LOCUS       NM_029780               3084 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus v-raf-leukemia viral oncogene 1 (Raf1), transcript
            variant 1, mRNA.
ACCESSION   NM_029780
VERSION     NM_029780.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3084)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3084)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3084)
  AUTHORS   Liu,H., Niu,T., Qiu,G., Cui,S. and Zhang,D.
  TITLE     Taurine promotes insulin synthesis by enhancing Isl-1 expression
            through miR-7a/RAF1/ERK1/2 pathway
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (1), 23-35 (2024)
   PUBMED   38117455
  REMARK    GeneRIF: Taurine promotes insulin synthesis by enhancing Isl-1
            expression through miR-7a/RAF1/ERK1/2 pathway.
REFERENCE   4  (bases 1 to 3084)
  AUTHORS   Geng,W., Cao,M., Dong,K., An,J. and Gao,H.
  TITLE     SHOC2 mediates the drug-resistance of triple-negative breast cancer
            cells to everolimus
  JOURNAL   Cancer Biol Ther 24 (1), 2206362 (2023)
   PUBMED   37170083
  REMARK    GeneRIF: SHOC2 mediates the drug-resistance of triple-negative
            breast cancer cells to everolimus.
REFERENCE   5  (bases 1 to 3084)
  AUTHORS   Zhong,S. and Borlak,J.
  TITLE     Sex disparities in non-small cell lung cancer: mechanistic insights
            from a cRaf transgenic disease model
  JOURNAL   EBioMedicine 95, 104763 (2023)
   PUBMED   37625265
  REMARK    GeneRIF: Sex disparities in non-small cell lung cancer: mechanistic
            insights from a cRaf transgenic disease model.
REFERENCE   6  (bases 1 to 3084)
  AUTHORS   Kyriakis,J.M., App,H., Zhang,X.F., Banerjee,P., Brautigan,D.L.,
            Rapp,U.R. and Avruch,J.
  TITLE     Raf-1 activates MAP kinase-kinase
  JOURNAL   Nature 358 (6385), 417-421 (1992)
   PUBMED   1322500
REFERENCE   7  (bases 1 to 3084)
  AUTHORS   Ludwig,T., Ruther,U., Metzger,R., Copeland,N.G., Jenkins,N.A.,
            Lobel,P. and Hoflack,B.
  TITLE     Gene and pseudogene of the mouse cation-dependent mannose
            6-phosphate receptor. Genomic organization, expression, and
            chromosomal localization
  JOURNAL   J Biol Chem 267 (17), 12211-12219 (1992)
   PUBMED   1376319
REFERENCE   8  (bases 1 to 3084)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 3084)
  AUTHORS   Danciger,M., Chakraborti,A., Farber,D.B. and Kozak,C.A.
  TITLE     Localization of the gene for a third G protein beta-subunit to
            mouse chromosome 6 near Raf-1
  JOURNAL   Genomics 12 (4), 688-692 (1992)
   PUBMED   1572642
REFERENCE   10 (bases 1 to 3084)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141745.1 and BF455519.1.
            
            On Mar 12, 2018 this sequence version replaced NM_029780.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141745.1, BC056439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3066              AK141745.1         2-3067
            3067-3084           BF455519.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.62 cM"
     gene            1..3084
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /note="v-raf-leukemia viral oncogene 1"
                     /db_xref="GeneID:110157"
                     /db_xref="MGI:MGI:97847"
     exon            1..400
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            401..633
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..2373
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     murine sarcoma 3611 oncogene 1; RAF proto-oncogene
                     serine/threonine-protein kinase; proto-oncogene c-RAF;
                     Craf1 transforming"
                     /codon_start=1
                     /product="RAF proto-oncogene serine/threonine-protein
                     kinase isoform 1"
                     /protein_id="NP_084056.1"
                     /db_xref="CCDS:CCDS20441.1"
                     /db_xref="GeneID:110157"
                     /db_xref="MGI:MGI:97847"
                     /translation="MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASD
                     DGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLL
                     QEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLL
                     NGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTVGDSGVPAPPSFPMRRMR
                     ESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLHVDSRM
                     IEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRG
                     QRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRN
                     EVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIAR
                     QTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS
                     VLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYA
                     SPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS
                     LHRAAHTEDINACTLTTSPRLPVF"
     exon            634..746
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            747..849
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1007
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1106
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1260
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1288
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1416
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1534
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1619
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1796
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1843
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1962
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2094
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2229
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..3070
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3023..3028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /note="hexamer: AATAAA"
     regulatory      3033..3038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /note="hexamer: ATTAAA"
     polyA_site      3042
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
                     /note="major polyA site"
     polyA_site      3049
                     /gene="Raf1"
                     /gene_synonym="6430402F14Rik; c-Raf; cRaf; Craf1;
                     D830050J10Rik; Raf-1; v-Raf"
ORIGIN      
        1 gcggactgcc gagcccagga gctcgcgcag aggcagtgag cccggcggcg ccgcaggtcg
       61 tggagacgag tgtcgagcgc agggctagct cgcccgggat agcctgagag cgtcttcttc
      121 gcgggtgctg gtgccgccat cttggatggc gggagttaga gccgagcgga cttgaggcgg
      181 gaaggcttct ctgttgttct ccgcaggccc tcggacgggc cagctggccg agctttgggg
      241 cgcgtgccct gaggcgcggg gcgctagtgc agcgatgcgg ggcctccccg gggccccgtc
      301 ccccgggctg gggacacgcc gaatgtgacc gcaaccaacg cgttctctca accaccgctg
      361 ccgctgcacg acgggacccg gcactgcccg gctccctcag gtataagtat tgtttaaact
      421 gcatcaatgg agcacataca gggagcttgg aagacgatca gcaatggctt tggactcaaa
      481 gatgcggtgt ttgatggctc cagctgcatc tcccctacca ttgttcagca gtttggctat
      541 cagcgccggg cctcagatga tggcaagctc acggattctt ctaagacaag caatactatc
      601 cgggttttct tgccgaataa gcaaaggact gtggtcaatg tgcggaatgg aatgagctta
      661 catgactgcc ttatgaaagc tctgaaggtg agaggcctgc agccagagtg ctgtgcagtg
      721 ttcagacttc tccaggaaca caaaggtaag aaagcacgct tagattggaa caccgatgcc
      781 gcctctctga ttggagaaga actgcaagtg gattttttgg atcatgttcc actcacaact
      841 cacaactttg ctcggaaaac gttcctgaag cttgcattct gtgacatctg tcagaagttc
      901 ctgctaaatg gatttcgatg tcagacttgt ggctacaagt ttcatgagca ctgtagcacc
      961 aaagtaccta ctatgtgtgt ggactggagt aatatcagac agctcttgct gtttccaaat
     1021 tccactgttg gtgacagtgg agtcccagca ccaccttctt tcccaatgcg tcggatgcga
     1081 gaatctgttt cccggatgcc tgctagttcc cagcacagat actctacacc ccatgccttc
     1141 actttcaaca cctccagccc ttcctcagaa ggttccctgt cccagaggca gaggtcaacg
     1201 tccactccca atgtccacat ggtcagcacc accctgcatg tggacagcag gatgattgag
     1261 gatgcaattc gaagtcacag tgaatcagcc tcaccttcag ccctgtccag cagcccaaac
     1321 aacctgagtc caacaggctg gtcacagccc aaaacccctg tgccagcaca aagagagcgg
     1381 gcaccaggat ctgggaccca ggaaaaaaac aaaattaggc ctcgtgggca gagagactcg
     1441 agttattact gggaaataga agccagtgag gtgatgctgt ctactcggat cgggtcaggt
     1501 tcctttggca ctgtgtacaa gggcaagtgg catggagatg ttgcagtaaa gatcctaaag
     1561 gtggttgacc caactccaga gcaacttcag gccttcagga acgaggtggc tgttttgcgc
     1621 aaaacacggc atgttaacat cctgctgttc atggggtaca tgacaaagga caacctggcg
     1681 attgtgactc agtggtgtga aggcagcagt ctctacaaac acctgcatgt ccaggagacc
     1741 aaattccaga tgttccagct aattgacatt gcccgacaga cagctcaggg aatggactat
     1801 ttgcatgcaa agaacatcat ccacagagac atgaaatcca acaatatatt tctccatgaa
     1861 ggcctcacgg tgaaaattgg agattttggt ttggcaacag tgaagtcacg ctggagtggt
     1921 tctcagcagg ttgaacagcc cactggctct gtgctgtgga tggccccaga agtaatccgg
     1981 atgcaggatg acaacccgtt cagcttccag tccgacgtgt actcgtacgg catcgtgctg
     2041 tacgagctga tggctgggga gcttccctac gcccacatca acaaccgaga ccagatcatc
     2101 ttcatggtag gccgtgggta tgcatcccct gatctcagca ggctctacaa gaactgcccc
     2161 aaggcaatga agaggttggt ggctgactgt gtgaagaaag tcaaagaaga gagacctttg
     2221 tttccccaga tcctgtcttc catcgagctg cttcagcact ctctgccgaa aatcaacagg
     2281 agcgcctctg agccttccct gcatcgggca gctcacactg aggacatcaa tgcttgcacg
     2341 ctgactacat ccccaaggct accagtcttc tagctgatga tgtagctgtt cttaggccac
     2401 caggggacga agaagagtca gcaggcacca ctttctgttt ccttgggggc agaatgcatg
     2461 tttttggaaa agctgctgct gctaaggacc tagactactc acagggcctt aacttcatat
     2521 tgccttcttt tctacccctc ctgccctgga aatggaagct gtccaccaag aaagcctgct
     2581 cagctccaga ggtatacaag tcagctgagt atttgtaggg caagtggcct tggagaaggt
     2641 agggcactcc ggctgctgca gggacatgca attgggaact tggctccttg agcctatatg
     2701 gacagtggtg cagtgccagt tttgcacatg gagtcctggc cacctggggg agcctgcttt
     2761 ggtactacag aactttgtgg acaaactgtg tctaaggtgt cctgtgtgga tggctttcca
     2821 agcgcggtgc tccacctttg gcagcctccc acgtgctgaa tctgtcttcc aggagctgcc
     2881 cctatggggt gggccgcggc ccaaccctat ctgtagccac atccttgtct gtaagaaagc
     2941 caggaataca ggttttctta atgattttgg gttttaattt tgtttttatt gagccaatac
     3001 agttggttcc ttatgttatt ttaataaaat aaattaaatt taggtttaat ggctactgac
     3061 tccttcaaaa aaaaaaaaaa aaaa
//
