LOCUS       NP_001369782             422 aa            linear   ROD 01-JUN-2024
DEFINITION  cell cycle checkpoint control protein RAD9B isoform 2 [Mus
            musculus].
ACCESSION   NP_001369782 XP_006530370
VERSION     NP_001369782.1
DBSOURCE    REFSEQ: accession NM_001382853.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Broustas,C.G., Zhu,A. and Lieberman,H.B.
  TITLE     Rad9 protein contributes to prostate tumor progression by promoting
            cell migration and anoikis resistance
  JOURNAL   J Biol Chem 287 (49), 41324-41333 (2012)
   PUBMED   23066031
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Leloup,C., Hopkins,K.M., Wang,X., Zhu,A., Wolgemuth,D.J. and
            Lieberman,H.B.
  TITLE     Mouse Rad9b is essential for embryonic development and promotes
            resistance to DNA damage
  JOURNAL   Dev Dyn 239 (11), 2837-2850 (2010)
   PUBMED   20842695
  REMARK    GeneRIF: Fndings thus indicate that Mrad9b is essential for
            embryonic development and mediates resistance to certain DNA
            damaging agents.
REFERENCE   4  (residues 1 to 422)
  AUTHORS   He,W., Zhao,Y., Zhang,C., An,L., Hu,Z., Liu,Y., Han,L., Bi,L.,
            Xie,Z., Xue,P., Yang,F. and Hang,H.
  TITLE     Rad9 plays an important role in DNA mismatch repair through
            physical interaction with MLH1
  JOURNAL   Nucleic Acids Res 36 (20), 6406-6417 (2008)
   PUBMED   18842633
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Dufault,V.M., Oestreich,A.J., Vroman,B.T. and Karnitz,L.M.
  TITLE     Identification and characterization of RAD9B, a paralog of the RAD9
            checkpoint gene
  JOURNAL   Genomics 82 (6), 644-651 (2003)
   PUBMED   14611806
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Hopkins,K.M., Wang,X., Berlin,A., Hang,H., Thaker,H.M. and
            Lieberman,H.B.
  TITLE     Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint
            control genes in normal and cancerous testicular tissue
  JOURNAL   Cancer Res 63 (17), 5291-5298 (2003)
   PUBMED   14500360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113285.9 and AC093473.6.
            
            On May 27, 2020 this sequence version replaced XP_006530370.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.131629.1,
                                           SRR7345562.1601754.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.3 cM"
     Protein         1..422
                     /product="cell cycle checkpoint control protein RAD9B
                     isoform 2"
                     /EC_number="3.1.11.2"
                     /note="cell cycle checkpoint control protein RAD9B
                     homolog; mRAD9B; DNA repair exonuclease rad9 homolog B;
                     RAD9 homolog B"
                     /calculated_mol_wt=46635
     mat_peptide     1..403
                     /product="Cell cycle checkpoint control protein RAD9B.
                     /id=PRO_0000226700"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6WBX7.1)"
                     /calculated_mol_wt=44852
     Region          14..271
                     /region_name="Rad9"
                     /note="pfam04139"
                     /db_xref="CDD:427739"
     Region          285..347
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6WBX7.1)"
     Site            354
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6WBX7.1)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6WBX7.1)"
     CDS             1..422
                     /gene="Rad9b"
                     /gene_synonym="A630082N15Rik"
                     /coded_by="NM_001382853.1:31..1299"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:231724"
                     /db_xref="MGI:MGI:2385231"
ORIGIN      
        1 mlkcgmtggq vkvfgkavqt lsrvsdelwl dpsekglalr svnschstyg yvlfssmffq
       61 hyqwspfatm sdtdlplnln cklaiksvlp ifrclnyler svekctvvar adkcrvviqf
      121 fgkhgikrth nvyfqdsqpl kiifekslca nilmikprll teaialltsn qeevtfsvtp
      181 gnfclkslsg elldltssvy semsfgpeef dffqvgldte itfcfkelkg iltfsevmha
      241 plaiyfdfpg kpvvlsvedm lleanfilat lvdypsrtss pqllplsqar rshpiqssap
      301 edksrvsqtp esisraapkr lfpkdspdss saaetkrasa gqddifevpe svvsdmeeer
      361 spshlrkfsc mffgavsceq qeyaghplds lavasdseed psaalvpvrs avggrkhavk
      421 sv
//
