LOCUS       NM_198193               1298 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus retinoic acid early transcript 1E (Raet1e), transcript
            variant 3, mRNA.
ACCESSION   NM_198193 XM_001005623
VERSION     NM_198193.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1298)
  AUTHORS   Trembath,A.P., Krausz,K.L., Sharma,N., Gerling,I.C., Mathews,C.E.
            and Markiewicz,M.A.
  TITLE     NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes
            and Increases Protective Central Memory CD8+ T-Cell Numbers
  JOURNAL   Diabetes 69 (8), 1749-1762 (2020)
   PUBMED   32535552
  REMARK    Erratum:[Diabetes. 2021 Sep;70(9):2159. doi: 10.2337/db21-er09a..
            PMID: 34244240]
REFERENCE   2  (bases 1 to 1298)
  AUTHORS   Thompson,T.W., Kim,A.B., Li,P.J., Wang,J., Jackson,B.T.,
            Huang,K.T.H., Zhang,L. and Raulet,D.H.
  TITLE     Endothelial cells express NKG2D ligands and desensitize antitumor
            NK responses
  JOURNAL   Elife 6, e30881 (2017)
   PUBMED   29231815
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1298)
  AUTHORS   Manils,J., Casas,E., Vina-Vilaseca,A., Lopez-Cano,M.,
            Diez-Villanueva,A., Gomez,D., Marruecos,L., Ferran,M., Benito,C.,
            Perrino,F.W., Vavouri,T., de Anta,J.M., Ciruela,F. and Soler,C.
  TITLE     The Exonuclease Trex2 Shapes Psoriatic Phenotype
  JOURNAL   J Invest Dermatol 136 (12), 2345-2355 (2016)
   PUBMED   27365293
REFERENCE   4  (bases 1 to 1298)
  AUTHORS   Djelloul,M., Popa,N., Pelletier,F., Raguenez,G. and Boucraut,J.
  TITLE     RAE-1 expression is induced during experimental autoimmune
            encephalomyelitis and is correlated with microglia cell
            proliferation
  JOURNAL   Brain Behav Immun 58, 209-217 (2016)
   PUBMED   27444966
  REMARK    GeneRIF: Study reports that retinoic acid early induced
            transcript-1-d and retinoic acid early induced transcript-1-e
            (Raet1) genes are induced early upon experimental autoimmune
            encephalomyelitis onset and reach a maximal expression at the peak
            of the pathology. Study also shows that macrophages as well as
            microglia, are cellular sources of Raet1 transcripts.
REFERENCE   5  (bases 1 to 1298)
  AUTHORS   Deng,W., Gowen,B.G., Zhang,L., Wang,L., Lau,S., Iannello,A., Xu,J.,
            Rovis,T.L., Xiong,N. and Raulet,D.H.
  TITLE     Antitumor immunity. A shed NKG2D ligand that promotes natural
            killer cell activation and tumor rejection
  JOURNAL   Science 348 (6230), 136-139 (2015)
   PUBMED   25745066
REFERENCE   6  (bases 1 to 1298)
  AUTHORS   Oppenheim,D.E., Roberts,S.J., Clarke,S.L., Filler,R., Lewis,J.M.,
            Tigelaar,R.E., Girardi,M. and Hayday,A.C.
  TITLE     Sustained localized expression of ligand for the activating NKG2D
            receptor impairs natural cytotoxicity in vivo and reduces tumor
            immunosurveillance
  JOURNAL   Nat Immunol 6 (9), 928-937 (2005)
   PUBMED   16116470
REFERENCE   7  (bases 1 to 1298)
  AUTHORS   Xie,X., He,H., Colonna,M., Seya,T., Takai,T. and Croy,B.A.
  TITLE     Pathways participating in activation of mouse uterine natural
            killer cells during pregnancy
  JOURNAL   Biol Reprod 73 (3), 510-518 (2005)
   PUBMED   15878887
REFERENCE   8  (bases 1 to 1298)
  AUTHORS   Hamerman,J.A., Ogasawara,K. and Lanier,L.L.
  TITLE     Cutting edge: Toll-like receptor signaling in macrophages induces
            ligands for the NKG2D receptor
  JOURNAL   J Immunol 172 (4), 2001-2005 (2004)
   PUBMED   14764662
REFERENCE   9  (bases 1 to 1298)
  AUTHORS   Lodoen,M., Ogasawara,K., Hamerman,J.A., Arase,H., Houchins,J.P.,
            Mocarski,E.S. and Lanier,L.L.
  TITLE     NKG2D-mediated natural killer cell protection against
            cytomegalovirus is impaired by viral gp40 modulation of retinoic
            acid early inducible 1 gene molecules
  JOURNAL   J Exp Med 197 (10), 1245-1253 (2003)
   PUBMED   12756263
REFERENCE   10 (bases 1 to 1298)
  AUTHORS   Girardi,M., Oppenheim,D.E., Steele,C.R., Lewis,J.M., Glusac,E.,
            Filler,R., Hobby,P., Sutton,B., Tigelaar,R.E. and Hayday,A.C.
  TITLE     Regulation of cutaneous malignancy by gammadelta T cells
  JOURNAL   Science 294 (5542), 605-609 (2001)
   PUBMED   11567106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV561218.1, FJ594067.1 and AK012289.1.
            
            On Jan 18, 2018 this sequence version replaced NM_198193.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012289.1, BY711449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-756               CV561218.1         1-756
            757-1124            FJ594067.1         837-1204
            1125-1298           AK012289.1         1101-1274
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.89 cM"
     gene            1..1298
                     /gene="Raet1e"
                     /note="retinoic acid early transcript 1E"
                     /db_xref="GeneID:379043"
                     /db_xref="MGI:MGI:2675273"
     exon            1..40
                     /gene="Raet1e"
                     /inference="alignment:Splign:2.1.0"
     exon            41..131
                     /gene="Raet1e"
                     /inference="alignment:Splign:2.1.0"
     exon            132..249
                     /gene="Raet1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..914
                     /gene="Raet1e"
                     /note="retinoic acid early-inducible protein 1-epsilon;
                     Rae-1 epsilon"
                     /codon_start=1
                     /product="retinoic acid early-inducible protein 1-epsilon
                     precursor"
                     /protein_id="NP_937836.1"
                     /db_xref="CCDS:CCDS35865.1"
                     /db_xref="GeneID:379043"
                     /db_xref="MGI:MGI:2675273"
                     /translation="MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDP
                     TSADLPWCDVKCSVDEITILHLNNINKTMTSGDPGKMANATGKCLTQPLNDLCQELRD
                     KVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSA
                     NDESGVIMNKWKDDGDLVQQLKYFIPQCRQKIDEFLKQSKEKPRSTSRSPSITQLTST
                     SPLPPPSHSTSKKGFISVGLIFISLLFAFAFAM"
     exon            250..504
                     /gene="Raet1e"
                     /inference="alignment:Splign:2.1.0"
     exon            505..768
                     /gene="Raet1e"
                     /inference="alignment:Splign:2.1.0"
     exon            769..938
                     /gene="Raet1e"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1298
                     /gene="Raet1e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggaagag gggtggcggt gagcagagct attgcggagg atttcagagg ctgcagttca
       61 agacaccaac ttttttcttt cttcaccttt cctgacacta ttgccaatag tccctgaggg
      121 cgcagctgtt gccacagtca catctgtcag aagaaaccat ggccaaggca gcagtgacca
      181 agcgccatca ttttatgatt cagaagctgt taattctact gagctatgga tacaccaacg
      241 ggctggatga tgcacactct cttaggtgca acttgaccat caaggatcct acctcagcag
      301 accttccctg gtgtgacgtg aagtgctcag tggatgaaat aactatcctc catttaaata
      361 acataaacaa gaccatgact tcaggtgacc cagggaagat ggcaaatgcc actggcaaat
      421 gtttgacaca acctctgaac gatttgtgcc aggagttgag ggacaaggtg tctaacacca
      481 aagtggacac tcacaagacc aatggttacc cacatttaca agtcaccatg atttatccgc
      541 aaagccaggg ccaaactcct agtgccacct gggaattcaa catcagtgac agttacttct
      601 tcaccttcta cacagagaat atgagctgga gatcagctaa tgatgaatca ggggttatca
      661 tgaataaatg gaaagatgat ggggaccttg tgcaacaatt gaaatacttc ataccccaat
      721 gcagacagaa aattgatgaa ttcttaaagc agtccaagga aaagccaaga tcaacctcaa
      781 ggtcccccag tatcacccag cttacatcaa cttccccgct tccacctccc agccactcta
      841 cttctaagaa aggatttatc tctgtgggac tcatcttcat atctttatta tttgcatttg
      901 catttgcgat gtgaagagga aatattatac ccaaggagag gccagaggag ggcatcggat
      961 cctgtggaac tggagttaca gttggtttcc aatactggga actgaatcca ggacctctcc
     1021 aagaacagca agtgctcttt gctactgagc cttatctccc tcctctaata catttcttaa
     1081 taagagaata tactctgaat attattaaac ccagggcaag tcccacagta aggttcacaa
     1141 taaagtttat tgtttcagaa tcaaaaagga aaacacattt taaaatgact gtcatggcca
     1201 gttatcacat cgtttgtagc aatgtatgat tgaggacgtc caggtccatc taaaaaaatg
     1261 ccaggcaata cagcaacatc taataaaact ggtaaatt
//
