LOCUS       NM_020030               1287 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus retinoic acid early transcript delta (Raet1d), mRNA.
ACCESSION   NM_020030 XM_001006085
VERSION     NM_020030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1287)
  AUTHORS   Thompson,T.W., Jackson,B.T., Li,P.J., Wang,J., Kim,A.B.,
            Huang,K.T.H., Zhang,L. and Raulet,D.H.
  TITLE     Tumor-derived CSF-1 induces the NKG2D ligand RAE-1delta on
            tumor-infiltrating macrophages
  JOURNAL   Elife 7, e32919 (2018)
   PUBMED   29757143
  REMARK    GeneRIF: The authors find that a soluble factor produced by tumor
            cells is responsible for macrophage RAE-1delta induction, and they
            identify tumor-derived colony-stimulating factor-1 (CSF-1) as
            necessary and sufficient for macrophage RAE-1delta induction in
            vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1287)
  AUTHORS   Thompson,T.W., Kim,A.B., Li,P.J., Wang,J., Jackson,B.T.,
            Huang,K.T.H., Zhang,L. and Raulet,D.H.
  TITLE     Endothelial cells express NKG2D ligands and desensitize antitumor
            NK responses
  JOURNAL   Elife 6, e30881 (2017)
   PUBMED   29231815
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1287)
  AUTHORS   Djelloul,M., Popa,N., Pelletier,F., Raguenez,G. and Boucraut,J.
  TITLE     RAE-1 expression is induced during experimental autoimmune
            encephalomyelitis and is correlated with microglia cell
            proliferation
  JOURNAL   Brain Behav Immun 58, 209-217 (2016)
   PUBMED   27444966
  REMARK    GeneRIF: Study reports that retinoic acid early induced
            transcript-1-d and retinoic acid early induced transcript-1-e
            (Raet1) genes are induced early upon experimental autoimmune
            encephalomyelitis onset and reach a maximal expression at the peak
            of the pathology. Study also shows that macrophages as well as
            microglia, are cellular sources of Raet1 transcripts.
REFERENCE   4  (bases 1 to 1287)
  AUTHORS   Deng,W., Gowen,B.G., Zhang,L., Wang,L., Lau,S., Iannello,A., Xu,J.,
            Rovis,T.L., Xiong,N. and Raulet,D.H.
  TITLE     Antitumor immunity. A shed NKG2D ligand that promotes natural
            killer cell activation and tumor rejection
  JOURNAL   Science 348 (6230), 136-139 (2015)
   PUBMED   25745066
REFERENCE   5  (bases 1 to 1287)
  AUTHORS   Cedile,O., Popa,N., Pollet-Villard,F., Garmy,N., Ibrahim,E.C. and
            Boucraut,J.
  TITLE     The NKG2D ligands RAE-1delta and RAE-1epsilon differ with respect
            to their receptor affinity, expression profiles and transcriptional
            regulation
  JOURNAL   PLoS One 5 (10), e13466 (2010)
   PUBMED   20976056
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1287)
  AUTHORS   Samarakoon,A., Chu,H. and Malarkannan,S.
  TITLE     Murine NKG2D ligands: 'double, double toil and trouble'
  JOURNAL   Mol Immunol 46 (6), 1011-1019 (2009)
   PUBMED   19081632
  REMARK    Review article
REFERENCE   7  (bases 1 to 1287)
  AUTHORS   Xie,X., He,H., Colonna,M., Seya,T., Takai,T. and Croy,B.A.
  TITLE     Pathways participating in activation of mouse uterine natural
            killer cells during pregnancy
  JOURNAL   Biol Reprod 73 (3), 510-518 (2005)
   PUBMED   15878887
REFERENCE   8  (bases 1 to 1287)
  AUTHORS   Hamerman,J.A., Ogasawara,K. and Lanier,L.L.
  TITLE     Cutting edge: Toll-like receptor signaling in macrophages induces
            ligands for the NKG2D receptor
  JOURNAL   J Immunol 172 (4), 2001-2005 (2004)
   PUBMED   14764662
REFERENCE   9  (bases 1 to 1287)
  AUTHORS   Lodoen,M., Ogasawara,K., Hamerman,J.A., Arase,H., Houchins,J.P.,
            Mocarski,E.S. and Lanier,L.L.
  TITLE     NKG2D-mediated natural killer cell protection against
            cytomegalovirus is impaired by viral gp40 modulation of retinoic
            acid early inducible 1 gene molecules
  JOURNAL   J Exp Med 197 (10), 1245-1253 (2003)
   PUBMED   12756263
REFERENCE   10 (bases 1 to 1287)
  AUTHORS   Cerwenka,A., Bakker,A.B., McClanahan,T., Wagner,J., Wu,J.,
            Phillips,J.H. and Lanier,L.L.
  TITLE     Retinoic acid early inducible genes define a ligand family for the
            activating NKG2D receptor in mice
  JOURNAL   Immunity 12 (6), 721-727 (2000)
   PUBMED   10894171
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC106190.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_020030.3.
            
            On Jul 23, 2006 this sequence version replaced NM_020030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106190.1, SRR11927934.375667.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 10.02 cM"
     gene            1..1287
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /note="retinoic acid early transcript delta"
                     /db_xref="GeneID:56554"
                     /db_xref="MGI:MGI:1861032"
     exon            1..16
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /inference="alignment:Splign:2.1.0"
     exon            17..107
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /inference="alignment:Splign:2.1.0"
     exon            108..225
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..884
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /note="retinoic acid early-inducible protein 1-delta;
                     retinoic acid early transcript 1D; RAE-1-delta"
                     /codon_start=1
                     /product="retinoic acid early-inducible protein 1-delta
                     precursor"
                     /protein_id="NP_064414.1"
                     /db_xref="CCDS:CCDS35866.1"
                     /db_xref="GeneID:56554"
                     /db_xref="MGI:MGI:1861032"
                     /translation="MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKAP
                     TPADEVKCFVGEILILHLSNINKTMTSGDPGETANATEVGECLTQPLKDLCQKLRDKV
                     SNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTEIMSWRSAND
                     ESGVIMNKWKDDGEFVKQLKFLIHGCSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSP
                     LPPTSHSTSKKGFISVGLIFISLLFAFAFAM"
     exon            226..474
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /inference="alignment:Splign:2.1.0"
     exon            475..738
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /inference="alignment:Splign:2.1.0"
     exon            739..908
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1271
                     /gene="Raet1d"
                     /gene_synonym="RAE-1delta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagaggg gtggcgattt cagaggctgc agttcaagac accaactttt ttctttcttc
       61 acctttcctg acactattgc caatagtccc tgagggccca gctgttgcca cagtcacatc
      121 tgtcagaaga aaccatggcc aaggcagcag tgaccaagcg ccatcatttt atgattcaga
      181 agctgttaat tctactgagc tatggataca ccaacgggct agatgatgca cactctctta
      241 ggtgcaactt gaccatcaag gctcctaccc cagcagatga agtgaagtgc ttcgtgggtg
      301 aaatacttat cctccattta agtaacataa acaagaccat gacttcaggt gacccagggg
      361 agacagcaaa tgccactgaa gtgggggaat gtttaacaca acctctgaaa gatttgtgcc
      421 agaagttgag ggacaaggtg tctaacacca aagtggacac tcacaagacc aatggttacc
      481 cacatttaca agtcaccatg atttatccgc aaagccaggg ccaaactcct agtgccacct
      541 gggaattcaa catcagtgac agttacttct tcaccttcta cacagagatt atgagctgga
      601 gatcagctaa tgatgaatca ggggttatca tgaataaatg gaaagatgat ggggaatttg
      661 tgaaacaatt gaaattcttg atacacggat gcagtcagaa aatggatgaa ttcttaaagc
      721 agtccaagga aaagccaaga tcaacctcaa ggtcccccag tatcacccag cttacatcaa
      781 cttccccgct tccacctacc agccactcta cttctaagaa aggatttatc tctgtgggac
      841 tcatcttcat atctttatta tttgcatttg catttgcaat gtgaagagga aatattatac
      901 ccaaggagag gccagaggag ggcatcggat cctgtggaac tggagttaca gttggtttcc
      961 aatactggga actgaatcca ggacctctcc aagaacagca agtgctcttt gctactgagc
     1021 cttatctccc tcctctaata catttcttaa taaaagaata tagtttgaat attattaaac
     1081 ccagggcaag tcccacagta agcttcacaa taaagttgat tgtttcagaa tcaaaaagga
     1141 aaacacattt taaaatgact gtcatggcca gttatcacat cgtttgtagc aatgtatgat
     1201 ggaggacgtc caggtccgtc taaaaaaatg ccaggcaata cagcaacatc taataaaact
     1261 ggtaaattta aaaaaaaaaa aaaaaaa
//
