LOCUS       NM_175112               1755 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ribonucleic acid export 1 (Rae1), mRNA.
ACCESSION   NM_175112
VERSION     NM_175112.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Dong,W., Li,X., Cheng,L., Yang,J., Zhao,Z., Qiang,X., Li,P., Wu,J.
            and Guo,L.
  TITLE     RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal
            transition
  JOURNAL   Arch Biochem Biophys 754, 109896 (2024)
   PUBMED   38417691
  REMARK    GeneRIF: RAE1 promotes gastric carcinogenesis and
            epithelial-mesenchymal transition.
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Chen,F., Jiao,X.F., Meng,F., Wang,Y.S., Ding,Z.M., Miao,Y.L.,
            Xiong,J.J. and Huo,L.J.
  TITLE     Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That
            Participates in Chromosome Alignment in Mouse Oocytes
  JOURNAL   Int J Mol Sci 22 (9), 4841 (2021)
   PUBMED   34063622
  REMARK    GeneRIF: Ribonucleic Acid Export 1 Is a Kinetochore-Associated
            Protein That Participates in Chromosome Alignment in Mouse Oocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Zheng,X., Zhao,X., Zhang,Y., Tan,H., Qiu,B., Ma,T., Zeng,J.,
            Tao,D., Liu,Y., Lu,Y. and Ma,Y.
  TITLE     RAE1 promotes BMAL1 shuttling and regulates degradation and
            activity of CLOCK: BMAL1 heterodimer
  JOURNAL   Cell Death Dis 10 (2), 62 (2019)
   PUBMED   30683868
  REMARK    GeneRIF: RAE1 and NUP98 participate inBMAL1 shuttling and promote
            the degradation and activity of BMAL1 and CLOCK.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Qian,L., Liu,Y., Wang,S., Gong,W., Jia,X., Liu,L., Ye,F., Ding,J.,
            Xu,Y., Fu,Y. and Tian,F.
  TITLE     NKG2D ligand RAE1epsilon induces generation and enhances the
            inhibitor function of myeloid-derived suppressor cells in mice
  JOURNAL   J Cell Mol Med 21 (9), 2046-2054 (2017)
   PUBMED   28276625
  REMARK    GeneRIF: surface NKG2D ligand RAE1epsilon on tumour cells induces
            CD11b(+) Gr-1(+) myeloid-derived suppressor cell (MDSC) via NKG2D
            in vitro and in vivo.
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Faria,P.A., Chakraborty,P., Levay,A., Barber,G.N., Ezelle,H.J.,
            Enninga,J., Arana,C., van Deursen,J. and Fontoura,B.M.
  TITLE     VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway
  JOURNAL   Mol Cell 17 (1), 93-102 (2005)
   PUBMED   15629720
  REMARK    GeneRIF: VSV M protein blocks mRNA export by disrupting Rae1
            function, which can be reverted by induction of Rae1 expression.
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Babu,J.R., Jeganathan,K.B., Baker,D.J., Wu,X., Kang-Decker,N. and
            van Deursen,J.M.
  TITLE     Rae1 is an essential mitotic checkpoint regulator that cooperates
            with Bub3 to prevent chromosome missegregation
  JOURNAL   J Cell Biol 160 (3), 341-353 (2003)
   PUBMED   12551952
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   Girardi,M., Oppenheim,D.E., Steele,C.R., Lewis,J.M., Glusac,E.,
            Filler,R., Hobby,P., Sutton,B., Tigelaar,R.E. and Hayday,A.C.
  TITLE     Regulation of cutaneous malignancy by gammadelta T cells
  JOURNAL   Science 294 (5542), 605-609 (2001)
   PUBMED   11567106
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Wang,X., Babu,J.R., Harden,J.M., Jablonski,S.A., Gazi,M.H.,
            Lingle,W.L., de Groen,P.C., Yen,T.J. and van Deursen,J.M.
  TITLE     The mitotic checkpoint protein hBUB3 and the mRNA export factor
            hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing
            proteins
  JOURNAL   J Biol Chem 276 (28), 26559-26567 (2001)
   PUBMED   11352911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928599.5, BC059051.1 and CO041965.1.
            
            On Mar 18, 2011 this sequence version replaced NM_175112.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079383.1, BC059051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AL928599.5         18864-18941
            79-1681             BC059051.1         1-1603
            1682-1755           CO041965.1         1-74                c
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.66 cM"
     gene            1..1755
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /note="ribonucleic acid export 1"
                     /db_xref="GeneID:66679"
                     /db_xref="MGI:MGI:1913929"
     exon            1..260
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            261..355
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1372
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /note="rae1 protein homolog; mRNA-associated protein mrnp
                     41; RAE1 RNA export 1 homolog"
                     /codon_start=1
                     /product="mRNA export factor"
                     /protein_id="NP_780321.1"
                     /db_xref="CCDS:CCDS17138.1"
                     /db_xref="GeneID:66679"
                     /db_xref="MGI:MGI:1913929"
                     /translation="MSLFGSTSGFGTGGTSMFGSTTTDNHNPMKDIEVTSSPDDSIGC
                     LSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVF
                     TASCDKTAKMWDLNSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRS
                     SNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCV
                     AIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAV
                     NGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPIAACCFNHNGNIFAYAS
                     SYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK"
     exon            356..460
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            461..553
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            554..640
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            641..727
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            728..799
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            800..907
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1014
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1090
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1285
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1742
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /note="hexamer: AATAAA"
     polyA_site      1683
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
                     /note="major polyA site"
     polyA_site      1742
                     /gene="Rae1"
                     /gene_synonym="3230401I12Rik; D2Ertd342e; MNRP; MNRP41"
ORIGIN      
        1 ggcagtcccg gaagtggctc gtggcgcgtg cgcggtgctt ctgtggtaac ggggcagttt
       61 ccaccggctt gaggcggacg actcggcggt ctggggtctc ccggctgcgc cccctctgcc
      121 ccgcgccaga gcaggtccgt ggcttcgggc cccgccgcgt gcgtgttcct caggcggccg
      181 ccgcgctccc tccgggaagc ccgggcccgc gtgaggagac cgagcccctc tctgcagccg
      241 gaccccgtgc gctccgctag ccaacatgag tctgtttgga tcaacctctg gatttgggac
      301 tggtgggacc agcatgtttg ggagcacaac cacagataac cacaatccaa tgaaggatat
      361 cgaagtgaca tcttctcctg atgacagcat cggttgtctg tctttcagcc cgccaacttt
      421 accaggcaac ttccttattg caggatcatg ggcgaatgat gttcgctgct gggaagtgca
      481 ggacagtggg caaaccattc caaaggccca gcagatgcac acggggccag tgcttgacgt
      541 ctgctggagt gatgatggga gcaaagtatt cacagcatcg tgtgacaaga cagccaagat
      601 gtgggacctg aacagcaacc aggccattca gatagcacag catgatgctc ctgttaagac
      661 catacattgg atcaaagccc caaactacag ctgtgtgatg accgggagct gggataagac
      721 tctgaagttc tgggatacgc ggtcctcaaa tcctatgatg gtcttgcaac tccctgaacg
      781 ctgttactgt gcagatgtga tatacccgat ggctgtggta gccactgcag agaggggcct
      841 gattgtctat cagctggaga accagccctc tgagttcagg agaatcgagt ctcccctgaa
      901 gcaccagcat cggtgtgtgg ctatttttaa agacaaacag aacaagccga ctgggtttgc
      961 tctgggcagc attgagggga gagttgccat tcactacatc aaccctccaa atccggccaa
     1021 agataacttc accttcaaat gccatcgatc caacggtacc aacacttcgg ctcctcaaga
     1081 catctatgca gtgaatggga ttgccttcca tcctgtccat ggtacccttg ccactgtggg
     1141 ctccgatggt aggttcagct tctgggacaa agatgccagg accaaactaa agacttcgga
     1201 acagttagat cagcccatcg cagcttgctg cttcaatcac aatggaaaca tatttgccta
     1261 tgcttccagc tacgactggt ccaagggaca tgagttttat aatccccaaa agaaaaatta
     1321 cattttcttg cgtaatgcag ctgaagagct aaagccaagg aataagaaat agtggcctga
     1381 agctgggact gttggagttt catctcctct ctgcccaaac ttgggctcaa gccctcggtg
     1441 gcccacagcc ctggccatgg gtgtccactc ctggagggac tgttcttgtt gagcatcagc
     1501 acagcatcct ggcgacttgc cgtctctcca ttcagctccc tgctgcggtt ttcctgaaac
     1561 tgagattctc aactggagtc agatcttggg ggcactgtgt ccagcagtgt gtatttgaca
     1621 gtgttgggtg ggaactgttg gtgagccctg tgttgtgttt tataataaaa tattttgaag
     1681 atggcctgcc ccttcatccc tttccccaac tcctcaggaa atagccatca atctcagaat
     1741 aaaaaaaaaa aaaaa
//
