LOCUS       NM_009020               3429 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus recombination activating gene 2 (Rag2), mRNA.
ACCESSION   NM_009020
VERSION     NM_009020.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3429)
  AUTHORS   Danielson,M., Nicolai,C.J., Vo,T.T., Wolf,N.K. and Burke,T.P.
  TITLE     Cytosolic bacterial pathogens activate TLR pathways in tumors that
            synergistically enhance STING agonist cancer therapies
  JOURNAL   iScience 27 (12), 111385 (2024)
   PUBMED   39669426
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3429)
  AUTHORS   Rao,Z., Liu,S., Li,Z., Wang,Q., Gao,F., Peng,H., Ren,D., Zang,Y.,
            Li,H., Li,Y., Hu,Q., He,D. and Xu,H.
  TITLE     Alarmin-loaded extracellular lipid droplets induce airway
            neutrophil infiltration during type 2 inflammation
  JOURNAL   Immunity 57 (11), 2514-2529 (2024)
   PUBMED   39366382
REFERENCE   3  (bases 1 to 3429)
  AUTHORS   Assendorp,N., Fossati,M., Libe-Philippot,B., Christopoulou,E.,
            Depp,M., Rapone,R., Dingli,F., Loew,D., Vanderhaeghen,P. and
            Charrier,C.
  TITLE     CTNND2 moderates the pace of synaptic maturation and links human
            evolution to synaptic neoteny
  JOURNAL   Cell Rep 43 (10), 114797 (2024)
   PUBMED   39352808
REFERENCE   4  (bases 1 to 3429)
  AUTHORS   Sati,S., Huang,J., Kersh,A.E., Jones,P., Ahart,O., Murphy,C.,
            Prouty,S.M., Hedberg,M.L., Jain,V., Gregory,S.G., Leung,D.H.,
            Seykora,J.T., Rosenbach,M. and Leung,T.H.
  TITLE     Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes
            sarcoidosis from other skin granulomatous diseases
  JOURNAL   J Clin Invest 134 (17), e178711 (2024)
   PUBMED   39225100
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3429)
  AUTHORS   Nennig,K., Murthy,S., Maloney,S., Shaw,T.M., Sharobim,M.,
            Matkovic,E., Fadiran,S., Larsen,M., Ramuta,M.D., Kim,A.S.,
            Teijaro,J.R., Grove,J., Stremlau,M., Sharma,H., Trivedi,S.,
            Blum,M.J., O'Connor,D.H., Hyde,J.L., Stapleton,J.T., Kapoor,A. and
            Bailey,A.L.
  TITLE     Determinants of pegivirus persistence, cross-species infection, and
            adaptation in the laboratory mouse
  JOURNAL   PLoS Pathog 20 (8), e1012436 (2024)
   PUBMED   39196893
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3429)
  AUTHORS   Oettinger,M.A.
  TITLE     Activation of V(D)J recombination by RAG1 and RAG2
  JOURNAL   Trends Genet 8 (12), 413-416 (1992)
   PUBMED   1492366
  REMARK    Review article
REFERENCE   7  (bases 1 to 3429)
  AUTHORS   Mombaerts,P., Iacomini,J., Johnson,R.S., Herrup,K., Tonegawa,S. and
            Papaioannou,V.E.
  TITLE     RAG-1-deficient mice have no mature B and T lymphocytes
  JOURNAL   Cell 68 (5), 869-877 (1992)
   PUBMED   1547488
REFERENCE   8  (bases 1 to 3429)
  AUTHORS   Shinkai,Y., Rathbun,G., Lam,K.P., Oltz,E.M., Stewart,V.,
            Mendelsohn,M., Charron,J., Datta,M., Young,F., Stall,A.M. et al.
  TITLE     RAG-2-deficient mice lack mature lymphocytes owing to inability to
            initiate V(D)J rearrangement
  JOURNAL   Cell 68 (5), 855-867 (1992)
   PUBMED   1547487
REFERENCE   9  (bases 1 to 3429)
  AUTHORS   Schatz,D.G., Oettinger,M.A. and Schlissel,M.S.
  TITLE     V(D)J recombination: molecular biology and regulation
  JOURNAL   Annu Rev Immunol 10, 359-383 (1992)
   PUBMED   1590991
  REMARK    Review article
REFERENCE   10 (bases 1 to 3429)
  AUTHORS   Banville,D., Rotaru,M. and Boie,Y.
  TITLE     The intracisternal A particle derived solo LTR promoter of the rat
            oncomodulin gene is not present in the mouse gene
  JOURNAL   Genetica 86 (1-3), 85-97 (1992)
   PUBMED   1468649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB654295.1 and AK040375.1.
            
            On Apr 24, 2018 this sequence version replaced NM_009020.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040375.1, AK031014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BB654295.1         1-36
            37-3429             AK040375.1         2-3394
FEATURES             Location/Qualifiers
     source          1..3429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 53.87 cM"
     gene            1..3429
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /note="recombination activating gene 2"
                     /db_xref="GeneID:19374"
                     /db_xref="MGI:MGI:97849"
     exon            1..159
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /inference="alignment:Splign:2.1.0"
     exon            160..222
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /inference="alignment:Splign:2.1.0"
     exon            223..3429
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /note="hexamer: AATAAA"
     polyA_site      2152
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
     regulatory      2902..2907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2922
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /note="major polyA site"
     regulatory      3405..3410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /note="hexamer: AATAAA"
     polyA_site      3428
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
ORIGIN      
        1 accagtgctc actggaacat ctgtaggcac acaaacactc taccctgcag ccttcagctt
       61 ggcacaaact aaacagtgac tcttccccaa gtgccgagtt taattcctgg cttggccgaa
      121 aggattcaga gagggataag cagcccctct ggccttcagt gccaaaataa gaaagagtat
      181 ttcacatcca caagcaggaa gtacacttca tacctctcta agataaaaga cctattcaca
      241 atcaaaaatg tccctgcaga tggtaacagt gggtcataac atagccttaa ttcaaccagg
      301 cttctcactt atgaattttg atggccaagt tttcttcttt ggccagaaag gctggcctaa
      361 gagatcctgt cctactggag tctttcattt tgatataaaa caaaatcatc tcaaactgaa
      421 gcctgcaatc ttctctaaag attcctgcta cctcccacct cttcgttatc cagctacttg
      481 ctcatacaaa ggcagcatag actctgacaa gcatcaatat atcattcacg gagggaaaac
      541 accaaacaat gagctttccg ataagattta tatcatgtct gtcgcttgca agaataacaa
      601 aaaagttact ttccgttgca cagagaaaga cttagtagga gatgtccctg aacccagata
      661 cggccattcc attgacgtgg tgtatagtcg agggaaaagc atgggtgttc tctttggagg
      721 acgttcatac atgccttcta cccagagaac cacagaaaaa tggaatagtg tagctgactg
      781 cctaccccat gttttcttga tagattttga atttgggtgt gctacatcat atattctccc
      841 agaacttcag gatgggctgt cttttcatgt ttctattgcc agaaacgata ccgtttatat
      901 tttgggagga cactcacttg ccagtaatat acgccctgct aacttgtata gaataagagt
      961 ggaccttccc ctgggtaccc cagcagtgaa ttgcacagtc ttgccaggag gaatctctgt
     1021 ctccagtgca atcctcactc aaacaaacaa tgatgaattt gttattgtgg gtggttatca
     1081 gctggaaaat cagaaaagga tggtctgcag ccttgtctct ctaggggaca acacgattga
     1141 aatcagtgag atggagactc ctgactggac ctcagatatt aagcatagca aaatatggtt
     1201 tggaagcaac atgggaaacg ggactatttt ccttggcata ccaggagaca ataagcaggc
     1261 tatgtcagaa gcattctatt tctatacttt gagatgctct gaagaggatt tgagtgaaga
     1321 tcagaaaatt gtctccaaca gtcagacatc aacagaagat cctggggact ccactccctt
     1381 tgaagactca gaggaatttt gtttcagtgc tgaagcaacc agttttgatg gtgacgatga
     1441 atttgacacc tacaatgaag atgatgaaga tgacgagtct gtaaccggct actggataac
     1501 atgttgccct acttgtgatg ttgacatcaa tacctgggtt ccgttctatt caacggagct
     1561 caataaaccc gccatgatct attgttctca tggggatggg cactgggtac atgcccagtg
     1621 catggatttg gaagaacgca cactcatcca cttgtcagaa ggaagcaaca agtattattg
     1681 caatgaacat gtacagatag caagagcatt gcaaactccc aaaagaaacc cccccttaca
     1741 aaaacctcca atgaaatccc tccacaaaaa aggctctggg aaagtcttga ctcctgccaa
     1801 gaaatccttc cttagaagac tgtttgatta atttagcaaa agcccctcag actcaggtat
     1861 attgctctct gaatctactt tcaatcataa acattatttt gatttttgtt tactgaaatc
     1921 tctatgttat gttttagtta tgtgaattaa gtgctgttgt gatttattgt taagtataac
     1981 tattctaatg tgtgtttttt aacatcttat ccaggaatgt cttaaatgag aaatgttata
     2041 cagttttcca ttaaggatat cagtgataaa gtatagaact cttacattat tttgtaacaa
     2101 tctacatatt gaatagtaac taaataccaa taaataaact aatgcacaaa aagttaagtt
     2161 cttttgtgta ataagtagcc tatagttggt ttaaacagtt aaaaccaaca gctatatccc
     2221 acactactgc tgtttataaa ttttaaggtg gcctctggtt tatacttatg agcagaatta
     2281 tatatattgg tcaataccat gaagaaaaat ttaattctat atcaagccag gcatggtgat
     2341 ggtgatacat gcctgtaatc ctggcactta ggaagtggaa gaaggaagtt tgtgagtttg
     2401 atgcttgttg aggtatgacc ttttgctatg tattgtagtg tatgagcccc aagacctgct
     2461 tgacccagag acaagagagt ccacacatag atccaagtaa tgctatgtga ccttgccccc
     2521 cggttacttg tgattaggtg aataaagatg tcaacagcca atagctgggc agaagagcca
     2581 aaagtgggga ttgagggtac cctggcttga tgtaggagga gaccatgagg aaaggggaga
     2641 aaaaagtgat ggaggaggag aaagatgcca tgagctagga gttaagaaag catggccatg
     2701 agtgctggcc aattggagtt aagagcagcc cagatgaaac atagtaagta ataactcagg
     2761 gttatcgata gaaaatagat tttagtgccg tactctcccc agccctagag ctgactatgg
     2821 cttactgtaa atataaagtt tgtatgtgtc ttttatccag gaactaaatg gtcaaaggtg
     2881 gagtagaaac tctggattgg gattaaattt ttctacaaca aatgctggcc tgggctagat
     2941 tttatctcat atccgaaggc tgacagaaca cagagcactg gtaacattgc cacctgccat
     3001 gcacaaagac ctgagtctaa tactgtggac attttcttga agtatctaca tgtacttctg
     3061 gagtgaaaac atattccaac aatatgcctt tgtttaaatc actcactcac tttgggccct
     3121 cacattatat cctttcaaaa tcaatggttc acccctttga aaatgcttag ccatagtccc
     3181 tcatcttcct taaagacagt tgtcatctct ggaaatagtc acatgtcatt caaggtccaa
     3241 tactgtgcag ctctgaagta tggcattacc actttaagtg aaaagtgaaa tatgaacatg
     3301 agctcagaca aaggtttggg actatcactc tcaaggaggc tctactgcta agtcctgaac
     3361 tgctttcaca tgaatacaga aattataaca aaaaatatgt aatcaataaa aagaaaactt
     3421 tcatattcc
//
