet,A., Jago,T., Pryor,R., Kaplan,J. and
            Justice,M.J.
  TITLE     Comparative mapping in the beige-satin region of mouse chromosome
            13
  JOURNAL   Genomics 39 (2), 136-146 (1997)
   PUBMED   9027500
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Park,S.H. and Weinberg,R.A.
  TITLE     A putative effector of Ral has homology to Rho/Rac GTPase
            activating proteins
  JOURNAL   Oncogene 11 (11), 2349-2355 (1995)
   PUBMED   8570186
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Jenkins,N.A., Justice,M.J., Gilbert,D.J., Chu,M.L. and
            Copeland,N.G.
  TITLE     Nidogen/entactin (Nid) maps to the proximal end of mouse chromosome
            13 linked to beige (bg) and identifies a new region of homology
            between mouse and human chromosomes
  JOURNAL   Genomics 9 (2), 401-403 (1991)
   PUBMED   1672300
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Drivas,G., Massey,R., Chang,H.Y., Rush,M.G. and D'Eustachio,P.
  TITLE     Ras-like genes and gene families in the mouse
  JOURNAL   Mamm Genome 1 (2), 112-117 (1991)
   PUBMED   1686838
REFERENCE   10 (residues 1 to 206)
  AUTHORS   Justice,M.J., Silan,C.M., Ceci,J.D., Buchberg,A.M., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     A molecular genetic linkage map of mouse chromosome 13 anchored by
            the beige (bg) and satin (sa) loci
  JOURNAL   Genomics 6 (2), 341-351 (1990)
   PUBMED   2307475
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT009754.11.
            
            On or before May 4, 2006 this sequence version replaced
            XP_990919.1, XP_990884.1, NP_062364.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031741.1, SRR7345562.5032854.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.05 cM"
     Protein         1..206
                     /product="ras-related protein Ral-A"
                     /EC_number="3.6.5.2"
                     /note="ral-A protein; RAS-like, family 1; v-ral simian
                     leukemia viral oncogene homolog A (ras related)"
                     /calculated_mol_wt=23422
     mat_peptide     1..203
                     /product="Ras-related protein Ral-A. /id=PRO_0000082694"
                     /note="propagated from UniProtKB/Swiss-Prot (P63321.1)"
                     /calculated_mol_wt=23223
     Region          15..177
                     /region_name="RalA_RalB"
                     /note="Ral (Ras-like) family containing highly homologous
                     RalA and RalB; cd04139"
                     /db_xref="CDD:206710"
     Site            21..28
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206710"
     Site            order(22..23,70..72,74..75,79,82,97,99,102..103,106..107,
                     110)
                     /site_type="active"
                     /note="GDI interaction site [active]"
                     /db_xref="CDD:206710"
     Site            order(23..29,39..40,46,71,127..128,130,157..158)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206710"
     Site            order(28..29,43,45,51..52,65..66,68,70..71,159)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206710"
     Site            order(36,38,47..52,56,60..61,160..163,165)
                     /site_type="active"
                     /note="effector interaction site [active]"
                     /db_xref="CDD:206710"
     Region          43..51
                     /region_name="Effector region"
                     /note="propagated from UniProtKB/Swiss-Prot (P63321.1)"
     Site            44..51
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206710"
     Site            46
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206710"
     Site            68..71
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206710"
     Site            70..88
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206710"
     Site            127..130
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206710"
     Site            order(139..140,143,147,155)
                     /site_type="active"
                     /note="alternate GDI interaction site [active]"
                     /db_xref="CDD:206710"
     Site            157..159
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206710"
     Site            194
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P11233; propagated from
                     UniProtKB/Swiss-Prot (P63321.1)"
     Site            203
                     /site_type="methylation"
                     /note="Cysteine methyl ester. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P63321.1)"
     CDS             1..206
                     /gene="Rala"
                     /gene_synonym="3010001O15Rik; Ral; Rasl1"
                     /coded_by="NM_019491.5:238..858"
                     /db_xref="CCDS:CCDS26255.1"
                     /db_xref="GeneID:56044"
                     /db_xref="MGI:MGI:1927243"
ORIGIN      
        1 maankpkgqn slalhkvimv gsggvgksal tlqfmydefv edyeptkads yrkkvvldge
       61 evqidildta gqedyaaird nyfrsgegfl cvfsitemes faatadfreq ilrvkedenv
      121 pfllvgnksd ledkrqvsve eaknradqwn vnyvetsakt ranvdkvffd lmreirarkm
      181 edskekngkk krkslakrir erccil
//
